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Conserved domains on  [gi|1900522660|ref|NP_001373770|]
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keratin-associated protein 4-1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-141 1.63e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660   7 GSVCSDQGCDQGLCQETCCRPSCCQTTCCCPSCVVSSCCRPSCSQTTCCQTTccRPSCCHPVCCQTTC-------RPSCG 79
Cdd:pfam01500  17 GGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--QPTCCQTSSCQTGCggigygqEGSSG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1900522660  80 VSSCCRPLCCQTTCHPSCGMSSCCRPLCCQTTC-RPSCGVSSCCRPLCCQTTCCRATCCRPSC 141
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCcQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-141 1.63e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660   7 GSVCSDQGCDQGLCQETCCRPSCCQTTCCCPSCVVSSCCRPSCSQTTCCQTTccRPSCCHPVCCQTTC-------RPSCG 79
Cdd:pfam01500  17 GGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--QPTCCQTSSCQTGCggigygqEGSSG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1900522660  80 VSSCCRPLCCQTTCHPSCGMSSCCRPLCCQTTC-RPSCGVSSCCRPLCCQTTCCRATCCRPSC 141
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCcQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
25-139 4.43e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 39.15  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660  25 CRPSCCqttCCCPSCVVSSCCRPSCSQTTCCQTTCCRPSCCHpvCCQttcrpscgvssCCRPLCCQTTCHPSCgmssCCR 104
Cdd:COG3901   603 FFFFRR---LCLLGLALAAAALARRRLWRRRRRECCCGCCCC--CCK-----------CCCIVIIIDGIIIIN----ECC 662

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1900522660 105 PLCCQttcrpscgvssCCRplCCQTTCCRATCCRP 139
Cdd:COG3901   663 CCCCL-----------CCR--RCQDDPLCPPRIKK 684
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-141 1.63e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 69.05  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660   7 GSVCSDQGCDQGLCQETCCRPSCCQTTCCCPSCVVSSCCRPSCSQTTCCQTTccRPSCCHPVCCQTTC-------RPSCG 79
Cdd:pfam01500  17 GGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC--QPTCCQTSSCQTGCggigygqEGSSG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1900522660  80 VSSCCRPLCCQTTCHPSCGMSSCCRPLCCQTTC-RPSCGVSSCCRPLCCQTTCCRATCCRPSC 141
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCcQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 28-146 8.61e-10

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 54.03  E-value: 8.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660  28 SCCQTTCC-CPSCVVSSCCRPSCSQTTCCQTTCCRPSCCHPVCCQTTCRPSCGVSSCCRPLCCQTTCHPSCGMSSC---- 102
Cdd:pfam01500   2 ACCGTSFCgFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSScqtg 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1900522660 103 ---------------------CRPLCC-QTTCRPSCGVSSCCRPLCCQTTCCRATCCRPSCCGSSC 146
Cdd:pfam01500  82 cggigygqegssgavssrtrwCRPDCRvEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSC 147
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
102-145 2.26e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.38  E-value: 2.26e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1900522660 102 CCRPLCCQTT-CRPSCGVSSCCRPLCCQTTCCRATCCRPSCCGSS 145
Cdd:pfam13885   1 CCQPSCCQPScCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
97-140 4.77e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.91  E-value: 4.77e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1900522660  97 CGMSSCCRPLCCQTTC-RPSCGVSSCCRPLCCQTTCCRATCCRPS 140
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCcQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 3-141 1.87e-06

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 45.19  E-value: 1.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660   3 NSCCGSVCSDQGCDQGLCQETCCRPSCCQTTCCCPSCVVSSCCRPscsQTTCCQTTCCRPSCCHPVCCQTTCRPSCGVSS 82
Cdd:pfam05287  39 DLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVP---SPCQRSCYSPRTSCVCSPCQTTSAGSLGFGSS 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1900522660  83 CCRPLCCQT-TCHPSCGMSSCCRPLCCQT-TCRPSCGVSSCCRPLCCQTTCCRATCCRPSC 141
Cdd:pfam05287 116 SCQSLGYGSnSCQPLGCGSSGFRPLGCLSkGFQSLGYGSSFCRPSYVSSRSYQPSCFRPSC 176
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
20-71 7.67e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.83  E-value: 7.67e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1900522660  20 CQETCCRPSCCQTTCCCPSCVVSSCCRPSCSqttccqttccRPSCCHPVCCQ 71
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCC----------RPSCCRSSCCQ 43
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-116 7.84e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 43.24  E-value: 7.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660   4 SCCGSVCSDQGCDQGLC----QETCCRPSCCQTTCCCPSCVVSSCCRPSCSQTTCCQTTCCRPSCCHPVCCQ-------- 71
Cdd:pfam01500  43 SCCQPTTFQSSCCRPTCqpccQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLppccvvsc 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1900522660  72 ---TTCRPSCGVSSCCRPLCCqttchpscgMSSCCRPLCCQTTCRPSC 116
Cdd:pfam01500 123 tppTCCQLHHAQASCCRPSYC---------GQSCCRPACCCQCSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
24-74 1.31e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.06  E-value: 1.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1900522660  24 CCRPSCCQTTCCCPSCVVSSCCRPscsqttccqtTCCRPSCCHPVCCQTTC 74
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQP----------SCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
64-105 1.67e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.67  E-value: 1.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1900522660  64 CCHPVCCQTT-CRPSCGVSSCCRPLCCQTT-CHPSCGMSSCCRP 105
Cdd:pfam13885   1 CCQPSCCQPScCQPSCCQPSCCQPSCCQPScCRPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
29-86 1.81e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.67  E-value: 1.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1900522660  29 CCQTTCCCPSCVVSSCCrpscsqttccqttccRPSCCHPVCCQTT-CRPSCGVSSCCRP 86
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCC---------------QPSCCQPSCCQPScCRPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
5-47 3.43e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.90  E-value: 3.43e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1900522660   5 CCGSVCSDQG-CDQGLCQETCCRPSCCQTTCCCPSCVVSSCCRP 47
Cdd:pfam13885   1 CCQPSCCQPScCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
25-139 4.43e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 39.15  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660  25 CRPSCCqttCCCPSCVVSSCCRPSCSQTTCCQTTCCRPSCCHpvCCQttcrpscgvssCCRPLCCQTTCHPSCgmssCCR 104
Cdd:COG3901   603 FFFFRR---LCLLGLALAAAALARRRLWRRRRRECCCGCCCC--CCK-----------CCCIVIIIDGIIIIN----ECC 662

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1900522660 105 PLCCQttcrpscgvssCCRplCCQTTCCRATCCRP 139
Cdd:COG3901   663 CCCCL-----------CCR--RCQDDPLCPPRIKK 684
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
121-146 5.99e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.82  E-value: 5.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 1900522660 121 CCRPLCCQTTCCRATCCRPSCCGSSC 146
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSC 26
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
116-146 7.84e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.44  E-value: 7.84e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1900522660 116 CGVSSCCRPLCCQTTCCRATCCRPSCCGSSC 146
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSC 31
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-83 1.33e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.08  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1900522660   3 NSCCGSVCSDQGCDQG------LCQETCCRPSCCQTTCCCPSCVVSSCCRPSCSQTTCCQTTCCRPSCCHPVCCQTTCRP 76
Cdd:pfam01500  75 TSSCQTGCGGIGYGQEgssgavSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCC 154


                  ....*..
gi 1900522660  77 SCGVSSC 83
Cdd:pfam01500 155 QCSEPTC 161
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
69-142 6.30e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 35.68  E-value: 6.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1900522660  69 CCQTTCRPSCGVSSCCRPLCCQTT--CHPSCGMSSCCRPLCCQTTCRPSCGVSSCCRPLCC-QTTCCRATCCRPSCC 142
Cdd:COG3901   606 FRRLCLLGLALAAAALARRRLWRRrrRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCClCCRRCQDDPLCPPRI 682
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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