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Conserved domains on  [gi|1885784878|ref|NP_001372985|]
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alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 4 [Homo sapiens]

Protein Classification

2OG-Fe(II) oxygenase family protein( domain architecture ID 229412)

2OG-Fe(II) oxygenase family protein belongs to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily and may share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of a target substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2OG-FeII_Oxy super family cl21496
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
 6-155 1.33e-09

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. This family includes the C-terminal of prolyl 4-hydroxylase alpha subunit. The holoenzyme has the activity EC:1.14.11.2 catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2. The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.


The actual alignment was detected with superfamily member pfam13532:

Pssm-ID: 473886  Cd Length: 191  Bit Score: 54.63  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885784878   6 LPPWLQRYVDKVSNLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPT--VSTISLGSHTVLDFyepRRPEDDDPTeqp 83
Cdd:pfam13532  73 FPEALLQLAERLAAEAGYPGWSPNACLVNFYRDGARMGLHQDRDESGPGapIVSLSLGASATFRF---GGKSRSDPT--- 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1885784878  84 rppprptTSLLLEPRSLLVLRGPayTRLL-HGIAAARvdaldaassppnaaacpsaRPGACLVRGTRVSLTIR 155
Cdd:pfam13532 147 -------ISLRLESGDVLVMGGE--SRLAyHGVPPIR-------------------RGTHPLLGGGRINLTFR 191
 
Name Accession Description Interval E-value
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
6-155 1.33e-09

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 54.63  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885784878   6 LPPWLQRYVDKVSNLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPT--VSTISLGSHTVLDFyepRRPEDDDPTeqp 83
Cdd:pfam13532  73 FPEALLQLAERLAAEAGYPGWSPNACLVNFYRDGARMGLHQDRDESGPGapIVSLSLGASATFRF---GGKSRSDPT--- 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1885784878  84 rppprptTSLLLEPRSLLVLRGPayTRLL-HGIAAARvdaldaassppnaaacpsaRPGACLVRGTRVSLTIR 155
Cdd:pfam13532 147 -------ISLRLESGDVLVMGGE--SRLAyHGVPPIR-------------------RGTHPLLGGGRINLTFR 191
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
1-157 6.99e-05

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 41.30  E-value: 6.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885784878   1 MVPERLPPWLQRYVDKVSNLSlfgGLPANHVLVNQYLPGEGIM-------PHEDgplYYPTVSTISLGSHTVLDFyepRR 73
Cdd:COG3145    78 PEPPPWPPALLALKRRVEAAA---GFPFNSCLLNLYRDGQDRMgwhqddeEELG---FNPPIASVSLGATRRFRF---GH 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885784878  74 PEDDDPTEqprppprpttSLLLEPRSLLVLRGPAYTRLLHGIAaarvdaldaassppnaaacPSARpgaclVRGTRVSLT 153
Cdd:COG3145   149 KERKDPTR----------SLPLEHGDLLVMGGPTQLAWQHGVP-------------------KTKK-----GTGPRINLT 194


                  ....
gi 1885784878 154 IRRV 157
Cdd:COG3145   195 FRRI 198
 
Name Accession Description Interval E-value
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
6-155 1.33e-09

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 54.63  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885784878   6 LPPWLQRYVDKVSNLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPT--VSTISLGSHTVLDFyepRRPEDDDPTeqp 83
Cdd:pfam13532  73 FPEALLQLAERLAAEAGYPGWSPNACLVNFYRDGARMGLHQDRDESGPGapIVSLSLGASATFRF---GGKSRSDPT--- 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1885784878  84 rppprptTSLLLEPRSLLVLRGPayTRLL-HGIAAARvdaldaassppnaaacpsaRPGACLVRGTRVSLTIR 155
Cdd:pfam13532 147 -------ISLRLESGDVLVMGGE--SRLAyHGVPPIR-------------------RGTHPLLGGGRINLTFR 191
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
1-157 6.99e-05

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 41.30  E-value: 6.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885784878   1 MVPERLPPWLQRYVDKVSNLSlfgGLPANHVLVNQYLPGEGIM-------PHEDgplYYPTVSTISLGSHTVLDFyepRR 73
Cdd:COG3145    78 PEPPPWPPALLALKRRVEAAA---GFPFNSCLLNLYRDGQDRMgwhqddeEELG---FNPPIASVSLGATRRFRF---GH 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1885784878  74 PEDDDPTEqprppprpttSLLLEPRSLLVLRGPAYTRLLHGIAaarvdaldaassppnaaacPSARpgaclVRGTRVSLT 153
Cdd:COG3145   149 KERKDPTR----------SLPLEHGDLLVMGGPTQLAWQHGVP-------------------KTKK-----GTGPRINLT 194


                  ....
gi 1885784878 154 IRRV 157
Cdd:COG3145   195 FRRI 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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