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Conserved domains on  [gi|1859877177|ref|NP_001371429|]
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interferon alpha/beta receptor 1 isoform 4 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414172)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 80-176 8.85e-17

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 74.30  E-value: 8.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877177  80 PPVFNIRSLSDSFHIYIGAPKQSGNTPVI--QDYP-LIYEIIFWENTSNAERK-IIEKKTDVTVPNLKPLTVYCVKARAH 155
Cdd:pfam09294   5 PPEVELEVEGGSLNVTVKDPETREGKNLSlrDLYGsLQYRVSYWKNSSNGEKKnTTSTNSFVVLSDLEPGTTYCVSVQAF 84

                          90       100
                  ....*....|....*....|.
gi 1859877177 156 TMdeKLNKSSVFSDAVCEKTK 176
Cdd:pfam09294  85 SP--LDNKSSQRSPPQCIRTT 103
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 22-64 1.93e-03

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 37.36  E-value: 1.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1859877177  22 KWKQIPDCENVKTTQC---VFPQNVFQKgiYLLRVQASDGNNTSFW 64
Cdd:pfam01108  64 DWKNVPNCTNITRTECdltDETSDLTET--YYARVRAVSGGGTSSW 107
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 80-176 8.85e-17

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 74.30  E-value: 8.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877177  80 PPVFNIRSLSDSFHIYIGAPKQSGNTPVI--QDYP-LIYEIIFWENTSNAERK-IIEKKTDVTVPNLKPLTVYCVKARAH 155
Cdd:pfam09294   5 PPEVELEVEGGSLNVTVKDPETREGKNLSlrDLYGsLQYRVSYWKNSSNGEKKnTTSTNSFVVLSDLEPGTTYCVSVQAF 84

                          90       100
                  ....*....|....*....|.
gi 1859877177 156 TMdeKLNKSSVFSDAVCEKTK 176
Cdd:pfam09294  85 SP--LDNKSSQRSPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 22-64 1.93e-03

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 37.36  E-value: 1.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1859877177  22 KWKQIPDCENVKTTQC---VFPQNVFQKgiYLLRVQASDGNNTSFW 64
Cdd:pfam01108  64 DWKNVPNCTNITRTECdltDETSDLTET--YYARVRAVSGGGTSSW 107
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 80-176 8.85e-17

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 74.30  E-value: 8.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877177  80 PPVFNIRSLSDSFHIYIGAPKQSGNTPVI--QDYP-LIYEIIFWENTSNAERK-IIEKKTDVTVPNLKPLTVYCVKARAH 155
Cdd:pfam09294   5 PPEVELEVEGGSLNVTVKDPETREGKNLSlrDLYGsLQYRVSYWKNSSNGEKKnTTSTNSFVVLSDLEPGTTYCVSVQAF 84

                          90       100
                  ....*....|....*....|.
gi 1859877177 156 TMdeKLNKSSVFSDAVCEKTK 176
Cdd:pfam09294  85 SP--LDNKSSQRSPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 22-64 1.93e-03

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 37.36  E-value: 1.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1859877177  22 KWKQIPDCENVKTTQC---VFPQNVFQKgiYLLRVQASDGNNTSFW 64
Cdd:pfam01108  64 DWKNVPNCTNITRTECdltDETSDLTET--YYARVRAVSGGGTSSW 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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