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Conserved domains on  [gi|1952076978|ref|NP_001376515|]
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DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3 [Homo sapiens]

Protein Classification

RPOL8c domain-containing protein( domain architecture ID 10652794)

RPOL8c domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
1-111 1.46e-55

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


:

Pssm-ID: 197821  Cd Length: 143  Bit Score: 169.12  E-value: 1.46e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076978    1 MDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTeaaTRLSAYV 80
Cdd:smart00658  36 MELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALIKSLADKYEYVMYGKVYRIEEDKTET---SKLSAYV 112
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952076978   81 SYGGLLMRLQGDANNLHGFEVDSRVYLLMKK 111
Cdd:smart00658 113 SFGGLLMRLKGDANNLKGFELDSNLYLLMRK 143
 
Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
1-111 1.46e-55

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


Pssm-ID: 197821  Cd Length: 143  Bit Score: 169.12  E-value: 1.46e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076978    1 MDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTeaaTRLSAYV 80
Cdd:smart00658  36 MELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALIKSLADKYEYVMYGKVYRIEEDKTET---SKLSAYV 112
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952076978   81 SYGGLLMRLQGDANNLHGFEVDSRVYLLMKK 111
Cdd:smart00658 113 SFGGLLMRLKGDANNLKGFELDSNLYLLMRK 143
RNA_pol_Rpb8 pfam03870
RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II ...
1-110 9.45e-55

RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III. Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.


Pssm-ID: 461079  Cd Length: 136  Bit Score: 166.89  E-value: 9.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076978   1 MDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPT---DDRPSRADQFEYVMYGKVYRIEGDETSTeaatRLS 77
Cdd:pfam03870  28 MDLTLDINTELYPVKVGDKFTLVLASTLSLDGTPDDGEYDQSwrpPGEPSLADDYDYVMYGKVYKFEEEESGD----KVA 103
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952076978  78 AYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMK 110
Cdd:pfam03870 104 VYASFGGLLMRLEGDPRKLSDLEVDQNVYLLIR 136
PTZ00167 PTZ00167
RNA polymerase subunit 8c; Provisional
2-111 4.18e-17

RNA polymerase subunit 8c; Provisional


Pssm-ID: 185493  Cd Length: 144  Bit Score: 71.73  E-value: 4.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076978   2 DLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNptdDRPSRADQFEYVMYGKVYRIEgdETSTEaatRLSAYVS 81
Cdd:PTZ00167   38 ELILDINSDLFPVREKQSLYIGLTNQLSSGPDDNVWESS---EPQSLMDQYEYVMYGKIFKFE--EKSSE---RRTLYAS 109
                          90       100       110
                  ....*....|....*....|....*....|
gi 1952076978  82 YGGLLMRLQGDANNLHGFEVDSRVYLLMKK 111
Cdd:PTZ00167  110 FGGLLMALTADKQVVGDLELDMRIYLLVRR 139
 
Name Accession Description Interval E-value
RPOL8c smart00658
RNA polymerase subunit 8; subunit of RNA polymerase I, II and III
1-111 1.46e-55

RNA polymerase subunit 8; subunit of RNA polymerase I, II and III


Pssm-ID: 197821  Cd Length: 143  Bit Score: 169.12  E-value: 1.46e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076978    1 MDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTeaaTRLSAYV 80
Cdd:smart00658  36 MELILDINSEIYPLAVGDKFRLVIASTLNEDGTPDSGENNPIALIKSLADKYEYVMYGKVYRIEEDKTET---SKLSAYV 112
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952076978   81 SYGGLLMRLQGDANNLHGFEVDSRVYLLMKK 111
Cdd:smart00658 113 SFGGLLMRLKGDANNLKGFELDSNLYLLMRK 143
RNA_pol_Rpb8 pfam03870
RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II ...
1-110 9.45e-55

RNA polymerase Rpb8; Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III. Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.


Pssm-ID: 461079  Cd Length: 136  Bit Score: 166.89  E-value: 9.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076978   1 MDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPT---DDRPSRADQFEYVMYGKVYRIEGDETSTeaatRLS 77
Cdd:pfam03870  28 MDLTLDINTELYPVKVGDKFTLVLASTLSLDGTPDDGEYDQSwrpPGEPSLADDYDYVMYGKVYKFEEEESGD----KVA 103
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1952076978  78 AYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMK 110
Cdd:pfam03870 104 VYASFGGLLMRLEGDPRKLSDLEVDQNVYLLIR 136
PTZ00167 PTZ00167
RNA polymerase subunit 8c; Provisional
2-111 4.18e-17

RNA polymerase subunit 8c; Provisional


Pssm-ID: 185493  Cd Length: 144  Bit Score: 71.73  E-value: 4.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952076978   2 DLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNptdDRPSRADQFEYVMYGKVYRIEgdETSTEaatRLSAYVS 81
Cdd:PTZ00167   38 ELILDINSDLFPVREKQSLYIGLTNQLSSGPDDNVWESS---EPQSLMDQYEYVMYGKIFKFE--EKSSE---RRTLYAS 109
                          90       100       110
                  ....*....|....*....|....*....|
gi 1952076978  82 YGGLLMRLQGDANNLHGFEVDSRVYLLMKK 111
Cdd:PTZ00167  110 FGGLLMALTADKQVVGDLELDMRIYLLVRR 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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