Cathelicidin; A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2131399652  75 NSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCH 135
Cdd:pfam07448   3 DEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRCR 63

Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2131399652  75 NSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCH 135
Cdd:pfam07448   3 DEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRCR 63

Secreted phosphoprotein 24 (Spp-24) cystatin-like domain; This family represents a conserved region approximately 60 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2131399652  75 NSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCH 135
Cdd:pfam07448   3 DEDSLSMDLEFSIRETTCRRDSGEDPSTCDFQRGYYVPAAVCRSTVQMSAEQVQDVWVRCR 63