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Conserved domains on  [gi|1908918702|ref|NP_001374132|]
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ataxin-2-like protein isoform 36 [Homo sapiens]

Protein Classification

LSm family protein( domain architecture ID 10627762)

LSm family protein such as eukaryotic LSm (Sm-like proteins) and bacterial LSm-related Hfq proteins, that have an Sm fold consisting of a five-stranded beta-sheet and an alpha-helix at the N-terminus, and are involved in processes associated with RNA processing and gene expression regulation; contains an Sm fold similar to that found in uncharacterized chimpanzee ataxin 2 like (ATXN2L)

Gene Ontology:  GO:0006396|GO:0010468
PubMed:  33827399

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 123-196 1.54e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.54e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1908918702  123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 766-928 4.72e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 4.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  766 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 843
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  844 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 923
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350


                   ....*
gi 1908918702  924 QVMLL 928
Cdd:pfam09770  351 QLAQL 355
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 598-878 4.71e-05

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 4.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  598 PNAKEFNP-------TKPLLSVNKSTS-TPTSPGPRTHSTPSIPVLTAgQSGLYSPQY-ISYIPQIHMGPAVQAPQMYPY 668
Cdd:PRK10263   302 PEYDEYDPllngapiTEPVAVAAAATTaTQSWAAPVEPVTQTPPVASV-DVPPAQPTVaWQPVPGPQTGEPVIAPAPEGY 380

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  669 PvsnsvPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQqfPGQPAMMQPMAHYPSQ 748
Cdd:PRK10263   381 P-----QQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPA--PEQPVAGNAWQAEEQQ 453

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  749 PVFAPmlqsNPRMLTSGSHPQAIVSSSTPQYPSAEQPT-----------------PQALYATVHQSYPHHATQLHA-HQ- 809
Cdd:PRK10263   454 STFAP----QSTYQTEQTYQQPAAQEPLYQQPQPVEQQpvvepepvveetkparpPLYYFEEVEEKRAREREQLAAwYQp 529

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1908918702  810 -PQPATTP---TGSQPQSQHAAPSPVQHQAGQAPhLGSGQPQQNLYHPGALTGTPPSLPP----GPSAQSPQSSFPQ 878
Cdd:PRK10263   530 iPEPVKEPepiKSSLKAPSVAAVPPVEAAAAVSP-LASGVKKATLATGAAATVAAPVFSLansgGPRPQVKEGIGPQ 605
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
338-489 9.15e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14971:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 9.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  338 AQVLRPVVSMEAQRPLRGAKTLSSPSNRpsgETSVPPPPAvgrmypprspksaAPAPISASCPEPPIGSAVPTSSASIPV 417
Cdd:PRK14971   376 KQHIKPVFTQPAAAPQPSAAAAASPSPS---QSSAAAQPS-------------APQSATQPAGTPPTVSVDPPAAVPVNP 439

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1908918702  418 TSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRtlEPQELARIAGKVPGLQNEQKRFQLEELRKFGAQF 489
Cdd:PRK14971   440 PSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQ--EKAEQATGNIKEAPTGTQKEIFTEEDLQYYWQEF 509
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 123-196 1.54e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.54e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1908918702  123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 766-928 4.72e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 4.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  766 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 843
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  844 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 923
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350


                   ....*
gi 1908918702  924 QVMLL 928
Cdd:pfam09770  351 QLAQL 355
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 598-878 4.71e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 4.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  598 PNAKEFNP-------TKPLLSVNKSTS-TPTSPGPRTHSTPSIPVLTAgQSGLYSPQY-ISYIPQIHMGPAVQAPQMYPY 668
Cdd:PRK10263   302 PEYDEYDPllngapiTEPVAVAAAATTaTQSWAAPVEPVTQTPPVASV-DVPPAQPTVaWQPVPGPQTGEPVIAPAPEGY 380

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  669 PvsnsvPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQqfPGQPAMMQPMAHYPSQ 748
Cdd:PRK10263   381 P-----QQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPA--PEQPVAGNAWQAEEQQ 453

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  749 PVFAPmlqsNPRMLTSGSHPQAIVSSSTPQYPSAEQPT-----------------PQALYATVHQSYPHHATQLHA-HQ- 809
Cdd:PRK10263   454 STFAP----QSTYQTEQTYQQPAAQEPLYQQPQPVEQQpvvepepvveetkparpPLYYFEEVEEKRAREREQLAAwYQp 529

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1908918702  810 -PQPATTP---TGSQPQSQHAAPSPVQHQAGQAPhLGSGQPQQNLYHPGALTGTPPSLPP----GPSAQSPQSSFPQ 878
Cdd:PRK10263   530 iPEPVKEPepiKSSLKAPSVAAVPPVEAAAAVSP-LASGVKKATLATGAAATVAAPVFSLansgGPRPQVKEGIGPQ 605
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
338-489 9.15e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 9.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  338 AQVLRPVVSMEAQRPLRGAKTLSSPSNRpsgETSVPPPPAvgrmypprspksaAPAPISASCPEPPIGSAVPTSSASIPV 417
Cdd:PRK14971   376 KQHIKPVFTQPAAAPQPSAAAAASPSPS---QSSAAAQPS-------------APQSATQPAGTPPTVSVDPPAAVPVNP 439

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1908918702  418 TSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRtlEPQELARIAGKVPGLQNEQKRFQLEELRKFGAQF 489
Cdd:PRK14971   440 PSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQ--EKAEQATGNIKEAPTGTQKEIFTEEDLQYYWQEF 509
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
807-882 1.30e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 1.30e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1908918702  807 AHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAphlgSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAV 882
Cdd:PRK14971   389 APQPSAAAAASPSPSQSSAAAQPSAPQSATQP----AGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPV 460
PHA03247 PHA03247
large tegument protein UL36; Provisional
 335-787 1.46e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  335 AALAQVLRPVVSMEAQRPL-----RGAKTLSSPSNRPSGETSVPPPPAVGRmyPPRSPKSAAPAPISASCPEPPIGSAVP 409
Cdd:PHA03247  2581 AVTSRARRPDAPPQSARPRapvddRGDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAP 2658

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  410 TSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELST----KEPGRTLEPQELARIAGKVPGLQNEQKRfqleelrkf 485
Cdd:PHA03247  2659 GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSladpPPPPPTPEPAPHALVSATPLPPGPAAAR--------- 2729

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  486 gaqfklqpSSSPENSLDPFPPrilkeePKGKEKEVDGllTSEPMGSPVSSKTESVSdkedKPPLAPSGGTEGPEQPPPPC 565
Cdd:PHA03247  2730 --------QASPALPAAPAPP------AVPAGPATPG--GPARPARPPTTAGPPAP----APPAAPAAGPPRRLTRPAVA 2789

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  566 PSQTGSPpvGLIKGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPllsvnKSTSTPTSPGPRthSTPSIPVLTAGqsGLYSP 645
Cdd:PHA03247  2790 SLSESRE--SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP-----PTSAQPTAPPPP--PGPPPPSLPLG--GSVAP 2858

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  646 QyisyipqihmGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYI 725
Cdd:PHA03247  2859 G----------GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1908918702  726 PYNPQQFPGQP-AMMQPMAHYPSQPV---FAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTP 787
Cdd:PHA03247  2929 PQPPPPPPPRPqPPLAPTTDPAGAGEpsgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTP 2994
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
 595-853 1.29e-03

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 42.76  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  595 TLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYipQIHMGPAVQAPQMYPYPvsnsv 674
Cdd:pfam03326  310 TLVPIAGSTGVTEVVSYGHNSTSPSSTPCPSTAVTEADHQTEPEVPWIATAHQESD--QRPIGPGPEKPTFLPPV----- 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  675 pgqqGKYRGAKGsLPPQRSDQHQPAsappmmQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPammqpmahypsqpvfapm 754
Cdd:pfam03326  383 ----GGKQFFQG-LRDSRSTSFLTA------PEATSAISDVFQGTEVCQPKRIRALHPPGSP------------------ 433

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  755 lqSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYAT--VHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQ 832
Cdd:pfam03326  434 --SANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDAApvATPEASHELQPPDEETPQPLDEDQALCGQQDASHPPPRG 511

                          250       260
                   ....*....|....*....|.
gi 1908918702  833 HQAGQAPHLGSGQPQQNLYHP 853
Cdd:pfam03326  512 QLDELTTTLESMTEDLNLDSP 532
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 123-196 1.54e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.54e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1908918702  123 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 196
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 766-928 4.72e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 4.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  766 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 843
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  844 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 923
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350


                   ....*
gi 1908918702  924 QVMLL 928
Cdd:pfam09770  351 QLAQL 355
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 589-853 1.30e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 49.26  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  589 EQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPrthSTPSIPVLTagqsGLYSPQYISYIPQIH-------MGPAVQ 661
Cdd:pfam09770   98 EQVRFNRQQPAARAAQSSAQPPASSLPQYQYASQQS---QQPSKPVRT----GYEKYKEPEPIPDLQvdaslwgVAPKKA 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  662 APQMYPYPVSNSVPGQQGKYRG--------AKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFP 733
Cdd:pfam09770  171 AAPAPAPQPAAQPASLPAPSRKmmsleeveAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQP 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  734 GQPAMMQPMAHYPSQpvfapmLQsnpRMlTSGSHPQAIVSSSTPQYPSAEQPTPQalyatvhqsyPHHATQLHAHQPQPA 813
Cdd:pfam09770  251 QQPQQHPGQGHPVTI------LQ---RP-QSPQPDPAQPSIQPQAQQFHQQPPPV----------PVQPTQILQNPNRLS 310

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1908918702  814 TTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQnLYHP 853
Cdd:pfam09770  311 AARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITHP 349
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 598-878 4.71e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 4.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  598 PNAKEFNP-------TKPLLSVNKSTS-TPTSPGPRTHSTPSIPVLTAgQSGLYSPQY-ISYIPQIHMGPAVQAPQMYPY 668
Cdd:PRK10263   302 PEYDEYDPllngapiTEPVAVAAAATTaTQSWAAPVEPVTQTPPVASV-DVPPAQPTVaWQPVPGPQTGEPVIAPAPEGY 380

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  669 PvsnsvPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQqfPGQPAMMQPMAHYPSQ 748
Cdd:PRK10263   381 P-----QQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPA--PEQPVAGNAWQAEEQQ 453

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  749 PVFAPmlqsNPRMLTSGSHPQAIVSSSTPQYPSAEQPT-----------------PQALYATVHQSYPHHATQLHA-HQ- 809
Cdd:PRK10263   454 STFAP----QSTYQTEQTYQQPAAQEPLYQQPQPVEQQpvvepepvveetkparpPLYYFEEVEEKRAREREQLAAwYQp 529

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1908918702  810 -PQPATTP---TGSQPQSQHAAPSPVQHQAGQAPhLGSGQPQQNLYHPGALTGTPPSLPP----GPSAQSPQSSFPQ 878
Cdd:PRK10263   530 iPEPVKEPepiKSSLKAPSVAAVPPVEAAAAVSP-LASGVKKATLATGAAATVAAPVFSLansgGPRPQVKEGIGPQ 605
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 728-945 4.78e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 4.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  728 NPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSG----SHPQAI----VSSS------TPQYPSAEQPTPQALYAT 793
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyekyKEPEPIpdlqVDASlwgvapKKAAAPAPAPQPAAQPAS 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  794 VHQSYPHHAT------QLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPP-- 865
Cdd:pfam09770  186 LPAPSRKMMSleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVti 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  866 --GPSAQSPQSSFPQPAAVYAIHHQQLPhgfTNMAHVTQA-------HVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGG 936
Cdd:pfam09770  266 lqRPQSPQPDPAQPSIQPQAQQFHQQPP---PVPVQPTQIlqnpnrlSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQ 342


                   ....*....
gi 1908918702  937 PPQGAVPQS 945
Cdd:pfam09770  343 APIITHPQQ 351
PHA03247 PHA03247
large tegument protein UL36; Provisional
 605-974 5.82e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 5.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  605 PTKPLLSVNKSTSTPTSPGPrTHSTPSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQ-QGKYRG 683
Cdd:PHA03247  2595 SARPRAPVDDRGDPRGPAPP-SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRaRRLGRA 2673

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  684 AKGSLPPQRSdqHQPASAPPMMQAAAAAGPPLVAATPYssyiPYNPQQFPGQPAMMQPMAHYPSQPVfAPMLQSNPRMLT 763
Cdd:PHA03247  2674 AQASSPPQRP--RRRAARPTVGSLTSLADPPPPPPTPE----PAPHALVSATPLPPGPAAARQASPA-LPAAPAPPAVPA 2746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  764 SGSHPQAIVSSSTPQYPSA-EQPTPQALYATVhqsyPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPhlG 842
Cdd:PHA03247  2747 GPATPGGPARPARPPTTAGpPAPAPPAAPAAG----PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP--P 2820

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  843 SGQPQQNLYHPGALTGTPPSLPPGPSAQS------------------PQSSFPQPAAVYAIHHQQLPHGFTNMAHVTQAH 904
Cdd:PHA03247  2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  905 VQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHPQGEQPGQAPG 974
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPG 2970
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
338-489 9.15e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 9.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  338 AQVLRPVVSMEAQRPLRGAKTLSSPSNRpsgETSVPPPPAvgrmypprspksaAPAPISASCPEPPIGSAVPTSSASIPV 417
Cdd:PRK14971   376 KQHIKPVFTQPAAAPQPSAAAAASPSPS---QSSAAAQPS-------------APQSATQPAGTPPTVSVDPPAAVPVNP 439

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1908918702  418 TSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRtlEPQELARIAGKVPGLQNEQKRFQLEELRKFGAQF 489
Cdd:PRK14971   440 PSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQ--EKAEQATGNIKEAPTGTQKEIFTEEDLQYYWQEF 509
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
807-882 1.30e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 1.30e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1908918702  807 AHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAphlgSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAV 882
Cdd:PRK14971   389 APQPSAAAAASPSPSQSSAAAQPSAPQSATQP----AGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPV 460
PHA03247 PHA03247
large tegument protein UL36; Provisional
 335-787 1.46e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  335 AALAQVLRPVVSMEAQRPL-----RGAKTLSSPSNRPSGETSVPPPPAVGRmyPPRSPKSAAPAPISASCPEPPIGSAVP 409
Cdd:PHA03247  2581 AVTSRARRPDAPPQSARPRapvddRGDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAP 2658

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  410 TSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELST----KEPGRTLEPQELARIAGKVPGLQNEQKRfqleelrkf 485
Cdd:PHA03247  2659 GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSladpPPPPPTPEPAPHALVSATPLPPGPAAAR--------- 2729

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  486 gaqfklqpSSSPENSLDPFPPrilkeePKGKEKEVDGllTSEPMGSPVSSKTESVSdkedKPPLAPSGGTEGPEQPPPPC 565
Cdd:PHA03247  2730 --------QASPALPAAPAPP------AVPAGPATPG--GPARPARPPTTAGPPAP----APPAAPAAGPPRRLTRPAVA 2789

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  566 PSQTGSPpvGLIKGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPllsvnKSTSTPTSPGPRthSTPSIPVLTAGqsGLYSP 645
Cdd:PHA03247  2790 SLSESRE--SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP-----PTSAQPTAPPPP--PGPPPPSLPLG--GSVAP 2858

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  646 QyisyipqihmGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYI 725
Cdd:PHA03247  2859 G----------GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1908918702  726 PYNPQQFPGQP-AMMQPMAHYPSQPV---FAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTP 787
Cdd:PHA03247  2929 PQPPPPPPPRPqPPLAPTTDPAGAGEpsgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTP 2994
PRK10927 PRK10927
cell division protein FtsN;
778-881 5.43e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 43.13  E-value: 5.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  778 QYPSAEQpTPQALYATVH-QSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGAL 856
Cdd:PRK10927   138 EVPWNEQ-TPEQRQQTLQrQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAH 216

                           90       100
                   ....*....|....*....|....*.
gi 1908918702  857 TGTPPSLP-PGPSAQSPQSsfPQPAA 881
Cdd:PRK10927   217 TTAQSKPQqAAPVTRAADA--PKPTA 240
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 730-879 6.60e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 6.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  730 QQFPG-QPAMMQPMAHypSQPVFAPMlqsnPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLHAH 808
Cdd:PRK10263   709 QRYSGeQPAGANPFSL--DDFEFSPM----KALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQ 782

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1908918702  809 QPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPgaltgTPPSLPPGPSAQSPQSSFPQP 879
Cdd:PRK10263   783 QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ-----PQYQQPQQPVAPQPQDTLLHP 848
PHA03369 PHA03369
capsid maturational protease; Provisional
 325-646 9.58e-04

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 43.06  E-value: 9.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  325 HLVALTIWTTAALAQVLRP---VVSMEAQRPLRGAKTLSSPSnRPSGETSVPPPPAVGRMYPPRSPKSAAPAPISASCPE 401
Cdd:PHA03369   344 HNEILKTASLTAPSRVLAAaakVAVIAAPQTHTGPADRQRPQ-RPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQ 422

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  402 PPIGSAVPTssasiPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEP--QELARIAGKVPGL--QNEQKRF 477
Cdd:PHA03369   423 SPGTSYGPE-----PVGPVPPQPTNPYVMPISMANMVYPGHPQEHGHERKRKRGGElkEELIETLKLVKKLkeEQESLAK 497

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  478 QLEELRKFGAQfklqpSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEG 557
Cdd:PHA03369   498 ELEATAHKSEI-----KKIAESEFKNAGAKTAAANIEPNCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVH 572

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  558 PEQPPPPCPSQTGSPpvgliKGEDKDEGPVAEQVKKSTLNPnaKEFNPTKPLLSVNKSTSTPTSPgPRTHSTPSIPVLTA 637
Cdd:PHA03369   573 SFTSTTLAAAAGQGS-----DTAEALAGAIETLLTQASAQP--AGLSLPAPAVPVNASTPASTPP-PLAPQEPPQPGTSA 644


                   ....*....
gi 1908918702  638 GQSGLYSPQ 646
Cdd:PHA03369   645 PSLETSLPQ 653
PHA03247 PHA03247
large tegument protein UL36; Provisional
 424-959 1.09e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  424 PGVGSISPASPKISLAPTDVKE--LSTKEPGRTLEPQELARIAGkvpglqneqkrfqLEELrkfgaqfklqpssSPENSL 501
Cdd:PHA03247  2496 PDPGGGGPPDPDAPPAPSRLAPaiLPDEPVGEPVHPRMLTWIRG-------------LEEL-------------ASDDAG 2549

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  502 DPFPPRILKEEPKGKEKEVDgllTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLIKGED 581
Cdd:PHA03247  2550 DPPPPLPPAAPPAAPDRSVP---PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  582 KDEGPVA------EQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPgPRTHSTPSIPVLTAGQSGLYSPQYISYIPqih 655
Cdd:PHA03247  2627 PPPSPSPaanepdPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRRAARPTVGSLTSLADPP--- 2702

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  656 mgPAVQAPQMYPYPVSNSVPGQQGKyRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPlvaaTPYSSYIPYNPQQFPGQ 735
Cdd:PHA03247  2703 --PPPPTPEPAPHALVSATPLPPGP-AAARQASPALPAAPAPPAVPAGPATPGGPARPA----RPPTTAGPPAPAPPAAP 2775

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  736 PAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQlhahQPQPATT 815
Cdd:PHA03247  2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG----PPPPSLP 2851

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  816 PTGS---------QPQSQHAAPSPVQHQAGQAPHLGSGQPQQNlyhPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIH 886
Cdd:PHA03247  2852 LGGSvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRS---TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1908918702  887 HQQLPHgftnmahvTQAHVQTGITAAPPPHPGAPHPPQVMllHPPQSHGGPPQGAVPQSGVPALSASTPSPYP 959
Cdd:PHA03247  2929 PQPPPP--------PPPRPQPPLAPTTDPAGAGEPSGAVP--QPWLGALVPGRVAVPRFRVPQPAPSREAPAS 2991
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
 595-853 1.29e-03

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 42.76  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  595 TLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYipQIHMGPAVQAPQMYPYPvsnsv 674
Cdd:pfam03326  310 TLVPIAGSTGVTEVVSYGHNSTSPSSTPCPSTAVTEADHQTEPEVPWIATAHQESD--QRPIGPGPEKPTFLPPV----- 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  675 pgqqGKYRGAKGsLPPQRSDQHQPAsappmmQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPammqpmahypsqpvfapm 754
Cdd:pfam03326  383 ----GGKQFFQG-LRDSRSTSFLTA------PEATSAISDVFQGTEVCQPKRIRALHPPGSP------------------ 433

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  755 lqSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYAT--VHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQ 832
Cdd:pfam03326  434 --SANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDAApvATPEASHELQPPDEETPQPLDEDQALCGQQDASHPPPRG 511

                          250       260
                   ....*....|....*....|.
gi 1908918702  833 HQAGQAPHLGSGQPQQNLYHP 853
Cdd:pfam03326  512 QLDELTTTLESMTEDLNLDSP 532
PHA03247 PHA03247
large tegument protein UL36; Provisional
 366-953 2.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  366 PSGETSVPPPPAVGRMYPPRSPKSAAPAPisASCPEPPIGSAV-PTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVK 444
Cdd:PHA03247  2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAP--AILPDEPVGEPVhPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDR 2566

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  445 ELSTKEPG-RTLEPQELARiaGKVPGLQNEQKRFQLEELRKFGAQFKLQPSSSPENSLDPFPPRILKEEPKGKEKEVDGL 523
Cdd:PHA03247  2567 SVPPPRPApRPSEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPP 2644

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  524 LTSEPMGSPVSSKTESVS------------------DKEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEG 585
Cdd:PHA03247  2645 TVPPPERPRDDPAPGRVSrprrarrlgraaqassppQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG 2724

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  586 P-VAEQVKKSTLNPNAKEFNPTKPLL--SVNKSTSTPTSPGPRTHSTPSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQA 662
Cdd:PHA03247  2725 PaAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPA-AGPPRRLTRPAVASLSESRESLPSPWD 2803

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  663 PQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPynPQQFPGQPAMMqpm 742
Cdd:PHA03247  2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPP--SRSPAAKPAAP--- 2878

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  743 AHYPSQPVFAPMLQSNPRMLTSGSHPQAivssSTPQYPSAEQPTPQALYATVHQSYPHHATQLHAHQPQPATTPTGSQPQ 822
Cdd:PHA03247  2879 ARPPVRRLARPAVSRSTESFALPPDQPE----RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE 2954

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  823 SQHAAPSP----VQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPpGPSAQSPQSSF-------PQPAAVYAIHHQQLP 891
Cdd:PHA03247  2955 PSGAVPQPwlgaLVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS-LSRVSSWASSLalheetdPPPVSLKQTLWPPDD 3033

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1908918702  892 HGFTNMAHVTQAHVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSAS 953
Cdd:PHA03247  3034 TEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSAN 3095
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 335-492 2.65e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  335 AALAQVLRPVVSMEAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRMYPPRSP-----KSAAPAPISASCPEPPIGSAVP 409
Cdd:PRK14951   376 AEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAApaaaaPAAAPAAAPAAVALAPAPPAQA 455

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  410 TSSASIPVTSSVSDPGVGS----ISPASPKISLAPTD--------VKELSTKEPGRTLePQELAriagkvpgLQNE---- 473
Cdd:PRK14951   456 APETVAIPVRVAPEPAVASaapaPAAAPAAARLTPTEegdvwhatVQQLAAAEAITAL-ARELA--------LQSElvar 526

                          170       180
                   ....*....|....*....|....
gi 1908918702  474 -----QKRFQLEELRKFGAQFKLQ 492
Cdd:PRK14951   527 dgdqwLLRVERESLNQPGARERLR 550
PRK12438 PRK12438
hypothetical protein; Provisional
 333-414 4.65e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 41.00  E-value: 4.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  333 TTAALAQVLRPVVSMEAQRPLRG-----AKTLS------------SPSNRPSGETSVPPPPAVGrmyPPRSPKSAAPAPI 395
Cdd:PRK12438   856 SSSTFPQLSRVLVSVREPRTEGGvrvgyAPTLAealdqvfgpgtgRVATAPGGDAASAPPPGAG---PPAPPQAVPPPRT 932

                           90
                   ....*....|....*....
gi 1908918702  396 SASCPEPPIGSAVPTSSAS 414
Cdd:PRK12438   933 TQPPAAPPRGPDVPPAAVA 951
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 605-882 9.02e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  605 PTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYIsyiPQIHmGPAVQAPQMYPYPVSNSVPGQQGKYRGA 684
Cdd:pfam03154  199 PTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPH-PPLQPMTQPPPPSQVSPQPLPQPSLHGQ 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  685 KGSLPP--QRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMM------QPMAHYPSQPVFAPMLQ 756
Cdd:pfam03154  275 MPPMPHslQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQsqlqsqQPPREQPLPPAPLSMPH 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918702  757 SNPRMLT---------SGSHPQAIVSSSTPQYPSAEQPTPQ----ALYATVHQSYPHHATQLHAHQPQPATTPTGSQP-- 821
Cdd:pfam03154  355 IKPPPTTpipqlpnpqSHKHPPHLSGPSPFQMNSNLPPPPAlkplSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPvl 434

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1908918702  822 -QSQHAAPSPVQHQAGQAPHLGSGQ---PQQNLYHPGALTGTPPSLPPG-----------PSAQSPQSSFPQPAAV 882
Cdd:pfam03154  435 tQSQSLPPPAASHPPTSGLHQVPSQspfPQHPFVPGGPPPITPPSGPPTstssampgiqpPSSASVSSSGPVPAAV 510
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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