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Conserved domains on  [gi|2017500061|ref|NP_001380905|]
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histone-lysine N-methyltransferase SETDB2 isoform e [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 210-561 6.43e-141

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


:

Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 408.07  E-value: 6.43e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 210 FSFNTYVQLARNYPKQKEVVSDVDISNGVesvpisfcneidsrklpqfkyrktvwpraynltnfssmFTDSCDCSEGCID 289
Cdd:cd10523     1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA--------------------------------------FVDSCDCTDGCID 42

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 290 ITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGV 369
Cdd:cd10523    43 ILKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 370 RCLDDIDRGTFVCIYSGRLLSRANTEKSYGI------DENGRDENTMKNIFSKKRKLEVacsdcevevlplglETHPRTA 443
Cdd:cd10523   123 RCLDDIDKGTFVCIYAGRVLSRARSPTEPLPpklelpSENEVEVVTSWLILSKKRKLRE--------------NVCFLDA 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 444 KTEKCPPKFSNnpkeltvetkydnisriqyhsvirdpesktaifqhngkkmHSCCPNLLVQNVFVETHNRNFPLVAFFTN 523
Cdd:cd10523   189 SKEGNVGRFLN----------------------------------------HSCCPNLFVQNVFVDTHDKNFPWVAFFTN 228

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2017500061 524 RYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKI 561
Cdd:cd10523   229 RVVKAGTELTWDYSYDAGTSPEQEIPCLCGVNKCQKKI 266
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 1.71e-25

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


:

Pssm-ID: 238689  Cd Length: 60  Bit Score: 99.38  E-value: 1.71e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017500061 152 PLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETeCNFLFTDNFSF 212
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
 
Name Accession Description Interval E-value
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 210-561 6.43e-141

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 408.07  E-value: 6.43e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 210 FSFNTYVQLARNYPKQKEVVSDVDISNGVesvpisfcneidsrklpqfkyrktvwpraynltnfssmFTDSCDCSEGCID 289
Cdd:cd10523     1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA--------------------------------------FVDSCDCTDGCID 42

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 290 ITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGV 369
Cdd:cd10523    43 ILKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 370 RCLDDIDRGTFVCIYSGRLLSRANTEKSYGI------DENGRDENTMKNIFSKKRKLEVacsdcevevlplglETHPRTA 443
Cdd:cd10523   123 RCLDDIDKGTFVCIYAGRVLSRARSPTEPLPpklelpSENEVEVVTSWLILSKKRKLRE--------------NVCFLDA 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 444 KTEKCPPKFSNnpkeltvetkydnisriqyhsvirdpesktaifqhngkkmHSCCPNLLVQNVFVETHNRNFPLVAFFTN 523
Cdd:cd10523   189 SKEGNVGRFLN----------------------------------------HSCCPNLFVQNVFVDTHDKNFPWVAFFTN 228

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2017500061 524 RYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKI 561
Cdd:cd10523   229 RVVKAGTELTWDYSYDAGTSPEQEIPCLCGVNKCQKKI 266
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 1.71e-25

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


Pssm-ID: 238689  Cd Length: 60  Bit Score: 99.38  E-value: 1.71e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017500061 152 PLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETeCNFLFTDNFSF 212
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 234-347 2.98e-18

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 80.16  E-value: 2.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 234 ISNGVESVPISFCNEIDS-RKLPQFKYRKTVWPraynLTNFSSMFTDSCDCsEGCIDiTKCACLQLTarnaktsplsSDK 312
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDePPPPDFTYITSYIY----PKEFLLIIPQGCDC-GDCSS-EKCSCAQLN----------GGE 64

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2017500061 313 ITTGYKYKRLQR-QIPTGIYECSLLCKCNRQlCQNR 347
Cdd:pfam05033  65 FRFPYDKDGLLVpESKPPIYECNPLCGCPPS-CPNR 99
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 355-539 1.03e-14

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 70.83  E-value: 1.03e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061  355 VRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGI-DENGRDENTMKNIFSKKrklevaCSDcevevlp 433
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAyDTDGAKAFYLFDIDSDL------CID------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061  434 lglethprtaktekcppkfsnnpkeltvETKYDNISRIqyhsvIRdpesktaifqhngkkmHSCCPNLLVQNVFVETHNR 513
Cdd:smart00317  68 ----------------------------ARRKGNLARF-----IN----------------HSCEPNCELLFVEVNGDDR 98

                          170       180
                   ....*....|....*....|....*.
gi 2017500061  514 nfplVAFFTNRYVKARTELTWDYGYE 539
Cdd:smart00317  99 ----IVIFALRDIKPGEELTIDYGSD 120
MBD smart00391
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...
 150-227 8.56e-12

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain


Pssm-ID: 128673  Cd Length: 77  Bit Score: 60.85  E-value: 8.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061  150 ENPLQLPIKCHFQRRHA--KTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVqlaRNYPKQKE 227
Cdd:smart00391   1 GDPLRLPLPCGWRRETKqrKSGRSAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATV---PVGPKFTP 77
MBD pfam01429
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...
 149-216 1.91e-08

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.


Pssm-ID: 396147 [Multi-domain]  Cd Length: 76  Bit Score: 51.21  E-value: 1.91e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 149 GENPLQLPIKCHFQR--RHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYV 216
Cdd:pfam01429   3 RKREDRLPLPPGWRReeRQRKSGSKAGKVDVFYYSPTGKKLRSKSEVARYLEANGGTSPKLEDFSFTVRS 72
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
495-560 5.59e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 40.33  E-value: 5.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017500061 495 HSCCPNLlvqnVFVETHNRNFplvaFFTNRYVKARTELTWDYGYEagtVPEKEIFCQCGvnKCRKK 560
Cdd:COG2940    82 HSCDPNC----EADEEDGRIF----IVALRDIAAGEELTYDYGLD---YDEEEYPCRCP--NCRGT 134
 
Name Accession Description Interval E-value
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 210-561 6.43e-141

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 408.07  E-value: 6.43e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 210 FSFNTYVQLARNYPKQKEVVSDVDISNGVesvpisfcneidsrklpqfkyrktvwpraynltnfssmFTDSCDCSEGCID 289
Cdd:cd10523     1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA--------------------------------------FVDSCDCTDGCID 42

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 290 ITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGV 369
Cdd:cd10523    43 ILKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 370 RCLDDIDRGTFVCIYSGRLLSRANTEKSYGI------DENGRDENTMKNIFSKKRKLEVacsdcevevlplglETHPRTA 443
Cdd:cd10523   123 RCLDDIDKGTFVCIYAGRVLSRARSPTEPLPpklelpSENEVEVVTSWLILSKKRKLRE--------------NVCFLDA 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 444 KTEKCPPKFSNnpkeltvetkydnisriqyhsvirdpesktaifqhngkkmHSCCPNLLVQNVFVETHNRNFPLVAFFTN 523
Cdd:cd10523   189 SKEGNVGRFLN----------------------------------------HSCCPNLFVQNVFVDTHDKNFPWVAFFTN 228

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2017500061 524 RYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKI 561
Cdd:cd10523   229 RVVKAGTELTWDYSYDAGTSPEQEIPCLCGVNKCQKKI 266
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 277-561 4.67e-118

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 348.76  E-value: 4.67e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 277 FTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVR 356
Cdd:cd10541    14 FLVGCDCTDGCRDKSKCACHQLTIQATACTPGGQDNPTAGYQYKRLEECLPTGVYECNKLCKCDPNMCQNRLVQHGLQVR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 357 LQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDengrdentMKNIFSKKRKLEVACSDCEvevlplgl 436
Cdd:cd10541    94 LQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLEM--------GDEYFANLDHIEESCYIID-------- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 437 ethprtAKTEKCPPKFSNnpkeltvetkydnisriqyhsvirdpesktaifqhngkkmHSCCPNLLVQNVFVETHNRNFP 516
Cdd:cd10541   158 ------AKLEGNLGRYLN----------------------------------------HSCSPNLFVQNVFVDTHDLRFP 191

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2017500061 517 LVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKI 561
Cdd:cd10541   192 WVAFFASKRIKAGTELTWDYNYEVGSVEGKELLCCCGSNECRGRL 236
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 233-562 1.29e-90

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 280.33  E-value: 1.29e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 233 DISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDK 312
Cdd:cd10517     8 DISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAATPGGQIN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 313 ITTGYKYKRLQRQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSR- 391
Cdd:cd10517    88 PSAGYQYRRLMEKLPTGVYECNSRCKCDKR-CYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILTEd 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 392 -ANTEKSYGIDEngrdentmknIFSKKRKLEVacsdceVEvlplglethprtaktekcppkfsnNPKEltvetKYDniSR 470
Cdd:cd10517   167 eANEEGLQYGDE----------YFAELDYIEV------VE------------------------KLKE-----GYE--SD 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 471 IQYHSVIRDPESKTAIfqhnGKKM-HSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIF 549
Cdd:cd10517   200 VEEHCYIIDAKSEGNL----GRYLnHSCSPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNYEVGSVPGKVLY 275

                         330
                  ....*....|...
gi 2017500061 550 CQCGVNKCRKKIL 562
Cdd:cd10517   276 CYCGSSNCRGRLL 288
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 256-537 3.12e-44

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 156.38  E-value: 3.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 256 QFKYRKTVWPRAYNLTNFSsmFTDSCDCSEGCIDiTKCACLQLTARNaktsplssdkitTGYKYKRLQR--QIPTGIYEC 333
Cdd:cd10538     4 TYIKDNIVGKNVQPFSNII--DSVGCKCKDDCLD-SKCACAAESDGI------------FAYTKNGLLRlnNSPPPIFEC 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 334 SLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDENTMKni 413
Cdd:cd10538    69 NSKCSCDDD-CKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGGSYLFD-- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 414 fskkrklevacSDCEVEVlplglethprtaktekcppkfSNNPKELTVE-TKYDNISR-IQyhsvirdpesktaifqhng 491
Cdd:cd10538   146 -----------LDEFSDS---------------------DGDGEELCVDaTFCGNVSRfIN------------------- 174

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2017500061 492 kkmHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYG 537
Cdd:cd10538   175 ---HSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 280-538 1.22e-38

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 141.39  E-value: 1.22e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 280 SCDCSEGCIDITK-CAClqlTARNAKTSPLSsdkittgyKYKRLQRQIPTgIYECSLLCKCNRQlCQNRVVQHGPQVRLQ 358
Cdd:cd10545    23 GCDCKNRCTDGASdCAC---VKKNGGEIPYN--------FNGRLIRAKPA-IYECGPLCKCPPS-CYNRVTQKGLRYRLE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 359 VFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDE---------NGRDENTMKnifskkrKLEVACSDCEv 429
Cdd:cd10545    90 VFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSGNDDylfdidnrqTNRGWDGGQ-------RLDVGMSDGE- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 430 evlplglethprtaktEKCPPKfsNNPKELTVETKY-DNISRiqyhsvirdpesktaiFQHngkkmHSCCPNLLVQNVFV 508
Cdd:cd10545   162 ----------------RSSAED--EESSEFTIDAGSfGNVAR----------------FIN-----HSCSPNLFVQCVLY 202

                         250       260       270
                  ....*....|....*....|....*....|
gi 2017500061 509 ETHNRNFPLVAFFTNRYVKARTELTWDYGY 538
Cdd:cd10545   203 DHNDLRLPRVMLFAADNIPPLQELTYDYGY 232
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 281-559 2.15e-37

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 138.58  E-value: 2.15e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 281 CDCSEGCIDITKCACLQLtarnaktsplsSDKITTGYKYKRLQRQIPTGIYECSLLCKCNrQLCQNRVVQHGPQVRLQVF 360
Cdd:cd10542    25 CECTEDCHNNNPTCCPAE-----------SGVKFAYDKQGRLRLPPGTPIYECNSRCKCG-PDCPNRVVQRGRKVPLCIF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 361 KTEQ-KGWGVRCLDDIDRGTFVCIYSGRLLSRANTE---KSYgiDENGR------DENTmknifskkrklevacSDCeve 430
Cdd:cd10542    93 RTSNgRGWGVKTLEDIKKGTFVMEYVGEIITSEEAErrgKIY--DANGRtylfdlDYND---------------DDC--- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 431 vlplglethprtaktekcppkfsnnpkELTVE-TKYDNISRiqyhsvirdpesktaiFQHngkkmHSCCPNLLVQNVFVE 509
Cdd:cd10542   153 ---------------------------EYTVDaAYYGNISH----------------FIN-----HSCDPNLAVYAVWIN 184

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2017500061 510 THNRNFPLVAFFTNRYVKARTELTWDY------GYEAGTVPEKE---IFCQCGVNKCRK 559
Cdd:cd10542   185 HLDPRLPRIAFFAKRDIKAGEELTFDYlmtgtgGSSESTIPKPKdvrVPCLCGSKNCRK 243
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 280-558 1.47e-34

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 130.15  E-value: 1.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 280 SCDCSEGCiDITKCACLQLTARNA--KTSPLSSDkittgykykrLQRQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRL 357
Cdd:cd10543    26 TCSCRDDC-SSDNCVCGRLSVRCWydKEGRLLPD----------FNKLDPPLIFECNRACSCWRN-CRNRVVQNGIRYRL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 358 QVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEK----SYGIDENGRDEntmknifskkrklEVACSDcevevlp 433
Cdd:cd10543    94 QLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSreddSYLFDLDNKDG-------------ETYCID------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 434 lglethprtAKtekcppkfsnnpkeltvetKYDNISRiqyhsvirdpesktaiFQHngkkmHSCCPNLLVQNVFVETHNR 513
Cdd:cd10543   154 ---------AR-------------------RYGNISR----------------FIN-----HLCEPNLIPVRVFVEHQDL 184

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2017500061 514 NFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCR 558
Cdd:cd10543   185 RFPRIAFFASRDIKAGEELGFDYGEKFWRIKGKYFTCRCGSPKCK 229
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 281-558 3.12e-29

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 115.42  E-value: 3.12e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 281 CDCSEGCIDiTKCACLQLTARnaktspLSSDKitTGYKYKRLQRQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRLQVF 360
Cdd:cd10535    27 CVCIDDCSS-SNCMCGQLSMR------CWYDK--DGRLLPEFNMAEPPLIFECNHACSCWRN-CRNRVVQNGLRARLQLY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 361 KTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANT----EKSYGIDENGRDEntmknifskkrklEVACSDCEVevlplgl 436
Cdd:cd10535    97 RTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEAdvreEDSYLFDLDNKDG-------------EVYCIDARF------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 437 ethprtaktekcppkfsnnpkeltvetkYDNISRIqyhsvirdpesktaifqhngkKMHSCCPNLLVQNVFVETHNRNFP 516
Cdd:cd10535   157 ----------------------------YGNVSRF---------------------INHHCEPNLVPVRVFMAHQDLRFP 187

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2017500061 517 LVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCR 558
Cdd:cd10535   188 RIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCR 229
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 281-558 6.59e-28

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 112.03  E-value: 6.59e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 281 CDCSEGCIDiTKCACLQLTARnaktspLSSDKitTGYKYKRLQRQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRLQVF 360
Cdd:cd10533    27 CTCVDDCSS-SNCLCGQLSIR------CWYDK--DGRLLQEFNKIEPPLIFECNQACSCWRN-CKNRVVQSGIKVRLQLY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 361 KTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANT----EKSYGIDENGRDEntmknifskkrklEVACSDCEVevlplgl 436
Cdd:cd10533    97 RTAKMGWGVRALQTIPQGTFICEYVGELISDAEAdvreDDSYLFDLDNKDG-------------EVYCIDARY------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 437 ethprtaktekcppkfsnnpkeltvetkYDNISRIqyhsvirdpesktaifqhngkKMHSCCPNLLVQNVFVETHNRNFP 516
Cdd:cd10533   157 ----------------------------YGNISRF---------------------INHLCDPNIIPVRVFMLHQDLRFP 187

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2017500061 517 LVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCR 558
Cdd:cd10533   188 RIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCK 229
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 255-560 4.28e-27

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 110.08  E-value: 4.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 255 PQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITtgyKYKRLqrqiptgIYECS 334
Cdd:cd10544     1 PDFQYTPENVPGPGADTDPNEITFPGCDCKTSSCEPETCSCLRKYGPNYDDDGCLLDFDG---KYSGP-------VFECN 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 335 LLCKCNRQlCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLsranteksyGIDENGR-----DENT 409
Cdd:cd10544    71 SMCKCSES-CQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVI---------GFEEARRrtksqTKGD 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 410 MKNIFSKKRKLevacSDCEVevlplgLETH--PrtaktekcppkfsnnpkeltveTKYDNISR-IQyhsvirdpesktai 486
Cdd:cd10544   141 MNYIIVLREHL----SSGKV------LETFvdP----------------------TYIGNIGRfLN-------------- 174

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017500061 487 fqhngkkmHSCCPNLLVQNVFVethNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKK 560
Cdd:cd10544   175 --------HSCEPNLFMVPVRV---DSMVPKLALFAARDIVAGEELSFDYSGEFSNSVESVTLARQDESKSRKP 237
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 1.71e-25

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


Pssm-ID: 238689  Cd Length: 60  Bit Score: 99.38  E-value: 1.71e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017500061 152 PLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETeCNFLFTDNFSF 212
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 275-559 8.20e-21

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 92.38  E-value: 8.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 275 SMFTDSCDCSEG--CIDITkCACLQLTARnaKTSPLSSDKI----TTGYKYKRLQRQIPTG---IYECSLLCKCNrQLCQ 345
Cdd:cd19473    20 EEFRSGCECTDDedCMYSG-CLCLQDVDP--DDDRDPGKKKnayhSSGAKKGCLRGHMLNSrlpIYECHEGCACS-DDCP 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 346 NRVVQHGPQVRLQVFKTEQ-KGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSygidengRDENTmknifSKKRKlevac 424
Cdd:cd19473    96 NRVVERGRKVPLQIFRTSDgRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRR-------RDAAT-----IAQRK----- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 425 sdcEVEVLPLGLETHPRTAKtekcpPKFSNNPKELTVE-----TKYDNisriqyhsvirdpesktaifqhngkkmHSCCP 499
Cdd:cd19473   159 ---DVYLFALDKFSDPDSLD-----PRLRGDPYEIDGEfmsgpTRFIN---------------------------HSCDP 203

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017500061 500 NLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDY------GYEAGTVPEKEIF---CQCGVNKCRK 559
Cdd:cd19473   204 NLRIFARVGDHADKHIHDLAFFAIKDIPRGTELTFDYvdgvtgLDDDAGDEEKEKEmtkCLCGSPKCRG 272
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 249-558 6.43e-19

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 86.47  E-value: 6.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 249 IDSRKLPQFKYRKTVWPRaynltnfSSMFTDSCDCS--EGCI--DITKCACLQltarnaktsplSSDKITTGY-KYKRLQ 323
Cdd:cd20073     1 IDFEFITSYRYGLGIEPP-------DPLFISGCSCSklGGCDlnNPGSCQCLE-----------DSNEKSFAYdEYGRVR 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 324 RQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSygidEN 403
Cdd:cd20073    63 ANTGSIIYECNENCDCGIN-CPNRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIR----GK 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 404 GRDENTMKNIFskkrklEVACSDCEVEvlplglETHPRTAKTEKCPPKFSNnpkeltvetkydnisriqyhsvirdpesk 483
Cdd:cd20073   138 KYDNVGVTYLF------DLDLFEDQVD------EYYTVDAQYCGDVTRFIN----------------------------- 176

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 484 taifqhngkkmHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDY---------GYEAGTVPEKEIF----- 549
Cdd:cd20073   177 -----------HSCDPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYsgrnnfdqlGFIGNRSNSKYINlknkr 245

                         330
                  ....*....|
gi 2017500061 550 -CQCGVNKCR 558
Cdd:cd20073   246 pCYCGSANCR 255
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 234-347 2.98e-18

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 80.16  E-value: 2.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 234 ISNGVESVPISFCNEIDS-RKLPQFKYRKTVWPraynLTNFSSMFTDSCDCsEGCIDiTKCACLQLTarnaktsplsSDK 312
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDePPPPDFTYITSYIY----PKEFLLIIPQGCDC-GDCSS-EKCSCAQLN----------GGE 64

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2017500061 313 ITTGYKYKRLQR-QIPTGIYECSLLCKCNRQlCQNR 347
Cdd:pfam05033  65 FRFPYDKDGLLVpESKPPIYECNPLCGCPPS-CPNR 99
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 320-558 4.68e-18

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 83.79  E-value: 4.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 320 KRLQRQIPTG--IYECSLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQ-KGWGVRCLDDIDRGTFVCIYSGRLLSRANTEk 396
Cdd:cd10532    48 EHGQLKIPPGtpIYECNSRCKCGPD-CPNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAE- 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 397 sygidengrdentmknifskkRKLEVACSDCEVEVLPLGLEThprtaktekcppkfsnnpKELTVE-TKYDNISriqyHS 475
Cdd:cd10532   126 ---------------------RRGQFYDSKGITYLFDLDYES------------------DEFTVDaARYGNVS----HF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 476 VirdpesktaifqhngkkMHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDY---GY------EAGTVPEK 546
Cdd:cd10532   163 V-----------------NHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYqmkGSgdlssdSIDNSPAK 225

                         250
                  ....*....|....*
gi 2017500061 547 E---IFCQCGVNKCR 558
Cdd:cd10532   226 KrvrTVCKCGAVTCR 240
MBD cd00122
MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of ...
 152-212 5.61e-18

MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1. The MBDs present in putative chromatin remodelling subunit, BAZ2A, and putative histone methyltransferase, CLLD8, represent two phylogenetically distinct groups within the MBD protein family.


Pssm-ID: 238069  Cd Length: 62  Bit Score: 78.13  E-value: 5.61e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017500061 152 PLQLPIKCHFQRRHAKTNSHS-SALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSF 212
Cdd:cd00122     1 PLRDPLPPGWKRELVIRKSGSaGKGDVYYYSPCGKKLRSKPEVARYLEKTGPSSLDLENFSF 62
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 330-559 1.91e-17

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 82.25  E-value: 1.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 330 IYECSLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQ-KGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIdengRDEN 408
Cdd:cd10525    62 IYECNSRCRCGPD-CPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQI----YDRQ 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 409 TMKNIFSKKRKLEVACSDCevevlplglethprtaktekcppkfsnnpkeltveTKYDNISriqyHSVirdpesktaifq 488
Cdd:cd10525   137 GATYLFDLDYVEDVYTVDA-----------------------------------AYYGNIS----HFV------------ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 489 hngkkMHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDY---------------------GYEAGTVPEKE 547
Cdd:cd10525   166 -----NHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYnmqvdpvdaestkmdsnfglaGLPGSPKKRVR 240

                         250
                  ....*....|..
gi 2017500061 548 IFCQCGVNKCRK 559
Cdd:cd10525   241 IECKCGVRSCRK 252
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 355-539 1.03e-14

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 70.83  E-value: 1.03e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061  355 VRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGI-DENGRDENTMKNIFSKKrklevaCSDcevevlp 433
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAyDTDGAKAFYLFDIDSDL------CID------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061  434 lglethprtaktekcppkfsnnpkeltvETKYDNISRIqyhsvIRdpesktaifqhngkkmHSCCPNLLVQNVFVETHNR 513
Cdd:smart00317  68 ----------------------------ARRKGNLARF-----IN----------------HSCEPNCELLFVEVNGDDR 98

                          170       180
                   ....*....|....*....|....*.
gi 2017500061  514 nfplVAFFTNRYVKARTELTWDYGYE 539
Cdd:smart00317  99 ----IVIFALRDIKPGEELTIDYGSD 120
MBD smart00391
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...
 150-227 8.56e-12

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain


Pssm-ID: 128673  Cd Length: 77  Bit Score: 60.85  E-value: 8.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061  150 ENPLQLPIKCHFQRRHA--KTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVqlaRNYPKQKE 227
Cdd:smart00391   1 GDPLRLPLPCGWRRETKqrKSGRSAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATV---PVGPKFTP 77
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 357-558 1.47e-10

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 59.19  E-value: 1.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 357 LQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRAnteksygidengrdentmknifSKKRKLEVACSDCEVEVLPLGL 436
Cdd:cd10531     2 LELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKK----------------------EFKERLDEYEELGKSNFYILSL 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 437 EthprtaktekcppkfsnnpKELTVE-TKYDNISR-IQyhsvirdpesktaifqhngkkmHSCCPNLLVQNVFVETHNRn 514
Cdd:cd10531    60 S-------------------DDVVIDaTRKGNLSRfIN----------------------HSCEPNCETQKWIVNGEYR- 97

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2017500061 515 fplVAFFTNRYVKARTELTWDYGYEagTVPEKEIFCQCGVNKCR 558
Cdd:cd10531    98 ---IGIFALRDIPAGEELTFDYNFV--NYNEAKQVCLCGAQNCR 136
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 357-561 8.11e-10

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 57.30  E-value: 8.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 357 LQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSranteksygidENGRDENTMKNIFSKKrklevaCSDCevevlpLGL 436
Cdd:cd19174     2 LERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVS-----------EQEFRRRMIEQYHNHS------HHYC------LNL 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 437 EthprtaktekcppkfsnnPKELTVETKYDNISRiqyhsvirdpesktaiFQHngkkmHSCCPNLLVQNVFVETHNRnfp 516
Cdd:cd19174    59 D------------------SGMVIDGYRMGNEAR----------------FVN-----HSCDPNCEMQKWSVNGVYR--- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2017500061 517 lVAFFTNRYVKARTELTWDYGYEAGTVPEKEIfCQCGVNKCRKKI 561
Cdd:cd19174    97 -IGLFALKDIPAGEELTYDYNFHSFNVEKQQP-CKCGSPNCRGVI 139
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 233-338 9.62e-10

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 55.89  E-value: 9.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061  233 DISNGVESVPISFCNEIDSRKLP-QFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSplssd 311
Cdd:smart00468   3 DISNGKENVPVPLVNEVDEDPPPpDFEYISEYIYGQGVPIDRSPSPLVGCSCSGDCSSSNKCECARKNGGEFAYE----- 77

                           90       100
                   ....*....|....*....|....*..
gi 2017500061  312 kittgyKYKRLQRQIPTGIYECSLLCK 338
Cdd:smart00468  78 ------LNGGLRLKRKPLIYECNSRCS 98
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 366-537 2.79e-09

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 54.84  E-value: 2.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 366 GWGVRCLDDIDRGTFVCIYSGR-LLSRANTEKSYGIDENGRDENTMKNIFSKKRKLEVACSDCEvevlplglethprtak 444
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDAR---------------- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 445 tekcppkfsnnpkeltvETKYDNISRIqyhsvIRdpesktaifqhngkkmHSCCPNLLVQNVFVETHNRnfplVAFFTNR 524
Cdd:pfam00856  65 -----------------ALYYGNWARF-----IN----------------HSCDPNCEVRVVYVNGGPR----IVIFALR 102

                         170
                  ....*....|...
gi 2017500061 525 YVKARTELTWDYG 537
Cdd:pfam00856 103 DIKPGEELTIDYG 115
MBD pfam01429
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...
 149-216 1.91e-08

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.


Pssm-ID: 396147 [Multi-domain]  Cd Length: 76  Bit Score: 51.21  E-value: 1.91e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 149 GENPLQLPIKCHFQR--RHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYV 216
Cdd:pfam01429   3 RKREDRLPLPPGWRReeRQRKSGSKAGKVDVFYYSPTGKKLRSKSEVARYLEANGGTSPKLEDFSFTVRS 72
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 356-561 3.95e-08

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 52.58  E-value: 3.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 356 RLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSrantEKSYgidengrdentmknifsKKRKLEVACSdcevevlplG 435
Cdd:cd19172     3 KVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLD----EKEF-----------------KRRMKEYARE---------G 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 436 LETHprtaktekcppKFSN-NPKELTVETKYDNISRiqyhsvirdpesktaiFQHngkkmHSCCPNLLVQNVFVETHNRn 514
Cdd:cd19172    53 NRHY-----------YFMAlKSDEIIDATKKGNLSR----------------FIN-----HSCEPNCETQKWTVNGELR- 99

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2017500061 515 fplVAFFTNRYVKARTELTWDYGYEA-GTVPEKeifCQCGVNKCRKKI 561
Cdd:cd19172   100 ---VGFFAKRDIPAGEELTFDYQFERyGKEAQK---CYCGSPNCRGYI 141
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 495-537 6.62e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 46.86  E-value: 6.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2017500061 495 HSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYG 537
Cdd:cd08161    34 HSCEPNCEFEEVYVGGKPR----VFIVALRDIKAGEELTVDYG 72
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 356-561 9.82e-06

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 45.49  E-value: 9.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 356 RLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEksygidengrdentmKNIFSKKRKLEVACSDCEVEvlplg 435
Cdd:cd19175     1 KMKLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCE---------------ERLWDMKHKGEKNFYMCEID----- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 436 lethprtaktekcppkfsnnpKELTVETKYD-NISRiqyhsvirdpesktaiFQHngkkmHSCCPNLLVQNVFVETHNRn 514
Cdd:cd19175    61 ---------------------KDMVIDATFKgNLSR----------------FIN-----HSCDPNCELQKWQVDGETR- 97

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2017500061 515 fplVAFFTNRYVKARTELTWDYGYEA-GTvpekEIFCQCGVNKCRKKI 561
Cdd:cd19175    98 ---IGVFAIRDIKKGEELTYDYQFVQfGA----DQDCHCGSKNCRGKL 138
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 495-559 5.42e-05

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 43.53  E-value: 5.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017500061 495 HSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYeagTVPEKEIFCQCGVNKCRK 559
Cdd:cd19170    92 HSCEPNCYSRVVNIDGKKH----IVIFALRRILRGEELTYDYKF---PIEDVKIPCTCGSKKCRK 149
HAT_MBD cd01397
Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as ...
 153-214 7.66e-05

Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The Drosophila melanogaster toutatis protein, a putative subunit of the chromatin-remodeling complex, and other such proteins in this group share a similar domain architecture with BAZ2A, as does the Caenorhabditis elegans flectin homolog.


Pssm-ID: 238691 [Multi-domain]  Cd Length: 73  Bit Score: 41.24  E-value: 7.66e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017500061 153 LQLPIKcHFQRRHAKTNSHSSALH--VSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNT 214
Cdd:cd01397     2 LRVPLE-LGWRRETRIRGLGGRIQgeVAYYAPCGKKLRQYPEVIKYLSKNGISLLSRENFSFSA 64
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 495-559 1.31e-04

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 42.42  E-value: 1.31e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017500061 495 HSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAGTvPEKEIFCQCGVNKCRK 559
Cdd:cd19171    92 HSCNPNCVAEVVTFDKEKK----IIIISNRRIAKGEELTYDYKFDFED-DQHKIPCLCGAPNCRK 151
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 355-557 2.05e-04

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 41.53  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 355 VRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLsranteksygidengrDENTMknifskKRKLEVACSDCEVEVLPL 434
Cdd:cd19173     2 PPTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELI----------------DEEEC------RRRLKKAHENNITNFYML 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 435 GLEthprtaktekcppkfSNN-----PKeltvetkyDNISRiqyhsvirdpesktaiFQHngkkmHSCCPNLLVQNVFVE 509
Cdd:cd19173    60 TLD---------------KDRiidagPK--------GNLSR----------------FMN-----HSCQPNCETQKWTVN 95

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2017500061 510 THNRnfplVAFFTNRYVKARTELTWDYGYEAGTVPEKEifCQCGVNKC 557
Cdd:cd19173    96 GDTR----VGLFAVRDIPAGEELTFNYNLDCLGNEKKV--CRCGAPNC 137
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 353-389 4.02e-04

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 40.68  E-value: 4.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2017500061 353 PQVrlQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLL 389
Cdd:cd19210     2 PEV--EIFRTLGRGWGLRCKTDIKKGEFVNEYVGELI 36
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 495-558 4.30e-04

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 41.04  E-value: 4.30e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017500061 495 HSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAgtVPEKEIFCQCGVNKCR 558
Cdd:cd10518    93 HSCDPNCYAKIITVDGEKH----IVIFAKRDIAPGEELTYDYKFPI--EDEEKIPCLCGAPNCR 150
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 347-449 4.40e-04

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 40.64  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 347 RVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANT---EKSYgidenGRDENTMKNIFSKKRKLEVA 423
Cdd:cd10528     9 ELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAkkrEALY-----AKDPSTGCYMYYFQYKGKTY 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 2017500061 424 CSDCEVEVLPLG-LETHPRTA---KTEKCP 449
Cdd:cd10528    84 CVDATKESGRLGrLINHSKKKpnlKTKLLV 113
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
495-560 5.59e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 40.33  E-value: 5.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017500061 495 HSCCPNLlvqnVFVETHNRNFplvaFFTNRYVKARTELTWDYGYEagtVPEKEIFCQCGvnKCRKK 560
Cdd:COG2940    82 HSCDPNC----EADEEDGRIF----IVALRDIAAGEELTYDYGLD---YDEEEYPCRCP--NCRGT 134
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 462-559 2.36e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 38.85  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017500061 462 ETKYDNISRIQYHSVIRDPESKTAIFQHNGKKM--HSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYE 539
Cdd:cd19206    57 EKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFinHSCEPNCYSRVINIDGQKH----IVIFAMRKIYRGEELTYDYKFP 132

                          90       100
                  ....*....|....*....|
gi 2017500061 540 AGTvPEKEIFCQCGVNKCRK 559
Cdd:cd19206   133 IED-ASNKLPCNCGAKKCRK 151
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 495-558 5.50e-03

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 37.79  E-value: 5.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017500061 495 HSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEagtVPEKEIFCQCGVNKCR 558
Cdd:cd20072    92 HCCDPNCTAKIIKVEGEKR----IVIYAKRDIAAGEELTYDYKFP---REEDKIPCLCGAPNCR 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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