NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4502993|ref|NP_001858|]
View 

cytochrome c oxidase subunit 7C, mitochondrial precursor [Homo sapiens]

Protein Classification

Cyt_c_Oxidase_VIIc domain-containing protein( domain architecture ID 10097118)

Cyt_c_Oxidase_VIIc domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cyt_c_Oxidase_VIIc cd00929
Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 17-62 7.13e-24

Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIc subunit is found only in eukaryotes and its specific function remains unclear. Peroxide inactivation of bovine CcO coincides with the direct oxidation of tryptophan (W19) within subunit VIIc, along with other structural changes in other subunits.


:

Pssm-ID: 238469  Cd Length: 46  Bit Score: 83.90  E-value: 7.13e-24
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
gi 4502993  17 SHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLK 62
Cdd:cd00929  1 SHYGEGPGSNLPFSVTNKWRLTALFHLFFGSGFSAPFIVVRHQLLK 46
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIIc cd00929
Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 17-62 7.13e-24

Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIc subunit is found only in eukaryotes and its specific function remains unclear. Peroxide inactivation of bovine CcO coincides with the direct oxidation of tryptophan (W19) within subunit VIIc, along with other structural changes in other subunits.


Pssm-ID: 238469  Cd Length: 46  Bit Score: 83.90  E-value: 7.13e-24
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
gi 4502993  17 SHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLK 62
Cdd:cd00929  1 SHYGEGPGSNLPFSVTNKWRLTALFHLFFGSGFSAPFIVVRHQLLK 46
COX7C pfam02935
Cytochrome c oxidase subunit VIIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 7-62 3.19e-20

Cytochrome c oxidase subunit VIIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIIc. The yeast member of this family is called COX VIII.


Pssm-ID: 427065  Cd Length: 57  Bit Score: 75.00  E-value: 3.19e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502993     7 RRFTTSVVRR-SHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLK 62
Cdd:pfam02935  1 RAFSTSARSSpGHYPEGPYSNLPFKVNRKIPFAVKYWGFFGVGFAAPFLIAYWQLKK 57
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIIc cd00929
Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 17-62 7.13e-24

Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIc subunit is found only in eukaryotes and its specific function remains unclear. Peroxide inactivation of bovine CcO coincides with the direct oxidation of tryptophan (W19) within subunit VIIc, along with other structural changes in other subunits.


Pssm-ID: 238469  Cd Length: 46  Bit Score: 83.90  E-value: 7.13e-24
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*.
gi 4502993  17 SHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLK 62
Cdd:cd00929  1 SHYGEGPGSNLPFSVTNKWRLTALFHLFFGSGFSAPFIVVRHQLLK 46
COX7C pfam02935
Cytochrome c oxidase subunit VIIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 7-62 3.19e-20

Cytochrome c oxidase subunit VIIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIIc. The yeast member of this family is called COX VIII.


Pssm-ID: 427065  Cd Length: 57  Bit Score: 75.00  E-value: 3.19e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502993     7 RRFTTSVVRR-SHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLK 62
Cdd:pfam02935  1 RAFSTSARSSpGHYPEGPYSNLPFKVNRKIPFAVKYWGFFGVGFAAPFLIAYWQLKK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH