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Conserved domains on  [gi|2074014176|ref|NP_001382577|]
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leucine-rich repeat-containing protein 9 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 1.47e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 117.96  E-value: 1.47e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2074014176  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1116-1361 2.21e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 2.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1116 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1193
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1194 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1267
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1268 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1344
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 2074014176 1345 LPNLQMLDGSPVNSDDR 1361
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 878-1066 3.18e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 93.70  E-value: 3.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  878 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 948
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  949 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 1019
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2074014176 1020 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1066
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
631-1016 2.31e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  631 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 710
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  711 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 789
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  790 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 865
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  866 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 945
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2074014176  946 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 1016
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 1.47e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 117.96  E-value: 1.47e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2074014176  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1116-1361 2.21e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 2.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1116 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1193
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1194 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1267
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1268 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1344
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 2074014176 1345 LPNLQMLDGSPVNSDDR 1361
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 878-1066 3.18e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 93.70  E-value: 3.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  878 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 948
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  949 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 1019
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2074014176 1020 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1066
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
631-1016 2.31e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  631 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 710
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  711 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 789
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  790 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 865
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  866 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 945
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2074014176  946 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 1016
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1023-1377 4.63e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 4.63e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1023 LCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTS 1102
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1103 SSIRTVDLIPVDQFRNVCNVNLQNNhltsfSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSrqlLYqkvpssgygqq 1182
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKE---LD----------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1183 gISKTN-RDIMSS-ENLPpimhSLEVLHLGYNGICNlIQLQLNRLRNLKFLFLQGNEISQV-EGLDNLVVLQELVVDHNR 1259
Cdd:COG4886    143 -LSNNQlTDLPEPlGNLT----NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1260 IRSFNDSaFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLdviSTLRELTVYGNPICRKMLHRH 1339
Cdd:COG4886    217 LTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKEL 292

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 2074014176 1340 MLIFRLPNLQMLDGSPVNSDDRAKAEFHLAELQAKKNS 1377
Cdd:COG4886    293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 694-828 9.18e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 9.18e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  694 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 743
Cdd:cd21340     46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  744 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVF 823
Cdd:cd21340    126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204


                   ....*
gi 2074014176  824 ISEEE 828
Cdd:cd21340    205 ITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-157 9.98e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 9.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   35 SKLEMFFLGYPRIVGLSLF----PNLTSLTIVAQDIKEISG-LEPCLQLKELWIAECCIEKI-EGLQECRNLEKLYLYFN 108
Cdd:COG4886    159 TNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2074014176  109 KISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSI 157
Cdd:COG4886    239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR_9 pfam14580
Leucine-rich repeat;
941-1085 5.26e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 5.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  941 NCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKsftlvelyisnnyiavnqeMHNL 1020
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDP-------------------LASL 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2074014176 1021 KGLCNLVILDmcgNIIIwNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE 1085
Cdd:pfam14580  113 KKLTFLSLLR---NPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR_9 pfam14580
Leucine-rich repeat;
1233-1365 1.85e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 49.76  E-value: 1.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1233 LQGNEISQVEGLDNLVVLQELVVDHNRIrsfndsafakpssllaLHLEENrlreLGklQSLVKLEKLFLGYNKIQDITEL 1312
Cdd:pfam14580   49 FSDNEIRKLDGFPLLRRLKTLLLNNNRI----------------CRIGEG----LG--EALPNLTELILTNNNLQELGDL 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2074014176 1313 EKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDDRAKAE 1365
Cdd:pfam14580  107 DPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR_8 pfam13855
Leucine rich repeat;
121-177 2.84e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.84e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  121 KLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLINSI-GRCLDSNEQLERLNLSGNQI 177
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
716-772 4.01e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 4.01e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2074014176  716 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 772
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-236 1.47e-29

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 117.96  E-value: 1.47e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   55 NLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNHNTIKN 134
Cdd:cd21340      3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  135 IEGLQTLKNLKDL------------------------------NLAGNLINSIgRCLDSNEQLERLNLSGNQICSFKELT 184
Cdd:cd21340     83 VEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2074014176  185 N-LTRLPCLKDLCLNDpqyttNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQ 236
Cdd:cd21340    162 DlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1116-1361 2.21e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.94  E-value: 2.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1116 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 1193
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1194 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1267
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1268 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1344
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 2074014176 1345 LPNLQMLDGSPVNSDDR 1361
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 878-1066 3.18e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 93.70  E-value: 3.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  878 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 948
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  949 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 1019
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2074014176 1020 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 1066
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
631-1016 2.31e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  631 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 710
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  711 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 789
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  790 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 865
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  866 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 945
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2074014176  946 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 1016
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1023-1377 4.63e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 4.63e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1023 LCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTS 1102
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1103 SSIRTVDLIPVDQFRNVCNVNLQNNhltsfSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSrqlLYqkvpssgygqq 1182
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKE---LD----------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1183 gISKTN-RDIMSS-ENLPpimhSLEVLHLGYNGICNlIQLQLNRLRNLKFLFLQGNEISQV-EGLDNLVVLQELVVDHNR 1259
Cdd:COG4886    143 -LSNNQlTDLPEPlGNLT----NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1260 IRSFNDSaFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLdviSTLRELTVYGNPICRKMLHRH 1339
Cdd:COG4886    217 LTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKEL 292

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 2074014176 1340 MLIFRLPNLQMLDGSPVNSDDRAKAEFHLAELQAKKNS 1377
Cdd:COG4886    293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 694-828 9.18e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 9.18e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  694 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 743
Cdd:cd21340     46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  744 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVF 823
Cdd:cd21340    126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204


                   ....*
gi 2074014176  824 ISEEE 828
Cdd:cd21340    205 ITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-157 9.98e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 9.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   35 SKLEMFFLGYPRIVGLSLF----PNLTSLTIVAQDIKEISG-LEPCLQLKELWIAECCIEKI-EGLQECRNLEKLYLYFN 108
Cdd:COG4886    159 TNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2074014176  109 KISKIENLEKLIKLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSI 157
Cdd:COG4886    239 QLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1112-1331 2.05e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 2.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1112 PVDQFRNVCNVNLQNNHLTSFSGLI-YLPNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVPSSGYGQQGISKTNRD 1190
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPEELaNLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1191 IMSS---ENLPPI---MHSLEVLHLGYNGICNLiQLQLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRSFN 1264
Cdd:COG4886    188 DLSNnqiTDLPEPlgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP 266

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2074014176 1265 DSafAKPSSLLALHLEENRLRE--LGKLQSLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNPI 1331
Cdd:COG4886    267 PL--ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
698-895 3.88e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 3.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  698 SLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKSG 776
Cdd:COG4886    209 ELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  777 NEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVFISEEEATAAMKFIAGTRITQLSLLRHSSTKEER 856
Cdd:COG4886    289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2074014176  857 PRILSIWPSAKILTQVSKLGPHLHLSGNCYLKITALNLD 895
Cdd:COG4886    369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
609-1006 5.04e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 5.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  609 DHDLVLPEYVVEFEYITMVKAPSLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLA 688
Cdd:COG4886      5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  689 KTSVYSHIVSL-NLHGNSLSKLRDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHL 765
Cdd:COG4886     85 LLLGLTDLGDLtNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSL 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  766 DLSWNQLKKSGNEINMLckhtTSLLTLDIQHNPWQK-PATLrlsviGRLKTLTHLNgvfISEEEATAAMKFIAgtRITQL 844
Cdd:COG4886    165 DLSNNQLTDLPEELGNL----TNLKELDLSNNQITDlPEPL-----GNLTNLEELD---LSGNQLTDLPEPLA--NLTNL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  845 SLLRHSSTKEERPRILSIWPSAKIL----TQVSKLGP--------HLHLSGNcylKITALNLDGQHLFEITNLEKLENLK 912
Cdd:COG4886    231 ETLDLSNNQLTDLPELGNLTNLEELdlsnNQLTDLPPlanltnlkTLDLSNN---QLTDLKLKELELLLGLNSLLLLLLL 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  913 WASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSL 992
Cdd:COG4886    308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387

                          410
                   ....*....|....
gi 2074014176  993 SGLQKSFTLVELYI 1006
Cdd:COG4886    388 TLLLLLLTTTAGVL 401
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 88-177 2.32e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 2.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   88 IEKIEGLQECRNLEKLYLYFNKISK------IENLEKLIKLKVLWLNHNTIKN------IEGLQTLKNLKDLNLAGNLI- 154
Cdd:COG5238    254 IALAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIg 333

                           90       100
                   ....*....|....*....|....*..
gi 2074014176  155 ----NSIGRCLDSNEQLERLNLSGNQI 177
Cdd:COG5238    334 aqgaIALAKALQENTTLHSLDLSDNQI 360
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
930-1313 2.84e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 2.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  930 CINLEELTLDGNCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNN 1009
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1010 YIAVNQEMHNLKGLCNLVILDMCGNIIIwnqenyrlfviFHLPELKALDgipiepsetdsakdLFGGRLTS--DMIAerq 1087
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGNEEL-----------SNLTNLESLD--------------LSGNQLTDlpEELA--- 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1088 ghsNFKQMQELNWTSSSIRTVDLiPVDQFRNVCNVNLQNNHLTSFS-GLIYLPNVKVLCLNYNHIESIMPRLkpqTHLTS 1166
Cdd:COG4886    134 ---NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPEPL---GNLTN 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1167 RQLLYqkvpssgygqqgISKTN-RDImsSENLPPiMHSLEVLHLGYNGICNLIQLQlnRLRNLKFLFLQGNEISQVEGLD 1245
Cdd:COG4886    207 LEELD------------LSGNQlTDL--PEPLAN-LTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPPLA 269

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2074014176 1246 NLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELE 1313
Cdd:COG4886    270 NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR_9 pfam14580
Leucine-rich repeat;
941-1085 5.26e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 5.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  941 NCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKsftlvelyisnnyiavnqeMHNL 1020
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDP-------------------LASL 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2074014176 1021 KGLCNLVILDmcgNIIIwNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE 1085
Cdd:pfam14580  113 KKLTFLSLLR---NPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-189 5.69e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 5.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   50 LSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLIKLKVLWLNH 129
Cdd:COG4886     26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2074014176  130 NtikniEGLQTLKNLKDLNLAGNLINSIGRCLDSNEQLERLNLSGNQI----CSFKELTNLTRL 189
Cdd:COG4886    106 N-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLtdlpEPLGNLTNLKSL 164
LRR_9 pfam14580
Leucine-rich repeat;
1233-1365 1.85e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 49.76  E-value: 1.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1233 LQGNEISQVEGLDNLVVLQELVVDHNRIrsfndsafakpssllaLHLEENrlreLGklQSLVKLEKLFLGYNKIQDITEL 1312
Cdd:pfam14580   49 FSDNEIRKLDGFPLLRRLKTLLLNNNRI----------------CRIGEG----LG--EALPNLTELILTNNNLQELGDL 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2074014176 1313 EKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDDRAKAE 1365
Cdd:pfam14580  107 DPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR_8 pfam13855
Leucine rich repeat;
1250-1306 2.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 2.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2074014176 1250 LQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGK--LQSLVKLEKLFLGYNKI 1306
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
121-177 2.84e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.84e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  121 KLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLINSI-GRCLDSNEQLERLNLSGNQI 177
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
716-772 4.01e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 4.01e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2074014176  716 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 772
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-138 1.94e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.00  E-value: 1.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2074014176   99 NLEKLYLYFNKISKIENLEKLIKLKVLWLNHNT-IKNIEGL 138
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
932-989 9.56e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 9.56e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  932 NLEELTLDGNCISKIEGIS--KMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRI 989
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
953-1011 9.75e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 9.75e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2074014176  953 TKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGlqKSFT----LVELYISNNYI 1011
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP--GAFSglpsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
694-750 2.23e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 2.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2074014176  694 SHIVSLNLHGNSLSKLRD--LSKLTGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHV 750
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
98-154 2.23e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 2.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2074014176   98 RNLEKLYLYFNKISKI--ENLEKLIKLKVLWLNHNTIKNIEG--LQTLKNLKDLNLAGNLI 154
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-152 2.93e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.93e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2074014176  121 KLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGN 152
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-178 3.76e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 3.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   84 AECCIEKIEGLQECRNLEKLYLYFNKISK------IENLEKLIKLKVLWLNHNTIKNI------EGLQTLKNLKDLNLAG 151
Cdd:cd00116    151 GASCEALAKALRANRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGD 230

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2074014176  152 NLINSIGRC------LDSNEQLERLNLSGNQIC 178
Cdd:cd00116    231 NNLTDAGAAalasalLSPNISLLTLSLSCNDIT 263
LRR_9 pfam14580
Leucine-rich repeat;
108-242 5.59e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.44  E-value: 5.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  108 NKISKIENLEKLIKLKVLWLNHNTIKNI-EGL-QTLKNLKDLNLAGNLINSIGrcldsneQLERLnlsgnqiCSFKELTN 185
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELG-------DLDPL-------ASLKKLTF 117

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2074014176  186 LTRLpclkdlclndpqytTNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQIKELAD 242
Cdd:pfam14580  118 LSLL--------------RNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
901-1360 1.13e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  901 EITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNLltgweehTFDNMLHLH 980
Cdd:COG4886     44 SLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  981 SLSLENNRITSLSGLQKSFT-LVELYISNNYIAVNQEmhNLKGLCNLVILDMCGNiiiwnqenyrlfvifhlpelkALDG 1059
Cdd:COG4886    117 SLDLSGNQLTDLPEELANLTnLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNN---------------------QLTD 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1060 IPIEpsetdsakdlfggrltsdmiaerqghsnFKQMQELNWtsssirtvdlipvdqfrnvcnVNLQNNHLTSFSGLIY-L 1138
Cdd:COG4886    174 LPEE----------------------------LGNLTNLKE---------------------LDLSNNQITDLPEPLGnL 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1139 PNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVpssgygqqgisktnrdimssENLPPI--MHSLEVLHLGYNGICN 1216
Cdd:COG4886    205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL--------------------TDLPELgnLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1217 LiqLQLNRLRNLKFLFLQGNEIS-----QVEGLDNLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGKLQ 1291
Cdd:COG4886    265 L--PPLANLTNLKTLDLSNNQLTdlklkELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2074014176 1292 SLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDD 1360
Cdd:COG4886    343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR_8 pfam13855
Leucine rich repeat;
1203-1260 1.23e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 1.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176 1203 SLEVLHLGYNGICNLIQLQLNRLRNLKFLFLQGNEISQVEG--LDNLVVLQELVVDHNRI 1260
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-242 2.47e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   50 LSLFPNLTSLTIVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIeNLEKLIKLKVLWLNH 129
Cdd:COG4886    224 LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLL 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176  130 NTIKNIEGLQTLKNLKDLNLAgNLINSIGRCLDSNEQLERLNLSGNQICSFKELTNLTRLPCLKDLCLNDPQYTTNPVCL 209
Cdd:COG4886    303 LLLLLLNLLELLILLLLLTTL-LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                          170       180       190
                   ....*....|....*....|....*....|...
gi 2074014176  210 LCNYSTHVLYHLPCLQRFDTLDVSAKQIKELAD 242
Cdd:COG4886    382 LALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-118 4.31e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 4.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2074014176   77 QLKELWIAECCIEKIEGLQECRNLEKLYLYFN-KISKIENLEK 118
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 932-963 7.48e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 7.48e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2074014176  932 NLEELTLDGNCISKIEGISKMTKLTRLSINNN 963
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 99-177 9.04e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 9.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2074014176   99 NLEKLYLYFNKISKiENLEKLIK-------LKVLWLNHNTIKN------IEGLQTLKNLKDLNLAGNLIN-----SIGRC 160
Cdd:COG5238    181 SVETVYLGCNQIGD-EGIEELAEaltqnttVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGdegviALAEA 259

                           90
                   ....*....|....*..
gi 2074014176  161 LDSNEQLERLNLSGNQI 177
Cdd:COG5238    260 LKNNTTVETLYLSGNQI 276
LRR_8 pfam13855
Leucine rich repeat;
1226-1284 9.28e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 9.28e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2074014176 1226 RNLKFLFLQGNEISQVEG--LDNLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRL 1284
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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