|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
7.35e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
:
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 7.35e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245081 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
4.05e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 163.63 E-value: 4.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245081 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1526-1821 |
2.34e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.16 E-value: 2.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1526 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1605
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1606 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1683
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1684 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1763
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245081 1764 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1821
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
7.05e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.81 E-value: 7.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245081 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1298-1657 |
5.05e-21 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 98.32 E-value: 5.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1298 PRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRP 1377
Cdd:COG5238 156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1378 AGLFSLSISETQqqlcvqlefprqeenpeavalrlahcdlgahhsllvgqlmetcarlqqlslsqvnlcedddasslllq 1457
Cdd:COG5238 236 KSLTTLDLSNNQ-------------------------------------------------------------------- 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1458 slllslselktfrltsscVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1537
Cdd:COG5238 248 ------------------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1538 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSIS 1617
Cdd:COG5238 310 IALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIG 389
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1864245081 1618 SAGGVQLAESLVLcRRLEELMLGCNALGDPTALGLAQELP 1657
Cdd:COG5238 390 KQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
5.16e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.92 E-value: 5.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245081 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
9.17e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 9.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245081 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1009-1306 |
1.81e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDL----------RSLHHATLHFRSNEEEEGVC 1218
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLanngigdagiRALAEGLKANCNLEVLDLNN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1219 CGFT--GCSLsqehvesLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL-LDLSHNSISQESALYLLETLP 1295
Cdd:cd00116 203 NGLTdeGASA-------LAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLtLSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1864245081 1296 SCPRVREASVN 1306
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| LRR super family |
cl34836 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
3.16e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
The actual alignment was detected with superfamily member COG4886:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.31 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245081 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
7.35e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 7.35e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245081 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
4.05e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 163.63 E-value: 4.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245081 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1526-1821 |
2.34e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.16 E-value: 2.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1526 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1605
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1606 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1683
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1684 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1763
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245081 1764 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1821
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1492-1792 |
1.46e-32 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 130.17 E-value: 1.46e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1492 HHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSST--LALLTHRLSQMTCLQSLRLNRNSIGDVGCcHLS 1569
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1570 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE-LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPT 1648
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1649 ALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAggvlrfcmelpllrqidlvsckiDNQT 1726
Cdd:cd00116 182 IRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLT-----------------------DAGA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245081 1727 AKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQ 1792
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLE 304
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
7.05e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.81 E-value: 7.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245081 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1298-1657 |
5.05e-21 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 98.32 E-value: 5.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1298 PRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRP 1377
Cdd:COG5238 156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1378 AGLFSLSISETQqqlcvqlefprqeenpeavalrlahcdlgahhsllvgqlmetcarlqqlslsqvnlcedddasslllq 1457
Cdd:COG5238 236 KSLTTLDLSNNQ-------------------------------------------------------------------- 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1458 slllslselktfrltsscVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1537
Cdd:COG5238 248 ------------------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1538 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSIS 1617
Cdd:COG5238 310 IALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIG 389
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1864245081 1618 SAGGVQLAESLVLcRRLEELMLGCNALGDPTALGLAQELP 1657
Cdd:COG5238 390 KQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1412-1637 |
2.61e-20 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 93.96 E-value: 2.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1412 LAHCDLGAHHS-------LLVGQLMETCARLQQLSLSQVNLCEDddasSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1484
Cdd:cd00116 53 LKELCLSLNETgriprglQSLLQGLTKGCGLQELDLSDNALGPD----GCGVLESLLRSSSLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1485 ASGLGHCHH-----------------------------LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1535
Cdd:cd00116 129 AKGLKDLPPaleklvlgrnrlegascealakalranrdLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1536 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN 1614
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....
gi 1864245081 1615 SISSAGGVQLAESLV-LCRRLEEL 1637
Cdd:cd00116 289 KFGEEGAQLLAESLLePGNELESL 312
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
5.16e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.92 E-value: 5.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245081 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
690-1069 |
1.22e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 67.77 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 690 NLSFKSRKCGDAFAEALSRSLPTMgrlQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQL--SDQVVLNIVEVLP 767
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 768 HLPRLRKLDLSSNSICvstllclarvAVTCPTVrmlqareadlifllspptettAELQRAPDLQEsdgqrkgaqsrsltL 847
Cdd:cd00116 79 KGCGLQELDLSDNALG----------PDGCGVL---------------------ESLLRSSSLQE--------------L 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 848 RLQKCQLQVhDAEALIA--LLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAvsac 925
Cdd:cd00116 114 KLNNNGLGD-RGLRLLAkgLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG---- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 926 wtlaelhislqhktvifmfaqepeeqkgpqeraafldslmLQMPSELplssRRMRLTHCGLQEKHLEQLCKALGGSCHLg 1005
Cdd:cd00116 189 ----------------------------------------LKANCNL----EVLDLNNNGLTDEGASALAETLASLKSL- 223
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245081 1006 hLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:cd00116 224 -EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRG 287
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
9.17e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 9.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245081 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1009-1306 |
1.81e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDL----------RSLHHATLHFRSNEEEEGVC 1218
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLanngigdagiRALAEGLKANCNLEVLDLNN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1219 CGFT--GCSLsqehvesLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL-LDLSHNSISQESALYLLETLP 1295
Cdd:cd00116 203 NGLTdeGASA-------LAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLtLSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1864245081 1296 SCPRVREASVN 1306
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1550-1616 |
2.88e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 2.88e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245081 1550 LQSLRLNRNSIGDVGcchlSEALRAATSLEELDLSHNQIGdagvqhlaTILP----GLPELRKIDLSGNSI 1616
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLLT--------TLSPgafsGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
3.16e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.31 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245081 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
1518-1617 |
1.37e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1518 GKWMLKRLDLShlllNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVgcchLSEALRAATSLEELDLSHNQIGDAgvqhLA 1597
Cdd:PLN03150 416 GKWFIDGLGLD----NQGLRGFIPNDISKLRHLQSINLSGNSIRGN----IPPSLGSITSLEVLDLSYNSFNGS----IP 483
|
90 100
....*....|....*....|
gi 1864245081 1598 TILPGLPELRKIDLSGNSIS 1617
Cdd:PLN03150 484 ESLGQLTSLRILNLNGNSLS 503
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1576-1597 |
6.40e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 35.85 E-value: 6.40e-03
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
705-783 |
8.60e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 39.77 E-value: 8.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340 117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
7.35e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 7.35e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245081 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
4.05e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 163.63 E-value: 4.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245081 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1526-1821 |
2.34e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.16 E-value: 2.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1526 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1605
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1606 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1683
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1684 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1763
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245081 1764 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1821
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1492-1792 |
1.46e-32 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 130.17 E-value: 1.46e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1492 HHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSST--LALLTHRLSQMTCLQSLRLNRNSIGDVGCcHLS 1569
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1570 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE-LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPT 1648
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1649 ALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAggvlrfcmelpllrqidlvsckiDNQT 1726
Cdd:cd00116 182 IRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLT-----------------------DAGA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245081 1727 AKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQ 1792
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLE 304
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1482-1771 |
6.54e-32 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 131.07 E-value: 6.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1482 AHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIG 1561
Cdd:COG5238 170 AISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1562 DVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGC 1641
Cdd:COG5238 250 DEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAY 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1642 NALGDPTALGLAQELPQHLRV--LHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLagGVLRFcMELPLLRQIdlvs 1719
Cdd:COG5238 330 NGIGAQGAIALAKALQENTTLhsLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNI--GKQGA-EALIDALQT---- 402
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1864245081 1720 ckidNQTAKLLtssftscpalevilLSWNLLGDEAAAELAQVLPqmgRLKRV 1771
Cdd:COG5238 403 ----NRLHTLI--------------LDGNLIGAEAQQRLEQLLE---RIKSV 433
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1467-1683 |
3.98e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 119.89 E-value: 3.98e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1467 KTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQ 1546
Cdd:COG5238 211 TTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQG 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1547 MTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAE 1626
Cdd:COG5238 291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245081 1627 SLVLCRRLEELMLGCNALGDPTALGLAQELpQHLRVLHLPFS--HLGPGGALSLAQALD 1683
Cdd:COG5238 371 YLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDgnLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1477-1698 |
1.06e-27 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 115.92 E-value: 1.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1477 STEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGkWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRL 1555
Cdd:cd00116 66 IPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1556 NRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLE 1635
Cdd:cd00116 145 GRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLE 224
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245081 1636 ELMLGCNALGDPTALGLAQELP---QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL 1698
Cdd:cd00116 225 VLNLGDNNLTDAGAAALASALLspnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
7.05e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.81 E-value: 7.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245081 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1298-1657 |
5.05e-21 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 98.32 E-value: 5.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1298 PRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRP 1377
Cdd:COG5238 156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1378 AGLFSLSISETQqqlcvqlefprqeenpeavalrlahcdlgahhsllvgqlmetcarlqqlslsqvnlcedddasslllq 1457
Cdd:COG5238 236 KSLTTLDLSNNQ-------------------------------------------------------------------- 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1458 slllslselktfrltsscVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1537
Cdd:COG5238 248 ------------------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1538 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSIS 1617
Cdd:COG5238 310 IALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIG 389
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1864245081 1618 SAGGVQLAESLVLcRRLEELMLGCNALGDPTALGLAQELP 1657
Cdd:COG5238 390 KQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1412-1637 |
2.61e-20 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 93.96 E-value: 2.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1412 LAHCDLGAHHS-------LLVGQLMETCARLQQLSLSQVNLCEDddasSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1484
Cdd:cd00116 53 LKELCLSLNETgriprglQSLLQGLTKGCGLQELDLSDNALGPD----GCGVLESLLRSSSLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1485 ASGLGHCHH-----------------------------LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1535
Cdd:cd00116 129 AKGLKDLPPaleklvlgrnrlegascealakalranrdLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1536 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN 1614
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....
gi 1864245081 1615 SISSAGGVQLAESLV-LCRRLEEL 1637
Cdd:cd00116 289 KFGEEGAQLLAESLLePGNELESL 312
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1488-1804 |
1.94e-18 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 89.99 E-value: 1.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1488 LGHCHHLEELDLSNNQfdeegtkalmrALEGKWMLKRLDLSHLLLNSstlalLTHRLSQMTCLQSLRLNRNSIGDvgcch 1567
Cdd:COG4886 92 LGDLTNLTELDLSGNE-----------ELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTD----- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1568 LSEALRAATSLEELDLSHNQIGDagvqhLATILPGLPELRKIDLSGNSISSaggvqLAESLVLCRRLEELMLGCNALGDp 1647
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD- 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1648 talgLAQELPQ--HLRVLHLPFSHlgpggaLSLAQALDGSPHLEEISLAENNLAGgvLRFCMELPLLRQIDLVSCKIDNQ 1725
Cdd:COG4886 220 ----LPEPLANltNLETLDLSNNQ------LTDLPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDL 287
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245081 1726 TAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNN 1804
Cdd:COG4886 288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1549-1817 |
2.43e-16 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 82.02 E-value: 2.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1549 CLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIG--DAGVQHLATILPGLPELRKIDLSGNSISsAGGVQLAE 1626
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALG-PDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1627 SLVLCRRLEELMLGCNALGDptalglaqelpQHLRVLhlpfshlgpGGALslaqaLDGSPHLEEISLAENNLAGGvlrfC 1706
Cdd:cd00116 103 SLLRSSSLQELKLNNNGLGD-----------RGLRLL---------AKGL-----KDLPPALEKLVLGRNRLEGA----S 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1707 MElpllrqidlvsckidnQTAKLLTSSftscPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLL 1786
Cdd:cd00116 154 CE----------------ALAKALRAN----RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASAL 213
|
250 260 270
....*....|....*....|....*....|.
gi 1864245081 1787 AEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQ 1817
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASA 244
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1273-1600 |
2.79e-16 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 82.02 E-value: 2.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1273 GLLDLSHNSISQESALYLLETLPSC--PRVREASVN-LGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS 1349
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLCLqvLRLEGNTLGeEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLTKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1350 LQLTELTLTQCCLGQKQlaillslvgrPAGLFSLSISETQQQLcvqlefprqeenpeavalRLAHCDLG-AHHSLLVGQL 1428
Cdd:cd00116 81 CGLQELDLSDNALGPDG----------CGVLESLLRSSSLQEL------------------KLNNNGLGdRGLRLLAKGL 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1429 METCARLQQLSLSQVNLcedDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEG 1508
Cdd:cd00116 133 KDLPPALEKLVLGRNRL---EGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1509 TKALMRALEGKWMLKRLDLSH-LLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQ 1587
Cdd:cd00116 210 ASALAETLASLKSLEVLNLGDnNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNK 289
|
330
....*....|...
gi 1864245081 1588 IGDAGVQHLATIL 1600
Cdd:cd00116 290 FGEEGAQLLAESL 302
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
5.16e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.92 E-value: 5.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245081 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
687-915 |
2.68e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 77.52 E-value: 2.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 687 QIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVL 766
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 767 PHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFllspptETTAELqrAPDLQESDGQRkgaqsrslT 846
Cdd:COG5238 261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGD------EGAIAL--AEGLQGNKTLH--------T 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245081 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGV 915
Cdd:COG5238 325 LNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1481-1699 |
8.61e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 75.74 E-value: 8.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1481 LAHLASGLGHCHHLEELDLSNNQFDEegtkaLMRALEGKWMLKRLDLSHLLLNSstlalLTHRLSQMTCLQSLRLNRNSI 1560
Cdd:COG4886 148 LTDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1561 GDvgcchLSEALRAATSLEELDLSHNQIGDAGVqhlatiLPGLPELRKIDLSGNSISSaggvqLAESLVLcRRLEELMLG 1640
Cdd:COG4886 218 TD-----LPEPLANLTNLETLDLSNNQLTDLPE------LGNLTNLEELDLSNNQLTD-----LPPLANL-TNLKTLDLS 280
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245081 1641 CNALGDP--TALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA 1699
Cdd:COG4886 281 NNQLTDLklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
715-1052 |
1.37e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 75.21 E-value: 1.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 715 RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVA 794
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 795 VTCPTVRmlqareadlifllspptettaelqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEE 874
Cdd:COG5238 261 KNNTTVE--------------------------------------------TLYLSGNQIGAEGAIALAKALQGNTTLTS 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 875 VDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVsacWTLAELHIslqhktvifmfaqepeeqkgp 954
Cdd:COG5238 297 LDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL---QENTTLHS--------------------- 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 955 qeraafldslmlqmpselplssrrmrlthcglqekhleqlckalggschlghlhLDFSGNALGDEGAARLAQLLPGLGAL 1034
Cdd:COG5238 353 ------------------------------------------------------LDLSDNQIGDEGAIALAKYLEGNTTL 378
|
330
....*....|....*...
gi 1864245081 1035 QSLNLSENGLSLDAVLGL 1052
Cdd:COG5238 379 RELNLGKNNIGKQGAEAL 396
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
690-1069 |
1.22e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 67.77 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 690 NLSFKSRKCGDAFAEALSRSLPTMgrlQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQL--SDQVVLNIVEVLP 767
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 768 HLPRLRKLDLSSNSICvstllclarvAVTCPTVrmlqareadlifllspptettAELQRAPDLQEsdgqrkgaqsrsltL 847
Cdd:cd00116 79 KGCGLQELDLSDNALG----------PDGCGVL---------------------ESLLRSSSLQE--------------L 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 848 RLQKCQLQVhDAEALIA--LLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAvsac 925
Cdd:cd00116 114 KLNNNGLGD-RGLRLLAkgLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG---- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 926 wtlaelhislqhktvifmfaqepeeqkgpqeraafldslmLQMPSELplssRRMRLTHCGLQEKHLEQLCKALGGSCHLg 1005
Cdd:cd00116 189 ----------------------------------------LKANCNL----EVLDLNNNGLTDEGASALAETLASLKSL- 223
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245081 1006 hLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:cd00116 224 -EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRG 287
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
680-910 |
2.27e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 68.28 E-value: 2.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238 230 EALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 760 LNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavtcptvrmlqaREADLIFLLspptettAELQRAPDLQesdgqrkg 839
Cdd:COG5238 310 IALAEGLQGNKTLHTLNLAYNGI-----------------------GAQGAIALA-------KALQENTTLH-------- 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245081 840 aqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAeAASQLHIARKLDLSNNGL 910
Cdd:COG5238 352 ------SLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALI-DALQTNRLHTLILDGNLI 415
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
661-893 |
8.74e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 65.45 E-value: 8.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 661 REAPIHLDFDGCPLePHCPEALvgcgqiENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPL 740
Cdd:cd00116 119 GLGDRGLRLLAKGL-KDLPPAL------EKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 741 CPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvsTLLCLARVAvtcptvrmlqareadlifllspptet 820
Cdd:cd00116 192 NCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL---TDAGAAALA-------------------------- 242
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864245081 821 taelqrapdlqesDGQRKGAQSRsLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEA 893
Cdd:cd00116 243 -------------SALLSPNISL-LTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1574-1806 |
1.54e-10 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 65.58 E-value: 1.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1574 AATSLEELDLSHNQIGDAGVQHLATILPGLPElrkIDLSGNSISSAGGVQLAESLVLC-RRLEELMLGCNALGDPTALGL 1652
Cdd:COG5238 124 AKTLEDSLILYLALPRRINLIQVLKDPLGGNA---VHLLGLAARLGLLAAISMAKALQnNSVETVYLGCNQIGDEGIEEL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1653 AQELPQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLeeislaennlaggvlrfcmelpllRQIDLVsckiDNQtakll 1730
Cdd:COG5238 201 AEALTQNttVTTLWLKRNPIGDEGAEILAEALKGNKSL------------------------TTLDLS----NNQ----- 247
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245081 1731 tssftscpalevillswnlLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1806
Cdd:COG5238 248 -------------------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRI 304
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1487-1637 |
2.15e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 62.50 E-value: 2.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1487 GLGHCHHLEELDLSNNQFDE-EGtkalmraLEGKWMLKRLDLSH--------LLLNSSTLALLTHrlsqmtCLQSLRLNR 1557
Cdd:cd21340 63 NLENLVNLKKLYLGGNRISVvEG-------LENLTNLEELHIENqrlppgekLTFDPRSLAALSN------SLRVLNISG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1558 NSIGDVgcchlsEALRAATSLEELDLSHNQIGDagVQHLATILPGLPELRKIDLSGNSISSagGVQLAESLVL-CRRLEE 1636
Cdd:cd21340 130 NNIDSL------EPLAPLRNLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVCK--KPKYRDKIILaSKSLEV 199
|
.
gi 1864245081 1637 L 1637
Cdd:cd21340 200 L 200
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
9.17e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 9.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245081 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
666-914 |
5.31e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 53.51 E-value: 5.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 666 HLDFDGCPLEPHCPEALVGCGQI---ENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLC 741
Cdd:cd00116 85 ELDLSDNALGPDGCGVLESLLRSsslQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRAN 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 742 PQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavTCPTVRMLQAREADLIFLLspptett 821
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGL-------------TDEGASALAETLASLKSLE------- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 822 aelqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALI-ALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA 900
Cdd:cd00116 225 ------------------------VLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
|
250
....*....|....
gi 1864245081 901 RKLDLSNNGLSVAG 914
Cdd:cd00116 281 LELDLRGNKFGEEG 294
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1525-1806 |
1.31e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.01 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1525 LDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLP 1604
Cdd:COG4886 17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1605 ELRKIDLSGNsissaggvqlaESLVLCRRLEELMLGCNALGDptalgLAQELPQ--HLRVLHLPFSHLGpggalSLAQAL 1682
Cdd:COG4886 97 NLTELDLSGN-----------EELSNLTNLESLDLSGNQLTD-----LPEELANltNLKELDLSNNQLT-----DLPEPL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1683 DGSPHLEEISLAENNLAGgvlrfcmelpllrqidlvsckidnqtaklLTSSFTSCPALEVILLSWNLLGDeaaaeLAQVL 1762
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTD-----------------------------LPEELGNLTNLKELDLSNNQITD-----LPEPL 201
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1864245081 1763 PQMGRLKRVDLEKNQITALGawllaEGLAQGSSIQVIRLWNNPI 1806
Cdd:COG4886 202 GNLTNLEELDLSGNQLTDLP-----EPLANLTNLETLDLSNNQL 240
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1009-1306 |
1.81e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDL----------RSLHHATLHFRSNEEEEGVC 1218
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLanngigdagiRALAEGLKANCNLEVLDLNN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1219 CGFT--GCSLsqehvesLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL-LDLSHNSISQESALYLLETLP 1295
Cdd:cd00116 203 NGLTdeGASA-------LAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLtLSLSCNDITDDGAKDLAEVLA 275
|
330
....*....|.
gi 1864245081 1296 SCPRVREASVN 1306
Cdd:cd00116 276 EKESLLELDLR 286
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1481-1674 |
4.51e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.09 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1481 LAHLASGLGHCHHLEELDLSNNQFdeegtKALMRALEGKWMLKRLDLSHLLLnsSTLAllthRLSQMTCLQSLRLNRNSI 1560
Cdd:COG4886 194 ITDLPEPLGNLTNLEELDLSGNQL-----TDLPEPLANLTNLETLDLSNNQL--TDLP----ELGNLTNLEELDLSNNQL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1561 GDVGcchlseALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLG 1640
Cdd:COG4886 263 TDLP------PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336
|
170 180 190
....*....|....*....|....*....|....
gi 1864245081 1641 CNALGDPTALGLAQELPQHLRVLHLPFSHLGPGG 1674
Cdd:COG4886 337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
704-911 |
1.10e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 49.93 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 704 EALSRSLPTMGRLQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSIc 783
Cdd:COG4886 126 TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQI- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 784 vSTL-LCLARvavtCPTVRMLQAREADLifllsppTETTAELQRAPDLQesdgqrkgaqsrslTLRLQKCQLQVhdaeal 862
Cdd:COG4886 195 -TDLpEPLGN----LTNLEELDLSGNQL-------TDLPEPLANLTNLE--------------TLDLSNNQLTD------ 242
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1864245081 863 IALLQEGPHLEEVDLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886 243 LPELGNLTNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLT 285
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1488-1665 |
2.79e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.47 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1488 LGHCHHLEELDLSNNQfdeegtkalmralegkwmLKRLDlshlllNSSTLALLTH------------RLSQMTCLQSLRL 1555
Cdd:cd21340 20 LSLCKNLKVLYLYDNK------------------ITKIE------NLEFLTNLTHlylqnnqiekieNLENLVNLKKLYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1556 NRNSIGDVgcchlsEALRAATSLEELDLSHNQIgDAGVQHL---ATILPGLPELRKIDLSGNSISSaggvqlAESLVLCR 1632
Cdd:cd21340 76 GGNRISVV------EGLENLTNLEELHIENQRL-PPGEKLTfdpRSLAALSNSLRVLNISGNNIDS------LEPLAPLR 142
|
170 180 190
....*....|....*....|....*....|....
gi 1864245081 1633 RLEELMLGCNALGDPTAL-GLAQELPQhLRVLHL 1665
Cdd:cd21340 143 NLEQLDASNNQISDLEELlDLLSSWPS-LRELDL 175
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1522-1780 |
5.82e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 46.32 E-value: 5.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1522 LKRLdlSHLLLNSSTLALLtHRLSQMTCLQSLRLNRNSIGDVgcchlsEALRAATSLEELDLSHNQIgdagvqhlATI-- 1599
Cdd:cd21340 1 LKRI--THLYLNDKNITKI-DNLSLCKNLKVLYLYDNKITKI------ENLEFLTNLTHLYLQNNQI--------EKIen 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1600 LPGLPELRKIDLSGNSISSaggvqlAESLVLCRRLEELMLGCnalgdptalglaQELPQHLRVLHLPFSHLgpggalsla 1679
Cdd:cd21340 64 LENLVNLKKLYLGGNRISV------VEGLENLTNLEELHIEN------------QRLPPGEKLTFDPRSLA--------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1680 qaldgsphleeiSLAENnlaggvlrfcmelplLRQIDLVSCKIDNqtakllTSSFTSCPALEVILLSWNLLGDeaAAELA 1759
Cdd:cd21340 117 ------------ALSNS---------------LRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD--LEELL 161
|
250 260
....*....|....*....|.
gi 1864245081 1760 QVLPQMGRLKRVDLEKNQITA 1780
Cdd:cd21340 162 DLLSSWPSLRELDLTGNPVCK 182
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
716-911 |
6.86e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.62 E-value: 6.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 716 LQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSICVstllcLARVAV 795
Cdd:COG4886 115 LESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELG 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 796 TCPTVRMLQAREADLifllsppTETTAELQRAPDLQEsdgqrkgaqsrsltLRLQKCQLQvhDAEALIALLqegPHLEEV 875
Cdd:COG4886 180 NLTNLKELDLSNNQI-------TDLPEPLGNLTNLEE--------------LDLSGNQLT--DLPEPLANL---TNLETL 233
|
170 180 190
....*....|....*....|....*....|....*.
gi 1864245081 876 DLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886 234 DLSNNQLTD------LPELGNLTNLEELDLSNNQLT 263
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1550-1616 |
2.88e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 2.88e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245081 1550 LQSLRLNRNSIGDVGcchlSEALRAATSLEELDLSHNQIGdagvqhlaTILP----GLPELRKIDLSGNSI 1616
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLLT--------TLSPgafsGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
3.16e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.31 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245081 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| LRR_6 |
pfam13516 |
Leucine Rich repeat; |
1576-1597 |
6.94e-04 |
|
Leucine Rich repeat;
Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 38.37 E-value: 6.94e-04
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
1518-1617 |
1.37e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1518 GKWMLKRLDLShlllNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVgcchLSEALRAATSLEELDLSHNQIGDAgvqhLA 1597
Cdd:PLN03150 416 GKWFIDGLGLD----NQGLRGFIPNDISKLRHLQSINLSGNSIRGN----IPPSLGSITSLEVLDLSYNSFNGS----IP 483
|
90 100
....*....|....*....|
gi 1864245081 1598 TILPGLPELRKIDLSGNSIS 1617
Cdd:PLN03150 484 ESLGQLTSLRILNLNGNSLS 503
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
650-782 |
2.37e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 42.61 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 650 DLATLTNIlehreapIHLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITAr 729
Cdd:COG4886 131 ELANLTNL-------KELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD- 196
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1864245081 730 gishLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 197 ----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQL 240
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
680-772 |
3.26e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.08 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALpLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238 342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQ 420
|
90
....*....|...
gi 1864245081 760 LNIVEVLPHLPRL 772
Cdd:COG5238 421 QRLEQLLERIKSV 433
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
1576-1614 |
3.94e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.84 E-value: 3.94e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1864245081 1576 TSLEELDLSHNQIGDAGvqhlatILPGLPELRKIDLSGN 1614
Cdd:pfam12799 1 PNLEVLDLSNNQITDIP------PLAKLPNLETLDLSGN 33
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1576-1597 |
6.40e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 35.85 E-value: 6.40e-03
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1494-1779 |
6.63e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1494 LEELDLSNNQFDEE-----GTKALMRALE--GKWMLKRLDLShlLLNSSTLALLT-----------HRLSQMTCLQSLRL 1555
Cdd:PLN00113 142 LETLDLSNNMLSGEipndiGSFSSLKVLDlgGNVLVGKIPNS--LTNLTSLEFLTlasnqlvgqipRELGQMKSLKWIYL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1556 NRNSIGDvgccHLSEALRAATSLEELDLSHNQIgdagvqhLATILPGLPELRKID---LSGNSISSaggvQLAESLVLCR 1632
Cdd:PLN00113 220 GYNNLSG----EIPYEIGGLTSLNHLDLVYNNL-------TGPIPSSLGNLKNLQylfLYQNKLSG----PIPPSIFSLQ 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1633 RLEELMLGCNALGDPTALGLAQElpQHLRVLHLPFSHLG---PGGALSLaqaldgsPHLEEISLAENNLAGGVLRFCMEL 1709
Cdd:PLN00113 285 KLISLDLSDNSLSGEIPELVIQL--QNLEILHLFSNNFTgkiPVALTSL-------PRLQVLQLWSNKFSGEIPKNLGKH 355
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 1710 PLLRQIDLVSckiDNQTAKLLTSSFTSCPALEVILLSWNLLGdeaaaELAQVLPQMGRLKRVDLEKNQIT 1779
Cdd:PLN00113 356 NNLTVLDLST---NNLTGEIPEGLCSSGNLFKLILFSNSLEG-----EIPKSLGACRSLRRVRLQDNSFS 417
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
705-783 |
8.60e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 39.77 E-value: 8.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245081 705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340 117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
|
|
| |
