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Conserved domains on  [gi|4502987|ref|NP_001855|]
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cytochrome c oxidase subunit 7A1, mitochondrial precursor [Homo sapiens]

Protein Classification

cytochrome c oxidase subunit VIIa family protein( domain architecture ID 10097117)

cytochrome c oxidase VIIa family protein such as cytochrome c oxidase subunit 7A1 (COX7A1), and cytochrome c oxidase subunit 7A2 like (COX7A2L) which are components of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation, and cytochrome c oxidase subunit 7A2 pseudogene 2 (COX7A2P2)

PubMed:  16199211

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_c_Oxidase_VIIa cd00928
Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 22-76 2.73e-29

Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIIa has two tissue-specific isoforms that are expressed in a developmental manner. VIIa-H is expressed in heart and skeletal muscle but not smooth muscle. VIIa-L is expressed in liver and non-muscle tissues.


:

Pssm-ID: 238468  Cd Length: 55  Bit Score: 98.49  E-value: 2.73e-29
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*
gi 4502987  22 FQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYSLGWASF 76
Cdd:cd00928  1 GKNKVKELQKKFQADDGLPVHLKGGVVDRILYRLTMALTVVGTGYSLYLLYMLSF 55
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIIa cd00928
Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 22-76 2.73e-29

Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIIa has two tissue-specific isoforms that are expressed in a developmental manner. VIIa-H is expressed in heart and skeletal muscle but not smooth muscle. VIIa-L is expressed in liver and non-muscle tissues.


Pssm-ID: 238468  Cd Length: 55  Bit Score: 98.49  E-value: 2.73e-29
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*
gi 4502987  22 FQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYSLGWASF 76
Cdd:cd00928  1 GKNKVKELQKKFQADDGLPVHLKGGVVDRILYRLTMALTVVGTGYSLYLLYMLSF 55
COX7a pfam02238
Cytochrome c oxidase subunit VII; Cytochrome c oxidase, a 13 sub-unit complex, is the terminal ...
 24-76 1.91e-07

Cytochrome c oxidase subunit VII; Cytochrome c oxidase, a 13 sub-unit complex, is the terminal oxidase in the mitochondrial electron transport chain. This family also contains both heart and liver isoforms of cytochrome c oxidase subunit VIIa.


Pssm-ID: 426673  Cd Length: 53  Bit Score: 42.92  E-value: 1.91e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4502987    24 NRVREKQKLFQEDNDIPLYLKGGiVDNILYRVTMTLCLGGTVYSLYSLGWASF 76
Cdd:pfam02238  1 NRVPELQRLFQASDHKPLWLRGP-RSKLYVYPYYALFAVGLGGSLYGMYRMIL 52
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIIa cd00928
Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 22-76 2.73e-29

Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIIa has two tissue-specific isoforms that are expressed in a developmental manner. VIIa-H is expressed in heart and skeletal muscle but not smooth muscle. VIIa-L is expressed in liver and non-muscle tissues.


Pssm-ID: 238468  Cd Length: 55  Bit Score: 98.49  E-value: 2.73e-29
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*
gi 4502987  22 FQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYSLGWASF 76
Cdd:cd00928  1 GKNKVKELQKKFQADDGLPVHLKGGVVDRILYRLTMALTVVGTGYSLYLLYMLSF 55
COX7a pfam02238
Cytochrome c oxidase subunit VII; Cytochrome c oxidase, a 13 sub-unit complex, is the terminal ...
 24-76 1.91e-07

Cytochrome c oxidase subunit VII; Cytochrome c oxidase, a 13 sub-unit complex, is the terminal oxidase in the mitochondrial electron transport chain. This family also contains both heart and liver isoforms of cytochrome c oxidase subunit VIIa.


Pssm-ID: 426673  Cd Length: 53  Bit Score: 42.92  E-value: 1.91e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4502987    24 NRVREKQKLFQEDNDIPLYLKGGiVDNILYRVTMTLCLGGTVYSLYSLGWASF 76
Cdd:pfam02238  1 NRVPELQRLFQASDHKPLWLRGP-RSKLYVYPYYALFAVGLGGSLYGMYRMIL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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