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Conserved domains on  [gi|1905532673|ref|NP_001373926|]
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transcriptional repressor CTCFL isoform 14 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-443 9.84e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 9.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 259 CDVCMFTSSRMSSFNRHMKT--HTSE--KPHLC--HLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNM------AFVTSG 326
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfspLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 327 ELVRHRRYKHTHEKPFKCSM--CKYASVEASKLKRHVRSHTGERPFQCcqcsyasrdtyklkrhmrthsgvhmrnlhays 404
Cdd:COG5048   372 PQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNC-------------------------------- 419

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1905532673 405 aaelKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSY 443
Cdd:COG5048   420 ----KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-475 9.28e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.28e-03
                          10        20
                  ....*....|....*....|..
gi 1905532673 454 HIRTHTGEKPFTCLSCNKCFRQ 475
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-443 9.84e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 9.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 259 CDVCMFTSSRMSSFNRHMKT--HTSE--KPHLC--HLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNM------AFVTSG 326
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfspLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 327 ELVRHRRYKHTHEKPFKCSM--CKYASVEASKLKRHVRSHTGERPFQCcqcsyasrdtyklkrhmrthsgvhmrnlhays 404
Cdd:COG5048   372 PQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNC-------------------------------- 419

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1905532673 405 aaelKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSY 443
Cdd:COG5048   420 ----KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-296 1.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 1905532673 271 SFNRHMKTHTSEKPHLCHLCLKTFRT 296
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 409-442 2.80e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1905532673 409 KCRYCSAVFHERYALIQHQKthknEKRFKCKHCS 442
Cdd:cd20908     3 WCYYCDREFDDEKILIQHQK----AKHFKCHICH 32
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-475 9.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.28e-03
                          10        20
                  ....*....|....*....|..
gi 1905532673 454 HIRTHTGEKPFTCLSCNKCFRQ 475
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-443 9.84e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 9.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 259 CDVCMFTSSRMSSFNRHMKT--HTSE--KPHLC--HLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNM------AFVTSG 326
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSsskfspLLNNEP 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 327 ELVRHRRYKHTHEKPFKCSM--CKYASVEASKLKRHVRSHTGERPFQCcqcsyasrdtyklkrhmrthsgvhmrnlhays 404
Cdd:COG5048   372 PQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNC-------------------------------- 419

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1905532673 405 aaelKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSY 443
Cdd:COG5048   420 ----KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-414 5.56e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 5.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 338 HEKPFKCSMCKYASVEASKLKRHVRSHTGERPFQC--CQCSYASRDTYKLKRHMRTHS-GVHMRNLHAYSAAELKCRYCS 414
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKASSSS 109
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-520 1.01e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 256 TFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHL--CLKTFRTVTLLRNHVNTHTGTRPYKCNDCNmafvtSGELVRHRR 333
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSL-----PLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 334 YKHTHE-----KPFKCSMCKYASVEASKLKRHVRSHT--GERPFQCCQCSYASRDTYKLKRH------------MRTHSG 394
Cdd:COG5048   108 SSLSSSssnsnDNNLLSSHSLPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpsSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 395 VHMRNLHAYSAAE--------------------------LKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSYACKQE 448
Cdd:COG5048   188 ISSNVSTSIPSSSensplsssysipssssdqnlenssssLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 449 RHMTAHIRTHTGE-------KPFTCLSCNKCFRQKQLLNAHFRKYHD--ANFIPTVYKCSKCGKGFSRWINLHRHSEKCG 519
Cdd:COG5048   268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHsgESLKPFSCPYSLCGKLFSRNDALKRHILLHT 347


                  .
gi 1905532673 520 S 520
Cdd:COG5048   348 S 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-296 1.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 1905532673 271 SFNRHMKTHTSEKPHLCHLCLKTFRT 296
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 409-442 2.80e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1905532673 409 KCRYCSAVFHERYALIQHQKthknEKRFKCKHCS 442
Cdd:cd20908     3 WCYYCDREFDDEKILIQHQK----AKHFKCHICH 32
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-378 6.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.20e-03
                          10        20
                  ....*....|....*....|..
gi 1905532673 357 LKRHVRSHTGERPFQCCQCSYA 378
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-482 7.64e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 7.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 265 TSSRMSSFNRHMKTHTSEKPHLChLCLKTFRTVTLLRNHVNTHTG-TRPYKCNDCNMAFVTSGELVRHRR-YKHT--HEK 340
Cdd:COG5048   242 SQSPSSLSSSDSSSSASESPRSS-LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsVNHSgeSLK 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532673 341 PFKC--SMCKYASVEASKLKRHVRSHTGERPFQCCQC----SYASRDTYKLKRHMRTHSGVHMRNLHAYSAAElkcryCS 414
Cdd:COG5048   321 PFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnsssKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS-----CI 395

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1905532673 415 AVFHERYALIQHQKTHKNEKR--FKCKHCsYACKQeRHMTA--HIRTHTGEKPFtCLSCNKCFRQKQLLNAH 482
Cdd:COG5048   396 RNFKRDSNLSLHIITHLSFRPynCKNPPC-SKSFN-RHYNLipHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-475 9.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.28e-03
                          10        20
                  ....*....|....*....|..
gi 1905532673 454 HIRTHTGEKPFTCLSCNKCFRQ 475
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-324 9.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.38e-03
                          10        20
                  ....*....|....*....|....*
gi 1905532673 300 LRNHVNTHTGTRPYKCNDCNMAFVT 324
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
436-460 9.39e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.06  E-value: 9.39e-03
                          10        20
                  ....*....|....*....|....*
gi 1905532673 436 FKCKHCSYACKQERHMTAHIRTHTG 460
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-447 9.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 1905532673 422 ALIQHQKTHKNEKRFKCKHCSYACKQ 447
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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