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Conserved domains on  [gi|1862755539|ref|NP_001371778|]
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microtubule-associated protein 4 isoform 21 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 979-1008 1.73e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.73e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755539  979 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 1008
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1010-1039 2.69e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.69e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755539 1010 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1039
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 562-906 2.01e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 2.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  562 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 640
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  641 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 720
Cdd:PHA03247  2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  721 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 798
Cdd:PHA03247  2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  799 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 872
Cdd:PHA03247  2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1862755539  873 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 906
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1041-1071 5.37e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.37e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862755539 1041 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1071
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 918-939 2.78e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.78e-08
                           10        20
                   ....*....|....*....|..
gi 1862755539  918 DLKNVRSKVGSTENIKHQPGGG 939
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 979-1008 1.73e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.73e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755539  979 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 1008
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1010-1039 2.69e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.69e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755539 1010 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1039
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 562-906 2.01e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 2.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  562 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 640
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  641 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 720
Cdd:PHA03247  2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  721 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 798
Cdd:PHA03247  2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  799 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 872
Cdd:PHA03247  2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1862755539  873 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 906
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1041-1071 5.37e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.37e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862755539 1041 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1071
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 918-939 2.78e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.78e-08
                           10        20
                   ....*....|....*....|..
gi 1862755539  918 DLKNVRSKVGSTENIKHQPGGG 939
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 652-973 3.40e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.99  E-value: 3.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  652 TSGIARPEegrpVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMS 729
Cdd:pfam05109  436 TTGFAAPN----TTTGLPSSTHVPTNLTAPAStgPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTS 511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  730 LASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRA----------------------SPSKPASAPASRSG 787
Cdd:pfam05109  512 AVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNAtsptpavttptpnatiptlgktSPTSAVTTPTPNAT 591

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  788 SKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGK----PAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLS 863
Cdd:pfam05109  592 SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQhnitSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLT 671

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  864 GTAPAAG-----VVPSRVK------ATPMPsRPSTTPFID---KKPTSAKP------------SSTTPRLSRlATNTSAP 917
Cdd:pfam05109  672 SAHPTGGenitqVTPASTSthhvstSSPAP-RPGTTSQASgpgNSSTSTKPgevnvtkgtppkNATSPQAPS-GQKTAVP 749

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1862755539  918 DLKNVRSKVGSTENIKHQPG-GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK 973
Cdd:pfam05109  750 TVTSTGGKANSTTGGKHTTGhGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSK 806
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 979-1008 1.73e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.73e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755539  979 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 1008
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1010-1039 2.69e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.69e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755539 1010 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1039
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 562-906 2.01e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 2.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  562 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 640
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  641 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 720
Cdd:PHA03247  2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  721 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 798
Cdd:PHA03247  2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  799 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 872
Cdd:PHA03247  2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1862755539  873 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 906
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1041-1071 5.37e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.37e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862755539 1041 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1071
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 918-939 2.78e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.78e-08
                           10        20
                   ....*....|....*....|..
gi 1862755539  918 DLKNVRSKVGSTENIKHQPGGG 939
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 655-912 6.30e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 6.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  655 IARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTS----LPKQPAPTTIGGLNKKPmSL 730
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESReslpSPWDPADPPAAVLAPAA-AL 2818

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  731 ASGLVPAAP-PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS 809
Cdd:PHA03247  2819 PPAASPAGPlPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  810 SRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADlsRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTP 889
Cdd:PHA03247  2899 ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR 2976

                          250       260
                   ....*....|....*....|....*
gi 1862755539  890 FI--DKKPTSAKPSSTTPRLSRLAT 912
Cdd:PHA03247  2977 FRvpQPAPSREAPASSTPPLTGHSL 3001
PHA03247 PHA03247
large tegument protein UL36; Provisional
 640-911 3.55e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  640 PCNSQPSELSSETSGIARPEEGRPVVSG--TGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAP 717
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRD 2654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  718 TTIGG---LNKKPMSLASGLVPAAPPKRPAVASARPSI---------------------------------------LPS 755
Cdd:PHA03247  2655 DPAPGrvsRPRRARRLGRAAQASSPPQRPRRRAARPTVgsltsladpppppptpepaphalvsatplppgpaaarqaSPA 2734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  756 KDVKPKPIADAKAPEKRASPSKPASaPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVkk 835
Cdd:PHA03247  2735 LPAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV-- 2811

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  836 mtakSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKP----SSTTPRLSRLA 911
Cdd:PHA03247  2812 ----LAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAakpaAPARPPVRRLA 2887
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 560-917 1.66e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.48  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  560 AKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERK 639
Cdd:PHA03307    15 AEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLST 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  640 PCNSQPSELSSETSGIARPEEGRPvvsgtgndiTTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTt 719
Cdd:PHA03307    95 LAPASPAREGSPTPPGPSSPDPPP---------PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAS- 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  720 iGGLNKKPMSLASGLVPAA-----PPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTV 794
Cdd:PHA03307   165 -DAASSRQAALPLSSPEETarapsSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  795 AKTTTAAAVASTGPSSRSPSTLLPKKPTAIktEGKPAEVKKMTAKSVPADLSR-----------PKSTSTSSMKKTTTLS 863
Cdd:PHA03307   244 SSGCGWGPENECPLPRPAPITLPTRIWEAS--GWNGPSSRPGPASSSSSPRERspspspsspgsGPAPSSPRASSSSSSS 321

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1862755539  864 GTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 917
Cdd:PHA03307   322 RESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAP 375
PHA03247 PHA03247
large tegument protein UL36; Provisional
 647-975 1.66e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  647 ELSSETSGIARPEEGrPVVSGTGNDITTPPNKELPPSPE-----KKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPttig 721
Cdd:PHA03247  2542 ELASDDAGDPPPPLP-PAAPPAAPDRSVPPPRPAPRPSEpavtsRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---- 2616

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  722 glnkkpmslasgLVPAAPPKRPAVASARPSilPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAA 801
Cdd:PHA03247  2617 ------------LPPDTHAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR 2682

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  802 AVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPM 881
Cdd:PHA03247  2683 PRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  882 PSRPSTTpfidkKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIkhQPGGGRAKVEKKTEAAATTRKPESnAV 961
Cdd:PHA03247  2763 TAGPPAP-----APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP--AAVLAPAAALPPAASPAGPLPPPT-SA 2834

                          330
                   ....*....|....
gi 1862755539  962 TKTAGPIASAQKQP 975
Cdd:PHA03247  2835 QPTAPPPPPGPPPP 2848
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
714-976 7.88e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 7.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  714 QPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASAR-------PSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRS 786
Cdd:PRK07003   359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASavpavtaVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  787 GSKSTQtvaktttaaavastgpssrSPSTLLPKKPTAIKTEGKPAEvkkmtAKSVPADLSRPKSTSTSSMKKTTTLSGTA 866
Cdd:PRK07003   439 GDDAAD-------------------GDAPVPAKANARASADSRCDE-----RDAQPPADSGSASAPASDAPPDAAFEPAP 494

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  867 PAAGVVPSRVKATPMPSRPSTTPFIDK-------KPTSAKPSSTTPRLSRLATNTSAP--DLKNVRSKVGSTeniKHQPG 937
Cdd:PRK07003   495 RAAAPSAATPAAVPDARAPAAASREDApaaaappAPEARPPTPAAAAPAARAGGAAAAldVLRNAGMRVSSD---RGARA 571

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1862755539  938 GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPA 976
Cdd:PRK07003   572 AAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPP 610
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 652-973 3.40e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.99  E-value: 3.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  652 TSGIARPEegrpVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMS 729
Cdd:pfam05109  436 TTGFAAPN----TTTGLPSSTHVPTNLTAPAStgPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTS 511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  730 LASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRA----------------------SPSKPASAPASRSG 787
Cdd:pfam05109  512 AVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNAtsptpavttptpnatiptlgktSPTSAVTTPTPNAT 591

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  788 SKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGK----PAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLS 863
Cdd:pfam05109  592 SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQhnitSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLT 671

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  864 GTAPAAG-----VVPSRVK------ATPMPsRPSTTPFID---KKPTSAKP------------SSTTPRLSRlATNTSAP 917
Cdd:pfam05109  672 SAHPTGGenitqVTPASTSthhvstSSPAP-RPGTTSQASgpgNSSTSTKPgevnvtkgtppkNATSPQAPS-GQKTAVP 749

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1862755539  918 DLKNVRSKVGSTENIKHQPG-GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK 973
Cdd:pfam05109  750 TVTSTGGKANSTTGGKHTTGhGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSK 806
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 565-917 7.24e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.22  E-value: 7.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  565 PLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTF----MISPE---TVTGTGKKCSLPAEEDSVLEklge 637
Cdd:pfam05109  425 PESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstadVTSPTpagTTSGASPVTPSPSPRDNGTE---- 500

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  638 rkpcnSQPSELSSETSGIARPEegrPVVSGTGNDITTP-PNKELP-------------PSPEKKTKPLATTQPAKTST-- 701
Cdd:pfam05109  501 -----SKAPDMTSPTSAVTTPT---PNATSPTPAVTTPtPNATSPtlgktsptsavttPTPNATSPTPAVTTPTPNATip 572

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  702 SKAKTQPTSLPKQPAPT------------------TIGGLNKKPmslasglVPAAPPKRP--AVASARPSILPSK----D 757
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNatsptvgetspqanttnhTLGGTSSTP-------VVTSPPKNAtsAVTTGQHNITSSStssmS 645

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  758 VKPKPIADAKAPEK--RASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG-PSSRSPSTLLPKKPTAIKTEGKPAEV- 833
Cdd:pfam05109  646 LRPSSISETLSPSTsdNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSsPAPRPGTTSQASGPGNSSTSTKPGEVn 725

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  834 -------KKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVvPSRVKATPMPSR--PSTTPFIDKKPTSAKPSSTT 904
Cdd:pfam05109  726 vtkgtppKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGH-GARTSTEPTTDYggDSTTPRTRYNATTYLPPSTS 804

                          410
                   ....*....|...
gi 1862755539  905 PRLSRLATNTSAP 917
Cdd:pfam05109  805 SKLRPRWTFTSPP 817
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 625-981 2.28e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 2.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  625 PAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKT-----KPLATTQPAKT 699
Cdd:pfam03154  151 PQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATsqppnQTQSTAAPHTL 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  700 STSKAKTQPTSLPK-----QPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKdVKPKPIADAKAPEKRAS 774
Cdd:pfam03154  231 IQQTPTLHPQRLPSphpplQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHP-VPPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  775 PSKPASA-----------PASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAiKTEGKPAEVKKMTAKSVPA 843
Cdd:pfam03154  310 PPGPSPAapgqsqqrihtPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNP-QSHKHPPHLSGPSPFQMNS 388

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  844 DLSRPKSTST-SSMKKTTTLSGTAPAAGVVPsrvKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNV 922
Cdd:pfam03154  389 NLPPPPALKPlSSLSTHHPPSAHPPPLQLMP---QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQH 465

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1862755539  923 RSKVGSTENIKHQPGggrakVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQI 981
Cdd:pfam03154  466 PFVPGGPPPITPPSG-----PPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQI 519
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
652-917 6.99e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 6.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  652 TSGIARPEEGRPVVSGT--GNDITTPPNKELPPSPEKKTKPLATTQPA--KTSTSKAKTQPTSLPKQPAPTTIGGLNKKP 727
Cdd:PRK07003   363 TGGGAPGGGVPARVAGAvpAPGARAAAAVGASAVPAVTAVTGAAGAALapKAAAAAAATRAEAPPAAPAPPATADRGDDA 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  728 MSlasglVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG 807
Cdd:PRK07003   443 AD-----GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAS 517

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  808 PSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST 887
Cdd:PRK07003   518 REDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVP 597

                          250       260       270
                   ....*....|....*....|....*....|
gi 1862755539  888 TPFIDKKPTSAKPSSTTPRLSRLATNTSAP 917
Cdd:PRK07003   598 TPRARAATGDAPPNGAARAEQAAESRGAPP 627
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 739-900 1.69e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  739 PPKRPAvASARPsilpskdvkPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSP 813
Cdd:PTZ00449   510 PPEGPE-ASGLP---------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKP 579

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  814 StlLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--P 889
Cdd:PTZ00449   580 E--FPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiI 654

                          170
                   ....*....|.
gi 1862755539  890 FIDKKPTSAKP 900
Cdd:PTZ00449   655 KSPKPPKSPKP 665
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 659-915 1.89e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 1.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  659 EEGRPVVSGTGNDITTP-PNKELPPS--------PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPttigglnKKPMS 729
Cdd:PTZ00449   545 EGGKPGETKEGEVGKKPgPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSP-------KLPEL 617

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  730 LAsglVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPA---------------SAPASRSGSKSTQTV 794
Cdd:PTZ00449   618 LD---IPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKppfdpkfkekfyddyLDAAAKSKETKTTVV 694

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  795 AKTTTAAAVASTGPSS-----RSPSTLLPKKPTAIKTEGKPaeVKKMTAKSV-PADLSRPKSTSTSSMKKTttlSGTAPA 868
Cdd:PTZ00449   695 LDESFESILKETLPETpgtpfTTPRPLPPKLPRDEEFPFEP--IGDPDAEQPdDIEFFTPPEEERTFFHET---PADTPL 769

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1862755539  869 AGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP------------RLSRLATNTS 915
Cdd:PTZ00449   770 PDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPpgdhpslpkkrhRLDGLALSTT 828
PHA03378 PHA03378
EBNA-3B; Provisional
 659-979 3.08e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 3.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  659 EEGRPVVSGTGNDITTPPNK----ELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGL 734
Cdd:PHA03378   549 ESDEPASTEPVHDQLLPAPGlgplQIQPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL 628

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  735 VP-AAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSP 813
Cdd:PHA03378   629 RPiPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPA 708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  814 STLLPKKPTAIKTEGKPAEVKKMTAKSVPADL---SRPKSTSTSSMKKTTTLSGTAPAAGVVPSRvkATPMPsRPSTTPF 890
Cdd:PHA03378   709 APPGRAQRPAAATGRARPPAAAPGRARPPAAApgrARPPAAAPGRARPPAAAPGRARPPAAAPGA--PTPQP-PPQAPPA 785

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  891 IDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRskvGSTENIKHQPGGGRAKvekktEAAATTRKPESNAVTKTAGPIAS 970
Cdd:PHA03378   786 PQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQ---GPTKQILRQLLTGGVK-----RGRPSLKKPAALERQAAAGPTPS 857


                   ....*....
gi 1862755539  971 AQKQPAGKV 979
Cdd:PHA03378   858 PGSGTSDKI 866
PHA03247 PHA03247
large tegument protein UL36; Provisional
 544-882 3.67e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  544 PLAKDGVLTLANNVTPAkdvPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKkcs 623
Cdd:PHA03247  2686 RAARPTVGSLTSLADPP---PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR--- 2759

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  624 lPAEEDSVLEKLGERKPCNSQPSELS---SETSGIARPEEGRPVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAK 698
Cdd:PHA03247  2760 -PPTTAGPPAPAPPAAPAAGPPRRLTrpaVASLSESRESLPSPWDPADPPAAVLAPAAALPPAasPAGPLPPPTSAQPTA 2838

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  699 TSTSKAKTQPtSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDV------------KPKPIADA 766
Cdd:PHA03247  2839 PPPPPGPPPP-SLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfalppdqperppQPQAPPPP 2917

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  767 KAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPkkptaikteGKPAEVKKMTAKSVPadlS 846
Cdd:PHA03247  2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP---------GRVAVPRFRVPQPAP---S 2985

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1862755539  847 RPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMP 882
Cdd:PHA03247  2986 REAPASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021
PHA03247 PHA03247
large tegument protein UL36; Provisional
 434-788 6.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  434 ARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPET 513
Cdd:PHA03247  2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  514 EVVLIKNVCLP-----PEMEVALTEDQVPALKTEAPLAKDGVLTLANNvTPAKDVPPLSETEATPVPIKDMEIAQTQKGI 588
Cdd:PHA03247  2747 GPATPGGPARParpptTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES-RESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  589 SEDSHLESLQDVGQSAAPTFMISPETVTGTgkkcSLPAEEdsvlekLGERKPCNSQPSELSSETSGIARpEEGRPVVSGT 668
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGS----VAPGGD------VRRRPPSRSPAAKPAAPARPPVR-RLARPAVSRS 2894

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  669 GNDITTPPNK-ELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGglnKKPMSLASGLVPAapPKRPAVAS 747
Cdd:PHA03247  2895 TESFALPPDQpERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---PAGAGEPSGAVPQ--PWLGALVP 2969

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1862755539  748 ARPSILPSKDVKPKPIADAKAPekraSPSKPASAPASRSGS 788
Cdd:PHA03247  2970 GRVAVPRFRVPQPAPSREAPAS----STPPLTGHSLSRVSS 3006
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 495-908 9.49e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.09  E-value: 9.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  495 PLSETEMALGKDVTPPPETEVvliKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAkDVPPLSETEATPV 574
Cdd:PRK14949   343 PKSGLEMALLRAVAFVPEKPV---KRWQVDDPAEISLPEGQTPSALAAAVQAPHANEPQFVNAAPA-EKKTALTEQTTAQ 418

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  575 PIKDMEIAQTQKGISEDSHLESLQDVG---QSAAPTFMISPETV-------TGTGKKCSLPAEEDSVLEKLGErKPCNSQ 644
Cdd:PRK14949   419 QQVQAANAEAVAEADASAEPADTVEQAlddESELLAALNAEQAVilsqaqsQGFEASSSLDADNSAVPEQIDS-TAEQSV 497

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  645 PSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEK-----KTKPLATTQP---AKTSTSKAKTQPTSLPKQPA 716
Cdd:PRK14949   498 VNPSVTDTQVDDTSASNNSAADNTVDDNYSAEDTLESNGLDEgdyaqDSAPLDAYQDdyvAFSSESYNALSDDEQHSANV 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  717 PTTIGGLNKKPMSLASGLVPAAPPKRP---------AVASARPSIL-------PSKDVKPKPIADAK--APEKRASPSKP 778
Cdd:PRK14949   578 QSAQSAAEAQPSSQSLSPISAVTTAAAsladddildAVLAARDSLLsdldalsPKEGDGKKSSADRKpkTPPSRAPPASL 657

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755539  779 ASAPAS-RSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKkmtAKSVPADLSRPKSTSTSSMK 857
Cdd:PRK14949   658 SKPASSpDASQTSASFDLDPDFELATHQSVPEAALASGSAPAPPPVPDPYDRPPWEE---APEVASANDGPNNAAEGNLS 734

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1862755539  858 KTTTLSGTAPAAGVVPsrvKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLS 908
Cdd:PRK14949   735 ESVEDASNSELQAVEQ---QATHQPQVQAEAQSPASTTALTQTSSEVQDTE 782
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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