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Conserved domains on  [gi|1908832867|ref|NP_001374144|]
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protein ENTREP2 isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 175-382 1.89e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  175 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVtsiGQQVAESSSGDPNTSAGFSTPV-PADSTSLLVSEGTA 253
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA---ARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTA 2764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  254 TPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSE 333
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1908832867  334 AVPGSASMSRSataacraqLSPAGDpdtwkTDQRPTPEPFPATSKERPR 382
Cdd:PHA03247  2845 PPPPSLPLGGS--------VAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
CD20 super family cl04401
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 1-103 1.96e-03

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


The actual alignment was detected with superfamily member pfam04103:

Pssm-ID: 461174  Cd Length: 155  Bit Score: 38.78  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867   1 MLLSAVCVMLNLAGSILSCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCsnlgetlklnplqENCNAVRLTL 77
Cdd:pfam04103  63 LLLNLLSLFTAVAGIILLSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECR-------------AYCSSLRGLF 129

                          90       100
                  ....*....|....*....|....*.
gi 1908832867  78 KDLLFSVCALNVLSTIVCALATAMCC 103
Cdd:pfam04103 130 TGILSMLLILTVLELLVSLLSAILGC 155
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 175-382 1.89e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  175 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVtsiGQQVAESSSGDPNTSAGFSTPV-PADSTSLLVSEGTA 253
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA---ARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTA 2764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  254 TPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSE 333
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1908832867  334 AVPGSASMSRSataacraqLSPAGDpdtwkTDQRPTPEPFPATSKERPR 382
Cdd:PHA03247  2845 PPPPSLPLGGS--------VAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 191-372 1.76e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 191 GLLYPAELPPPYEAVVGQP-PASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstSLLVSEGTATPGSSPSPDGPVgAPA 269
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATSQPPNQTQSTAAPH-----TLIQQTPTLHPQRLPSPHPPL-QPM 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 270 PSEPalPPGHVSPE---DPGMGSQVQPGPGRVSrstSDPTLCTSSMAGDASSHRPSCSQ-DLEAGLSEAVPGSASmSRSA 345
Cdd:pfam03154 253 TQPP--PPSQVSPQplpQPSLHGQMPPMPHSLQ---TGPSHMQHPVPPQPFPLTPQSSQsQVPPGPSPAAPGQSQ-QRIH 326

                         170       180
                  ....*....|....*....|....*..
gi 1908832867 346 TAACRAQLSPAGDPDTWKTDQRPTPEP 372
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPAPLSMP 353
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 1-103 1.96e-03

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 38.78  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867   1 MLLSAVCVMLNLAGSILSCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCsnlgetlklnplqENCNAVRLTL 77
Cdd:pfam04103  63 LLLNLLSLFTAVAGIILLSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECR-------------AYCSSLRGLF 129

                          90       100
                  ....*....|....*....|....*.
gi 1908832867  78 KDLLFSVCALNVLSTIVCALATAMCC 103
Cdd:pfam04103 130 TGILSMLLILTVLELLVSLLSAILGC 155
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 175-382 1.89e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  175 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVtsiGQQVAESSSGDPNTSAGFSTPV-PADSTSLLVSEGTA 253
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA---ARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTA 2764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  254 TPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSE 333
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1908832867  334 AVPGSASMSRSataacraqLSPAGDpdtwkTDQRPTPEPFPATSKERPR 382
Cdd:PHA03247  2845 PPPPSLPLGGS--------VAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 227-394 2.02e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 2.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  227 GDPNTSAGFSTPVPADSTSLLVSEGTATPGSS--------PSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRV 298
Cdd:PHA03307    69 TGPPPGPGTEAPANESRSTPTWSLSTLAPASParegsptpPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPP 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  299 SRSTSDPTLCTSSMAGDASShrPSCSQDLEAGLSEAVPGSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSK 378
Cdd:PHA03307   149 AASPPAAGASPAAVASDAAS--SRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGR 226

                          170       180
                   ....*....|....*....|
gi 1908832867  379 E----RPRSLVDSKAYADAR 394
Cdd:PHA03307   227 SaaddAGASSSDSSSSESSG 246
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 195-383 9.43e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 9.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  195 PAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTA------TPGSSPSPDGPVGAP 268
Cdd:PHA03307   190 PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpeneCPLPRPAPITLPTRI 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  269 APSEPALP----PGHVSPEDPGMGSQVQPGPGR-VSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSR 343
Cdd:PHA03307   270 WEASGWNGpssrPGPASSSSSPRERSPSPSPSSpGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSR 349

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1908832867  344 SATAAcraqlSPAGDPDTWKTDQRPTPE---PFPATSKERPRS 383
Cdd:PHA03307   350 SPSPS-----RPPPPADPSSPRKRPRPSrapSSPAASAGRPTR 387
PHA03247 PHA03247
large tegument protein UL36; Provisional
 184-374 2.47e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  184 DVAINSPGLLYPAELPPPYEAVVGQP-PASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPD 262
Cdd:PHA03247  2546 DDAGDPPPPLPPAAPPAAPDRSVPPPrPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  263 GPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRstsdptlctssmagdassHRPSCSQDLEAGLSEAVPGSasmS 342
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR------------------PRRARRLGRAAQASSPPQRP---R 2684

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1908832867  343 RSATAACRAQLSPAGDPdtwkTDQRPTPEPFP 374
Cdd:PHA03247  2685 RRAARPTVGSLTSLADP----PPPPPTPEPAP 2712
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
173-382 1.01e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 173 DFAPSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPntsagfstPVPADSTSLLVSEGT 252
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS--------PAPEALAAARQASAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 253 ATPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPScsqDLEAGLS 332
Cdd:PRK12323  443 GPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPA---QPDAAPA 519

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1908832867 333 EAVpgSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPR 382
Cdd:PRK12323  520 GWV--AESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567
PHA03378 PHA03378
EBNA-3B; Provisional
 189-395 1.43e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 189 SPGLLYPAELPPpyeaVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPAdSTSLLVSEGTATPGSSPSPDGPVGAP 268
Cdd:PHA03378  700 APTPMRPPAAPP----GRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPA-AAPGRARPPAAAPGRARPPAAAPGAP 774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 269 APSEPALPPghvspedPGMGSQVQPGPGRVSRSTSDPT---LCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSA 345
Cdd:PHA03378  775 TPQPPPQAP-------PAPQQRPRGAPTPQPPPQAGPTsmqLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALE 847

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1908832867 346 TAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPRSLVDSKAYADARV 395
Cdd:PHA03378  848 RQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGSVRAAAASTV 897
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 222-302 1.53e-03

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 40.96  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 222 AESSSGDPNTSAGfsTPVPADSTSLLVSEGTATPGSSPSPDGPVGAPAPSEP-ALPPGHVSPEDPGMGSQVQPGPGRVSR 300
Cdd:PRK13729  120 VKALGANPVTATG--EPVPQMPASPPGPEGEPQPGNTPVSFPPQGSVAVPPPtAFYPGNGVTPPPQVTYQSVPVPNRIQR 197


                  ..
gi 1908832867 301 ST 302
Cdd:PRK13729  198 KT 199
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 191-372 1.76e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 191 GLLYPAELPPPYEAVVGQP-PASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstSLLVSEGTATPGSSPSPDGPVgAPA 269
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATSQPPNQTQSTAAPH-----TLIQQTPTLHPQRLPSPHPPL-QPM 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 270 PSEPalPPGHVSPE---DPGMGSQVQPGPGRVSrstSDPTLCTSSMAGDASSHRPSCSQ-DLEAGLSEAVPGSASmSRSA 345
Cdd:pfam03154 253 TQPP--PPSQVSPQplpQPSLHGQMPPMPHSLQ---TGPSHMQHPVPPQPFPLTPQSSQsQVPPGPSPAAPGQSQ-QRIH 326

                         170       180
                  ....*....|....*....|....*..
gi 1908832867 346 TAACRAQLSPAGDPDTWKTDQRPTPEP 372
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPAPLSMP 353
PRK12495 PRK12495
hypothetical protein; Provisional
 219-359 1.77e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 39.85  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 219 QQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRV 298
Cdd:PRK12495   66 QPVTEDGAAGDDAGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATDEAATDPPATAAARDGPTPDPT 145

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1908832867 299 SRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRaQLSPAGDP 359
Cdd:PRK12495  146 AQPATPDERRSPRQRPPVSGEPPTPSTPDAHVAGTLQAARESLVETLARFAR-RAAATDDP 205
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 1-103 1.96e-03

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 38.78  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867   1 MLLSAVCVMLNLAGSILSCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCsnlgetlklnplqENCNAVRLTL 77
Cdd:pfam04103  63 LLLNLLSLFTAVAGIILLSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECR-------------AYCSSLRGLF 129

                          90       100
                  ....*....|....*....|....*.
gi 1908832867  78 KDLLFSVCALNVLSTIVCALATAMCC 103
Cdd:pfam04103 130 TGILSMLLILTVLELLVSLLSAILGC 155
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 189-383 2.41e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  189 SPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAG---FSTPVPADSTSLLVSEGTATPGSSPSPDGPV 265
Cdd:PHA03307   125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRqaaLPLSSPEETARAPSSPPAEPPPSTPPAAASP 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  266 GAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPScSQDLEAGLSEAVPGSASMSRSA 345
Cdd:PHA03307   205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPA-PITLPTRIWEASGWNGPSSRPG 283

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1908832867  346 TAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPRS 383
Cdd:PHA03307   284 PASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSS 321
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 199-403 3.51e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 199 PPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPDGPvGAPAPSEPALPPG 278
Cdd:PRK07764  610 EEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGG-AAPAAPPPAPAPA 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 279 HVSPEDPGMGSQVQPGP------GRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRAq 352
Cdd:PRK07764  689 APAAPAGAAPAQPAPAPaatppaGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPA- 767

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1908832867 353 lSPAGDPDTWKTDQRPTPEPFPATSKERPRSLVDSKAYADA---RVLVAKFLEH 403
Cdd:PRK07764  768 -AAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMElleEELGAKKIEE 820
motB PRK12799
flagellar motor protein MotB; Reviewed
 211-322 3.61e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 39.70  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867 211 ASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTAT--PGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMG 288
Cdd:PRK12799  303 AVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAValSSAGVLPSDVTLPGTVALPAAEPVNMQPQPMSTT 382

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1908832867 289 SQVQPGPGRVSRSTSDPTlcTSSMAGDASSHRPS 322
Cdd:PRK12799  383 ETQQSSTGNITSTANGPT--TSLPAAPASNIPVS 414
DUF4641 pfam15483
Domain of unknown function (DUF4641); This family of proteins is found in eukaryotes. Proteins ...
 222-278 5.63e-03

Domain of unknown function (DUF4641); This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.


Pssm-ID: 464741  Cd Length: 443  Bit Score: 38.96  E-value: 5.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1908832867 222 AESSSGDPNTSAGfstPVPADSTSLLVSEGTATP-GSSPSPD--GPVGAPAPSE-PALPPG 278
Cdd:pfam15483 360 GEFSSGDPNIRAP---QVPGNSQPSALSQGGVRPrGPAPSGDqePPVRPPRPERqQQPPPG 417
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 207-359 8.30e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 38.61  E-value: 8.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908832867  207 GQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTsllvsegtatPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPG 286
Cdd:PHA03307   305 SGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS----------PGPSPSRSPSPSRPPPPADPSSPRKRPRPSRA 374

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1908832867  287 MGSQVQPgPGRVSRSTSDPTLCTSSMAGDASSHRPscsqdleAGLSEAVPGSASMSRSATAACRAQLSPAGDP 359
Cdd:PHA03307   375 PSSPAAS-AGRPTRRRARAAVAGRARRRDATGRFP-------AGRPRPSPLDAGAASGAFYARYPLLTPSGEP 439
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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