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Conserved domains on  [gi|2103987643|ref|NP_001383005|]
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GTPase IMAP family member 7-like 5 [Gallus gallus]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 132-327 8.33e-68

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd01852:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 201  Bit Score: 211.24  E-value: 8.33e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 132 LRILLVGKAGNGKSSTGNTILGKNTFNTGCAASGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTDFSRGTANKIKDGLRCL 211
Cdd:cd01852     1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 212 NEGVHAILLVMRLGQITQEMMQVAEWVTKIFHTDGERYTILLFTRADELEDPSgLKGFIEGS-QFLKGLVAKCGNRYIAF 290
Cdd:cd01852    81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGS-LEDYLEDScEALKRLLEKCGGRYVAF 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2103987643 291 NNKATREAKDRQVAELIQMIDDMVENNHNApCYTREM 327
Cdd:cd01852   160 NNKAKGREQEQQVKELLAKVEEMVRENGGK-PYTNEM 195
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 2-112 2.24e-24

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd01852:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 201  Bit Score: 98.38  E-value: 2.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643   2 QLGQVTEECEQVAEWVTKIFLTEALRYTILLFTRAEDLQKpEDLKGLIGDS-KYLMGLAAKCGNRYIAFSNTATGEARDR 80
Cdd:cd01852    92 PLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEG-GSLEDYLEDScEALKRLLEKCGGRYVAFNNKAKGREQEQ 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2103987643  81 QVAKLIEMIDAMVEQNCDAPrYTREMLEKHKE 112
Cdd:cd01852   171 QVKELLAKVEEMVRENGGKP-YTNEMYEEAEE 201
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 132-327 8.33e-68

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 211.24  E-value: 8.33e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 132 LRILLVGKAGNGKSSTGNTILGKNTFNTGCAASGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTDFSRGTANKIKDGLRCL 211
Cdd:cd01852     1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 212 NEGVHAILLVMRLGQITQEMMQVAEWVTKIFHTDGERYTILLFTRADELEDPSgLKGFIEGS-QFLKGLVAKCGNRYIAF 290
Cdd:cd01852    81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGS-LEDYLEDScEALKRLLEKCGGRYVAF 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2103987643 291 NNKATREAKDRQVAELIQMIDDMVENNHNApCYTREM 327
Cdd:cd01852   160 NNKAKGREQEQQVKELLAKVEEMVRENGGK-PYTNEM 195
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 132-327 1.03e-50

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 167.40  E-value: 1.03e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 132 LRILLVGKAGNGKSSTGNTILGKNTFNTGCAASGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTDFSRGTANKIKDGLRCL 211
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 212 NEGVHAILLVMRLGQITQEMMQVAEWVTKIFHTDGERYTILLFTRADELEDpSGLKGFIEGS--QFLKGLVAkcgnryia 289
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLED-DSLDDYLSDGcpEFLKEVLR-------- 151

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2103987643 290 fnnKATREAKDRQVAELIQMIDDMVENNHNAPcYTREM 327
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKP-YTNDL 185
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 2-112 2.24e-24

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 98.38  E-value: 2.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643   2 QLGQVTEECEQVAEWVTKIFLTEALRYTILLFTRAEDLQKpEDLKGLIGDS-KYLMGLAAKCGNRYIAFSNTATGEARDR 80
Cdd:cd01852    92 PLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEG-GSLEDYLEDScEALKRLLEKCGGRYVAFNNKAKGREQEQ 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2103987643  81 QVAKLIEMIDAMVEQNCDAPrYTREMLEKHKE 112
Cdd:cd01852   171 QVKELLAKVEEMVRENGGKP-YTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 1-112 1.01e-15

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 74.57  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643   1 MQLGQVTEECEQVAEWVTKIFLTEALRYTILLFTRAEDLQkPEDLKGLIGDS--KYLMGLAAkcgnryiafsnTATGEAR 78
Cdd:pfam04548  91 LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLE-DDSLDDYLSDGcpEFLKEVLR-----------TADGEEK 158

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2103987643  79 DRQVAKLIEMIDAMVEQNCDAPrYTREMLEKHKE 112
Cdd:pfam04548 159 EEQVQQLLALVEAIVKENGGKP-YTNDLYEKIKE 191
YeeP COG3596
Predicted GTPase [General function prediction only];
122-261 8.38e-09

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 55.93  E-value: 8.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 122 RAECVSKGSPLRILLVGKAGNGKSSTGNTILGKNTFNTGC--AASGVTQEYkeDKSCIHGRTIVVVDTPGVFDntdfSRG 199
Cdd:COG3596    30 LERLLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGVgrPCTREIQRY--RLESDGLPGLVLLDTPGLGE----VNE 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2103987643 200 TANKIKDGLRCLNEgVHAILLVMRLGQITQEMmqVAEWVTKIFHTDGERYTILLFTRADELE 261
Cdd:COG3596   104 RDREYRELRELLPE-ADLILWVVKADDRALAT--DEEFLQALRAQYPDPPVLVVLTQVDRLE 162
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 130-266 9.34e-06

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 46.82  E-value: 9.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 130 SPLRILLVGKAGNGKSSTGNTILGKNTFNTGCAASGVTQEYKEDKScIHGRTIVVVDTPGVFDNTDFSRGTANKIKDGLr 209
Cdd:TIGR00991  37 SSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVSRT-RAGFTLNIIDTPGLIEGGYINDQAVNIIKRFL- 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2103987643 210 cLNEGVHAILLVMRLGQITQEMM--QVAEWVTKIFHTDGERYTILLFTRAdELEDPSGL 266
Cdd:TIGR00991 115 -LGKTIDVLLYVDRLDAYRVDTLdgQVIRAITDSFGKDIWRKSLVVLTHA-QFSPPDGL 171
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 132-327 8.33e-68

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 211.24  E-value: 8.33e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 132 LRILLVGKAGNGKSSTGNTILGKNTFNTGCAASGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTDFSRGTANKIKDGLRCL 211
Cdd:cd01852     1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 212 NEGVHAILLVMRLGQITQEMMQVAEWVTKIFHTDGERYTILLFTRADELEDPSgLKGFIEGS-QFLKGLVAKCGNRYIAF 290
Cdd:cd01852    81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGS-LEDYLEDScEALKRLLEKCGGRYVAF 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2103987643 291 NNKATREAKDRQVAELIQMIDDMVENNHNApCYTREM 327
Cdd:cd01852   160 NNKAKGREQEQQVKELLAKVEEMVRENGGK-PYTNEM 195
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 132-327 1.03e-50

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 167.40  E-value: 1.03e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 132 LRILLVGKAGNGKSSTGNTILGKNTFNTGCAASGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTDFSRGTANKIKDGLRCL 211
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 212 NEGVHAILLVMRLGQITQEMMQVAEWVTKIFHTDGERYTILLFTRADELEDpSGLKGFIEGS--QFLKGLVAkcgnryia 289
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLED-DSLDDYLSDGcpEFLKEVLR-------- 151

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2103987643 290 fnnKATREAKDRQVAELIQMIDDMVENNHNAPcYTREM 327
Cdd:pfam04548 152 ---TADGEEKEEQVQQLLALVEAIVKENGGKP-YTNDL 185
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 2-112 2.24e-24

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 98.38  E-value: 2.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643   2 QLGQVTEECEQVAEWVTKIFLTEALRYTILLFTRAEDLQKpEDLKGLIGDS-KYLMGLAAKCGNRYIAFSNTATGEARDR 80
Cdd:cd01852    92 PLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEG-GSLEDYLEDScEALKRLLEKCGGRYVAFNNKAKGREQEQ 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2103987643  81 QVAKLIEMIDAMVEQNCDAPrYTREMLEKHKE 112
Cdd:cd01852   171 QVKELLAKVEEMVRENGGKP-YTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 1-112 1.01e-15

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 74.57  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643   1 MQLGQVTEECEQVAEWVTKIFLTEALRYTILLFTRAEDLQkPEDLKGLIGDS--KYLMGLAAkcgnryiafsnTATGEAR 78
Cdd:pfam04548  91 LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLE-DDSLDDYLSDGcpEFLKEVLR-----------TADGEEK 158

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2103987643  79 DRQVAKLIEMIDAMVEQNCDAPrYTREMLEKHKE 112
Cdd:pfam04548 159 EEQVQQLLALVEAIVKENGGKP-YTNDLYEKIKE 191
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 136-263 2.63e-09

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 55.33  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 136 LVGKAGNGKSSTGNTILGKNTFNTGcAASGVTQEYKEDKSCIHG-RTIVVVDTPGVFDNTDFSRGTANKIKDGLrclnEG 214
Cdd:cd00880     2 IFGRPNVGKSSLLNALLGQNVGIVS-PIPGTTRDPVRKEWELLPlGPVVLIDTPGLDEEGGLGRERVEEARQVA----DR 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2103987643 215 VHAILLVMRLGQITQEMMQVAEWvtkiFHTDGERyTILLFTRADELEDP 263
Cdd:cd00880    77 ADLVLLVVDSDLTPVEEEAKLGL----LRERGKP-VLLVLNKIDLVPES 120
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 130-257 7.60e-09

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 55.79  E-value: 7.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 130 SPLRILLVGKAGNGKSSTGNTILG--KNTFNtgcAASGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTD--FSRGTANKIK 205
Cdd:cd01853    30 FSLTILVLGKTGVGKSSTINSIFGerKVSVS---AFQSETLRPREVSRTVDGFKLNIIDTPGLLESQDqrVNRKILSIIK 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2103987643 206 DGLrcLNEGVHAILLVMRLGQITQEM--MQVAEWVTKIFHTDGERYTILLFTRA 257
Cdd:cd01853   107 RFL--KKKTIDVVLYVDRLDMYRVDNldVPLLRAITDSFGPSIWRNAIVVLTHA 158
YeeP COG3596
Predicted GTPase [General function prediction only];
122-261 8.38e-09

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 55.93  E-value: 8.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 122 RAECVSKGSPLRILLVGKAGNGKSSTGNTILGKNTFNTGC--AASGVTQEYkeDKSCIHGRTIVVVDTPGVFDntdfSRG 199
Cdd:COG3596    30 LERLLVELPPPVIALVGKTGAGKSSLINALFGAEVAEVGVgrPCTREIQRY--RLESDGLPGLVLLDTPGLGE----VNE 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2103987643 200 TANKIKDGLRCLNEgVHAILLVMRLGQITQEMmqVAEWVTKIFHTDGERYTILLFTRADELE 261
Cdd:COG3596   104 RDREYRELRELLPE-ADLILWVVKADDRALAT--DEEFLQALRAQYPDPPVLVVLTQVDRLE 162
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 135-310 4.26e-08

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 52.07  E-value: 4.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 135 LLVGKAGNGKSSTGNTILGKNTFNTGcAASGVTQE--YKEDKSCIHGRTIVVVDTPGVFDNTDFSRGTANKIKDglrcln 212
Cdd:cd00882     1 VVVGRGGVGKSSLLNALLGGEVGEVS-DVPGTTRDpdVYVKELDKGKVKLVLVDTPGLDEFGGLGREELARLLL------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 213 EGVHAILLVMRLGQITQEMMQVAEWVTKIFhtDGERYTILLFTRADELEDPSglkgfIEGSQFLKGLVAKCGNRYIAFNN 292
Cdd:cd00882    74 RGADLILLVVDSTDRESEEDAKLLILRRLR--KEGIPIILVGNKIDLLEERE-----VEELLRLEELAKILGVPVFEVSA 146

                         170
                  ....*....|....*...
gi 2103987643 293 KaTREakdrQVAELIQMI 310
Cdd:cd00882   147 K-TGE----GVDELFEKL 159
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 133-256 1.28e-07

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 49.54  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 133 RILLVGKAGNGKSSTGNTILGKN--TFNTgcaaSGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTDFSRGTANKIKDGLRC 210
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKaiVSDY----PGTTRDPNEGRLELKGKQIILVDTPGLIEGASEGEGLGRAFLAIIEA 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2103987643 211 lnegvHAILLVM-RLGQITQEMMQVAEWVTKIfhtdgERYTILLFTR 256
Cdd:pfam01926  77 -----DLILFVVdSEEGITPLDEELLELLREN-----KKPIILVLNK 113
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 130-266 9.34e-06

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 46.82  E-value: 9.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 130 SPLRILLVGKAGNGKSSTGNTILGKNTFNTGCAASGVTQEYKEDKScIHGRTIVVVDTPGVFDNTDFSRGTANKIKDGLr 209
Cdd:TIGR00991  37 SSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVSRT-RAGFTLNIIDTPGLIEGGYINDQAVNIIKRFL- 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2103987643 210 cLNEGVHAILLVMRLGQITQEMM--QVAEWVTKIFHTDGERYTILLFTRAdELEDPSGL 266
Cdd:TIGR00991 115 -LGKTIDVLLYVDRLDAYRVDTLdgQVIRAITDSFGKDIWRKSLVVLTHA-QFSPPDGL 171
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 132-190 5.71e-05

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 44.94  E-value: 5.71e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2103987643 132 LRILLVGKAGNGKSSTGNTILGKNTFNTGCAASGvTQEYKEDKSCIHGRTIVVVDTPGV 190
Cdd:TIGR00993 119 LNILVLGKSGVGKSATINSIFGEVKFSTDAFGMG-TTSVQEIEGLVQGVKIRVIDTPGL 176
FeoB_N pfam02421
Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) ...
 132-197 6.64e-04

Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 460552 [Multi-domain]  Cd Length: 156  Bit Score: 39.74  E-value: 6.64e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2103987643 132 LRILLVGKAGNGKSSTGNTILGKNTF--NTgcaaSGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTDFS 197
Cdd:pfam02421   1 ITIALVGNPNVGKTTLFNALTGANQHvgNW----PGVTVEKKEGKFKYKGYEIEIVDLPGIYSLSPYS 64
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 30-191 1.56e-03

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 38.66  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643  30 ILLFTRAeDLQKPEDLKGLIgdsKYLmglaAKCGNRYIAFSNTatgeaRDRQVAKLIEMIDAMVEQNcdaprytrEMLEK 109
Cdd:cd01856    50 LIVLNKA-DLADPAKTKKWL---KYF----KSQGEPVLFVNAK-----NGKGVKKLLKKAKKLLKEN--------EKLKA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103987643 110 HKEKSPgqapswraecvskgsPLRILLVGKAGNGKSSTGNTILGKNTFNTGcAASGVTQeykeDKSCIH-GRTIVVVDTP 188
Cdd:cd01856   109 KGLLPR---------------PLRAMVVGIPNVGKSTLINRLRGKKVAKVG-NKPGVTR----GQQWIRiGPNIELLDTP 168


                  ...
gi 2103987643 189 GVF 191
Cdd:cd01856   169 GIL 171
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 131-190 2.03e-03

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 38.13  E-value: 2.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2103987643 131 PLRILLVGKAGNGKSSTGNTILGKNTFNTGcAASGVT---QEYKEDKscihgrTIVVVDTPGV 190
Cdd:cd01849    91 GIRVGVVGLPNVGKSSFINALLNKFKLKVG-SIPGTTklqQDVKLDK------EIYLYDTPGI 146
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 133-189 3.38e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 37.74  E-value: 3.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2103987643 133 RILLVGKAGNGKSSTGNTILGKNTFNTGcAASGVTQEYKEDKSCIHGRTIVV--VDTPG 189
Cdd:TIGR00231   3 KIVIVGHPNVGKSTLLNSLLGNKGSITE-YYPGTTRNYVTTVIEEDGKTYKFnlLDTAG 60
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 136-197 7.42e-03

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 36.67  E-value: 7.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2103987643 136 LVGKAGNGKSSTGNTILGKNTfNTGcAASGVTQEYKEDKSCIHGRTIVVVDTPGVFDNTDFS 197
Cdd:cd01879     2 LVGNPNVGKTTLFNALTGARQ-KVG-NWPGVTVEKKEGEFKLGGKEIEIVDLPGTYSLTPYS 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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