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Conserved domains on  [gi|19882256|ref|NP_001891|]
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cystatin-D precursor [Homo sapiens]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 29-139 1.09e-36

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 121.38  E-value: 1.09e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882256     29 TLAGGIHATDLNDKSVQCALDFAISEYNKVINkDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFN 108
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSN-DKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFL 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 19882256    109 DQPklkeEEFCSFQINEVPWEDKISILNYKC 139
Cdd:smart00043  80 DQG----EKFCTAKVWEKPWENKIKLVEFKC 106
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 29-139 1.09e-36

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 121.38  E-value: 1.09e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882256     29 TLAGGIHATDLNDKSVQCALDFAISEYNKVINkDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFN 108
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSN-DKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFL 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 19882256    109 DQPklkeEEFCSFQINEVPWEDKISILNYKC 139
Cdd:smart00043  80 DQG----EKFCTAKVWEKPWENKIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 32-139 1.49e-32

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 111.03  E-value: 1.49e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882256  32 GGIHATDLNDKSVQCALDFAISEYNKVINKDeyYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDnCPFNDQP 111
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDK--YLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLL 77

                        90       100
                ....*....|....*....|....*...
gi 19882256 112 KLKEEEFCSFQINEVPWEDKISILNYKC 139
Cdd:cd00042  78 EEGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 32-128 2.66e-32

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 109.73  E-value: 2.66e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882256    32 GGIHATDLNDKSVQCALDFAISEYNKviNKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQp 111
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNA--KTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDE- 77

                          90
                  ....*....|....*..
gi 19882256   112 klKEEEFCSFQINEVPW 128
Cdd:pfam00031  78 --KWLGLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 29-139 1.09e-36

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 121.38  E-value: 1.09e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882256     29 TLAGGIHATDLNDKSVQCALDFAISEYNKVINkDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFN 108
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSN-DKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFL 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 19882256    109 DQPklkeEEFCSFQINEVPWEDKISILNYKC 139
Cdd:smart00043  80 DQG----EKFCTAKVWEKPWENKIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 32-139 1.49e-32

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 111.03  E-value: 1.49e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882256  32 GGIHATDLNDKSVQCALDFAISEYNKVINKDeyYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDnCPFNDQP 111
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDK--YLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLL 77

                        90       100
                ....*....|....*....|....*...
gi 19882256 112 KLKEEEFCSFQINEVPWEDKISILNYKC 139
Cdd:cd00042  78 EEGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 32-128 2.66e-32

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 109.73  E-value: 2.66e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19882256    32 GGIHATDLNDKSVQCALDFAISEYNKviNKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQp 111
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNA--KTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDE- 77

                          90
                  ....*....|....*..
gi 19882256   112 klKEEEFCSFQINEVPW 128
Cdd:pfam00031  78 --KWLGLCSAQVYKVPW 92
SQAPI pfam16845
Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, ...
 38-84 7.19e-03

Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, inhibits a wide range of aspartic proteinases. This particular family of PAAPIs (proteinaceous aspartic acid inhibitors) seems to have evolved quite recently from an ancestral cystatin. Structurally it consists of a four-stranded anti-parallel beta-sheet gripping an alpha-helix in much the same manner that a hand grips a tennis racket. The unstructured N-terminus and the loop connecting beta-strands 1 and 2 are important for pepsin inhibition, but the loop connecting strands 3 and 4 is not.


Pssm-ID: 407092  Cd Length: 83  Bit Score: 33.55  E-value: 7.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 19882256    38 DLNDKSVQCALDFAISEYNKVINKDEYYSRplqVMAAYQQIVGGVNY 84
Cdd:pfam16845   3 DVSDPHVVEIAKFAVSEHNKQSKANLVFVK---VVKGETQVVSGTNY 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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