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Conserved domains on  [gi|2073496283|ref|NP_001382575|]
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leucine-rich repeat-containing protein 3B precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183727)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
69-125 5.56e-12

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 5.56e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2073496283  69 LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAEtLQTLDLSDNRI 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-68 4.14e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 4.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2073496283   33 MCPKGCLCSssgGLNVTCSNANLKEIPRDLPPETVL 68
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
69-125 5.56e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 5.56e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2073496283  69 LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAEtLQTLDLSDNRI 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-137 7.54e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 7.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  51 SNANLKEIPRDLPPETVL--LYLDSNQITSIPNEIfKDLHQLRVLNLSKNGIEFIDEHAFKgvAETLQTLDLSDNRIQSV 128
Cdd:COG4886   121 SGNQLTDLPEELANLTNLkeLDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDL 197


                  ....*....
gi 2073496283 129 HKnAFNNLK 137
Cdd:COG4886   198 PE-PLGNLT 205
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
52-145 3.81e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  52 NANLKEIPRDLPPETVLLYLDSNQITSIPnEIFKDlhQLRVLNLSKNGIEFIDEHafkgVAETLQTLDLSDNRIQSVHKN 131
Cdd:PRK15370  208 NNELKSLPENLQGNIKTLYANSNQLTSIP-ATLPD--TIQEMELSINRITELPER----LPSALQSLDLFHNKISCLPEN 280

                          90
                  ....*....|....
gi 2073496283 132 AFNNLKARARIANN 145
Cdd:PRK15370  281 LPEELRYLSVYDNS 294
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-68 4.14e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 4.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2073496283   33 MCPKGCLCSssgGLNVTCSNANLKEIPRDLPPETVL 68
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-63 3.85e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.53  E-value: 3.85e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2073496283  33 MCPKGCLCSssgGLNVTCSNANLKEIPRDLP 63
Cdd:pfam01462   1 ACPVPCHCS---ATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-128 6.14e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  69 LYLDSNQITSIPNeiFKDLHQLRVLNLSKNGIEFI---------------------------DEHAFKGVAETLQTLDLS 121
Cdd:cd21340    51 LYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfDPRSLAALSNSLRVLNIS 128


                  ....*..
gi 2073496283 122 DNRIQSV 128
Cdd:cd21340   129 GNNIDSL 135
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
69-125 5.56e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 5.56e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2073496283  69 LYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAEtLQTLDLSDNRI 125
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-137 7.54e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 7.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  51 SNANLKEIPRDLPPETVL--LYLDSNQITSIPNEIfKDLHQLRVLNLSKNGIEFIDEHAFKgvAETLQTLDLSDNRIQSV 128
Cdd:COG4886   121 SGNQLTDLPEELANLTNLkeLDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDL 197


                  ....*....
gi 2073496283 129 HKnAFNNLK 137
Cdd:COG4886   198 PE-PLGNLT 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-127 4.48e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 4.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  50 CSNANLKEIPRDLPPETVL--LYLDSNQITSIPNEIFKdLHQLRVLNLSKNGIEFIDEhAFKGvAETLQTLDLSDNRIQS 127
Cdd:COG4886   143 LSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPE-PLGN-LTNLEELDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-137 1.40e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2073496283  69 LYLDSNQITSIPNEIfKDLHQLRVLNLSKNGIEFIDEhaFKGVAETLQTLDLSDNRIQSVhKNAFNNLK 137
Cdd:COG4886   118 LDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDL-PEELGNLT 182
LRR_8 pfam13855
Leucine rich repeat;
89-138 2.45e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 2.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2073496283  89 QLRVLNLSKNGIEFIDEHAFKGVaETLQTLDLSDNRIQSVHKNAFNNLKA 138
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGAFSGLPS 50
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-137 4.60e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 4.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  50 CSNANLKEIPRDLPPETVL--LYLDSNQITSIPNEIfKDLHQLRVLNLSKNGIEFIDEhaFKGVAEtLQTLDLSDNRIQS 127
Cdd:COG4886   189 LSNNQITDLPEPLGNLTNLeeLDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTN-LEELDLSNNQLTD 264

                          90
                  ....*....|.
gi 2073496283 128 VHKNA-FNNLK 137
Cdd:COG4886   265 LPPLAnLTNLK 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-138 7.46e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 7.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  50 CSNANLKEIPRDLPPETVL--LYLDSNQITSIPNeiFKDLHQLRVLNLSKNGIEFIDEHAFkgvAETLQTLDLSDNRIQS 127
Cdd:COG4886   212 LSGNQLTDLPEPLANLTNLetLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN---LTNLKTLDLSNNQLTD 286

                          90
                  ....*....|.
gi 2073496283 128 VHKNAFNNLKA 138
Cdd:COG4886   287 LKLKELELLLG 297
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
52-145 3.81e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  52 NANLKEIPRDLPPETVLLYLDSNQITSIPnEIFKDlhQLRVLNLSKNGIEFIDEHafkgVAETLQTLDLSDNRIQSVHKN 131
Cdd:PRK15370  208 NNELKSLPENLQGNIKTLYANSNQLTSIP-ATLPD--TIQEMELSINRITELPER----LPSALQSLDLFHNKISCLPEN 280

                          90
                  ....*....|....
gi 2073496283 132 AFNNLKARARIANN 145
Cdd:PRK15370  281 LPEELRYLSVYDNS 294
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-68 4.14e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 4.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2073496283   33 MCPKGCLCSssgGLNVTCSNANLKEIPRDLPPETVL 68
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-63 3.85e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.53  E-value: 3.85e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2073496283  33 MCPKGCLCSssgGLNVTCSNANLKEIPRDLP 63
Cdd:pfam01462   1 ACPVPCHCS---ATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-128 6.14e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  69 LYLDSNQITSIPNeiFKDLHQLRVLNLSKNGIEFI---------------------------DEHAFKGVAETLQTLDLS 121
Cdd:cd21340    51 LYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfDPRSLAALSNSLRVLNIS 128


                  ....*..
gi 2073496283 122 DNRIQSV 128
Cdd:cd21340   129 GNNIDSL 135
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-162 6.52e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.92  E-value: 6.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  43 SGGLNVTCSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKdlhQLRVLNLSKNGIEFIDEhafkGVAETLQTLDLSD 122
Cdd:PRK15370  304 SGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPP---ELQVLDVSKNQITVLPE----TLPPTITTLDVSR 376

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2073496283 123 NRIQSVHKN----------AFNNL----------------KARARIANNPWhCDCTLQQVLRSMAS 162
Cdd:PRK15370  377 NALTNLPENlpaalqimqaSRNNLvrlpeslphfrgegpqPTRIIVEYNPF-SERTIQNMQRLMSS 441
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-130 1.22e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 1.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2073496283  68 LLYLD--SNQITSIpnEIFKDLHQLRVLNLSKNGIEFIDEhaFKGVAET---LQTLDLSDNRIQSVHK 130
Cdd:cd21340   122 LRVLNisGNNIDSL--EPLAPLRNLEQLDASNNQISDLEE--LLDLLSSwpsLRELDLTGNPVCKKPK 185
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 51-135 2.92e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 36.75  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  51 SNANLKEIprDLPpetvllyldsNQITSIPNEIFKDLHQLRVLNLSkNGIEFIDEHAFKGVAetLQTLDLSDNrIQSVHK 130
Cdd:pfam13306   9 YNCSLTSI--TIP----------SSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS--LTSITIPSS-LTSIGE 72


                  ....*
gi 2073496283 131 NAFNN 135
Cdd:pfam13306  73 YAFSN 77
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-125 3.30e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.11  E-value: 3.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2073496283  67 VLLYLDSNQIT----SIPNEIFKDLHQLRVLNLSKN-----GIEFIDEhAFKGVAETLQTLDLSDNRI 125
Cdd:cd00116   196 EVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNnltdaGAAALAS-ALLSPNISLLTLSLSCNDI 262
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 51-135 4.73e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 36.37  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2073496283  51 SNANLKEIprDLPpetvllyldsNQITSIPNEIFKDLHQLRVLNLSKNgIEFIDEHAFKGvaETLQTLDLSDNrIQSVHK 130
Cdd:pfam13306  54 YNCSLTSI--TIP----------SSLTSIGEYAFSNCSNLKSITLPSN-LTSIGSYAFSN--CSLKSITIPSS-VTTIGS 117


                  ....*
gi 2073496283 131 NAFNN 135
Cdd:pfam13306 118 YAFSN 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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