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Conserved domains on  [gi|4502183|ref|NP_001642|]
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aquaporin-5 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 6.20e-80

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 240.30  E-value: 6.20e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183      4 EVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     79 GNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502183    159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPAHWVFWVGPIVGAVLAAILY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 6.20e-80

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 240.30  E-value: 6.20e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183      4 EVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     79 GNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502183    159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPAHWVFWVGPIVGAVLAAILY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-224 4.86e-69

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 212.50  E-value: 4.86e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   12 KAVFAEFLATLIFVFFGLGSALKW---PSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   89 FYVAAQLVGAIAGAGILYGV---------APLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTD-SRRTSPV 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLyyglyleflGANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502183  159 GSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS--PAHWVFWVGPIVGAVLAAILYFYL 224
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-221 3.29e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 199.83  E-value: 3.29e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     16 AEFLATLIFVFFGLGSAL-------KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     89 FYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNN-TTQGQAMVVELILTFQLALCIFASTDSRRTSPVG-SPALSIG 166
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502183    167 LSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-PAHWVFWVGPIVGAVLAAILY 221
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGwGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-225 5.31e-55

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 176.86  E-value: 5.31e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   10 FLKAVFAEFLATLIFVFFGLGSA--LKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRA 87
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   88 FFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALN--------NNTTQGQAMVVELILTFQLALCIFASTDSRRTsPVG 159
Cdd:COG0580  82 LPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA-PGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502183  160 SPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-----PAHWVFWVGPIVGAVLAAILYFYLL 225
Cdd:COG0580 161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsdwGYLWVPIVAPILGAALAALLYRALF 231
PRK05420 PRK05420
aquaporin Z; Provisional
 11-225 1.00e-40

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 140.10  E-value: 1.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    11 LKAVFAEFLATLIFVFFGLGSALkWPSALPTI----LQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLR 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV-LAAAFPELgigfLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    87 AFFYVAAQLVGAIAGAGILY----GVAPLNARGNLAVNALNNNTTQGQ-----AMVVELILTFQLALCIFASTDSRrtSP 157
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYliasGKAGFDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATDKR--AP 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502183   158 VGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAH-WVFWVGPIVGAVLAAILYFYLL 225
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEQlWLFWVAPIVGAIIGGLIYRLLL 227
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 6.20e-80

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 240.30  E-value: 6.20e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183      4 EVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     79 GNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502183    159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPAHWVFWVGPIVGAVLAAILY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-224 4.86e-69

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 212.50  E-value: 4.86e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   12 KAVFAEFLATLIFVFFGLGSALKW---PSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   89 FYVAAQLVGAIAGAGILYGV---------APLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTD-SRRTSPV 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLyyglyleflGANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502183  159 GSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS--PAHWVFWVGPIVGAVLAAILYFYL 224
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-221 3.29e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 199.83  E-value: 3.29e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     16 AEFLATLIFVFFGLGSAL-------KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     89 FYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNN-TTQGQAMVVELILTFQLALCIFASTDSRRTSPVG-SPALSIG 166
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502183    167 LSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-PAHWVFWVGPIVGAVLAAILY 221
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGwGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-225 5.31e-55

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 176.86  E-value: 5.31e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   10 FLKAVFAEFLATLIFVFFGLGSA--LKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRA 87
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   88 FFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALN--------NNTTQGQAMVVELILTFQLALCIFASTDSRRTsPVG 159
Cdd:COG0580  82 LPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA-PGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502183  160 SPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-----PAHWVFWVGPIVGAVLAAILYFYLL 225
Cdd:COG0580 161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsdwGYLWVPIVAPILGAALAALLYRALF 231
PRK05420 PRK05420
aquaporin Z; Provisional
 11-225 1.00e-40

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 140.10  E-value: 1.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    11 LKAVFAEFLATLIFVFFGLGSALkWPSALPTI----LQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLR 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV-LAAAFPELgigfLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    87 AFFYVAAQLVGAIAGAGILY----GVAPLNARGNLAVNALNNNTTQGQ-----AMVVELILTFQLALCIFASTDSRrtSP 157
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYliasGKAGFDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATDKR--AP 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502183   158 VGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAH-WVFWVGPIVGAVLAAILYFYLL 225
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEQlWLFWVAPIVGAIIGGLIYRLLL 227
PLN00166 PLN00166
aquaporin TIP2; Provisional
 7-221 1.79e-35

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 127.36  E-value: 1.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     7 SVAFLKAVFAEFLATLIFVFFGLGSALKWP-----SAL--PTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVG 79
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFAkltsdAALdpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    80 NQISLLRAFFYVAAQLVGAIAGAGILYGVAplNARGNLAVNALNNNTTQgQAMVVELILTFQLALCIFASTDSRRTSPVG 159
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVT--NGESVPTHGVAAGLGAI-EGVVMEIVVTFALVYTVYATAADPKKGSLG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502183   160 SPA-LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpAHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00166 171 TIApIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFS-QIWIYWVGPLVGGALAGLIY 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 11-221 2.31e-32

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 119.12  E-value: 2.31e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    11 LKAVFAEFLATLIFVFFGLGSALKW-------PSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQIS 83
Cdd:PLN00027  20 LKAALAEFISTLIFVFAGEGSGMAFnkltdngSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    84 LLRAFFYVAAQLVGAIAGAGIL---YGVAPLNARGnlavnaLNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGS 160
Cdd:PLN00027 100 LLRGILYWIAQLLGSVVACLLLkfsTGGLETSAFS------LSSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGI 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502183   161 PA-LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpAHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00027 174 IApIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWT-NHWVYWAGPLIGGGIAGLVY 234
PLN00167 PLN00167
aquaporin TIP5; Provisional
 3-228 1.76e-31

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 116.93  E-value: 1.76e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     3 KEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALP-------TILQIALAFGLAIGTLAQALGPVSGGHINPAITLA 75
Cdd:PLN00167  14 QQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPdaasdpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    76 LLVGNQISLLRAFFYVAAQLVGAIAgAGILYGVAPLNARgnLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRT 155
Cdd:PLN00167  94 MAVGGHISVPTAMFYWISQMLASVM-ACLFLKVTTVGQH--VPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRG 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502183   156 SPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpAHWVFWVGPIVGAVLAAILYFYLLFPN 228
Cdd:PLN00167 171 LLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFK-NQAVYWVGPLLGGAVAGLLYDNVVFPT 242
PLN00184 PLN00184
aquaporin NIP1; Provisional
 7-221 7.69e-25

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 100.10  E-value: 7.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     7 SVAFLKAVFAEFLATLIFVFFGLGSAL--KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISL 84
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASVVvnMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    85 LRAFFYVAAQLVGAIAGAG---ILYGVAPLNARGNLAVNALNNNT-TQGQAMVVELILTFQLALCIFA-STDSRRTSPVG 159
Cdd:PLN00184 130 KQVPAYVISQVIGSTLAAAtlrLLFGLDHDVCSGKHDVFIGSSPVgSDLQAFVMEFIVTFYLMFIISGvATDNRAIGELA 209

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502183   160 spALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpAHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00184 210 --GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYK-GIWIYIVAPTLGAIAGAWVY 268
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 16-227 2.14e-24

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 99.04  E-value: 2.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    16 AEFLATLIFVFFGLG---------SALKWPSalptiLQIALAFGLAIGTLAQAlgPVSGGHINPAITLALLVGNQISLLR 86
Cdd:PTZ00016  55 AEFLGTFVLLFFGEGvvatthtvgNNGDYLA-----ITIGWGLGVTFGLLVSA--GISGGHLNPAVTLGNAVFGKFPWKK 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    87 AFFYVAAQLVGAIAGAGILYGV----------APLNARGNLAVNALNNNTTQGQ----AMVVELILTFQLALCIFASTDS 152
Cdd:PTZ00016 128 LPGYFVAQLLGAFVGAACVYGLyygffkdhgiPELPWETMANGFAGVFATYPREgnfyAIFSELILTAILLLVILAITDP 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   153 RRTSPVGSPALSIGLSVTlghLVGIYF---TGCSMNPARSFGPAVVM------NRFSPAHWVFW---VGPIVGAVLAAIL 220
Cdd:PTZ00016 208 NNCPAFNYLPVAVGLLVF---VIGISFggnTGYALNPARDLGPRLFSailwgsEVFTKDNYYFWvplVAPFVGAVLGMFL 284


                 ....*..
gi 4502183   221 YFYLLFP 227
Cdd:PTZ00016 285 YDKFIPP 291
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 1-226 4.46e-24

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 98.06  E-value: 4.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     1 MKKEVCS----VAFLKAVFAEFLATLIFVFFGLGSAL--KWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITL 74
Cdd:PLN00182  28 IETAICTspsiVCLTQKLIAEMIGTYFIIFSGCGVVVvnVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    75 ALLVGNQISLLRAFFYVAAQLVGAIAGAGIL---YGVAPLNARGNLAVnalnnnTTQGQAMVVELILTFQLALCIFA-ST 150
Cdd:PLN00182 108 TFAIFRRFPWYQVPLYIGAQLTGSLLASLTLrlmFNVTPEAFFGTTPT------DSSGQALVAEIIISFLLMFVISGvAT 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502183   151 DSRRTSPVGspALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpAHWVFWVGPIVGAVLAAILYFYLLF 226
Cdd:PLN00182 182 DSRAVGELA--GIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYK-GIWVYIVGPFVGIIAGGFVYNLIRF 254
PLN00026 PLN00026
aquaporin NIP; Provisional
 8-221 1.35e-22

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 94.16  E-value: 1.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183     8 VAFLKAVFAEFLATLIFVFFGLGSAL---KWPSAlPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISL 84
Cdd:PLN00026  68 VSLTRKLGAEFVGTFILIFAATAGPIvnqKYDGA-ETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    85 LRAFFYVAAQLVGAIAGAGILYGV-APLNARGNLAVNALNnnttqGQAMVVELILTFQLALCIFA-STDSRrtsPVGSPA 162
Cdd:PLN00026 147 KHVPAYIAAQVSASICASFALKGVfHPFMSGGVTVPSVST-----GQAFALEFIITFNLLFVVTAvATDTR---AVGELA 218

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183   163 -LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpAHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00026 219 gIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYR-AIWIYLVAPTLGALAGAGTY 277
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 11-221 6.30e-20

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 86.45  E-value: 6.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    11 LKAVFAEFLATLIFVF--FGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAF 88
Cdd:PLN00183  45 ARMVLAEMVGTFILMFcvCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502183    89 FYVAAQLVGAIAG---AGILYGVAPlnargnlAVNALNNNTTQGQAMVVELILTFqLALCIFASTDSRRTSPVGSPALSI 165
Cdd:PLN00183 125 LYITAQTVGSVLAtyvGVSVYGVKA-------DLMTTKPAQGCSSAFWVEFIATF-IVMFLAASLTSQPQSLGHLSGFVI 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502183   166 GLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAhWVFWVGPIVGAVLAAILY 221
Cdd:PLN00183 197 GIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDI-WIYITAPTIGAVAGALMF 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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