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Conserved domains on  [gi|1852860117|ref|NP_001371182|]
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patched domain-containing protein 4 isoform 3 [Homo sapiens]

Protein Classification

patched/dispatched family protein( domain architecture ID 1904021)

patched/dispatched family protein may be involved in hedgehog (Hh) signaling, similar to Drosophila melanogaster proteins patched and dispatched, that acts as a receptor for Hh and a regulator of Hh trafficking, respectively

Gene Ontology:  GO:0007165|GO:0016020
PubMed:  36932157|21778405

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Patched super family cl44384
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
145-809 1.38e-77

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


The actual alignment was detected with superfamily member pfam02460:

Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 267.68  E-value: 1.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 145 FIGHQLGGVVEVPNSKdqrVKSARAIQITYYLQtYGSATQDLIGEKWENEFCKLIRKlQEEHQELQLYSLASFSLWRDFH 224
Cdd:pfam02460 135 YLGPHFGGVDFEPPGN---ISYAKAIVLWYFLK-FDEEEVEEDSKEWEDELSQLLHN-KYASEHIQFTIFHDQILNDELV 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 225 KTSILARSKVLVSLVL-----ILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAM 299
Cdd:pfam02460 210 RNALTLTPFFVIGFFLlltfsIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVL 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 300 GHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGAspFTNIEAVKVFCQNMCVSILLNYFYI 379
Cdd:pfam02460 290 AIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGT--YTPTPAIQLFCAYTAVAIFFDFIYQ 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 380 FSFFGSCLVFAGQLEQNRYHSIFCCKipsaeyldrkPVWFQTVMSDGHQQTSHHETNPyqhhFIQHFLREHYNEWITNIY 459
Cdd:pfam02460 368 ITFFAAIMAICAKPEAEGRHCLFVWA----------TSSPQRIDSEGSEPDKSHNIEQ----LKSRFFLDIYCPFLLNPS 433
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 460 VKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLC 539
Cdd:pfam02460 434 VRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMV 513
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 540 SGFTAVS----------WVEQYYQFLKVSNVSANN--KSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDEsnIIASRLYL 607
Cdd:pfam02460 514 DEFENTPyslgpnstlfWLREYENFLSTLNMEEEEdeEKEWSYGNLPSFLKAPGNSHWAGDLVWDDNTTM--VTKFRFTL 591
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 608 VARTSRDKQ------KEITEVLEKLRPLSLSksirfiVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLG 681
Cdd:pfam02460 592 AGKGLSTWNdrtralQEWRSIADQYPEFNVT------VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPC 665
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 682 NFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVT 761
Cdd:pfam02460 666 VFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGL 745
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 1852860117 762 SFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPP 809
Cdd:pfam02460 746 STILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLFVT 793
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
145-809 1.38e-77

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 267.68  E-value: 1.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 145 FIGHQLGGVVEVPNSKdqrVKSARAIQITYYLQtYGSATQDLIGEKWENEFCKLIRKlQEEHQELQLYSLASFSLWRDFH 224
Cdd:pfam02460 135 YLGPHFGGVDFEPPGN---ISYAKAIVLWYFLK-FDEEEVEEDSKEWEDELSQLLHN-KYASEHIQFTIFHDQILNDELV 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 225 KTSILARSKVLVSLVL-----ILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAM 299
Cdd:pfam02460 210 RNALTLTPFFVIGFFLlltfsIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVL 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 300 GHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGAspFTNIEAVKVFCQNMCVSILLNYFYI 379
Cdd:pfam02460 290 AIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGT--YTPTPAIQLFCAYTAVAIFFDFIYQ 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 380 FSFFGSCLVFAGQLEQNRYHSIFCCKipsaeyldrkPVWFQTVMSDGHQQTSHHETNPyqhhFIQHFLREHYNEWITNIY 459
Cdd:pfam02460 368 ITFFAAIMAICAKPEAEGRHCLFVWA----------TSSPQRIDSEGSEPDKSHNIEQ----LKSRFFLDIYCPFLLNPS 433
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 460 VKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLC 539
Cdd:pfam02460 434 VRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMV 513
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 540 SGFTAVS----------WVEQYYQFLKVSNVSANN--KSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDEsnIIASRLYL 607
Cdd:pfam02460 514 DEFENTPyslgpnstlfWLREYENFLSTLNMEEEEdeEKEWSYGNLPSFLKAPGNSHWAGDLVWDDNTTM--VTKFRFTL 591
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 608 VARTSRDKQ------KEITEVLEKLRPLSLSksirfiVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLG 681
Cdd:pfam02460 592 AGKGLSTWNdrtralQEWRSIADQYPEFNVT------VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPC 665
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 682 NFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVT 761
Cdd:pfam02460 666 VFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGL 745
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 1852860117 762 SFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPP 809
Cdd:pfam02460 746 STILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLFVT 793
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
161-807 5.89e-23

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 105.38  E-value: 5.89e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  161 DQRVKSARAIQITYYLQTYGSATQDL-IGEKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLV 239
Cdd:TIGR00917  503 GNNFSEASAFVVTFPVNNFVNKTNKTeKAVAWEKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITIAISYL 582
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  240 LILTTATLS-SSMKDCLR----SKPFLGLLGVLTVCISIITAAGIFFITDGKynSTLL---GIPFFAMGHGTKGVFELLS 311
Cdd:TIGR00917  583 VMFAYISLTlGDSPRLKSlyvtSKVLLGLSGILIVMLSVLGSVGVFSAVGLK--STLIimeVIPFLVLAVGVDNIFILVF 660
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  312 GWR-----------RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGAspFTNIEAVKVFCQNMCVSILLNYFYIF 380
Cdd:TIGR00917  661 FYFyleyfyrqvgvDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGA--LIKMPAVRVFSMFAVLAVFLDFLLQI 738
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  381 SFFGSCLVFAGQLEQNRYHSIFCCkipsaeyldrkpvwFQTVMSDGHQQTShheTNPYQHHFIQHFLREHYNEWITNIYV 460
Cdd:TIGR00917  739 TAFVALLVLDFKRTEDKRVDCFPC--------------IKTSKSSISAEKG---SGQRKAGLLTRYFKEVYAPVLLHWIV 801
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  461 KPFVVILYLIYASFSFMGCLQISDGANIINLLASDspsvSYAMVQQKYFSNY---SPVIGFYVYEPLEYWNSSVQDDLRR 537
Cdd:TIGR00917  802 KIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQD----SYLQIYFASLTPLlevGPPFYIVIKGDYNYTDFESQNKLCT 877
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  538 LCS----------------GFTAVSWVEQYYQFLKVSNVSA---NNKSDFISV----------LQSSFLKKPEFQHFRND 588
Cdd:TIGR00917  878 MGGcdkdsivnvfnnlsyiAKPASSWLDDYLVWLSPQASCCcrkFTNGTFCNGpdpqcfrcadLSSDAQGRPSTTQFKEK 957
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  589 IIF------------------SKA----GDESNIIASRlYLVARTSRDKQKEITEVLEKLRPLS--LSKSIRFIVFNPS- 643
Cdd:TIGR00917  958 LPWflnalpsadcakgghaaySSAvdlqGYATIIQASS-FRTYHTPLNTQVDFINAMRAAQEFAakVSRSSKMEVYPYSv 1036
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  644 -FVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLV-IHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNF 721
Cdd:TIGR00917 1037 fYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGI 1116
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  722 AIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVT-SFLIGLVPLLFVPSNL-TFTLFKCLLLTGGCTLLHCFVI 799
Cdd:TIGR00917 1117 AIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITlTKLVGVVVLGFSRSEIfVVYYFRMYLALVLLGFLHGLVF 1196

                   ....*...
gi 1852860117  800 LPVFLTFF 807
Cdd:TIGR00917 1197 LPVLLSVL 1204
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
145-809 1.38e-77

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 267.68  E-value: 1.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 145 FIGHQLGGVVEVPNSKdqrVKSARAIQITYYLQtYGSATQDLIGEKWENEFCKLIRKlQEEHQELQLYSLASFSLWRDFH 224
Cdd:pfam02460 135 YLGPHFGGVDFEPPGN---ISYAKAIVLWYFLK-FDEEEVEEDSKEWEDELSQLLHN-KYASEHIQFTIFHDQILNDELV 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 225 KTSILARSKVLVSLVL-----ILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAM 299
Cdd:pfam02460 210 RNALTLTPFFVIGFFLlltfsIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVL 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 300 GHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGAspFTNIEAVKVFCQNMCVSILLNYFYI 379
Cdd:pfam02460 290 AIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGT--YTPTPAIQLFCAYTAVAIFFDFIYQ 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 380 FSFFGSCLVFAGQLEQNRYHSIFCCKipsaeyldrkPVWFQTVMSDGHQQTSHHETNPyqhhFIQHFLREHYNEWITNIY 459
Cdd:pfam02460 368 ITFFAAIMAICAKPEAEGRHCLFVWA----------TSSPQRIDSEGSEPDKSHNIEQ----LKSRFFLDIYCPFLLNPS 433
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 460 VKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLC 539
Cdd:pfam02460 434 VRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMV 513
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 540 SGFTAVS----------WVEQYYQFLKVSNVSANN--KSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDEsnIIASRLYL 607
Cdd:pfam02460 514 DEFENTPyslgpnstlfWLREYENFLSTLNMEEEEdeEKEWSYGNLPSFLKAPGNSHWAGDLVWDDNTTM--VTKFRFTL 591
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 608 VARTSRDKQ------KEITEVLEKLRPLSLSksirfiVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLG 681
Cdd:pfam02460 592 AGKGLSTWNdrtralQEWRSIADQYPEFNVT------VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPC 665
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 682 NFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVT 761
Cdd:pfam02460 666 VFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGL 745
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 1852860117 762 SFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPP 809
Cdd:pfam02460 746 STILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLFVT 793
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
161-807 5.89e-23

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 105.38  E-value: 5.89e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  161 DQRVKSARAIQITYYLQTYGSATQDL-IGEKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLV 239
Cdd:TIGR00917  503 GNNFSEASAFVVTFPVNNFVNKTNKTeKAVAWEKAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITIAISYL 582
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  240 LILTTATLS-SSMKDCLR----SKPFLGLLGVLTVCISIITAAGIFFITDGKynSTLL---GIPFFAMGHGTKGVFELLS 311
Cdd:TIGR00917  583 VMFAYISLTlGDSPRLKSlyvtSKVLLGLSGILIVMLSVLGSVGVFSAVGLK--STLIimeVIPFLVLAVGVDNIFILVF 660
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  312 GWR-----------RTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGAspFTNIEAVKVFCQNMCVSILLNYFYIF 380
Cdd:TIGR00917  661 FYFyleyfyrqvgvDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGA--LIKMPAVRVFSMFAVLAVFLDFLLQI 738
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  381 SFFGSCLVFAGQLEQNRYHSIFCCkipsaeyldrkpvwFQTVMSDGHQQTShheTNPYQHHFIQHFLREHYNEWITNIYV 460
Cdd:TIGR00917  739 TAFVALLVLDFKRTEDKRVDCFPC--------------IKTSKSSISAEKG---SGQRKAGLLTRYFKEVYAPVLLHWIV 801
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  461 KPFVVILYLIYASFSFMGCLQISDGANIINLLASDspsvSYAMVQQKYFSNY---SPVIGFYVYEPLEYWNSSVQDDLRR 537
Cdd:TIGR00917  802 KIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQD----SYLQIYFASLTPLlevGPPFYIVIKGDYNYTDFESQNKLCT 877
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  538 LCS----------------GFTAVSWVEQYYQFLKVSNVSA---NNKSDFISV----------LQSSFLKKPEFQHFRND 588
Cdd:TIGR00917  878 MGGcdkdsivnvfnnlsyiAKPASSWLDDYLVWLSPQASCCcrkFTNGTFCNGpdpqcfrcadLSSDAQGRPSTTQFKEK 957
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  589 IIF------------------SKA----GDESNIIASRlYLVARTSRDKQKEITEVLEKLRPLS--LSKSIRFIVFNPS- 643
Cdd:TIGR00917  958 LPWflnalpsadcakgghaaySSAvdlqGYATIIQASS-FRTYHTPLNTQVDFINAMRAAQEFAakVSRSSKMEVYPYSv 1036
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  644 -FVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLV-IHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNF 721
Cdd:TIGR00917 1037 fYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGI 1116
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  722 AIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVT-SFLIGLVPLLFVPSNL-TFTLFKCLLLTGGCTLLHCFVI 799
Cdd:TIGR00917 1117 AIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITlTKLVGVVVLGFSRSEIfVVYYFRMYLALVLLGFLHGLVF 1196

                   ....*...
gi 1852860117  800 LPVFLTFF 807
Cdd:TIGR00917 1197 LPVLLSVL 1204
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
254-404 1.35e-18

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 83.40  E-value: 1.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117 254 CLRSKPFLGLLGVLTVCISIITAAGIFFITdgKYNSTLLG---IPFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADAY 330
Cdd:pfam12349   1 MVKSKFGLGLAGVIIVLASVASSLGLCAYF--GLPLTLIIsevIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEAL 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1852860117 331 SDVMVTYTMTSSLYFITFGMGAspFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAGQ-LEQNRyHSIFCC 404
Cdd:pfam12349  79 GEVGPSITLTSLTEILAFLLGA--LTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrLESNR-LDVACC 150
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
189-548 5.98e-18

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 89.17  E-value: 5.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  189 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLT 268
Cdd:TIGR00918  357 EAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTMLRWDCAKSQGSVGLAGVLL 436
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  269 VCISiiTAAGIFFitdgkynSTLLGI----------PFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYT 338
Cdd:TIGR00918  437 VALS--VAAGLGL-------CALLGIsfnaattqvlPFLALGVGVDDVFLLAHAFSETGQNIPFEERTGECLKRTGASVV 507
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  339 MTSSLYFITFGMGAspFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCC----------KIPS 408
Cdd:TIGR00918  508 LTSISNVTAFFMAA--LIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCffspcsarviQIEP 585
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  409 AEYLDRKPV-----WFQTVMS-----DGHQQTSHHETNPYQHHFIQ---------------------------------- 444
Cdd:TIGR00918  586 QAYADGSAPpvyssHMQSTVQlrteyDPGTQHYYTTNEPRSHLSVQpsdplscqspdiagstrdllsqfedskaaclslp 665
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852860117  445 -------HFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSNYSpvig 517
Cdd:TIGR00918  666 carwtlaTFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYN---- 741
                          410       420       430
                   ....*....|....*....|....*....|.
gi 1852860117  518 FYVYEPLEYWNSSVQDDLRRLCSGFTAVSWV 548
Cdd:TIGR00918  742 MYAVTQGNFDYPTQQQLLYDLHQSFSSVKYV 772
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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