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Conserved domains on  [gi|1983575715|ref|NP_001380397|]
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ankyrin repeat and MYND domain-containing protein 1 isoform 16 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-488 1.94e-22

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.10  E-value: 1.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 364 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgkcarDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNE 431
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL--------EIVKLLLEAGADVNAKdNDGKTALDLAAENGNL 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1983575715 432 LVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADIL 488
Cdd:COG0666   233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
2-67 7.85e-15

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 7.85e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575715   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.48e-03

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575715  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-488 1.94e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.10  E-value: 1.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 364 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgkcarDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNE 431
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL--------EIVKLLLEAGADVNAKdNDGKTALDLAAENGNL 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1983575715 432 LVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADIL 488
Cdd:COG0666   233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-67 7.85e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 7.85e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575715   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 288-486 1.34e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 70.02  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 288 LSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQlsTLTPLHIAAALpgeE 366
Cdd:PHA02875   39 IKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESeLHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPLHLATIL---K 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 367 GVQIVELLLHAITDVDAKASDEDDTYKPGKCARDI--VRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGAD 443
Cdd:PHA02875  114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIkgIELLIDHKACLDIEdCCGCTPLIIAMAKGDIAICKMLLDSGAN 193

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1983575715 444 PNLPLTKGLGSALCVACDltyehqrnmDSKLALIDRLISHGAD 486
Cdd:PHA02875  194 IDYFGKNGCVAALCYAIE---------NNKIDIVRLFIKRGAD 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
320-446 7.99e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 7.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 320 LFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalpgEEGVQivelllhaitdvdakasdeddtykpgkcar 399
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK---NGRTALHLAA----KNGHL------------------------------ 43

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1983575715 400 DIVRLLLSHgANPNLLWSGHSPLSLSIASGNELVVKELLTQGADPNL 446
Cdd:pfam12796  44 EIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-61 7.66e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 65.24  E-value: 7.66e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1983575715   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Cdd:PLN03185   33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 320-444 1.25e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 320 LFLAVKAGDVDGVRLLLEHgARTDICfppQLSTL--TPLHIAAALPGEEGVQIV-----ELLLHAITdvdakasdeDDTY 392
Cdd:cd22192    21 LLLAAKENDVQAIKKLLKC-PSCDLF---QRGALgeTALHVAALYDNLEAAVVLmeaapELVNEPMT---------SDLY 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575715 393 KpGKCARDI---------VRLLLSHGA---NP------------NLLWSGHSPLSLSIASGNELVVKELLTQGADP 444
Cdd:cd22192    88 Q-GETALHIavvnqnlnlVRELIARGAdvvSPratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADI 162
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 25-47 3.66e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 3.66e-04
                          10        20
                  ....*....|....*....|...
gi 1983575715  25 YHGQFYRDHCHGLGTYMWPDGSS 47
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
24-44 8.50e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.93  E-value: 8.50e-04
                           10        20
                   ....*....|....*....|.
gi 1983575715   24 SYHGQFYRDHCHGLGTYMWPD 44
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.48e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575715  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-109 2.57e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1983575715  77 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 109
Cdd:PHA03100  206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-488 1.94e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.10  E-value: 1.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 364 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgkcarDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNE 431
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL--------EIVKLLLEAGADVNAKdNDGKTALDLAAENGNL 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1983575715 432 LVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADIL 488
Cdd:COG0666   233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
320-489 5.04e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.78  E-value: 5.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 320 LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAlpgEEGVQIVELLLHAITDVDAK----------ASDED 389
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADVNA---RDKDGETPLHLAAY---NGNLEIVKLLLEAGADVNAQdndgntplhlAAANG 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 390 DTykpgkcarDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGlGSALCVACdltyehqr 468
Cdd:COG0666   165 NL--------EIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG-KTALDLAA-------- 227

                         170       180
                  ....*....|....*....|.
gi 1983575715 469 nMDSKLALIDRLISHGADILK 489
Cdd:COG0666   228 -ENGNLEIVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-67 7.85e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 7.85e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575715   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-66 2.27e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 70.76  E-value: 2.27e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575715   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK 66
Cdd:COG4642   150 YEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYA 214
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-64 5.39e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 69.60  E-value: 5.39e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1983575715   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 64
Cdd:COG4642   173 YEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 288-486 1.34e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 70.02  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 288 LSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQlsTLTPLHIAAALpgeE 366
Cdd:PHA02875   39 IKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESeLHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPLHLATIL---K 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 367 GVQIVELLLHAITDVDAKASDEDDTYKPGKCARDI--VRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGAD 443
Cdd:PHA02875  114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIkgIELLIDHKACLDIEdCCGCTPLIIAMAKGDIAICKMLLDSGAN 193

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1983575715 444 PNLPLTKGLGSALCVACDltyehqrnmDSKLALIDRLISHGAD 486
Cdd:PHA02875  194 IDYFGKNGCVAALCYAIE---------NNKIDIVRLFIKRGAD 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
320-446 7.99e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 7.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 320 LFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalpgEEGVQivelllhaitdvdakasdeddtykpgkcar 399
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK---NGRTALHLAA----KNGHL------------------------------ 43

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1983575715 400 DIVRLLLSHgANPNLLWSGHSPLSLSIASGNELVVKELLTQGADPNL 446
Cdd:pfam12796  44 EIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-61 7.66e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 65.24  E-value: 7.66e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1983575715   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Cdd:PLN03185   33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 283-446 1.98e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 283 MRRMALSMIERRKRWRTIKLLLRRGADPN------LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQlstLTPL 356
Cdd:PHA03100   34 KPVLPLYLAKEARNIDVVKILLDNGADINsstknnSTPLHYLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNG---ITPL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 357 HIAAALPGEEgVQIVELLLHAITDVDAKASD------------EDDTykpgkcarDIVRLLLSHGANPN------LLWS- 417
Cdd:PHA03100  111 LYAISKKSNS-YSIVEYLLDNGANVNIKNSDgenllhlylesnKIDL--------KILKLLIDKGVDINaknrvnYLLSy 181

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1983575715 418 ----------GHSPLSLSIASGNELVVKELLTQGADPNL 446
Cdd:PHA03100  182 gvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNL 220
Ank_2 pfam12796
Ankyrin repeats (3 copies);
299-384 1.90e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 299 TIKLLLRRGADPNLC-CVPMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLSTLTPLHIAAalpgEEG-VQIVELLLH 376
Cdd:pfam12796  12 LVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 1983575715 377 AITDVDAK 384
Cdd:pfam12796  83 KGADINVK 90
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-64 2.93e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.43  E-value: 2.93e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1983575715   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 64
Cdd:COG4642   126 GYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLT 189
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-52 4.55e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.04  E-value: 4.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1983575715   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTF 52
Cdd:COG4642   219 YEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
334-487 1.58e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 1.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 334 LLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKCARDIVRLLLSHGANPN 413
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575715 414 LL-WSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGlGSALCVACdltyehqrnMDSKLALIDRLISHGADI 487
Cdd:COG0666    82 AKdDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDG-ETPLHLAA---------YNGNLEIVKLLLEAGADV 146
PHA03095 PHA03095
ankyrin-like protein; Provisional
 328-487 8.11e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.03  E-value: 8.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 328 DVDGVRLLLEHGArtDICFPPQLSTlTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDED---DTYKPGKCARDIVRL 404
Cdd:PHA03095   26 TVEEVRRLLAAGA--DVNFRGEYGK-TPLHLYLHYSSEKVKDIVRLLLEAGADVNAPERCGFtplHLYLYNATTLDVIKL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 405 LLSHGANPNL-LWSGHSPLS--LSIASGNELVVKELLTQGADPNlpltkglgsalcvACDLtYEHQ------RNMDSKLA 475
Cdd:PHA03095  103 LIKAGADVNAkDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVN-------------ALDL-YGMTplavllKSRNANVE 168

                         170
                  ....*....|..
gi 1983575715 476 LIDRLISHGADI 487
Cdd:PHA03095  169 LLRLLIDAGADV 180
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 300-460 1.01e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.89  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 300 IKLLLRRGADPNLCC--VPMQVLFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAALPGEEGVQIVeLLLHA 377
Cdd:PHA02878  150 TKLLLSYGADINMKDrhKGNTALHYATENKDQRLTELLLSYGANVNI---PDKTNNSPLHHAVKHYNKPIVHIL-LENGA 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 378 ITDVDAKASDEDDTYKPGKCAR-DIVRLLLSHGANPNLLWS--GHSPLSLSIASgnELVVKELLTQGADPNL-------P 447
Cdd:PHA02878  226 STDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAKSYilGLTALHSSIKS--ERKLKLLLEYGADINSlnsykltP 303

                         170
                  ....*....|...
gi 1983575715 448 LTKGLGSALCVAC 460
Cdd:PHA02878  304 LSSAVKQYLCINI 316
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 287-426 1.52e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.50  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 287 ALSMIERRKRWRTIKLLLRRGADPNlccVPMQV----LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAL 362
Cdd:PHA02878  171 ALHYATENKDQRLTELLLSYGANVN---IPDKTnnspLHHAVKHYNKPIVHILLENGASTDA---RDKCGNTPLHISVGY 244

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575715 363 PgeEGVQIVELLLHAITDVDAKASDEDDT-YKPGKCARDIVRLLLSHGANPNLL-WSGHSPLSLSI 426
Cdd:PHA02878  245 C--KDYDILKLLLEHGVDVNAKSYILGLTaLHSSIKSERKLKLLLEYGADINSLnSYKLTPLSSAV 308
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 288-415 1.62e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.23  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 288 LSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDI--CFppqlsTLTPLHIAAAlpg 364
Cdd:PHA02875  106 LHLATILKKLDIMKLLIARGADPDIPNTDkFSPLHLAVMMGDIKGIELLIDHKACLDIedCC-----GCTPLIIAMA--- 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1983575715 365 EEGVQIVELLLHAITDVDAKASDEDDT---YKPGKCARDIVRLLLSHGANPNLL 415
Cdd:PHA02875  178 KGDIAICKMLLDSGANIDYFGKNGCVAalcYAIENNKIDIVRLFIKRGADCNIM 231
PHA03095 PHA03095
ankyrin-like protein; Provisional
 299-446 4.57e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 4.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 299 TIKLLLRRGADPNLC----CVPMQVlFLAVKAGDVDGVRLLLEHGAR---TDICFppqlstLTPLHIAAALPgEEGVQIV 371
Cdd:PHA03095  134 VIRLLLRKGADVNALdlygMTPLAV-LLKSRNANVELLRLLIDAGADvyaVDDRF------RSLLHHHLQSF-KPRARIV 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 372 ELLLHAITDVDAKASDEDDTY----KPGKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPNL 446
Cdd:PHA03095  206 RELIRAGCDPAATDMLGNTPLhsmaTGSSCKRSLVLPLLIAGISINARnRYGQTPLHYAAVFNNPRACRRLIALGADINA 285
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 2-72 1.22e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 51.76  E-value: 1.22e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575715   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK-TRLFQT 72
Cdd:PLN03185  126 YLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVFYPAgSRVPAV 197
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 2-67 2.34e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.52  E-value: 2.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575715   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTmYMKT 67
Cdd:PLN03185   11 YSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGT 75
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
13-66 3.85e-05

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 46.10  E-value: 3.85e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1983575715  13 GYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK 66
Cdd:COG4642   115 GGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYA 168
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 320-444 1.25e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 320 LFLAVKAGDVDGVRLLLEHgARTDICfppQLSTL--TPLHIAAALPGEEGVQIV-----ELLLHAITdvdakasdeDDTY 392
Cdd:cd22192    21 LLLAAKENDVQAIKKLLKC-PSCDLF---QRGALgeTALHVAALYDNLEAAVVLmeaapELVNEPMT---------SDLY 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575715 393 KpGKCARDI---------VRLLLSHGA---NP------------NLLWSGHSPLSLSIASGNELVVKELLTQGADP 444
Cdd:cd22192    88 Q-GETALHIavvnqnlnlVRELIARGAdvvSPratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADI 162
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 369-487 3.32e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.72  E-value: 3.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 369 QIVELLLHAITDVDAKASDEDDT---YKPGKCARDIVRLLLSHGANPNLLWSG-HSPLSLSIASGNELVVKELLTQGADP 444
Cdd:PHA02878  148 EITKLLLSYGADINMKDRHKGNTalhYATENKDQRLTELLLSYGANVNIPDKTnNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1983575715 445 NLpltkglgSALCVACDLTYEHQRNMDskLALIDRLISHGADI 487
Cdd:PHA02878  228 DA-------RDKCGNTPLHISVGYCKD--YDILKLLLEHGVDV 261
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 25-47 3.66e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 3.66e-04
                          10        20
                  ....*....|....*....|...
gi 1983575715  25 YHGQFYRDHCHGLGTYMWPDGSS 47
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 273-408 6.01e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 273 PCTSSFDKGTMRRMALSMIErrKRWRTIKLLLRRGADPNLCCVPMQVL------FLAVK------AGDVDGVRLLLEHGA 340
Cdd:PTZ00322   29 AKPISFERMAAIQEEIARID--THLEALEATENKDATPDHNLTTEEVIdpvvahMLTVElcqlaaSGDAVGARILLTGGA 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1983575715 341 RTDIcfpPQLSTLTPLHIAAALpGEegVQIVELLLHaiTDVDAKASDEDDTyKPGKCA-----RDIVRLLLSH 408
Cdd:PTZ00322  107 DPNC---RDYDGRTPLHIACAN-GH--VQVVRVLLE--FGADPTLLDKDGK-TPLELAeengfREVVQLLSRH 170
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
24-44 8.50e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.93  E-value: 8.50e-04
                           10        20
                   ....*....|....*....|.
gi 1983575715   24 SYHGQFYRDHCHGLGTYMWPD 44
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.48e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575715  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-109 2.57e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1983575715  77 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 109
Cdd:PHA03100  206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
Ank_4 pfam13637
Ankyrin repeats (many copies);
317-375 3.28e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 3.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575715 317 MQVLFLAVKAGDVDGVRLLLEHGA---RTDICFppqlstLTPLHIAAAlpgEEGVQIVELLL 375
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGAdinAVDGNG------ETALHFAAS---NGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 5.93e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.17  E-value: 5.93e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575715  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPL 190
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 354-384 6.86e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 6.86e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1983575715 354 TPLHIAAALPGeeGVQIVELLLHAITDVDAK 384
Cdd:pfam00023   4 TPLHLAAGRRG--NLEIVKLLLSKGADVNAR 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 402-446 7.92e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 7.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1983575715 402 VRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPNL 446
Cdd:PTZ00322   98 ARILLTGGADPNCRdYDGRTPLHIACANGHVQVVRVLLEFGADPTL 143
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 298-441 9.49e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.79  E-value: 9.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 298 RTIKLLLRRGADPNLCC--VPmQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLS--------------------TLTP 355
Cdd:PHA02874   49 KIVELFIKHGADINHINtkIP-HPLLTAIKIGAHDIIKLLIDNGVDTSILPIPCIEkdmiktildcgidvnikdaeLKTF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575715 356 LHIAAAlpgEEGVQIVELLLHAITDVDAKasDEDDTYKPGKCAR----DIVRLLLSHGANPNLL-WSGHSPLSLSIASGN 430
Cdd:PHA02874  128 LHYAIK---KGDLESIKMLFEYGADVNIE--DDNGCYPIHIAIKhnffDIIKLLLEKGAYANVKdNNGESPLHNAAEYGD 202

                         170
                  ....*....|.
gi 1983575715 431 ELVVKELLTQG 441
Cdd:PHA02874  203 YACIKLLIDHG 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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