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Conserved domains on  [gi|1847916925|ref|NP_001371090|]
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fibulin-5 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
151-189 9.60e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 9.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1847916925  151 DVNECATENPCVQ--TCVNTYGSFICRCDPGYeleEDGVHC 189
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNC 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 202-230 1.07e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.93  E-value: 1.07e-06
                          10        20
                  ....*....|....*....|....*....
gi 1847916925 202 CQHECVNQPGTYFCSCPPGYILLDDNRSC 230
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
71-102 2.33e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 2.33e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1847916925  71 DVDECATDSHQCNPTQICINTEGGYTCSCTDG 102
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 119-149 6.98e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 6.98e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1847916925 119 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSC 149
Cdd:pfam14670   6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
151-189 9.60e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 9.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1847916925  151 DVNECATENPCVQ--TCVNTYGSFICRCDPGYeleEDGVHC 189
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNC 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 202-230 1.07e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.93  E-value: 1.07e-06
                          10        20
                  ....*....|....*....|....*....
gi 1847916925 202 CQHECVNQPGTYFCSCPPGYILLDDNRSC 230
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
71-102 2.33e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 2.33e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1847916925  71 DVDECATDSHQCNPTQICINTEGGYTCSCTDG 102
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 189-229 3.07e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 47.76  E-value: 3.07e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1847916925 189 CSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRS 229
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 151-182 3.23e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 3.23e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1847916925 151 DVNECATENPCV--QTCVNTYGSFICRCDPGYEL 182
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTG 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 69-109 3.50e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 47.76  E-value: 3.50e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1847916925  69 CVDVDECATDSHQCNptQICINTEGGYTCSCTDGYWLLEGQ 109
Cdd:cd01475   184 CVVPDLCATLSHVCQ--QVCISTPGSYLCACTEGYALLEDN 222
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 119-149 6.98e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 6.98e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1847916925 119 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSC 149
Cdd:pfam14670   6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 105-148 4.84e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 4.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1847916925 105 LLEGQCLDIDECRYG--YCQQLCANVPGSYSCTCNPGFTLNEDGRS 148
Cdd:cd01475   179 FQGKICVVPDLCATLshVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
71-103 7.14e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 7.14e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1847916925   71 DVDECATDsHQCNPTQICINTEGGYTCSCTDGY 103
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
151-179 9.64e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 9.64e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1847916925 151 DVNECATE-NPCVQ--TCVNTYGSFICRCDPG 179
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
112-150 2.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 2.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1847916925  112 DIDEC-RYGYCQQ--LCANVPGSYSCTCNPGFTlneDGRSCQ 150
Cdd:smart00179   1 DIDECaSGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
191-231 2.51e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 2.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1847916925  191 DMDECSfSEFLCQH--ECVNQPGTYFCSCPPGYIlldDNRSCQ 231
Cdd:smart00179   1 DIDECA-SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
151-189 9.60e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 9.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1847916925  151 DVNECATENPCVQ--TCVNTYGSFICRCDPGYeleEDGVHC 189
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNC 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 202-230 1.07e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.93  E-value: 1.07e-06
                          10        20
                  ....*....|....*....|....*....
gi 1847916925 202 CQHECVNQPGTYFCSCPPGYILLDDNRSC 230
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
71-102 2.33e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 2.33e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1847916925  71 DVDECATDSHQCNPTQICINTEGGYTCSCTDG 102
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 189-229 3.07e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 47.76  E-value: 3.07e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1847916925 189 CSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRS 229
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 151-182 3.23e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 3.23e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1847916925 151 DVNECATENPCV--QTCVNTYGSFICRCDPGYEL 182
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTG 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 69-109 3.50e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 47.76  E-value: 3.50e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1847916925  69 CVDVDECATDSHQCNptQICINTEGGYTCSCTDGYWLLEGQ 109
Cdd:cd01475   184 CVVPDLCATLSHVCQ--QVCISTPGSYLCACTEGYALLEDN 222
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 119-149 6.98e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 6.98e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1847916925 119 GYCQQLCANVPGSYSCTCNPGFTLNEDGRSC 149
Cdd:pfam14670   6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 140-187 9.49e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 46.61  E-value: 9.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1847916925 140 FTLNEDGRSCQDVNECATENP-CVQTCVNTYGSFICRCDPGYELEEDGV 187
Cdd:cd01475   175 LTKKFQGKICVVPDLCATLSHvCQQVCISTPGSYLCACTEGYALLEDNK 223
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 105-148 4.84e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 4.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1847916925 105 LLEGQCLDIDECRYG--YCQQLCANVPGSYSCTCNPGFTLNEDGRS 148
Cdd:cd01475   179 FQGKICVVPDLCATLshVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 71-105 6.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 6.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1847916925  71 DVDECATDsHQCNPTQICINTEGGYTCSCTDGYWL 105
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 133-154 6.57e-05

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 39.70  E-value: 6.57e-05
                          10        20
                  ....*....|....*....|..
gi 1847916925 133 SCTCNPGFTLNEDGRSCQDVNE 154
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
71-103 7.14e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 7.14e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1847916925   71 DVDECATDsHQCNPTQICINTEGGYTCSCTDGY 103
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 215-235 1.59e-04

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 38.54  E-value: 1.59e-04
                          10        20
                  ....*....|....*....|.
gi 1847916925 215 CSCPPGYILLDDNRSCQDINE 235
Cdd:pfam12662   2 CSCPPGYQLDPDGRTCVDIDE 22
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 75-103 2.49e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 2.49e-04
                          10        20
                  ....*....|....*....|....*....
gi 1847916925  75 CATDSHQCNPTQICINTEGGYTCSCTDGY 103
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGY 29
EGF_CA pfam07645
Calcium-binding EGF domain;
151-179 9.64e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 9.64e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1847916925 151 DVNECATE-NPCVQ--TCVNTYGSFICRCDPG 179
Cdd:pfam07645   1 DVDECATGtHNCPAntVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 155-189 1.09e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 1.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1847916925 155 CATEN-PCVQTCVNTYGSFICRCDPGYELEEDGVHC 189
Cdd:pfam14670   1 CSVNNgGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
112-150 2.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 2.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1847916925  112 DIDEC-RYGYCQQ--LCANVPGSYSCTCNPGFTlneDGRSCQ 150
Cdd:smart00179   1 DIDECaSGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
191-231 2.51e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 2.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1847916925  191 DMDECSfSEFLCQH--ECVNQPGTYFCSCPPGYIlldDNRSCQ 231
Cdd:smart00179   1 DIDECA-SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 191-223 4.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.53  E-value: 4.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1847916925 191 DMDECSfSEFLCQH--ECVNQPGTYFCSCPPGYIL 223
Cdd:cd00054     1 DIDECA-SGNPCQNggTCVNTVGSYRCSCPPGYTG 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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