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Conserved domains on  [gi|2031835736|ref|NP_001381654|]
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protein GPR108 isoform 11 [Homo sapiens]

Protein Classification

lung seven transmembrane receptor family protein( domain architecture ID 229834)

lung seven transmembrane receptor (LU7TM) family protein similar to Arabidopsis thaliana protein CANDIDATE G-PROTEIN COUPLED RECEPTORS 6 and 7 that play roles in plants and microbes interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lung_7-TM_R super family cl21735
Lung seven transmembrane receptor; This family represents a conserved region with eukaryotic ...
 1-208 2.18e-74

Lung seven transmembrane receptor; This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins.


The actual alignment was detected with superfamily member pfam06814:

Pssm-ID: 473945  Cd Length: 294  Bit Score: 229.52  E-value: 2.18e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031835736   1 MIREKNPDGFLSAAEMPLFKLYMVMSACFLAAGIFWVSILCRNTYSVFKIHWLMAALAFTKSISLLFHSINYYFINSQGH 80
Cdd:pfam06814  29 TVVWKNPYGYLSASEAPLMPFYGIMSLAYVLLGILWSFILFKYWHDILPIQKYIAAVIALGMAELAFHYIDYAFINSKGS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031835736  81 PIEGLAVMYYIAHLLKGALLFITIALIGSGWAFIKYVLSDKEKKVFGIVIPMQVLANVAYIIIESREEGASDYVLWKEIL 160
Cdd:pfam06814 109 SIEVLAVFASILSAAKKTLSRILLLIISLGYGIVKPTLGDTLSKVCGIGLLYFVAACVLFIVRESGEEGDSSYKLWLVLF 188

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2031835736 161 FLVDLicCGAILFPVVWSIRHLQDaSGTDGKVAVNLAKLKLFRHYYVM 208
Cdd:pfam06814 189 FLLPL--ALLDLFFVVWIFRSLQK-TLRDLRLRRNLVKLSLYRHFTNM 233
 
Name Accession Description Interval E-value
Lung_7-TM_R pfam06814
Lung seven transmembrane receptor; This family represents a conserved region with eukaryotic ...
 1-208 2.18e-74

Lung seven transmembrane receptor; This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins.


Pssm-ID: 369089  Cd Length: 294  Bit Score: 229.52  E-value: 2.18e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031835736   1 MIREKNPDGFLSAAEMPLFKLYMVMSACFLAAGIFWVSILCRNTYSVFKIHWLMAALAFTKSISLLFHSINYYFINSQGH 80
Cdd:pfam06814  29 TVVWKNPYGYLSASEAPLMPFYGIMSLAYVLLGILWSFILFKYWHDILPIQKYIAAVIALGMAELAFHYIDYAFINSKGS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031835736  81 PIEGLAVMYYIAHLLKGALLFITIALIGSGWAFIKYVLSDKEKKVFGIVIPMQVLANVAYIIIESREEGASDYVLWKEIL 160
Cdd:pfam06814 109 SIEVLAVFASILSAAKKTLSRILLLIISLGYGIVKPTLGDTLSKVCGIGLLYFVAACVLFIVRESGEEGDSSYKLWLVLF 188

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2031835736 161 FLVDLicCGAILFPVVWSIRHLQDaSGTDGKVAVNLAKLKLFRHYYVM 208
Cdd:pfam06814 189 FLLPL--ALLDLFFVVWIFRSLQK-TLRDLRLRRNLVKLSLYRHFTNM 233
 
Name Accession Description Interval E-value
Lung_7-TM_R pfam06814
Lung seven transmembrane receptor; This family represents a conserved region with eukaryotic ...
 1-208 2.18e-74

Lung seven transmembrane receptor; This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins.


Pssm-ID: 369089  Cd Length: 294  Bit Score: 229.52  E-value: 2.18e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031835736   1 MIREKNPDGFLSAAEMPLFKLYMVMSACFLAAGIFWVSILCRNTYSVFKIHWLMAALAFTKSISLLFHSINYYFINSQGH 80
Cdd:pfam06814  29 TVVWKNPYGYLSASEAPLMPFYGIMSLAYVLLGILWSFILFKYWHDILPIQKYIAAVIALGMAELAFHYIDYAFINSKGS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031835736  81 PIEGLAVMYYIAHLLKGALLFITIALIGSGWAFIKYVLSDKEKKVFGIVIPMQVLANVAYIIIESREEGASDYVLWKEIL 160
Cdd:pfam06814 109 SIEVLAVFASILSAAKKTLSRILLLIISLGYGIVKPTLGDTLSKVCGIGLLYFVAACVLFIVRESGEEGDSSYKLWLVLF 188

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2031835736 161 FLVDLicCGAILFPVVWSIRHLQDaSGTDGKVAVNLAKLKLFRHYYVM 208
Cdd:pfam06814 189 FLLPL--ALLDLFFVVWIFRSLQK-TLRDLRLRRNLVKLSLYRHFTNM 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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