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Conserved domains on  [gi|1954668696|ref|NP_001376572|]
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ubiquitin carboxyl-terminal hydrolase 29 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PH_USP37_like cd13312
Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37; Members here ...
4-106 8.86e-52

Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37; Members here include USP37, USP29, and USP26. All of these contain a single PH-like domain. USP37 (also called ubiquitin carboxyl-terminal hydrolase 37, ubiquitin thiolesterase 37, deubiquitinating enzyme 37, and tmp_locus_50) is a deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), resulting in promoting S phase entry. USP37 mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex and 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). USP29 (also called ubiquitin carboxyl-terminal hydrolase 29, ubiquitin thiolesterase 29, deubiquitinating enzyme 29, and HOM-TES-84/86) plays a role in apoptosis and oxidative stress. In response to oxidative stress, JTV1 dissociates from the ARS complex, translocates to the nucleus, associates with far upstream element binding protein (FBP) and co-activates the transcription of USP29 which binds to, cleaves poly-ubiquitin chains from, and stabilizes p53 leading to apoptosis. The X-linked deubiquitination enzyme USP26 (also called ubiquitin carboxyl-terminal hydrolase 26, ubiquitin thiolesterase 26, and deubiquitinating enzyme 26) is a regulator of androgen receptor (AR) signaling. It binds to AR using three nuclear receptor interaction motifs (LXXLL, FXXLF and FXXFF) and modulates AR ubiquitination. Polymorphism of Usp26 correlates with idiopathic male infertility. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


:

Pssm-ID: 270122  Cd Length: 103  Bit Score: 176.34  E-value: 8.86e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696   4 LKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKFIRIFQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFLF 83
Cdd:cd13312     1 LKIHGFVQIWSKKTGMTKWKEAFIEIVEGKKKVKLVVYFKTGGKPKTFQLSNNIKSVVLRSYGGNQNHLHLTLKNNSFLF 80
                          90       100
                  ....*....|....*....|...
gi 1954668696  84 IDKLSYRDAKQLNMFLDIIHQNK 106
Cdd:cd13312    81 IDKLSSTDAEQLKEFLDKVHQKK 103
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
286-552 1.54e-43

Ubiquitin carboxyl-terminal hydrolase;


:

Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 160.69  E-value: 1.54e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQ-------GVPWEYIPFEALIMTLTQLLALKDFCSTKIKRellgnVKKVI 358
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFRDYLLRIsplsedsRYNKDINLLCALRDLFKALQKNSKSSSVSPKM-----FKKSL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 359 SAVAEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTgkecgdensspqmhvgsaatkvfvCPVVANFEFELQLSLIC 438
Cdd:pfam00443  77 GKLNPDFSGYKQQDAQEFLLFLLDGLHEDLNGNHSTENE------------------------SLITDLFRGQLKSRLKC 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 439 KACGHAVLKVEPNNYLSINLHQETKPLP-LSIQNSLDLFFKEEELE-----YNCQMCKQKSCVARHTFSRLSRVLIIHLK 512
Cdd:pfam00443 133 LSCGEVSETFEPFSDLSLPIPGDSAELKtASLQICFLQFSKLEELDdeekyYCDKCGCKQDAIKQLKISRLPPVLIIHLK 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1954668696 513 RYSFNNaWLLVKNNEQVYIPKSLSLSSYCNESTKPPLPLS 552
Cdd:pfam00443 213 RFSYNR-STWEKLNTEVEFPLELDLSRYLAEELKPKTNNL 251
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
823-883 1.03e-13

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


:

Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 72.13  E-value: 1.03e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1954668696 823 YRLISVVSHIGSSPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEA--RLHSGYIFFYM 883
Cdd:cd02257   193 YELVAVVVHSGTSADSGHYVAYVKDPSDGKWYKFNDDKVTEVSEEEVLEFgsLSSSAYILFYE 255
 
Name Accession Description Interval E-value
PH_USP37_like cd13312
Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37; Members here ...
4-106 8.86e-52

Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37; Members here include USP37, USP29, and USP26. All of these contain a single PH-like domain. USP37 (also called ubiquitin carboxyl-terminal hydrolase 37, ubiquitin thiolesterase 37, deubiquitinating enzyme 37, and tmp_locus_50) is a deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), resulting in promoting S phase entry. USP37 mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex and 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). USP29 (also called ubiquitin carboxyl-terminal hydrolase 29, ubiquitin thiolesterase 29, deubiquitinating enzyme 29, and HOM-TES-84/86) plays a role in apoptosis and oxidative stress. In response to oxidative stress, JTV1 dissociates from the ARS complex, translocates to the nucleus, associates with far upstream element binding protein (FBP) and co-activates the transcription of USP29 which binds to, cleaves poly-ubiquitin chains from, and stabilizes p53 leading to apoptosis. The X-linked deubiquitination enzyme USP26 (also called ubiquitin carboxyl-terminal hydrolase 26, ubiquitin thiolesterase 26, and deubiquitinating enzyme 26) is a regulator of androgen receptor (AR) signaling. It binds to AR using three nuclear receptor interaction motifs (LXXLL, FXXLF and FXXFF) and modulates AR ubiquitination. Polymorphism of Usp26 correlates with idiopathic male infertility. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 270122  Cd Length: 103  Bit Score: 176.34  E-value: 8.86e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696   4 LKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKFIRIFQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFLF 83
Cdd:cd13312     1 LKIHGFVQIWSKKTGMTKWKEAFIEIVEGKKKVKLVVYFKTGGKPKTFQLSNNIKSVVLRSYGGNQNHLHLTLKNNSFLF 80
                          90       100
                  ....*....|....*....|...
gi 1954668696  84 IDKLSYRDAKQLNMFLDIIHQNK 106
Cdd:cd13312    81 IDKLSSTDAEQLKEFLDKVHQKK 103
UCH_N pfam16674
N-terminal of ubiquitin carboxyl-terminal hydrolase 37; UCH_N is a domain found at the ...
3-105 2.08e-49

N-terminal of ubiquitin carboxyl-terminal hydrolase 37; UCH_N is a domain found at the N-terminus of ubiquitin carboxyl-terminal hydrolase 37 or 26. The function is not known.


Pssm-ID: 465227  Cd Length: 102  Bit Score: 169.72  E-value: 2.08e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696   3 SLKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKfIRIFQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFL 82
Cdd:pfam16674   1 PLKVHGFVQIWSKKTGMSKWKEAFIEIVEKKKKVKLVVYFNTGG-PKTFQLNNNIKSVVLRSYGEKQNRLHLTLKNNSFL 79
                          90       100
                  ....*....|....*....|...
gi 1954668696  83 FIDKLSYRDAKQLNMFLDIIHQN 105
Cdd:pfam16674  80 FIDKLSSTDAEELKMFLDRVHQN 102
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
286-552 1.54e-43

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 160.69  E-value: 1.54e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQ-------GVPWEYIPFEALIMTLTQLLALKDFCSTKIKRellgnVKKVI 358
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFRDYLLRIsplsedsRYNKDINLLCALRDLFKALQKNSKSSSVSPKM-----FKKSL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 359 SAVAEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTgkecgdensspqmhvgsaatkvfvCPVVANFEFELQLSLIC 438
Cdd:pfam00443  77 GKLNPDFSGYKQQDAQEFLLFLLDGLHEDLNGNHSTENE------------------------SLITDLFRGQLKSRLKC 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 439 KACGHAVLKVEPNNYLSINLHQETKPLP-LSIQNSLDLFFKEEELE-----YNCQMCKQKSCVARHTFSRLSRVLIIHLK 512
Cdd:pfam00443 133 LSCGEVSETFEPFSDLSLPIPGDSAELKtASLQICFLQFSKLEELDdeekyYCDKCGCKQDAIKQLKISRLPPVLIIHLK 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1954668696 513 RYSFNNaWLLVKNNEQVYIPKSLSLSSYCNESTKPPLPLS 552
Cdd:pfam00443 213 RFSYNR-STWEKLNTEVEFPLELDLSRYLAEELKPKTNNL 251
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
286-548 7.35e-33

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 127.98  E-value: 7.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFaipsfaddlltqgvpweyipfealimtltqllalkdfcstkikrellgnvkkvisavaeif 365
Cdd:cd02257     1 GLNNLGNTCYLNSVLQALF------------------------------------------------------------- 19
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 366 sgNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKECgdensspqmhvgsaatkvfVCPVVANFEFELQLSLICKACGHAV 445
Cdd:cd02257    20 --SEQQDAHEFLLFLLDKLHEELKKSSKRTSDSSSL-------------------KSLIHDLFGGKLESTIVCLECGHES 78
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 446 LKVEPNNYLSINLHQETKPlPLSIQNSLDLFFKEEELE----YNCQMCKQKSCVARHTFSRLSRVLIIHLKRYSFNNAWL 521
Cdd:cd02257    79 VSTEPELFLSLPLPVKGLP-QVSLEDCLEKFFKEEILEgdncYKCEKKKKQEATKRLKIKKLPPVLIIHLKRFSFNEDGT 157
                         250       260
                  ....*....|....*....|....*..
gi 1954668696 522 LVKNNEQVYIPKSLSLSSYCNESTKPP 548
Cdd:cd02257   158 KEKLNTKVSFPLELDLSPYLSEGEKDS 184
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
823-883 1.03e-13

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 72.13  E-value: 1.03e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1954668696 823 YRLISVVSHIGSSPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEA--RLHSGYIFFYM 883
Cdd:cd02257   193 YELVAVVVHSGTSADSGHYVAYVKDPSDGKWYKFNDDKVTEVSEEEVLEFgsLSSSAYILFYE 255
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
818-882 4.06e-13

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 71.32  E-value: 4.06e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1954668696 818 DPLQAYRLISVVSHIGSsPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEArlHSGYIFFY 882
Cdd:pfam00443 249 NNLQDYRLVAVVVHSGS-LSSGHYIAYIKAYENNRWYKFDDEKVTEVDEETAVLS--SSAYILFY 310
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
286-470 1.77e-10

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 64.90  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQGVPWEYIPFEALIMTLTQLLALKDFCSTKIKRELLG----NVKKVISAV 361
Cdd:COG5560   267 GLRNLGNTCYMNSALQCLMHTWELRDYFLSDEYEESINEENPLGMHGSVASAYADLIKQLYDGNLHAftpsGFKKTIGSF 346
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 362 AEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKEcgDENSSPQMHVGSAAT------KVFVCPVVAN-FEFELQL 434
Cdd:COG5560   347 NEEFSGYDQQDSQEFIAFLLDGLHEDLNRIIKKPYTSKP--DLSPGDDVVVKKKAKecwwehLKRNDSIITDlFQGMYKS 424
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1954668696 435 SLICKACGHAVLKVEPNNYLSInlhqetkPLPLSIQ 470
Cdd:COG5560   425 TLTCPGCGSVSITFDPFMDLTL-------PLPVSMV 453
COG5533 COG5533
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
823-882 7.98e-07

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444284 [Multi-domain]  Cd Length: 284  Bit Score: 51.73  E-value: 7.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 823 YRLISVVSHIGSSpNSGHYISDVYdfQKQAWFTYNDLCVSEISETKMQEARLHSGYIFFY 882
Cdd:COG5533   225 YDLVGFVLHQGSL-EGGHYIAYVK--KGGKWEKANDSDVTPVSEEEAINEKAKNAYLYFY 281
 
Name Accession Description Interval E-value
PH_USP37_like cd13312
Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37; Members here ...
4-106 8.86e-52

Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37; Members here include USP37, USP29, and USP26. All of these contain a single PH-like domain. USP37 (also called ubiquitin carboxyl-terminal hydrolase 37, ubiquitin thiolesterase 37, deubiquitinating enzyme 37, and tmp_locus_50) is a deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), resulting in promoting S phase entry. USP37 mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex and 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). USP29 (also called ubiquitin carboxyl-terminal hydrolase 29, ubiquitin thiolesterase 29, deubiquitinating enzyme 29, and HOM-TES-84/86) plays a role in apoptosis and oxidative stress. In response to oxidative stress, JTV1 dissociates from the ARS complex, translocates to the nucleus, associates with far upstream element binding protein (FBP) and co-activates the transcription of USP29 which binds to, cleaves poly-ubiquitin chains from, and stabilizes p53 leading to apoptosis. The X-linked deubiquitination enzyme USP26 (also called ubiquitin carboxyl-terminal hydrolase 26, ubiquitin thiolesterase 26, and deubiquitinating enzyme 26) is a regulator of androgen receptor (AR) signaling. It binds to AR using three nuclear receptor interaction motifs (LXXLL, FXXLF and FXXFF) and modulates AR ubiquitination. Polymorphism of Usp26 correlates with idiopathic male infertility. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 270122  Cd Length: 103  Bit Score: 176.34  E-value: 8.86e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696   4 LKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKFIRIFQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFLF 83
Cdd:cd13312     1 LKIHGFVQIWSKKTGMTKWKEAFIEIVEGKKKVKLVVYFKTGGKPKTFQLSNNIKSVVLRSYGGNQNHLHLTLKNNSFLF 80
                          90       100
                  ....*....|....*....|...
gi 1954668696  84 IDKLSYRDAKQLNMFLDIIHQNK 106
Cdd:cd13312    81 IDKLSSTDAEQLKEFLDKVHQKK 103
UCH_N pfam16674
N-terminal of ubiquitin carboxyl-terminal hydrolase 37; UCH_N is a domain found at the ...
3-105 2.08e-49

N-terminal of ubiquitin carboxyl-terminal hydrolase 37; UCH_N is a domain found at the N-terminus of ubiquitin carboxyl-terminal hydrolase 37 or 26. The function is not known.


Pssm-ID: 465227  Cd Length: 102  Bit Score: 169.72  E-value: 2.08e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696   3 SLKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKfIRIFQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFL 82
Cdd:pfam16674   1 PLKVHGFVQIWSKKTGMSKWKEAFIEIVEKKKKVKLVVYFNTGG-PKTFQLNNNIKSVVLRSYGEKQNRLHLTLKNNSFL 79
                          90       100
                  ....*....|....*....|...
gi 1954668696  83 FIDKLSYRDAKQLNMFLDIIHQN 105
Cdd:pfam16674  80 FIDKLSSTDAEELKMFLDRVHQN 102
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
286-552 1.54e-43

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 160.69  E-value: 1.54e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQ-------GVPWEYIPFEALIMTLTQLLALKDFCSTKIKRellgnVKKVI 358
Cdd:pfam00443   2 GLVNLGNTCYMNSVLQSLFSIPPFRDYLLRIsplsedsRYNKDINLLCALRDLFKALQKNSKSSSVSPKM-----FKKSL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 359 SAVAEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTgkecgdensspqmhvgsaatkvfvCPVVANFEFELQLSLIC 438
Cdd:pfam00443  77 GKLNPDFSGYKQQDAQEFLLFLLDGLHEDLNGNHSTENE------------------------SLITDLFRGQLKSRLKC 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 439 KACGHAVLKVEPNNYLSINLHQETKPLP-LSIQNSLDLFFKEEELE-----YNCQMCKQKSCVARHTFSRLSRVLIIHLK 512
Cdd:pfam00443 133 LSCGEVSETFEPFSDLSLPIPGDSAELKtASLQICFLQFSKLEELDdeekyYCDKCGCKQDAIKQLKISRLPPVLIIHLK 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1954668696 513 RYSFNNaWLLVKNNEQVYIPKSLSLSSYCNESTKPPLPLS 552
Cdd:pfam00443 213 RFSYNR-STWEKLNTEVEFPLELDLSRYLAEELKPKTNNL 251
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
286-548 7.35e-33

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 127.98  E-value: 7.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFaipsfaddlltqgvpweyipfealimtltqllalkdfcstkikrellgnvkkvisavaeif 365
Cdd:cd02257     1 GLNNLGNTCYLNSVLQALF------------------------------------------------------------- 19
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 366 sgNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKECgdensspqmhvgsaatkvfVCPVVANFEFELQLSLICKACGHAV 445
Cdd:cd02257    20 --SEQQDAHEFLLFLLDKLHEELKKSSKRTSDSSSL-------------------KSLIHDLFGGKLESTIVCLECGHES 78
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 446 LKVEPNNYLSINLHQETKPlPLSIQNSLDLFFKEEELE----YNCQMCKQKSCVARHTFSRLSRVLIIHLKRYSFNNAWL 521
Cdd:cd02257    79 VSTEPELFLSLPLPVKGLP-QVSLEDCLEKFFKEEILEgdncYKCEKKKKQEATKRLKIKKLPPVLIIHLKRFSFNEDGT 157
                         250       260
                  ....*....|....*....|....*..
gi 1954668696 522 LVKNNEQVYIPKSLSLSSYCNESTKPP 548
Cdd:cd02257   158 KEKLNTKVSFPLELDLSPYLSEGEKDS 184
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-535 2.76e-22

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 98.55  E-value: 2.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQGVPWEYIPFEALIMTLTQLLALKD-FCSTKIKRELLGN----------- 353
Cdd:cd02658     1 GLRNLGNSCYLNSVLQVLFSIPSFQWRYDDLENKFPSDVVDPANDLNCQLIKLADgLLSGRYSKPASLKsendpyqvgik 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 354 ---VKKVISAVAEIFSGNMQNDAHEFLGQCLDQLkEDMEKLNATLNTGKecgdensspqmhvgsaatkvfvcpvvaNFEF 430
Cdd:cd02658    81 psmFKALIGKGHPEFSTMRQQDALEFLLHLIDKL-DRESFKNLGLNPND---------------------------LFKF 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 431 ELQLSLICKACGHAVLKVEPNNYLSINL---------HQETKPLPLSIQNSLDLFFKEEELEYNCQMCKQKSCVARHT-F 500
Cdd:cd02658   133 MIEDRLECLSCKKVKYTSELSEILSLPVpkdeatekeEGELVYEPVPLEDCLKAYFAPETIEDFCSTCKEKTTATKTTgF 212
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1954668696 501 SRLSRVLIIHLKRYSFNNAWLLVKNNEQVYIPKSL 535
Cdd:cd02658   213 KTFPDYLVINMKRFQLLENWVPKKLDVPIDVPEEL 247
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-550 5.55e-22

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 97.73  E-value: 5.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQGVPwEYIPFEALIMtltqLLALKDFCSTKIKRELLGNVKKVIS----AV 361
Cdd:cd02661     3 GLQNLGNTCFLNSVLQCLTHTPPLANYLLSREHS-KDCCNEGFCM----MCALEAHVERALASSGPGSAPRIFSsnlkQI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 362 AEIFSGNMQNDAHEFLGQCLDQLKedmeklNATLNTGKECGDENSSPQMhvgsaatKVFVCPVvanFEFELQLSLICKAC 441
Cdd:cd02661    78 SKHFRIGRQEDAHEFLRYLLDAMQ------KACLDRFKKLKAVDPSSQE-------TTLVQQI---FGGYLRSQVKCLNC 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 442 GHAVLKVEPNNYLSINLHQETkplplSIQNSLDLFFKEEELE----YNCQMCKQKScVARHTFS--RLSRVLIIHLKRYS 515
Cdd:cd02661   142 KHVSNTYDPFLDLSLDIKGAD-----SLEDALEQFTKPEQLDgenkYKCERCKKKV-KASKQLTihRAPNVLTIHLKRFS 215
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1954668696 516 FNNAWllvKNNEQVYIPKSLSLSSYCNESTKPPLP 550
Cdd:cd02661   216 NFRGG---KINKQISFPETLDLSPYMSQPNDGPLK 247
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-548 1.24e-21

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 97.33  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQgVPWEYIPFEALIMTLTQLLALKDFCSTK--IKRELLGNVKKVISAVAE 363
Cdd:cd02659     4 GLKNQGATCYMNSLLQQLYMTPEFRNAVYSI-PPTEDDDDNKSVPLALQRLFLFLQLSESpvKTTELTDKTRSFGWDSLN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 364 IFsgnMQNDAHEFLGQCLDQLKEDMEKLnatlntgkecGDENSSPQMHVGSAATKVfvcpvvanfefelqlslICKACGH 443
Cdd:cd02659    83 TF---EQHDVQEFFRVLFDKLEEKLKGT----------GQEGLIKNLFGGKLVNYI-----------------ICKECPH 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 444 AVLKVEPNNYLSINLHQETkplplSIQNSLDLFFKEEELE----YNCQMCKQKsCVA--RHTFSRLSRVLIIHLKRYSFN 517
Cdd:cd02659   133 ESEREEYFLDLQVAVKGKK-----NLEESLDAYVQGETLEgdnkYFCEKCGKK-VDAekGVCFKKLPPVLTLQLKRFEFD 206
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1954668696 518 -NAWLLVKNNEQVYIPKSLSLSSYCNESTKPP 548
Cdd:cd02659   207 fETMMRIKINDRFEFPLELDMEPYTEKGLAKK 238
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
289-548 4.53e-20

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 90.04  E-value: 4.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 289 NLGNTCYMNAVLQSLFaipsfaddlltqgvpweyipfealimtltqllalkdfcstkikrellgnvkkvisavaeifsgN 368
Cdd:cd02674     4 NLGNTCYMNSILQCLS---------------------------------------------------------------A 20
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 369 MQNDAHEFLGQCLDQLkedmeklnatlntgkecgdensspqmHvgSAatkvfvcpVVANFEFELQLSLICKACGHAVLKV 448
Cdd:cd02674    21 DQQDAQEFLLFLLDGL--------------------------H--SI--------IVDLFQGQLKSRLTCLTCGKTSTTF 64
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 449 EPNNYLSINLHQETKPLP-LSIQNSLDLFFKEEELEYNCQMC-----KQKSCVARHTFSRLSRVLIIHLKRYSFNNAWlL 522
Cdd:cd02674    65 EPFTYLSLPIPSGSGDAPkVTLEDCLRLFTKEETLDGDNAWKcpkckKKRKATKKLTISRLPKVLIIHLKRFSFSRGS-T 143
                         250       260
                  ....*....|....*....|....*..
gi 1954668696 523 VKNNEQVYIP-KSLSLSSYCNESTKPP 548
Cdd:cd02674   144 RKLTTPVTFPlNDLDLTPYVDTRSFTG 170
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
285-556 1.14e-19

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 91.28  E-value: 1.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 285 QGFPNLGNTCYMNAVLQSLFAIPSFADDLLTQG-VPWEYIPFEALIMTLTQLLALKDF----------------CSTKIK 347
Cdd:cd02660     1 RGLINLGATCFMNVILQALLHNPLLRNYFLSDRhSCTCLSCSPNSCLSCAMDEIFQEFyysgdrspygpinllyLSWKHS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 348 RELlgnvkkvisavaeifSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKECGdensspqmhvgsaatkvfvCPVVAN 427
Cdd:cd02660    81 RNL---------------AGYSQQDAHEFFQFLLDQLHTHYGGDKNEANDESHCN-------------------CIIHQT 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 428 FEFELQLSLICKACGHAVLKVEPNNYLSINLHQETKPLP----------LSIQNSLDLFFKEEELE---YNCQMCKQKSC 494
Cdd:cd02660   127 FSGSLQSSVTCQRCGGVSTTVDPFLDLSLDIPNKSTPSWalgesgvsgtPTLSDCLDRFTRPEKLGdfaYKCSGCGSTQE 206
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1954668696 495 VARH-TFSRLSRVLIIHLKRYSFNNAWLLVKNNEQVYIPKSLSLSSYCNESTKPPLPLSSSAP 556
Cdd:cd02660   207 ATKQlSIKKLPPVLCFQLKRFEHSLNKTSRKIDTYVQFPLELNMTPYTSSSIGDTQDSNSLDP 269
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-541 1.17e-16

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 81.28  E-value: 1.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTqgvpweyipfealimTLTQLLAlkDFCSTKIKrellgnvkkvisavaeiF 365
Cdd:cd02667     1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE---------------TPKELFS--QVCRKAPQ-----------------F 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 366 SGNMQNDAHEFLGQCLDQLKEDMEKLnatlntgkecgdensspqmhvgsaatkvfvcpvvanFEFELQLSLICKACGHAV 445
Cdd:cd02667    47 KGYQQQDSHELLRYLLDGLRTFIDSI------------------------------------FGGELTSTIMCESCGTVS 90
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 446 LKVEPNNYLSINLHQETKPlPLSIQNSLDLFFKEEELEYNCQMCKQKSCVARHTF--SRLSRVLIIHLKRYSFNNAWLLV 523
Cdd:cd02667    91 LVYEPFLDLSLPRSDEIKS-ECSIESCLKQFTEVEILEGNNKFACENCTKAKKQYliSKLPPVLVIHLKRFQQPRSANLR 169
                         250
                  ....*....|....*...
gi 1954668696 524 KNNEQVYIPKSLSLSSYC 541
Cdd:cd02667   170 KVSRHVSFPEILDLAPFC 187
Peptidase_C19F cd02662
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-540 5.12e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239127 [Multi-domain]  Cd Length: 240  Bit Score: 75.48  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFAddlltqgvpwEYIpfealimtltqllalkdfcstkikrellgnvKKVISavaeif 365
Cdd:cd02662     1 GLVNLGNTCFMNSVLQALASLPSLI----------EYL-------------------------------EEFLE------ 33
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 366 sgnmQNDAHEFLGQCLDQLKEDMeklnatlntgkecgdenSSPqmhvgsaatkvfvcpvvanFEFELQLSLICKACGHAV 445
Cdd:cd02662    34 ----QQDAHELFQVLLETLEQLL-----------------KFP-------------------FDGLLASRIVCLQCGESS 73
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 446 -LKVEPNNYLSINLHQETKPLPLSIQNSLDLFFKEEELE-YNCQMCKQKscvarhtFSRLSRVLIIHLKRYSFNNAWLLV 523
Cdd:cd02662    74 kVRYESFTMLSLPVPNQSSGSGTTLEHCLDDFLSTEIIDdYKCDRCQTV-------IVRLPQILCIHLSRSVFDGRGTST 146
                         250
                  ....*....|....*..
gi 1954668696 524 KNNEQVYIPKSLSLSSY 540
Cdd:cd02662   147 KNSCKVSFPERLPKVLY 163
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
823-883 1.03e-13

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 72.13  E-value: 1.03e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1954668696 823 YRLISVVSHIGSSPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEA--RLHSGYIFFYM 883
Cdd:cd02257   193 YELVAVVVHSGTSADSGHYVAYVKDPSDGKWYKFNDDKVTEVSEEEVLEFgsLSSSAYILFYE 255
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-517 1.78e-13

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 72.34  E-value: 1.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFaipsfaddlltqgvpweyipFEALimtltqLLALKD-FCSTKIKRELLGNV--KKVISAV- 361
Cdd:cd02663     1 GLENFGNTCYCNSVLQALY--------------------FENL------LTCLKDlFESISEQKKRTGVIspKKFITRLk 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 362 --AEIFSGNMQNDAHEFLGQCLDQLKEDMEKLN-ATLNTGKECGDENSSPQmhvgsaatKVFVCPVvanFEFELQLSLIC 438
Cdd:cd02663    55 reNELFDNYMHQDAHEFLNFLLNEIAEILDAERkAEKANRKLNNNNNAEPQ--------PTWVHEI---FQGILTNETRC 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 439 KACGHAVLKVEPNNYLSINLHQETkplplSIQNSLDLFFKEEEL----EYNCQMCK-----QKscvaRHTFSRLSRVLII 509
Cdd:cd02663   124 LTCETVSSRDETFLDLSIDVEQNT-----SITSCLRQFSATETLcgrnKFYCDECCslqeaEK----RMKIKKLPKILAL 194

                  ....*...
gi 1954668696 510 HLKRYSFN 517
Cdd:cd02663   195 HLKRFKYD 202
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
818-882 4.06e-13

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 71.32  E-value: 4.06e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1954668696 818 DPLQAYRLISVVSHIGSsPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEArlHSGYIFFY 882
Cdd:pfam00443 249 NNLQDYRLVAVVVHSGS-LSSGHYIAYIKAYENNRWYKFDDEKVTEVDEETAVLS--SSAYILFY 310
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-547 1.18e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 64.14  E-value: 1.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDL-----LTQGVPWEYIPFEALIMTLTQLLAlkdfcsTKIKRELLGNVKKVISa 360
Cdd:cd02671    26 GLNNLGNTCYLNSVLQVLYFCPGFKHGLkhlvsLISSVEQLQSSFLLNPEKYNDELA------NQAPRRLLNALREVNP- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 361 vaeIFSGNMQNDAHEFLGQCLDQLKEDMEKLnatlntgkecgdensspqmhvgsaatkvfvcpvvanFEFELQLSLICKA 440
Cdd:cd02671    99 ---MYEGYLQHDAQEVLQCILGNIQELVEKD------------------------------------FQGQLVLRTRCLE 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 441 C------------------GHAVLKVEPNNYLSINLHQETKPLPLSIQNsldlFFKEE----ELEYNCQMCKQKSCVARH 498
Cdd:cd02671   140 CetfterredfqdisvpvqESELSKSEESSEISPDPKTEMKTLKWAISQ----FASVErivgEDKYFCENCHHYTEAERS 215
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1954668696 499 -TFSRLSRVLIIHLKRYSFNNAWL-----LVKNNEQVYIPKSLSLSSYCNESTKP 547
Cdd:cd02671   216 lLFDKLPEVITIHLKCFAANGSEFdcyggLSKVNTPLLTPLKLSLEEWSTKPKND 270
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
286-470 1.77e-10

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 64.90  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQGVPWEYIPFEALIMTLTQLLALKDFCSTKIKRELLG----NVKKVISAV 361
Cdd:COG5560   267 GLRNLGNTCYMNSALQCLMHTWELRDYFLSDEYEESINEENPLGMHGSVASAYADLIKQLYDGNLHAftpsGFKKTIGSF 346
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 362 AEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKEcgDENSSPQMHVGSAAT------KVFVCPVVAN-FEFELQL 434
Cdd:COG5560   347 NEEFSGYDQQDSQEFIAFLLDGLHEDLNRIIKKPYTSKP--DLSPGDDVVVKKKAKecwwehLKRNDSIITDlFQGMYKS 424
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1954668696 435 SLICKACGHAVLKVEPNNYLSInlhqetkPLPLSIQ 470
Cdd:COG5560   425 TLTCPGCGSVSITFDPFMDLTL-------PLPVSMV 453
Peptidase_C19Q cd02673
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
358-540 3.11e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239138 [Multi-domain]  Cd Length: 245  Bit Score: 61.39  E-value: 3.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 358 ISAVAEIFSGNMQNDAHEFLG---QCLDQLKEDMEKLNATLNtgkecgdensspqmhvGSAATkvfVCPVVAnFEFELQL 434
Cdd:cd02673    21 IGKINTEFDNDDQQDAHEFLLtllEAIDDIMQVNRTNVPPSN----------------IEIKR---LNPLEA-FKYTIES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 435 SLICKACGHAVLKVEPNNYLSINLhqetKPLPLSIQNSLDL-FFKEEELEYNCQMCKQKSCVARHTFSRLSRVLIIHLKR 513
Cdd:cd02673    81 SYVCIGCSFEENVSDVGNFLDVSM----IDNKLDIDELLISnFKTWSPIEKDCSSCKCESAISSERIMTFPECLSINLKR 156
                         170       180
                  ....*....|....*....|....*...
gi 1954668696 514 YSFNNAWLL-VKNNEQVYIPKSLSLSSY 540
Cdd:cd02673   157 YKLRIATSDyLKKNEEIMKKYCGTDAKY 184
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-514 9.24e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 60.81  E-value: 9.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQGvPWEYIPFEALIMTLTQLLALKDFCSTKIKR----ELLGNVKKVISAV 361
Cdd:cd02657     1 GLTNLGNTCYLNSTLQCLRSVPELRDALKNYN-PARRGANQSSDNLTNALRDLFDTMDKKQEPvppiEFLQLLRMAFPQF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 362 AEIFSGN--MQNDAHEFLGQCLDQLKEDMEKLnatlntgkecGDENSspqmhvgsaatkvFVCpvvANFEFELQLSLICK 439
Cdd:cd02657    80 AEKQNQGgyAQQDAEECWSQLLSVLSQKLPGA----------GSKGS-------------FID---QLFGIELETKMKCT 133
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1954668696 440 ACGH-AVLKVEPNNYLSINLHQETkpLPLSIQNSLDLFFKEEELEYNCQMCKQKSCVARHTFSRLSRVLIIHLKRY 514
Cdd:cd02657   134 ESPDeEEVSTESEYKLQCHISITT--EVNYLQDGLKKGLEEEIEKHSPTLGRDAIYTKTSRISRLPKYLTVQFVRF 207
COG5533 COG5533
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
286-518 1.71e-09

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444284 [Multi-domain]  Cd Length: 284  Bit Score: 59.82  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSL-FAIPSFaDDLLTQgVPWEYIPFEALI----MTLTQLLALKDFCSTKIKRELlgnvkkvisA 360
Cdd:COG5533     1 GLPNLGNTCFMNSVLQILaLYLPKL-DELLDD-LSKELKVLKNVIrkpePDLNQEEALKLFTALWSSKEH---------K 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 361 VAEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNaTLNTGKECGDENSSpqmhvgsaATKVFvcpvvanFEFELQLSLICKA 440
Cdd:COG5533    70 VGWIPPMGSQEDAHELLGKLLDELKLDLVNSF-TIRIFKTTKDKKKT--------STGDW-------FDIIIELPDQTWV 133
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1954668696 441 CGHAVLKVEPNNYLSINlhqetkPLPLSIQNSLDlffkeEELEYNCQMCKQKScvarhtFSRLSRVLIIHLKRYSFNN 518
Cdd:COG5533   134 NNLKTLQEFIDNMEELV------DDETGVKAKEN-----EELEVQAKQEYEVS------FVKLPKILTIQLKRFANLG 194
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
823-872 6.95e-09

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 58.59  E-value: 6.95e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1954668696 823 YRLISVVSHIGSSPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEA 872
Cdd:cd02668   246 YELSGVLIHQGVSAYSGHYIAHIKDEQTGEWYKFNDEDVEEMPGKPLKLG 295
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-568 1.04e-08

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 57.89  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLTQGVPWEyiPFEALIMTLTQLLALKDFCStkiKRELLGNVKKVISAV-AEI 364
Cdd:cd02664     1 GLINLGNTCYMNSVLQALFMAKDFRRQVLSLNLPRL--GDSQSVMKKLQLLQAHLMHT---QRRAEAPPDYFLEASrPPW 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 365 FSGNMQNDAHEFLGQCLDQLKEDMEKLnatlntgkecgdensspqmhvgsaatkvfvcpvvanFEFELQLSLICKACGHA 444
Cdd:cd02664    76 FTPGSQQDCSEYLRYLLDRLHTLIEKM------------------------------------FGGKLSTTIRCLNCNST 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 445 VLKVEPNNYLSINLhqetkPlplSIQNSLDLFFKEEEL----EYNCQMCKQKSCVARH-TFSRLSRVLIIHLKRYSFNNA 519
Cdd:cd02664   120 SARTERFRDLDLSF-----P---SVQDLLNYFLSPEKLtgdnQYYCEKCASLQDAEKEmKVTGAPEYLILTLLRFSYDQK 191
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1954668696 520 WLL-VKNNEQVYIPKSLSLSSYCNESTKPPLPLSSSAPVGKCEVLEVSQE 568
Cdd:cd02664   192 THVrEKIMDNVSINEVLSLPVRVESKSSESPLEKKEEESGDDGELVTRQV 241
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
823-882 1.29e-08

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 56.53  E-value: 1.29e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 823 YRLISVVSHIGSSpNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEArlhSGYIFFY 882
Cdd:cd02674   174 YDLYAVVNHYGSL-NGGHYTAYCKNNETNDWYKFDDSRVTKVSESSVVSS---SAYILFY 229
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
818-882 2.68e-07

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 53.53  E-value: 2.68e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1954668696 818 DPLQAYRLISVVSHIGSSpNSGHYISDVYDfQKQAWFTYNDLCVSEISETKMQEARlhsGYIFFY 882
Cdd:cd02660   268 DPDYTYDLFAVVVHKGTL-DTGHYTAYCRQ-GDGQWFKFDDAMITRVSEEEVLKSQ---AYLLFY 327
COG5533 COG5533
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
823-882 7.98e-07

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444284 [Multi-domain]  Cd Length: 284  Bit Score: 51.73  E-value: 7.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 823 YRLISVVSHIGSSpNSGHYISDVYdfQKQAWFTYNDLCVSEISETKMQEARLHSGYIFFY 882
Cdd:COG5533   225 YDLVGFVLHQGSL-EGGHYIAYVK--KGGKWEKANDSDVTPVSEEEAINEKAKNAYLYFY 281
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
817-883 9.56e-07

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 51.51  E-value: 9.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1954668696 817 GDPLQAYRLISVVSHIGSSPNSGHYISDVYDFQKQaWFTYNDlcvSEISETKMQEARLHSGYIFFYM 883
Cdd:cd02661   242 NDGPLKYKLYAVLVHSGFSPHSGHYYCYVKSSNGK-WYNMDD---SKVSPVSIETVLSQKAYILFYI 304
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
823-882 1.53e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 51.18  E-value: 1.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1954668696 823 YRLISVVSHIGSSPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQeaRL------HSGYIFFY 882
Cdd:cd02657   241 YELVAVITHQGRSADSGHYVAWVRRKNDGKWIKFDDDKVSEVTEEDIL--KLsgggdwHIAYILLY 304
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
818-882 2.64e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 50.39  E-value: 2.64e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 818 DPLQAYRLISVVSHIGSSPNSGHYISDVYdfQKQAWFTYNDLCVSEISETKMQE-----ARLHSGYIFFY 882
Cdd:cd02663   232 NPDRLYELVAVVVHIGGGPNHGHYVSIVK--SHGGWLLFDDETVEKIDENAVEEffgdsPNQATAYVLFY 299
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-544 2.84e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 50.50  E-value: 2.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 286 GFPNLGNTCYMNAVLQSLF----------AIPSFADDLLTQGVP-WEYIPFEALImtltQLlalkdfcsTKIKRELLGNV 354
Cdd:cd02668     1 GLKNLGATCYVNSFLQLWFmnlefrkavyECNSTEDAELKNMPPdKPHEPQTIID----QL--------QLIFAQLQFGN 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 355 KKVI--SAVAEIFSGNM--QNDAHEFLGQCLDQLKEDMEKLNatlntgkecgdensspqmhvGSAATKVfvcpVVANFEF 430
Cdd:cd02668    69 RSVVdpSGFVKALGLDTgqQQDAQEFSKLFLSLLEAKLSKSK--------------------NPDLKNI----VQDLFRG 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 431 ELQLSLICKACGHAVLKVEPNNYLSINLhQETKPLPLSIQNsldlFFKEEELE----YNCQMCKQK-SCVARHTFSRLSR 505
Cdd:cd02668   125 EYSYVTQCSKCGRESSLPSKFYELELQL-KGHKTLEECIDE----FLKEEQLTgdnqYFCESCNSKtDATRRIRLTTLPP 199
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1954668696 506 VLIIHLKRYSFNNAWLLVKN-NEQVYIPKSLSLSSYCNES 544
Cdd:cd02668   200 TLNFQLLRFVFDRKTGAKKKlNASISFPEILDMGEYLAES 239
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
286-546 3.43e-06

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 51.02  E-value: 3.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696  286 GFPNLGNTCYMNAVLQSLFAIPSFADDLLtqGVPWEYIPFEALIMTLTQllalKDFCSTKIKRELLGNVKKVISAVAEIF 365
Cdd:COG5077    195 GLRNQGATCYMNSLLQSLFFIAKFRKDVY--GIPTDHPRGRDSVALALQ----RLFYNLQTGEEPVDTTELTRSFGWDSD 268
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696  366 SGNMQNDAHEFLGQCLDQLKEDMEKLNAtlntgkecgdENSSPQMHVGSaaTKVFVCPVVANFEfelqlslicKACGHAV 445
Cdd:COG5077    269 DSFMQHDIQEFNRVLQDNLEKSMRGTVV----------ENALNGIFVGK--MKSYIKCVNVNYE---------SARVEDF 327
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696  446 LKVEPNNYLSINLhqetkplplsiQNSLDLFFKEEELE-YNCQMCKQKSCVARHT---FSRLSRVLIIHLKRYSFN-NAW 520
Cdd:COG5077    328 WDIQLNVKGMKNL-----------QESFRRYIQVETLDgDNRYNAEKHGLQDAKKgviFESLPPVLHLQLKRFEYDfERD 396
                          250       260
                   ....*....|....*....|....*.
gi 1954668696  521 LLVKNNEQVYIPKSLSLSSYCNESTK 546
Cdd:COG5077    397 MMVKINDRYEFPLEIDLLPFLDRDAD 422
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
823-882 8.59e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 48.86  E-value: 8.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1954668696 823 YRLISVVSHIGSSPNSGHYIS----DVYDFQKqaWFTYND--LCVSEISETKMQearlhSGYIFFY 882
Cdd:cd02658   252 YELIAFISHKGTSVHSGHYVAhikkEIDGEGK--WVLFNDekVVASQDPPEMKK-----LGYIYFY 310
Peptidase_C19Q cd02673
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
804-882 1.79e-05

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239138 [Multi-domain]  Cd Length: 245  Bit Score: 47.14  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 804 RGEAKELTRNVKMGDPLQA----YRLISVVSHIGSSPNSGHYISDVYD-FQKQAWFTYNDLCVSEISETKMQEARLHSGY 878
Cdd:cd02673   161 IATSDYLKKNEEIMKKYCGtdakYSLVAVICHLGESPYDGHYIAYTKElYNGSSWLYCSDDEIRPVSKNDVSTNARSSGY 240

                  ....
gi 1954668696 879 IFFY 882
Cdd:cd02673   241 LIFY 244
Peptidase_C19J cd02666
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
628-867 8.38e-05

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239131 [Multi-domain]  Cd Length: 343  Bit Score: 45.95  E-value: 8.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 628 LESELVHFRDRAIG-EKELPVA-------DSLMDQGDISLPVMYEDGGKLISSPDTRLVEVHLQEVPQHPELQKYEKTNT 699
Cdd:cd02666    73 LFNDLIHSNTRSVTpSKELAYLalrqqdvTECIDNVLFQLEVALEPISNAFAGPDTEDDKEQSDLIKRLFSGKTKQQLVP 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 700 FVEFNFDSVTESTNGF----YDCKENRIPEGSQGMAEQLQQCIEESIIDEFLQQAPPPGVRKLD-AQEHTEETLNQSTel 774
Cdd:cd02666   153 ESMGNQPSVRTKTERFlsllVDVGKKGREIVVLLEPKDLYDALDRYFDYDSLTKLPQRSQVQAQlAQPLQRELISMDR-- 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 775 RLQKADLNHLGALGSDN--PGNKNILDAENTRGEAKELTRNVKMGDPLQAYRLISVVSHIGSSpNSGHYISDVYDFQKQA 852
Cdd:cd02666   231 YELPSSIDDIDELIREAiqSESSLVRQAQNELAELKHEIEKQFDDLKSYGYRLHAVFIHRGEA-SSGHYWVYIKDFEENV 309
                         250
                  ....*....|....*
gi 1954668696 853 WFTYNDLCVSEISET 867
Cdd:cd02666   310 WRKYNDETVTVVPAS 324
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
823-882 1.43e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 41.71  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954668696 823 YRLISVVSHIGSSPNSGHYIS------------DVYDFQKQA--------WFTYNDlcvSEISETKMQEA-------RLH 875
Cdd:cd02664   243 YRLYAVVVHSGYSSESGHYFTyardqtdadstgQECPEPKDAeendesknWYLFND---SRVTFSSFESVqnvtsrfPKD 319

                  ....*..
gi 1954668696 876 SGYIFFY 882
Cdd:cd02664   320 TPYILFY 326
Peptidase_C19I cd02665
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
823-865 4.87e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239130 [Multi-domain]  Cd Length: 228  Bit Score: 39.46  E-value: 4.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1954668696 823 YRLISVVSHIGSSpNSGHYISDVYDFQKQAWFTYNDLCVSEIS 865
Cdd:cd02665   164 YELHAVLVHEGQA-NAGHYWAYIYKQSRQEWEKYNDISVTESS 205
Peptidase_C19J cd02666
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
286-306 9.53e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239131 [Multi-domain]  Cd Length: 343  Bit Score: 39.40  E-value: 9.53e-03
                          10        20
                  ....*....|....*....|.
gi 1954668696 286 GFPNLGNTCYMNAVLQSLFAI 306
Cdd:cd02666     3 GLDNIGNTCYLNSLLQYFFTI 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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