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Conserved domains on  [gi|1858589213|ref|NP_001371277|]
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mitochondrial ribosome-associated GTPase 2 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Obg_CgtA super family cl37158
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome ...
 72-271 3.14e-60

Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal. [Protein synthesis, Other]


The actual alignment was detected with superfamily member TIGR02729:

Pssm-ID: 274271 [Multi-domain]  Cd Length: 328  Bit Score: 195.72  E-value: 3.14e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLSSVlsRYQGF----SGEDGGSKNCFG 147
Cdd:TIGR02729   1 FVDEAKIFVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGSVILEADENLNTLLDF--RYQRHfkaeNGENGMGKNRTG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVA 225
Cdd:TIGR02729  79 KSGEDLVIKVPVGTVVYdaDTGELLADLTEPGQRFLVAKGGRGGLGNAHFKSSTNRAPRFATPGEPGEERWLRLELKLLA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGH 271
Cdd:TIGR02729 159 DVGLVGLPNAGKSTLISAVSAAKPKIADYPFTTLVPNLGVVRVDDG 204
 
Name Accession Description Interval E-value
Obg_CgtA TIGR02729
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome ...
 72-271 3.14e-60

Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal. [Protein synthesis, Other]


Pssm-ID: 274271 [Multi-domain]  Cd Length: 328  Bit Score: 195.72  E-value: 3.14e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLSSVlsRYQGF----SGEDGGSKNCFG 147
Cdd:TIGR02729   1 FVDEAKIFVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGSVILEADENLNTLLDF--RYQRHfkaeNGENGMGKNRTG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVA 225
Cdd:TIGR02729  79 KSGEDLVIKVPVGTVVYdaDTGELLADLTEPGQRFLVAKGGRGGLGNAHFKSSTNRAPRFATPGEPGEERWLRLELKLLA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGH 271
Cdd:TIGR02729 159 DVGLVGLPNAGKSTLISAVSAAKPKIADYPFTTLVPNLGVVRVDDG 204
Obg COG0536
GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, ...
 72-297 1.95e-58

GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];


Pssm-ID: 440302 [Multi-domain]  Cd Length: 343  Bit Score: 191.35  E-value: 1.95e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFggpdggdggnggHVILRVDQQVKSLSSVlsRYQGF----SGEDGGSKNCFG 147
Cdd:COG0536     1 FVDEAKIYVKAGDGGNGCVSFRREKYVPKggpdggdggrggDVILVADENLNTLLDF--RYKRHfkaeNGENGMGKNRTG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIaalggaggkgNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVA 225
Cdd:COG0536    79 KNGEDLVIKVPVGTVVKdaETGEVLADLTEDGQRVVvakggrgglgNAHFKSSTNRAPRFAEPGEPGEERWLRLELKLLA 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGhlqiagrHKGFCgVA--PGLtaliIPGFH 297
Cdd:COG0536   159 DVGLVGLPNAGKSTLLSAVSAAKPKIADYPFTTLVPNLGVVRVGD-------GRSFV-IAdiPGL----IEGAS 220
obgE PRK12299
GTPase CgtA; Reviewed
 72-269 2.60e-56

GTPase CgtA; Reviewed


Pssm-ID: 237048 [Multi-domain]  Cd Length: 335  Bit Score: 185.66  E-value: 2.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFggpdggdggnggHVILRVDQQVKSLSSVlsRYQGF----SGEDGGSKNCFG 147
Cdd:PRK12299    2 FIDEAKIYVKAGDGGNGCVSFRREKFIPFggpdggdggrggSVILEADENLNTLIDF--RYKRHfkaeNGENGMGRNRTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVA 225
Cdd:PRK12299   80 KSGKDLVLKVPVGTQIYdaDTGELIADLTEHGQRFLVAKGGKGGLGNAHFKSSTNRAPRYATPGEPGEERWLRLELKLLA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYE 269
Cdd:PRK12299  160 DVGLVGLPNAGKSTLISAVSAAKPKIADYPFTTLHPNLGVVRVD 203
GTP1_OBG pfam01018
GTP1/OBG; The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three ...
 73-223 2.62e-33

GTP1/OBG; The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.


Pssm-ID: 460027 [Multi-domain]  Cd Length: 155  Bit Score: 120.14  E-value: 2.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  73 VDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLSSVLSR--YQGFSGEDGGSKNCFGRSG 150
Cdd:pfam01018   1 VDRAKIKVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGDVILVADENLNTLLDFRYKrhFKAENGENGGGKNCHGKNG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1858589213 151 AVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKT 223
Cdd:pfam01018  81 EDLIIKVPVGTVVKdaETGEVLADLTEPGQRVLVAKGGRGGRGNAHFKTSTNQAPRFAEPGEPGEERWLELELKL 155
Obg cd01898
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ...
 225-300 9.41e-27

Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.


Pssm-ID: 206685 [Multi-domain]  Cd Length: 170  Bit Score: 103.66  E-value: 9.41e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1858589213 225 AHAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGHLQIAgrhkgfcgVA--PGltalIIPGFHLDA 300
Cdd:cd01898     1 ADVGLVGLPNAGKSTLLSAISNAKPKIADYPFTTLVPNLGVVRVDDGRSFV--------IAdiPG----LIEGASEGK 66
 
Name Accession Description Interval E-value
Obg_CgtA TIGR02729
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome ...
 72-271 3.14e-60

Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal. [Protein synthesis, Other]


Pssm-ID: 274271 [Multi-domain]  Cd Length: 328  Bit Score: 195.72  E-value: 3.14e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLSSVlsRYQGF----SGEDGGSKNCFG 147
Cdd:TIGR02729   1 FVDEAKIFVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGSVILEADENLNTLLDF--RYQRHfkaeNGENGMGKNRTG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVA 225
Cdd:TIGR02729  79 KSGEDLVIKVPVGTVVYdaDTGELLADLTEPGQRFLVAKGGRGGLGNAHFKSSTNRAPRFATPGEPGEERWLRLELKLLA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGH 271
Cdd:TIGR02729 159 DVGLVGLPNAGKSTLISAVSAAKPKIADYPFTTLVPNLGVVRVDDG 204
Obg COG0536
GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, ...
 72-297 1.95e-58

GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];


Pssm-ID: 440302 [Multi-domain]  Cd Length: 343  Bit Score: 191.35  E-value: 1.95e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFggpdggdggnggHVILRVDQQVKSLSSVlsRYQGF----SGEDGGSKNCFG 147
Cdd:COG0536     1 FVDEAKIYVKAGDGGNGCVSFRREKYVPKggpdggdggrggDVILVADENLNTLLDF--RYKRHfkaeNGENGMGKNRTG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIaalggaggkgNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVA 225
Cdd:COG0536    79 KNGEDLVIKVPVGTVVKdaETGEVLADLTEDGQRVVvakggrgglgNAHFKSSTNRAPRFAEPGEPGEERWLRLELKLLA 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGhlqiagrHKGFCgVA--PGLtaliIPGFH 297
Cdd:COG0536   159 DVGLVGLPNAGKSTLLSAVSAAKPKIADYPFTTLVPNLGVVRVGD-------GRSFV-IAdiPGL----IEGAS 220
obgE PRK12299
GTPase CgtA; Reviewed
 72-269 2.60e-56

GTPase CgtA; Reviewed


Pssm-ID: 237048 [Multi-domain]  Cd Length: 335  Bit Score: 185.66  E-value: 2.60e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFggpdggdggnggHVILRVDQQVKSLSSVlsRYQGF----SGEDGGSKNCFG 147
Cdd:PRK12299    2 FIDEAKIYVKAGDGGNGCVSFRREKFIPFggpdggdggrggSVILEADENLNTLIDF--RYKRHfkaeNGENGMGRNRTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVA 225
Cdd:PRK12299   80 KSGKDLVLKVPVGTQIYdaDTGELIADLTEHGQRFLVAKGGKGGLGNAHFKSSTNRAPRYATPGEPGEERWLRLELKLLA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYE 269
Cdd:PRK12299  160 DVGLVGLPNAGKSTLISAVSAAKPKIADYPFTTLHPNLGVVRVD 203
obgE PRK12297
GTPase CgtA; Reviewed
 72-270 1.12e-52

GTPase CgtA; Reviewed


Pssm-ID: 237046 [Multi-domain]  Cd Length: 424  Bit Score: 178.76  E-value: 1.12e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSE---PR---------KefggpdggdggnGGHVILRVDQQVKSLSSVlsRYQGF---- 135
Cdd:PRK12297    2 FIDQAKIYVKAGDGGDGMVSFRREkyvPKggpdggdggK------------GGSVIFVADEGLRTLLDF--RYKRHfkae 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 136 SGEDGGSKNCFGRSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQ 213
Cdd:PRK12297   68 NGENGMGKNMHGRNGEDLIIKVPVGTVVKdaETGEVIADLVEPGQEVVVAKGGRGGRGNAHFATSTNQAPRIAENGEPGE 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1858589213 214 QRVLHLELKTVAHAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEG 270
Cdd:PRK12297  148 ERELRLELKLLADVGLVGFPNVGKSTLLSVVSNAKPKIANYHFTTLVPNLGVVETDD 204
obgE PRK12298
GTPase CgtA; Reviewed
 72-288 2.65e-50

GTPase CgtA; Reviewed


Pssm-ID: 237047 [Multi-domain]  Cd Length: 390  Bit Score: 171.59  E-value: 2.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLssVLSRYQGF----SGEDGGSKNCFG 147
Cdd:PRK12298    3 FVDEAKIRVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLEADENLNTL--IDYRFERHfraeRGQNGQGRDCTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVA 225
Cdd:PRK12298   81 KRGKDITIKVPVGTRVIdaDTGEVIGDLTEHGQRLLVAKGGWHGLGNTRFKSSVNRAPRQKTPGTPGEERELKLELKLLA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYeghlqiaGRHKGFCgVA--PGL 288
Cdd:PRK12298  161 DVGLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVRV-------DDERSFV-VAdiPGL 217
obgE PRK12296
GTPase CgtA; Reviewed
 72-266 4.70e-37

GTPase CgtA; Reviewed


Pssm-ID: 237045 [Multi-domain]  Cd Length: 500  Bit Score: 138.46  E-value: 4.70e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  72 FVDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLssVLSRYQGF----SGEDGGSKNCFG 147
Cdd:PRK12296    4 FVDRVVLHVKAGDGGNGCASVHREKFKPLGGPDGGNGGRGGSVVLVVDPQVTTL--LDFHFRPHrkatNGKPGMGDNRDG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213 148 RSGAVLYIRVPVGTLVK-EGGRVVADLSCVGDEYIAALGGAGGKGNRFfLANNNR-APVTCTPGQPGQQRVLHLELKTVA 225
Cdd:PRK12296   82 AAGEDLVLPVPDGTVVLdEDGEVLADLVGAGTRFVAAAGGRGGLGNAA-LASKARkAPGFALLGEPGEERDLVLELKSVA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIV 266
Cdd:PRK12296  161 DVGLVGFPSAGKSSLISALSAAKPKIADYPFTTLVPNLGVV 201
GTP1_OBG pfam01018
GTP1/OBG; The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three ...
 73-223 2.62e-33

GTP1/OBG; The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.


Pssm-ID: 460027 [Multi-domain]  Cd Length: 155  Bit Score: 120.14  E-value: 2.62e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589213  73 VDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVKSLSSVLSR--YQGFSGEDGGSKNCFGRSG 150
Cdd:pfam01018   1 VDRAKIKVKAGDGGNGCVSFRREKYVPKGGPDGGDGGRGGDVILVADENLNTLLDFRYKrhFKAENGENGGGKNCHGKNG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1858589213 151 AVLYIRVPVGTLVK--EGGRVVADLSCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKT 223
Cdd:pfam01018  81 EDLIIKVPVGTVVKdaETGEVLADLTEPGQRVLVAKGGRGGRGNAHFKTSTNQAPRFAEPGEPGEERWLELELKL 155
Obg cd01898
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ...
 225-300 9.41e-27

Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.


Pssm-ID: 206685 [Multi-domain]  Cd Length: 170  Bit Score: 103.66  E-value: 9.41e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1858589213 225 AHAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGHLQIAgrhkgfcgVA--PGltalIIPGFHLDA 300
Cdd:cd01898     1 ADVGLVGLPNAGKSTLLSAISNAKPKIADYPFTTLVPNLGVVRVDDGRSFV--------IAdiPG----LIEGASEGK 66
Rbg1 COG1163
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];
223-274 6.40e-15

Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440777 [Multi-domain]  Cd Length: 368  Bit Score: 74.45  E-value: 6.40e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1858589213 223 TVAhagMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEG-HLQI 274
Cdd:COG1163    65 TVV---LVGFPSVGKSTLLNKLTNAKSEVGAYEFTTLDVVPGMLEYKGaKIQI 114
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 226-271 3.81e-14

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 67.64  E-value: 3.81e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1858589213 226 HAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGH 271
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSDYPGTTRDPNEGRLELKGK 46
Nog1 COG1084
GTP-binding protein, GTP1/Obg family [General function prediction only];
220-274 7.98e-14

GTP-binding protein, GTP1/Obg family [General function prediction only];


Pssm-ID: 440701 [Multi-domain]  Cd Length: 330  Bit Score: 71.02  E-value: 7.98e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1858589213 220 ELKTVAHAGMvgfPNAGKSSLLRAISNARPAVASYPFTTLKPHVGivHYE-GHLQI 274
Cdd:COG1084   159 DLPTIVVAGY---PNVGKSSLVSKVTSAKPEIASYPFTTKGIIVG--HFErGHGRY 209
DRG cd01896
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding ...
 225-270 8.92e-14

Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding.


Pssm-ID: 206683 [Multi-domain]  Cd Length: 233  Bit Score: 69.50  E-value: 8.92e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1858589213 225 AHAGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEG 270
Cdd:cd01896     1 ARVALVGFPSVGKSTLLSKLTNTKSEVAAYEFTTLTCVPGVMEYKG 46
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 231-269 5.11e-12

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 63.35  E-value: 5.11e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1858589213 231 GFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGivHYE 269
Cdd:cd01897     7 GYPNVGKSSLVNKLTRAKPEVAPYPFTTKSLFVG--HFD 43
Obg_like cd01881
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ...
 228-268 7.10e-12

Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.


Pssm-ID: 206668 [Multi-domain]  Cd Length: 167  Bit Score: 62.80  E-value: 7.10e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1858589213 228 GMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHY 268
Cdd:cd01881     1 GLVGLPNVGKSTLLSALTSAKVEIASYPFTTLEPNVGVFEF 41
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 227-266 3.07e-10

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 60.42  E-value: 3.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1858589213 227 AGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIV 266
Cdd:COG0012     3 CGIVGLPNVGKSTLFNALTKAGAEAANYPFCTIEPNVGVV 42
YchF cd01900
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of ...
 227-266 1.22e-09

YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated with the ribosome. Several members of the family, including YchF, possess the TGS domain related to the RNA-binding proteins. Experimental data and genomic analysis suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translational factor.


Pssm-ID: 206687 [Multi-domain]  Cd Length: 274  Bit Score: 58.24  E-value: 1.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1858589213 227 AGMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIV 266
Cdd:cd01900     1 IGIVGLPNVGKSTLFNALTKSNAEAANYPFCTIEPNVGIV 40
Ygr210 cd01899
Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They ...
 228-268 1.11e-08

Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.


Pssm-ID: 206686 [Multi-domain]  Cd Length: 318  Bit Score: 55.70  E-value: 1.11e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1858589213 228 GMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHY 268
Cdd:cd01899     2 GLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVGYV 42
PRK09602 PRK09602
translation-associated GTPase; Reviewed
 228-267 1.93e-07

translation-associated GTPase; Reviewed


Pssm-ID: 236584 [Multi-domain]  Cd Length: 396  Bit Score: 52.12  E-value: 1.93e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1858589213 228 GMVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVH 267
Cdd:PRK09602    5 GLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVAY 44
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 228-261 5.23e-05

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 43.00  E-value: 5.23e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1858589213 228 GMVGFPNAGKSSLLRAISNARPA-VASYPFTTLKP 261
Cdd:cd00880     1 AIFGRPNVGKSSLLNALLGQNVGiVSPIPGTTRDP 35
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 228-266 2.03e-04

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 42.63  E-value: 2.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1858589213 228 GMVGFPNAGKSSLLRAISN-ARPAvASYPFTTLKPHVGIV 266
Cdd:PTZ00258   25 GIVGLPNVGKSTTFNALCKqQVPA-ENFPFCTIDPNTARV 63
HflX cd01878
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ...
 213-261 7.29e-04

HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.


Pssm-ID: 206666 [Multi-domain]  Cd Length: 204  Bit Score: 40.14  E-value: 7.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1858589213 213 QQRVLHL------ELKTVAhagMVGFPNAGKSSLLRAISNARPAVASYPFTTLKP 261
Cdd:cd01878    27 KQRELQRarrkrsGVPTVA---LVGYTNAGKSTLFNALTGADVLAEDQLFATLDP 78
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 229-271 8.25e-04

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 39.36  E-value: 8.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1858589213 229 MVGFPNAGKSSLLRAISNARPAVASYPFTTLKPHVGIVHYEGH 271
Cdd:cd01879     2 LVGNPNVGKTTLFNALTGARQKVGNWPGVTVEKKEGEFKLGGK 44
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 228-263 1.09e-03

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 38.90  E-value: 1.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1858589213 228 GMVGFPNAGKSSLLRAISNARPAVASY--PFTTLKPHV 263
Cdd:cd01849    95 GVVGLPNVGKSSFINALLNKFKLKVGSipGTTKLQQDV 132
HSR1_MMR1 cd01857
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ...
 225-263 3.55e-03

A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.


Pssm-ID: 206750 [Multi-domain]  Cd Length: 140  Bit Score: 37.21  E-value: 3.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1858589213 225 AHAGMVGFPNAGKSSLLRAISNA-RPAVASYP-----FTT--LKPHV 263
Cdd:cd01857    83 ATIGLVGYPNVGKSSLINALVGSkKVSVSSTPgktkhFQTifLEPGI 129
HflX COG2262
50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]; ...
 213-261 5.39e-03

50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441863 [Multi-domain]  Cd Length: 419  Bit Score: 38.14  E-value: 5.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1858589213 213 QQRVLH------LELKTVAhagMVGFPNAGKSSLLRAISNARPAVASYPFTTLKP 261
Cdd:COG2262   185 KQRELQrkrrkrSGIPTVA---LVGYTNAGKSTLFNRLTGADVLAEDKLFATLDP 236
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 230-272 6.28e-03

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 36.67  E-value: 6.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1858589213 230 VGFPNAGKSSLLRAISNA-RPAVASYPFTTLKPHVGIVHYEGHL 272
Cdd:cd00882     3 VGRGGVGKSSLLNALLGGeVGEVSDVPGTTRDPDVYVKELDKGK 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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