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Conserved domains on  [gi|1860596405|ref|NP_001371539|]
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SLIT and NTRK-like protein 5 precursor [Homo sapiens]

Protein Classification

SLIT and NTRK-like protein 5( domain architecture ID 17599378)

SLIT and NTRK-like protein 5 (SLITRK5) suppresses neurite outgrowth

Gene Symbol:  SLITRK5
Gene Ontology:  GO:0005515|GO:0007409
PubMed:  14747988|11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-235 9.32e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  86 LLLSGNLLNRLyPNEFVNYTGASILHLGSNVIQDIETgAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNYI 165
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 166 SVIePNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYvglLQHMDKVVELQLEEN 235
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
433-493 7.72e-15

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 7.72e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1860596405 433 TGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
412-563 8.12e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 8.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 412 KKMYLTENYIAVVRrTDFLEATGLDLLHLGNNRISMIqDRAFGDLTNLRRLYLNGNRIERLSPELfYGLQSLQYLFLQYN 491
Cdd:COG4886   139 KELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1860596405 492 LIREIqsgtfdpvpnlqllflnnnllqampSGVFSGLTLLR-LNLRSNHFTSLPvsgVLDQLKSLIQIDLHDN 563
Cdd:COG4886   216 QLTDL-------------------------PEPLANLTNLEtLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
235-273 1.43e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1860596405  235 NPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGR 273
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
563-599 1.00e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1860596405  563 NPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFA 599
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLR 37
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-235 9.32e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  86 LLLSGNLLNRLyPNEFVNYTGASILHLGSNVIQDIETgAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNYI 165
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 166 SVIePNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYvglLQHMDKVVELQLEEN 235
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
129-189 5.88e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 5.88e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1860596405 129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLL 189
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
433-493 7.72e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 7.72e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1860596405 433 TGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
412-563 8.12e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 8.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 412 KKMYLTENYIAVVRrTDFLEATGLDLLHLGNNRISMIqDRAFGDLTNLRRLYLNGNRIERLSPELfYGLQSLQYLFLQYN 491
Cdd:COG4886   139 KELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1860596405 492 LIREIqsgtfdpvpnlqllflnnnllqampSGVFSGLTLLR-LNLRSNHFTSLPvsgVLDQLKSLIQIDLHDN 563
Cdd:COG4886   216 QLTDL-------------------------PEPLANLTNLEtLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 391-563 1.84e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 391 VNCQERKIESIAELQPKPyNPKKMYLTENYIAVVRRTDFLeaTGLDLLHLGNNRISMIQDraFGDLTNLRRLYLNGNRIE 470
Cdd:cd21340     7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 471 RLspELFYGLQSLQYLFLQYNLIREIQSGTFDPvpnlqllflnnnllqampsgvFSGLTLLR----LNLRSNHFTSLpvs 546
Cdd:cd21340    82 VV--EGLENLTNLEELHIENQRLPPGEKLTFDP---------------------RSLAALSNslrvLNISGNNIDSL--- 135

                         170
                  ....*....|....*..
gi 1860596405 547 GVLDQLKSLIQIDLHDN 563
Cdd:cd21340   136 EPLAPLRNLEQLDASNN 152
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-236 3.08e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 3.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  85 HLLLSGNLLNRLypNEFVNYTGASILHLGSNVIQDIEtgAFHGLRGLRRLHLNNNKLELLRDdtFLGLENLEYLQVDYNY 164
Cdd:cd21340     6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 165 ISVIE----PNAFGKLHL------------------------LQVLILNDNLLSSLpNNLFRFVPLTHLDLRGNRLKLLP 216
Cdd:cd21340    80 ISVVEglenLTNLEELHIenqrlppgekltfdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLE 158

                         170       180
                  ....*....|....*....|.
gi 1860596405 217 YV-GLLQHMDKVVELQLEENP 236
Cdd:cd21340   159 ELlDLLSSWPSLRELDLTGNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
235-273 1.43e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1860596405  235 NPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGR 273
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-212 1.31e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  86 LLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
Cdd:PLN00113  169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL 248

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1860596405 166 SVIEPNAFGKLHLLQVLILNDNLLS-SLPNNLFRFVPLTHLDLRGNRL 212
Cdd:PLN00113  249 TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 381-495 2.36e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 381 NLQISDLGLNvNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEA----TGLDLLHLGNNRISMIQDRAFGDL 456
Cdd:COG5238   181 SVETVYLGCN-QIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAlkgnKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1860596405 457 ----TNLRRLYLNGNRIE----RLSPELFYGLQSLQYLFLQYNLIRE 495
Cdd:COG5238   260 lknnTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGD 306
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-599 1.00e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1860596405  563 NPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFA 599
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLR 37
LRR smart00370
Leucine-rich repeats, outliers;
456-479 3.37e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 3.37e-03
                           10        20
                   ....*....|....*....|....
gi 1860596405  456 LTNLRRLYLNGNRIERLSPELFYG 479
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-235 9.32e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  86 LLLSGNLLNRLyPNEFVNYTGASILHLGSNVIQDIETgAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNYI 165
Cdd:COG4886   118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 166 SVIePNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYvglLQHMDKVVELQLEEN 235
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-236 4.03e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 4.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  85 HLLLSGNLLNRLyPNEFVNYTGASILHLGSNVIQDIeTGAFHGLRGLRRLHLNNNKLELLrDDTFLGLENLEYLQVDYNY 164
Cdd:COG4886   140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1860596405 165 ISVIePNAFGKLHLLQVLILNDNLLSSLPNnLFRFVPLTHLDLRGNRLKLLPyvgLLQHMDKVVELQLEENP 236
Cdd:COG4886   217 LTDL-PEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
129-189 5.88e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 5.88e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1860596405 129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLL 189
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
433-493 7.72e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 7.72e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1860596405 433 TGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
412-563 8.12e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 8.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 412 KKMYLTENYIAVVRrTDFLEATGLDLLHLGNNRISMIqDRAFGDLTNLRRLYLNGNRIERLSPELfYGLQSLQYLFLQYN 491
Cdd:COG4886   139 KELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1860596405 492 LIREIqsgtfdpvpnlqllflnnnllqampSGVFSGLTLLR-LNLRSNHFTSLPvsgVLDQLKSLIQIDLHDN 563
Cdd:COG4886   216 QLTDL-------------------------PEPLANLTNLEtLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
109-165 2.84e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 2.84e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1860596405 109 ILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 391-563 1.84e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 391 VNCQERKIESIAELQPKPyNPKKMYLTENYIAVVRRTDFLeaTGLDLLHLGNNRISMIQDraFGDLTNLRRLYLNGNRIE 470
Cdd:cd21340     7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 471 RLspELFYGLQSLQYLFLQYNLIREIQSGTFDPvpnlqllflnnnllqampsgvFSGLTLLR----LNLRSNHFTSLpvs 546
Cdd:cd21340    82 VV--EGLENLTNLEELHIENQRLPPGEKLTFDP---------------------RSLAALSNslrvLNISGNNIDSL--- 135

                         170
                  ....*....|....*..
gi 1860596405 547 GVLDQLKSLIQIDLHDN 563
Cdd:cd21340   136 EPLAPLRNLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
154-212 5.76e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 5.76e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 154 NLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP-LTHLDLRGNRL 212
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
457-540 3.48e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 3.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 457 TNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIqsgtfdpvpnlqllflnnnllqamPSGVFSGLTLLR-LNL 535
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTL------------------------SPGAFSGLPSLRyLDL 56


                  ....*
gi 1860596405 536 RSNHF 540
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
412-469 2.79e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.79e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1860596405 412 KKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRI 469
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-236 3.08e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 3.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  85 HLLLSGNLLNRLypNEFVNYTGASILHLGSNVIQDIEtgAFHGLRGLRRLHLNNNKLELLRDdtFLGLENLEYLQVDYNY 164
Cdd:cd21340     6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 165 ISVIE----PNAFGKLHL------------------------LQVLILNDNLLSSLpNNLFRFVPLTHLDLRGNRLKLLP 216
Cdd:cd21340    80 ISVVEglenLTNLEELHIenqrlppgekltfdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLE 158

                         170       180
                  ....*....|....*....|.
gi 1860596405 217 YV-GLLQHMDKVVELQLEENP 236
Cdd:cd21340   159 ELlDLLSSWPSLRELDLTGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-235 4.23e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 4.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  86 LLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNyi 165
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 166 sviepNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVglLQHMDKVVELQLEEN 235
Cdd:COG4886   107 -----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNN 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-217 8.86e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 8.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  85 HLLLSGNLLNRLyPNEFVNYTGASILHLGSNVIQDIEtgAFHGLRGLRRLHLNNNKLELLrdDTFLGLENLEYLQVDYNY 164
Cdd:COG4886   209 ELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQ 283

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1860596405 165 ISVIEPNAFGKLHLLQVLILNDNLLSSLpNNLFRFVPLTHLDLRGNRLKLLPY 217
Cdd:COG4886   284 LTDLKLKELELLLGLNSLLLLLLLLNLL-ELLILLLLLTTLLLLLLLLKGLLV 335
LRRCT smart00082
Leucine rich repeat C-terminal domain;
235-273 1.43e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1860596405  235 NPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGR 273
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-496 8.40e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 8.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  66 ENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDI-ETGAFHGLRGLRRLHLNNNKLELL 144
Cdd:COG4886    49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLsGNEELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 145 rDDTFLGLENLEYLQVDYNYISVIePNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVglLQHM 224
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 225 DKVVELQLEENpwncscELISLKDWLDSISysalvgdvvcetpfrlhgrdldevskqelcprrlisdyemrpqtplsttg 304
Cdd:COG4886   205 TNLEELDLSGN------QLTDLPEPLANLT-------------------------------------------------- 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 305 ylhttpasvnsvatsssavykpplkppkgtrqpnkprvrptsrqpskdlgysnygpsiayqtkspvplecptacscNLQI 384
Cdd:COG4886   229 ----------------------------------------------------------------------------NLET 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 385 SDLGLNvncqerKIESIAELQpkpynpkkmyltenyiavvrrtdflEATGLDLLHLGNNRISMIqdRAFGDLTNLRRLYL 464
Cdd:COG4886   233 LDLSNN------QLTDLPELG-------------------------NLTNLEELDLSNNQLTDL--PPLANLTNLKTLDL 279

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1860596405 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREI 496
Cdd:COG4886   280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-212 1.31e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  86 LLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
Cdd:PLN00113  169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL 248

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1860596405 166 SVIEPNAFGKLHLLQVLILNDNLLS-SLPNNLFRFVPLTHLDLRGNRL 212
Cdd:PLN00113  249 TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 381-495 2.36e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 381 NLQISDLGLNvNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEA----TGLDLLHLGNNRISMIQDRAFGDL 456
Cdd:COG5238   181 SVETVYLGCN-QIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAlkgnKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1860596405 457 ----TNLRRLYLNGNRIE----RLSPELFYGLQSLQYLFLQYNLIRE 495
Cdd:COG5238   260 lknnTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGD 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
433-510 3.31e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 3.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1860596405 433 TGLDLLHLGNNRISMIqDRAFGDLTNLRRLYLNGNRIERLsPELFyGLQSLQYLFLQYNLIREIqsGTFDPVPNLQLL 510
Cdd:COG4886   205 TNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL-PELG-NLTNLEELDLSNNQLTDL--PPLANLTNLKTL 277
LRR_8 pfam13855
Leucine rich repeat;
179-236 4.10e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 4.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1860596405 179 LQVLILNDNLLSSLPNNLFRFVP-LTHLDLRGNRLKLLPYvGLLQHMDKVVELQLEENP 236
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
430-563 5.28e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 5.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405 430 LEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNrierlspELFYGLQSLQYLFLQYNLIREIqsgtfdpvPNLql 509
Cdd:COG4886    69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL--------PEE-- 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1860596405 510 lflnnnllqampsgvFSGLTLLR-LNLRSNHFTSLPVSgvLDQLKSLIQIDLHDN 563
Cdd:COG4886   132 ---------------LANLTNLKeLDLSNNQLTDLPEP--LGNLTNLKSLDLSNN 169
LRRCT smart00082
Leucine rich repeat C-terminal domain;
563-599 1.00e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1860596405  563 NPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFA 599
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLR 37
PLN03150 PLN03150
hypothetical protein; Provisional
 128-190 1.49e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 1.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1860596405 128 LRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLS 190
Cdd:PLN03150  441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 457-497 1.75e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1860596405 457 TNLRRLYLNGNRIERLSPelFYGLQSLQYLFLQYN-LIREIQ 497
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNnKITDLS 40
LRR smart00370
Leucine-rich repeats, outliers;
456-479 3.37e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 3.37e-03
                           10        20
                   ....*....|....*....|....
gi 1860596405  456 LTNLRRLYLNGNRIERLSPELFYG 479
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
456-479 3.37e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 3.37e-03
                           10        20
                   ....*....|....*....|....
gi 1860596405  456 LTNLRRLYLNGNRIERLSPELFYG 479
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 433-474 4.17e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 4.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1860596405 433 TGLDLLHLGNNRISMIQdrAFGDLTNLRRLYLNGN-RIERLSP 474
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNnKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-212 4.72e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860596405  85 HLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNY 164
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1860596405 165 ISVIEPNAFGKLHLLQVLILNDNLLS-SLPNNLFRFVPLTHLDLRGNRL 212
Cdd:PLN00113  320 FTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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