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Conserved domains on  [gi|1862722898|ref|NP_001371755|]
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microtubule-associated protein 4 isoform 113 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 841-870 1.26e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.26e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862722898  841 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 870
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 872-901 2.03e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.03e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862722898  872 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 901
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 903-933 4.13e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.13e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862722898  903 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 933
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 818-839 2.16e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.16e-08
                           10        20
                   ....*....|....*....|..
gi 1862722898  818 DLKNVRSKVGSTENIKHQPGGG 839
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 606-817 7.84e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 7.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  606 KLGERKPCNSQPSELSSETSGIARPEEGRPVVS-GTGNDITTPPNKELPPSPEKKTKPIADAkapekrASPSKPASAPAS 684
Cdd:PHA03247  2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRlGRAAQASSPPQRPRRRAARPTVGSLTSL------ADPPPPPPTPEP 2710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  685 RSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTtlsg 764
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAP--PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT---- 2784

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1862722898  765 tAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 817
Cdd:PHA03247  2785 -RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 841-870 1.26e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.26e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862722898  841 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 870
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 872-901 2.03e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.03e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862722898  872 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 901
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 903-933 4.13e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.13e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862722898  903 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 933
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 818-839 2.16e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.16e-08
                           10        20
                   ....*....|....*....|..
gi 1862722898  818 DLKNVRSKVGSTENIKHQPGGG 839
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 606-817 7.84e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 7.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  606 KLGERKPCNSQPSELSSETSGIARPEEGRPVVS-GTGNDITTPPNKELPPSPEKKTKPIADAkapekrASPSKPASAPAS 684
Cdd:PHA03247  2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRlGRAAQASSPPQRPRRRAARPTVGSLTSL------ADPPPPPPTPEP 2710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  685 RSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTtlsg 764
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAP--PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT---- 2784

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1862722898  765 tAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 817
Cdd:PHA03247  2785 -RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 841-870 1.26e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.26e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862722898  841 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 870
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 872-901 2.03e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.03e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862722898  872 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 901
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 903-933 4.13e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.13e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862722898  903 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 933
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 818-839 2.16e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.16e-08
                           10        20
                   ....*....|....*....|..
gi 1862722898  818 DLKNVRSKVGSTENIKHQPGGG 839
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 606-817 7.84e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 7.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  606 KLGERKPCNSQPSELSSETSGIARPEEGRPVVS-GTGNDITTPPNKELPPSPEKKTKPIADAkapekrASPSKPASAPAS 684
Cdd:PHA03247  2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRlGRAAQASSPPQRPRRRAARPTVGSLTSL------ADPPPPPPTPEP 2710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  685 RSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTtlsg 764
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAP--PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT---- 2784

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1862722898  765 tAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 817
Cdd:PHA03247  2785 -RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
PRK13914 PRK13914
invasion associated endopeptidase;
615-831 1.29e-03

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 42.48  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  615 SQPSELSSETSGIARPEEGRPVV-SGTGNDITTPPNKELPPSPEKKTKPIADAKAPEKRASPSKPASAPASRSGSKSTQT 693
Cdd:PRK13914   145 STPVAPTQEVKKETTTQQAAPAAeTKTEVKQTTQATTPAPKVAETKETPVVDQNATTHAVKSGDTIWALSVKYGVSVQDI 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  694 VAKTTTAAAVASTGPS---SRSPSTLLPKkpTAIKTEGKPAEvkKMTAKSVPADLSrpKSTSTSSMKKTTTLSGTAPAAG 770
Cdd:PRK13914   225 MSWNNLSSSSIYVGQKlaiKQTANTATPK--AEVKTEAPAAE--KQAAPVVKENTN--TNTATTEKKETTTQQQTAPKAP 298

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1862722898  771 VVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP-RLSRLATNTSAPDLKNVRSKVGSTEN 831
Cdd:PRK13914   299 TEAAKPAPAPSTNTNANKTNTNTNTNTNNTNTSTPsKNTNTNTNSNTNTNSNTNANQGSSNN 360
PHA03247 PHA03247
large tegument protein UL36; Provisional
 534-811 2.60e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  534 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 612
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  613 CNSQPSELSSETSGiARPEEGRPVVsGTGNDITTPPNKELPPSPEKK----TKPIADAKAPEKRASPSKP--------AS 680
Cdd:PHA03247  2669 RLGRAAQASSPPQR-PRRRAARPTV-GSLTSLADPPPPPPTPEPAPHalvsATPLPPGPAAARQASPALPaapappavPA 2746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  681 APASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTT 760
Cdd:PHA03247  2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1862722898  761 TLsgtAPAAGVVPSRVKATPMPSRPSTT---------PFIDKKPTSAKP----SSTTPRLSRLA 811
Cdd:PHA03247  2827 PL---PPPTSAQPTAPPPPPGPPPPSLPlggsvapggDVRRRPPSRSPAakpaAPARPPVRRLA 2887
PHA03247 PHA03247
large tegument protein UL36; Provisional
 612-806 3.76e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  612 PCNSQPSELSSETSGIARPEEGRPVVSGTGNDittPPNKELPPSPEKKTKPIADAKAPEKRASPSK-----PASAPASRS 686
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRG---DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEpdphpPPTVPPPER 2651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  687 GSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAiktegkPAEVKKMTAKSVPADLSR---PKSTSTSSMKKTTTLS 763
Cdd:PHA03247  2652 PRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAA------RPTVGSLTSLADPPPPPPtpePAPHALVSATPLPPGP 2725

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1862722898  764 GTAPAAGVVPSRVKATPMPSRPSTTPFIDKKP-----TSAKPSSTTPR 806
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARParpptTAGPPAPAPPA 2773
PHA03247 PHA03247
large tegument protein UL36; Provisional
 508-813 3.93e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  508 VPALKTEAPLAKDGVLTLANNVTPAKdvPPLSETEATPVPIKDMEIAQTQKGisedshleslqdvgqSAAPTfmisPETV 587
Cdd:PHA03247  2716 VSATPLPPGPAAARQASPALPAAPAP--PAVPAGPATPGGPARPARPPTTAG---------------PPAPA----PPAA 2774

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  588 TGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETSG--IARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPIAD 665
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLApaAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  666 AKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADL 745
Cdd:PHA03247  2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  746 SRPKSTS----TSSMKKTTTLSGTAPA---AGVVPSRVKAT------PMPSRPSTTPfidkkPTSAKPSSTTPRLSRLAT 812
Cdd:PHA03247  2935 PPPRPQPplapTTDPAGAGEPSGAVPQpwlGALVPGRVAVPrfrvpqPAPSREAPAS-----STPPLTGHSLSRVSSWAS 3009


                   .
gi 1862722898  813 N 813
Cdd:PHA03247  3010 S 3010
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 651-800 4.77e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 4.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  651 ELPPSPEKKTKPI---ADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSPStlLPKKPT 722
Cdd:PTZ00449   509 EPPEGPEASGLPPkapGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKPE--FPKDPK 586

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  723 AIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--PFIDKKPTSA 798
Cdd:PTZ00449   587 HPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiIKSPKPPKSP 663


                   ..
gi 1862722898  799 KP 800
Cdd:PTZ00449   664 KP 665
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 532-830 7.87e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 7.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  532 AKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERK 611
Cdd:PHA03307    15 AEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLST 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  612 PCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPIADAKAPEKRASPSKPASAPASRSGSkST 691
Cdd:PHA03307    95 LAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQ-AA 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  692 QTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTA----- 766
Cdd:PHA03307   174 LPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpen 253

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862722898  767 ------PAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTE 830
Cdd:PHA03307   254 ecplprPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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