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Conserved domains on  [gi|1973461652|ref|NP_001379002|]
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cysteine-rich protein 2-binding protein isoform 2 [Homo sapiens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 685-760 2.47e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.22  E-value: 2.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 685 AFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLYQKFGFKTEEYVLDFY 760
Cdd:COG0456     1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGarrLRLEVREDNeAAIALYEKLGFEEVGERPNYY 80
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 685-760 2.47e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.22  E-value: 2.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 685 AFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLYQKFGFKTEEYVLDFY 760
Cdd:COG0456     1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGarrLRLEVREDNeAAIALYEKLGFEEVGERPNYY 80
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 671-750 3.69e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 63.69  E-value: 3.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 671 PDFSVVVLYKKVIIAF-GFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLY 745
Cdd:pfam00583  32 SEGFFVAEEDGELVGFaSLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGcerIFLEVAADNlAAIALY 111


                  ....*
gi 1973461652 746 QKFGF 750
Cdd:pfam00583 112 EKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 674-726 2.52e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 45.34  E-value: 2.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1973461652 674 SVVVLYKKVIIAFGFMVP-DVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTC 726
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPdGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA 54
PRK09831 PRK09831
GNAT family N-acetyltransferase;
697-765 9.60e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 40.33  E-value: 9.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1973461652 697 EAYISFLFVHPEWRRAGIATFMIYHLIQTcmgkDVTLHVSASNPAMLLYQKFGFKT---------EEYVLDFYDKYYP 765
Cdd:PRK09831   72 EHYIDMLFVDPEYTRRGVASALLKPLIKS----ESELTVDASITAKPFFERYGFQTvkqqrvecrGEWFINFYMRYKP 145
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 685-760 2.47e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.22  E-value: 2.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 685 AFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLYQKFGFKTEEYVLDFY 760
Cdd:COG0456     1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGarrLRLEVREDNeAAIALYEKLGFEEVGERPNYY 80
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 671-750 3.69e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 63.69  E-value: 3.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 671 PDFSVVVLYKKVIIAF-GFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLY 745
Cdd:pfam00583  32 SEGFFVAEEDGELVGFaSLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGcerIFLEVAADNlAAIALY 111


                  ....*
gi 1973461652 746 QKFGF 750
Cdd:pfam00583 112 EKLGF 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 668-763 9.06e-11

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 60.45  E-value: 9.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 668 LQYPDFSVVVLYKKVIIAFG--FMVPDvkyNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVT---LHVSASNP-A 741
Cdd:COG0454    30 SLAGAEFIAVDDKGEPIGFAglRRLDD---KVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTaleLDTLDGNPaA 106

                          90       100
                  ....*....|....*....|...
gi 1973461652 742 MLLYQKFGFK-TEEYVLDFYDKY 763
Cdd:COG0454   107 IRFYERLGFKeIERYVAYVGGEF 129
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 675-780 2.20e-10

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 59.24  E-value: 2.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 675 VVVLYKKVIIAFGFMVPDVKyNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDV-TLHVSASNPAMLLYQKFGFKte 753
Cdd:COG1246    31 WVAEEDGEIVGCAALHPLDE-DLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLkRLFLLTTSAAIHFYEKLGFE-- 107

                          90       100
                  ....*....|....*....|....*..
gi 1973461652 754 eyVLDFYDKYYPLESTECKHAFFLRLR 780
Cdd:COG1246   108 --EIDKEDLPYAKVWQRDSVVMEKDLE 132
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 675-751 3.16e-10

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 57.08  E-value: 3.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1973461652 675 VVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTL-HVSASNPAMLLYQKFGFK 751
Cdd:pfam13508   6 FVAEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLlELETTNRAAAFYEKLGFE 83
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
683-751 1.45e-09

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 55.30  E-value: 1.45e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1973461652 683 IIAFGFMVPDVkYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCM---GKDVTLHVSASNPAML-LYQKFGFK 751
Cdd:COG3393     2 LVAMAGVRAES-PGVAEISGVYTHPEYRGRGLASALVAALAREALargARTPFLYVDADNPAARrLYERLGFR 73
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
643-761 3.25e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 55.86  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 643 RPNHIPTINSMCQEFFWPG--IDLSECLQ---YPDFSVVVLYKKVIIAFGFMVP---DVKYNEAYISFLFVHPEWRRAGI 714
Cdd:COG3153     5 TPEDAEAIAALLRAAFGPGreAELVDRLRedpAAGLSLVAEDDGEIVGHVALSPvdiDGEGPALLLGPLAVDPEYRGQGI 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1973461652 715 ATFMIYHLIQTCMGKDVT-LHVSASNPAMLLYQKFGFK-TEEYVLDFYD 761
Cdd:COG3153    85 GRALMRAALEAARERGARaVVLLGDPSLLPFYERFGFRpAGELGLTLGP 133
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 696-752 8.95e-08

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 51.50  E-value: 8.95e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 696 NEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLH---VSASNPAMLLYQKFGFKT 752
Cdd:pfam13673  50 DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSeltVNASPYAVPFYEKLGFRA 109
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
695-762 1.20e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 49.22  E-value: 1.20e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1973461652 695 YNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVT---LHVSASNPAML-LYQKFGFKTEEYVLDFYDK 762
Cdd:COG1247    78 YRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRrlvAVVLADNEASIaLYEKLGFEEVGTLPEVGFK 149
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 674-726 2.52e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 45.34  E-value: 2.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1973461652 674 SVVVLYKKVIIAFGFMVP-DVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTC 726
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPdGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA 54
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 686-781 4.86e-05

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 44.60  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 686 FGFMVPDVKYNEAYISFlFVHPEWRRAGIATFMIYHLIQTC---MG-KDVTLHVSASNPAML-LYQKFGFKTEEYVldfy 760
Cdd:COG1670    77 VGLYDIDRANRSAEIGY-WLAPAYWGKGYATEALRALLDYAfeeLGlHRVEAEVDPDNTASIrVLEKLGFRLEGTL---- 151

                          90       100
                  ....*....|....*....|.
gi 1973461652 761 DKYYPLESTECKHAFFLRLRR 781
Cdd:COG1670   152 RDALVIDGRYRDHVLYSLLRE 172
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
696-758 4.98e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 43.63  E-value: 4.98e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1973461652 696 NEAYISFLFVHPEWRRAGIATFMIYHLIQTCM---GKDVTLHvsASNPAMLLYQKFGFKT--EEYVLD 758
Cdd:COG2153    57 GEAKIGRVAVLPEYRGQGLGRALMEAAIEEARergARRIVLS--AQAHAVGFYEKLGFVPvgEEFLEA 122
PRK09831 PRK09831
GNAT family N-acetyltransferase;
697-765 9.60e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 40.33  E-value: 9.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1973461652 697 EAYISFLFVHPEWRRAGIATFMIYHLIQTcmgkDVTLHVSASNPAMLLYQKFGFKT---------EEYVLDFYDKYYP 765
Cdd:PRK09831   72 EHYIDMLFVDPEYTRRGVASALLKPLIKS----ESELTVDASITAKPFFERYGFQTvkqqrvecrGEWFINFYMRYKP 145
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 690-752 5.37e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 37.55  E-value: 5.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1973461652 690 VPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHV-SASNPAMllYQKFGFKT 752
Cdd:pfam13527  63 VPGKTLPAAGITGVATYPEYRGRGVMSRLLRRSLEEMRERGVPLSFlYPSSYPI--YRRFGYEI 124
PRK10514 PRK10514
putative acetyltransferase; Provisional
 687-766 7.96e-03

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 37.67  E-value: 7.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 687 GFMVPDVKYNEAyisfLFVHPEWRRAGIATFMIYHLIQtcMGKDVTLHVSASNP-AMLLYQKFGFK-TEEYVLDFYDKYY 764
Cdd:PRK10514   63 GFMLLSGGHMEA----LFVDPDVRGCGVGRMLVEHALS--LHPELTTDVNEQNEqAVGFYKKMGFKvTGRSEVDDQGRPY 136


                  ..
gi 1973461652 765 PL 766
Cdd:PRK10514  137 PL 138
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 687-765 8.91e-03

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 37.60  E-value: 8.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973461652 687 GFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVT---LHVSASN-PAMLLYQKFGFKTeeyvLDFYDK 762
Cdd:PRK09491   53 AFAITQVVLDEATLFNIAVDPDYQRQGLGRALLEHLIDELEKRGVAtlwLEVRASNaAAIALYESLGFNE----VTIRRN 128


                  ...
gi 1973461652 763 YYP 765
Cdd:PRK09491  129 YYP 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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