NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1879298387|ref|NP_001372616|]
View 

microtubule-associated protein 4 isoform 2 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2137-2166 4.84e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 4.84e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1879298387 2137 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 2166
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2168-2197 7.80e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 7.80e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1879298387 2168 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 2197
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1815-2064 4.59e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 4.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1815 RPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVP 1894
Cdd:PHA03247  2684 RRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1895 AAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPS 1972
Cdd:PHA03247  2761 PTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1973 TLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVVPSRVKATPMPSRPSTT 2046
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQPERPPQPQAPPPPQPQ 2920

                          250
                   ....*....|....*...
gi 1879298387 2047 PFIDKKPTSAKPSSTTPR 2064
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2199-2229 1.46e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 1.46e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1879298387 2199 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 2229
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2076-2097 7.48e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 7.48e-08
                           10        20
                   ....*....|....*....|..
gi 1879298387 2076 DLKNVRSKVGSTENIKHQPGGG 2097
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2137-2166 4.84e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 4.84e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1879298387 2137 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 2166
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2168-2197 7.80e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 7.80e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1879298387 2168 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 2197
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1815-2064 4.59e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 4.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1815 RPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVP 1894
Cdd:PHA03247  2684 RRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1895 AAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPS 1972
Cdd:PHA03247  2761 PTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1973 TLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVVPSRVKATPMPSRPSTT 2046
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQPERPPQPQAPPPPQPQ 2920

                          250
                   ....*....|....*...
gi 1879298387 2047 PFIDKKPTSAKPSSTTPR 2064
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2199-2229 1.46e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 1.46e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1879298387 2199 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 2229
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2076-2097 7.48e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 7.48e-08
                           10        20
                   ....*....|....*....|..
gi 1879298387 2076 DLKNVRSKVGSTENIKHQPGGG 2097
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1808-2131 3.27e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 52.61  E-value: 3.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1808 LKSAGIARPEegrpVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKP 1885
Cdd:pfam05109  434 LNTTGFAAPN----TTTGLPSSTHVPTNLTAPAStgPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSP 509

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1886 MSLASGLVPAAPPKRPAVASARPSIL--------PSKDV-KPKPIADAKAPE-------------KRASPSKPASAPASR 1943
Cdd:pfam05109  510 TSAVTTPTPNATSPTPAVTTPTPNATsptlgktsPTSAVtTPTPNATSPTPAvttptpnatiptlGKTSPTSAVTTPTPN 589

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1944 SGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGK----PAEVKKMTAKSVPADLSRPKSTSTSSMKKTTT 2019
Cdd:pfam05109  590 ATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQhnitSSSTSSMSLRPSSISETLSPSTSDNSTSHMPL 669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 2020 LSGTAPAAG-----VVPSRVK------ATPMPsRPSTTPFID---KKPTSAKP------------SSTTPRLSRlATNTS 2073
Cdd:pfam05109  670 LTSAHPTGGenitqVTPASTSthhvstSSPAP-RPGTTSQASgpgNSSTSTKPgevnvtkgtppkNATSPQAPS-GQKTA 747

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1879298387 2074 APDLKNVRSKVGSTENIKHQPG-GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK 2131
Cdd:pfam05109  748 VPTVTSTGGKANSTTGGKHTTGhGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSK 806
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2137-2166 4.84e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 4.84e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1879298387 2137 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 2166
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2168-2197 7.80e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 7.80e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1879298387 2168 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 2197
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1815-2064 4.59e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 4.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1815 RPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVP 1894
Cdd:PHA03247  2684 RRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1895 AAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPS 1972
Cdd:PHA03247  2761 PTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1973 TLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVVPSRVKATPMPSRPSTT 2046
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQPERPPQPQAPPPPQPQ 2920

                          250
                   ....*....|....*...
gi 1879298387 2047 PFIDKKPTSAKPSSTTPR 2064
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPR 2938
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1783-2071 1.64e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.80  E-value: 1.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1783 RPTKSRGLTPLlPKSTIQEQERHKQLKSAGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKA 1862
Cdd:PHA03247  2711 APHALVSATPL-PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1863 KTQPTS----LPKQPAPTTIGGLNKKPmSLASGLVPAAP-PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPA 1937
Cdd:PHA03247  2790 SLSESReslpSPWDPADPPAAVLAPAA-ALPPAASPAGPlPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS 2868

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1938 SAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADlsRPKSTSTSSMKKT 2017
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPT 2946

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1879298387 2018 TTLSGTAPAAG---------VVPSRVKAT------PMPSRPSTTPfidkkPTSAKPSSTTPRLSRLATN 2071
Cdd:PHA03247  2947 TDPAGAGEPSGavpqpwlgaLVPGRVAVPrfrvpqPAPSREAPAS-----STPPLTGHSLSRVSSWASS 3010
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2199-2229 1.46e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 1.46e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1879298387 2199 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 2229
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 2076-2097 7.48e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 7.48e-08
                           10        20
                   ....*....|....*....|..
gi 1879298387 2076 DLKNVRSKVGSTENIKHQPGGG 2097
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1762-2133 2.72e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 2.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1762 TPGEGKKEDKSRMAEPMKGYMRPTksrgltpLLPKSTIQEQERHKQLksAGIARPEEgrpVVSGTGNDITTP-PNKELPP 1840
Cdd:PHA03247  2495 APDPGGGGPPDPDAPPAPSRLAPA-------ILPDEPVGEPVHPRML--TWIRGLEE---LASDDAGDPPPPlPPAAPPA 2562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1841 SPEKKT-KPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLA--SGLVPAAPPKRPAVASARPSilPSKDVK 1917
Cdd:PHA03247  2563 APDRSVpPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAppSPLPPDTHAPDPPPPSPSPA--ANEPDP 2640

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1918 PKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAK 1997
Cdd:PHA03247  2641 HPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATP 2720

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1998 SVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTpfidkKPTSAKPSSTTPRLSRLATNTSAPDL 2077
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAP-----APPAAPAAGPPRRLTRPAVASLSESR 2795

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1879298387 2078 KNVRSKVGSTENIkhQPGGGRAKVEKKTEAAATTRKPESnAVTKTAGPIASAQKQP 2133
Cdd:PHA03247  2796 ESLPSPWDPADPP--AAVLAPAAALPPAASPAGPLPPPT-SAQPTAPPPPPGPPPP 2848
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1820-2069 5.32e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 5.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1820 RPVVSGTGNDITTPPnkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQP----APTTIGGLN---------KKPM 1886
Cdd:PHA03247  2634 AANEPDPHPPPTVPP----PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrraARPTVGSLTsladpppppPTPE 2709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1887 SLASGLVPAAPPkrPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASaPASRSGSKSTQTVAKTTTAAAVASTGP 1966
Cdd:PHA03247  2710 PAPHALVSATPL--PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAPAAGPPRRLTRP 2786

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1967 SSRSPSTLLPKKPTAIKTEGKPAEVkkmtakSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTT 2046
Cdd:PHA03247  2787 AVASLSESRESLPSPWDPADPPAAV------LAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG 2860

                          250       260
                   ....*....|....*....|....*..
gi 1879298387 2047 PFIDKKPTSAKP----SSTTPRLSRLA 2069
Cdd:PHA03247  2861 DVRRRPPSRSPAakpaAPARPPVRRLA 2887
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1752-2073 5.62e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 55.08  E-value: 5.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1752 QKMTEKSESKTPGEgKKEDKSRMAEPMKGymrpTKSRGLTPLLPKSTIQEQERHKQLKSAGIARpEEGRPVVSGTGNDIT 1831
Cdd:PTZ00449   486 KKLIKKSKKKLAPI-EEEDSDKHDEPPEG----PEASGLPPKAPGDKEGEEGEHEDSKESDEPK-EGGKPGETKEGEVGK 559

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1832 TP-PNKELPPS--------PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPttigglnKKPMSLAsglVPAAPPKRPA 1902
Cdd:PTZ00449   560 KPgPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSP-------KLPELLD---IPKSPKRPES 629

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1903 VASARPSILPSKDVKPKPIADAKAPEKRASPSKPA---------------SAPASRSGSKSTQTVAKTTTAAAVASTGPS 1967
Cdd:PTZ00449   630 PKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKppfdpkfkekfyddyLDAAAKSKETKTTVVLDESFESILKETLPE 709

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1968 S-----RSPSTLLPKKPTAIKTEGKPaeVKKMTAKSV-PADLSRPKSTSTSSMKKTttlSGTAPAAGVVPSRVKA----- 2036
Cdd:PTZ00449   710 TpgtpfTTPRPLPPKLPRDEEFPFEP--IGDPDAEQPdDIEFFTPPEEERTFFHET---PADTPLPDILAEEFKEediha 784

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 1879298387 2037 -TPMPSRPSTTPfidKKPT--SAKPSSTTP-------RLSRLATNTS 2073
Cdd:PTZ00449   785 eTGEPDEAMKRP---DSPSehEDKPPGDHPslpkkrhRLDGLALSTT 828
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1872-2134 1.49e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 53.70  E-value: 1.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1872 QPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASAR-------PSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRS 1944
Cdd:PRK07003   359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASavpavtaVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1945 GSKSTQtvaktttaaavastgpssrSPSTLLPKKPTAIKTEGKPAEvkkmtAKSVPADLSRPKSTSTSSMKKTTTLSGTA 2024
Cdd:PRK07003   439 GDDAAD-------------------GDAPVPAKANARASADSRCDE-----RDAQPPADSGSASAPASDAPPDAAFEPAP 494

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 2025 PAAGVVPSRVKATPMPSRPSTTPFIDK-------KPTSAKPSSTTPRLSRLATNTSAP--DLKNVRSKVGSTeniKHQPG 2095
Cdd:PRK07003   495 RAAAPSAATPAAVPDARAPAAASREDApaaaappAPEARPPTPAAAAPAARAGGAAAAldVLRNAGMRVSSD---RGARA 571

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1879298387 2096 GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPA 2134
Cdd:PRK07003   572 AAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPP 610
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1808-2131 3.27e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 52.61  E-value: 3.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1808 LKSAGIARPEegrpVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKP 1885
Cdd:pfam05109  434 LNTTGFAAPN----TTTGLPSSTHVPTNLTAPAStgPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSP 509

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1886 MSLASGLVPAAPPKRPAVASARPSIL--------PSKDV-KPKPIADAKAPE-------------KRASPSKPASAPASR 1943
Cdd:pfam05109  510 TSAVTTPTPNATSPTPAVTTPTPNATsptlgktsPTSAVtTPTPNATSPTPAvttptpnatiptlGKTSPTSAVTTPTPN 589

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1944 SGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGK----PAEVKKMTAKSVPADLSRPKSTSTSSMKKTTT 2019
Cdd:pfam05109  590 ATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQhnitSSSTSSMSLRPSSISETLSPSTSDNSTSHMPL 669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 2020 LSGTAPAAG-----VVPSRVK------ATPMPsRPSTTPFID---KKPTSAKP------------SSTTPRLSRlATNTS 2073
Cdd:pfam05109  670 LTSAHPTGGenitqVTPASTSthhvstSSPAP-RPGTTSQASgpgNSSTSTKPgevnvtkgtppkNATSPQAPS-GQKTA 747

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1879298387 2074 APDLKNVRSKVGSTENIKHQPG-GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK 2131
Cdd:pfam05109  748 VPTVTSTGGKANSTTGGKHTTGhGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSK 806
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1811-2088 4.12e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.48  E-value: 4.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1811 AGIARPEEGRPVVSGTGNDITTPPNKELPPSP---EKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPms 1887
Cdd:PHA03307    44 VSDSAELAAVTVVAGAAACDRFEPPTGPPPGPgteAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTP-- 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1888 lasglVPAAPPkrPAVASARPSILPSKDvKPKPIADAKAPEKRASPSKPASAPASRSGskSTQTVAKTTTAAAVASTGPS 1967
Cdd:PHA03307   122 -----PPASPP--PSPAPDLSEMLRPVG-SPGPPPAASPPAAGASPAAVASDAASSRQ--AALPLSSPEETARAPSSPPA 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1968 SRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTA-----------PAAGVVPSRVKA 2036
Cdd:PHA03307   192 EPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpenecplprPAPITLPTRIWE 271

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1879298387 2037 TPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTE 2088
Cdd:PHA03307   272 ASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1813-2135 3.50e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.40  E-value: 3.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1813 IARPEEGRPVVSGTGNDITT----PPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSL 1888
Cdd:PHA03307    78 EAPANESRSTPTWSLSTLAPaspaREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGA 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1889 ASGLVPAAPPKRPAVA--------SARPSILPSKDVKPKPIADAKAPEKRAsPSKPASAPASRSGSKSTQTVAKTTTAAA 1960
Cdd:PHA03307   158 SPAAVASDAASSRQAAlplsspeeTARAPSSPPAEPPPSTPPAAASPRPPR-RSSPISASASSPAPAPGRSAADDAGASS 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1961 VASTGPSSR----SPSTLLPKKPTAiktegkPAEVKKMTAKSVPADLSRPKSTSTSSmkkTTTLSGTAPAAgvVPSRVKA 2036
Cdd:PHA03307   237 SDSSSSESSgcgwGPENECPLPRPA------PITLPTRIWEASGWNGPSSRPGPASS---SSSPRERSPSP--SPSSPGS 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 2037 TPMPSRPSTTPFIDKKPTS--AKPSSTTPRLSRLATNTSAPdlknvrskvgSTENIKHQPGGGRAKVEKKTEAAATTRKP 2114
Cdd:PHA03307   306 GPAPSSPRASSSSSSSRESssSSTSSSSESSRGAAVSPGPS----------PSRSPSPSRPPPPADPSSPRKRPRPSRAP 375

                          330       340
                   ....*....|....*....|.
gi 1879298387 2115 ESNAVTKTAGPIASAQKQPAG 2135
Cdd:PHA03307   376 SSPAASAGRPTRRRARAAVAG 396
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1816-2075 3.67e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 49.14  E-value: 3.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1816 PEEGRPVVSGTG--NDITTPPNKELPPSPEKKTKPLATTQP--AKTSTSKAKTQPTslPKQPAPT-------------TI 1878
Cdd:pfam05109  532 PNATSPTLGKTSptSAVTTPTPNATSPTPAVTTPTPNATIPtlGKTSPTSAVTTPT--PNATSPTvgetspqanttnhTL 609

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1879 GGLNKKPmslasglVPAAPPKRP--AVASARPSILPSK----DVKPKPIADAKAPEK--RASPSKPASAPASRSGSKSTQ 1950
Cdd:pfam05109  610 GGTSSTP-------VVTSPPKNAtsAVTTGQHNITSSStssmSLRPSSISETLSPSTsdNSTSHMPLLTSAHPTGGENIT 682

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1951 TVAKTTTAAAVASTG-PSSRSPSTLLPKKPTAIKTEGKPAEV--------KKMTAKSVPADLSRPKSTSTSSMKKTTTLS 2021
Cdd:pfam05109  683 QVTPASTSTHHVSTSsPAPRPGTTSQASGPGNSSTSTKPGEVnvtkgtppKNATSPQAPSGQKTAVPTVTSTGGKANSTT 762

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1879298387 2022 GTAPAAGVvPSRVKATPMPSR--PSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 2075
Cdd:pfam05109  763 GGKHTTGH-GARTSTEPTTDYggDSTTPRTRYNATTYLPPSTSSKLRPRWTFTSPP 817
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1810-2075 3.85e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.61  E-value: 3.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1810 SAGIARPEEGRPVVSGT--GNDITTPPNKELPPSPEKKTKPLATTQPA--KTSTSKAKTQPTSLPKQPAPTTIGGLNKKP 1885
Cdd:PRK07003   363 TGGGAPGGGVPARVAGAvpAPGARAAAAVGASAVPAVTAVTGAAGAALapKAAAAAAATRAEAPPAAPAPPATADRGDDA 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1886 MSlasglVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG 1965
Cdd:PRK07003   443 AD-----GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAS 517

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1966 PSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST 2045
Cdd:PRK07003   518 REDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVP 597

                          250       260       270
                   ....*....|....*....|....*....|
gi 1879298387 2046 TPFIDKKPTSAKPSSTTPRLSRLATNTSAP 2075
Cdd:PRK07003   598 TPRARAATGDAPPNGAARAEQAAESRGAPP 627
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1792-2040 4.46e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1792 PLLPKSTIQEQERHKQLKSAGIARPEEGRPVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPtSL 1869
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAasPAGPLPPPTSAQPTAPPPPPGPPPP-SL 2850

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1870 PKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDV------------KPKPIADAKAPEKRASPSKPA 1937
Cdd:PHA03247  2851 PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfalppdqperppQPQAPPPPQPQPQPPPPPQPQ 2930

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1938 SAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPkkptaikteGKPAEVKKMTAKSVPadlSRPKSTSTSSMKKT 2017
Cdd:PHA03247  2931 PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP---------GRVAVPRFRVPQPAP---SREAPASSTPPLTG 2998

                          250       260
                   ....*....|....*....|...
gi 1879298387 2018 TTLSGTAPAAGVVPSRVKATPMP 2040
Cdd:PHA03247  2999 HSLSRVSSWASSLALHEETDPPP 3021
PHA03378 PHA03378
EBNA-3B; Provisional
 1817-2137 2.04e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1817 EEGRPVVSGTGNDITTPPNK----ELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGL 1892
Cdd:PHA03378   549 ESDEPASTEPVHDQLLPAPGlgplQIQPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL 628

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1893 VP-AAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSP 1971
Cdd:PHA03378   629 RPiPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPA 708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1972 STLLPKKPTAIKTEGKPAEVKKMTAKSVPADL---SRPKSTSTSSMKKTTTLSGTAPAAGVVPSRvkATPMPsRPSTTPF 2048
Cdd:PHA03378   709 APPGRAQRPAAATGRARPPAAAPGRARPPAAApgrARPPAAAPGRARPPAAAPGRARPPAAAPGA--PTPQP-PPQAPPA 785

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 2049 IDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRskvGSTENIKHQPGGGRAKvekktEAAATTRKPESNAVTKTAGPIAS 2128
Cdd:PHA03378   786 PQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQ---GPTKQILRQLLTGGVK-----RGRPSLKKPAALERQAAAGPTPS 857


                   ....*....
gi 1879298387 2129 AQKQPAGKV 2137
Cdd:PHA03378   858 PGSGTSDKI 866
PRK13808 PRK13808
adenylate kinase; Provisional
 1846-1987 6.86e-03

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 41.03  E-value: 6.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1879298387 1846 TKPLATTQPAKTSTSKAKTQPTSLPKQPAPTtigglnKKPMSLASGLVPAAPPKRPAVASARPsilPSKDVKPKPIADAK 1925
Cdd:PRK13808   199 AKKAAKTPAAKSGAKKASAKAKSAAKKVSKK------KAAKTAVSAKKAAKTAAKAAKKAKKT---AKKALKKAAKAVKK 269

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1879298387 1926 APEKraspSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGK 1987
Cdd:PRK13808   270 AAKK----AAKAAAKAAKGAAKATKGKAKAKKKAGKKAAAGSKAKATAKAPKRGAKGKKAKK 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH