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Conserved domains on  [gi|1845973720|ref|NP_001370174|]
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NAD(+) hydrolase tir-1 [Caenorhabditis elegans]

Protein Classification

SAM_SARM1-like_repeat2 and TIR domain-containing protein( domain architecture ID 10337237)

protein containing domains SAM_superfamily, SAM_SARM1-like_repeat2, and TIR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAM_SARM1-like_repeat2 cd09502
SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like ...
 42-111 2.08e-33

SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


:

Pssm-ID: 188901  Cd Length: 70  Bit Score: 118.17  E-value: 2.08e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720  42 DYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKH 111
Cdd:cd09502     1 DYSSCDTTNLHNWLQSLGPEYSQYTYQMLNAGIDRNSLPSLTEDQLLEDCGITNGIHRLRILNAIKGMEH 70
TIR smart00255
Toll - interleukin 1 - resistance;
123-266 3.66e-27

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 103.94  E-value: 3.66e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720  123 QIDVFISYRRSTGNQLASLIKVLLQLRGYR--VFIDVDKLYAGKFDsSLLKNIQAAKHFILVLTPNSLDRLLNDDncEDW 200
Cdd:smart00255   1 EYDVFISYSGKEDVRNEFLSHLLEKLRGYGlcVFIDDFEPGGGDLE-EIDEAIEKSRIAIVVLSPNYAESEWCLD--ELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1845973720  201 VHKELKCAfEHQKNIIPIFDTafEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGE 266
Cdd:smart00255  78 AALENALE-EGGLRVIPIFYE--VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
SAM_superfamily super family cl15755
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 1-41 4.63e-20

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


The actual alignment was detected with superfamily member cd09501:

Pssm-ID: 472832 [Multi-domain]  Cd Length: 69  Bit Score: 82.74  E-value: 4.63e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1845973720   1 MVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAA 41
Cdd:cd09501    29 QVDGDLLLQLTEDELKQDLGMSSGLLRKRFLRELVELKTSA 69
 
Name Accession Description Interval E-value
SAM_SARM1-like_repeat2 cd09502
SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like ...
 42-111 2.08e-33

SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


Pssm-ID: 188901  Cd Length: 70  Bit Score: 118.17  E-value: 2.08e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720  42 DYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKH 111
Cdd:cd09502     1 DYSSCDTTNLHNWLQSLGPEYSQYTYQMLNAGIDRNSLPSLTEDQLLEDCGITNGIHRLRILNAIKGMEH 70
TIR smart00255
Toll - interleukin 1 - resistance;
123-266 3.66e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 103.94  E-value: 3.66e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720  123 QIDVFISYRRSTGNQLASLIKVLLQLRGYR--VFIDVDKLYAGKFDsSLLKNIQAAKHFILVLTPNSLDRLLNDDncEDW 200
Cdd:smart00255   1 EYDVFISYSGKEDVRNEFLSHLLEKLRGYGlcVFIDDFEPGGGDLE-EIDEAIEKSRIAIVVLSPNYAESEWCLD--ELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1845973720  201 VHKELKCAfEHQKNIIPIFDTafEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGE 266
Cdd:smart00255  78 AALENALE-EGGLRVIPIFYE--VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
SAM_SARM1-like_repeat1 cd09501
SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of ...
 1-41 4.63e-20

SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


Pssm-ID: 188900 [Multi-domain]  Cd Length: 69  Bit Score: 82.74  E-value: 4.63e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1845973720   1 MVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAA 41
Cdd:cd09501    29 QVDGDLLLQLTEDELKQDLGMSSGLLRKRFLRELVELKTSA 69
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 126-246 3.85e-10

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 56.94  E-value: 3.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720 126 VFISYRRStGNQLASLIKVLLQLRGYRVFIDVDKLYAGK-FDSSLLKNIQAAKHFILVLTPNSLDRllnddnceDWVHKE 204
Cdd:pfam13676   1 VFISYAGE-DRAWAEWLADALEAAGYRVWLDRWDIRPGDdWVEEIEEAIENSDRVLVVLSPNYLES--------PWCRAE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1845973720 205 LKCAFEHQKN---IIPI-FDTAFEFPTKEDQIPNDIRMITKYNGVK 246
Cdd:pfam13676  72 WEAALADPEGrkrLIPVrLECDLELPGLAGLQYIDLRDGDEFDAFE 117
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 43-112 1.53e-08

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 50.76  E-value: 1.53e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720   43 YSSVDESNLDNFLMGLSpeLSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHP 112
Cdd:smart00454   1 VSQWSPESVADWLESIG--LEQYADNFRKNGIDGALLLLLTSEEDLKELGITKLGHRKKILKAIQKLKEQ 68
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 1-38 2.04e-07

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 47.26  E-value: 2.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1845973720   1 MVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTLK 38
Cdd:pfam00536  28 YIDGDALLQLTEDDLL-KLGVTLLGHRKKILYAIQRLK 64
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 2-38 1.12e-05

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 42.67  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1845973720    2 VDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLK 38
Cdd:smart00454  30 IDGALLLLLTSEEDLKELGITKLGHRKKILKAIQKLK 66
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
49-107 7.58e-03

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 34.55  E-value: 7.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720  49 SNLDNFLMGLSpeLSVYTYQMLTNGVN-RSLLSSLTDEMMQnACGITNPIHRLKLTQAFE 107
Cdd:pfam07647   7 ESVADWLRSIG--LEQYTDNFRDQGITgAELLLRLTLEDLK-RLGITSVGHRRKILKKIQ 63
 
Name Accession Description Interval E-value
SAM_SARM1-like_repeat2 cd09502
SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like ...
 42-111 2.08e-33

SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


Pssm-ID: 188901  Cd Length: 70  Bit Score: 118.17  E-value: 2.08e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720  42 DYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKH 111
Cdd:cd09502     1 DYSSCDTTNLHNWLQSLGPEYSQYTYQMLNAGIDRNSLPSLTEDQLLEDCGITNGIHRLRILNAIKGMEH 70
TIR smart00255
Toll - interleukin 1 - resistance;
123-266 3.66e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 103.94  E-value: 3.66e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720  123 QIDVFISYRRSTGNQLASLIKVLLQLRGYR--VFIDVDKLYAGKFDsSLLKNIQAAKHFILVLTPNSLDRLLNDDncEDW 200
Cdd:smart00255   1 EYDVFISYSGKEDVRNEFLSHLLEKLRGYGlcVFIDDFEPGGGDLE-EIDEAIEKSRIAIVVLSPNYAESEWCLD--ELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1845973720  201 VHKELKCAfEHQKNIIPIFDTafEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGE 266
Cdd:smart00255  78 AALENALE-EGGLRVIPIFYE--VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
SAM_SARM1-like_repeat1 cd09501
SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of ...
 1-41 4.63e-20

SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


Pssm-ID: 188900 [Multi-domain]  Cd Length: 69  Bit Score: 82.74  E-value: 4.63e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1845973720   1 MVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAA 41
Cdd:cd09501    29 QVDGDLLLQLTEDELKQDLGMSSGLLRKRFLRELVELKTSA 69
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 126-246 3.85e-10

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 56.94  E-value: 3.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720 126 VFISYRRStGNQLASLIKVLLQLRGYRVFIDVDKLYAGK-FDSSLLKNIQAAKHFILVLTPNSLDRllnddnceDWVHKE 204
Cdd:pfam13676   1 VFISYAGE-DRAWAEWLADALEAAGYRVWLDRWDIRPGDdWVEEIEEAIENSDRVLVVLSPNYLES--------PWCRAE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1845973720 205 LKCAFEHQKN---IIPI-FDTAFEFPTKEDQIPNDIRMITKYNGVK 246
Cdd:pfam13676  72 WEAALADPEGrkrLIPVrLECDLELPGLAGLQYIDLRDGDEFDAFE 117
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 43-112 1.53e-08

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 50.76  E-value: 1.53e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720   43 YSSVDESNLDNFLMGLSpeLSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHP 112
Cdd:smart00454   1 VSQWSPESVADWLESIG--LEQYADNFRKNGIDGALLLLLTSEEDLKELGITKLGHRKKILKAIQKLKEQ 68
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 125-229 9.14e-08

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 51.21  E-value: 9.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720 125 DVFISYRRS-TGNQLASLIKVLLQLRGYRVFIDVDKLYAGK-FDSSLLKNIQAAKHFILVLTPNSLdrllNDDNCEDWVH 202
Cdd:pfam01582   2 DVFLSFRGSdTREWFVSHLLKELKQKGIKLFIDDRDLEPGEaIAPELLSAIEKSRRSVVVLSPNYA----SSGWCLDELV 77

                          90       100
                  ....*....|....*....|....*..
gi 1845973720 203 KELKCAFEHQKNIIPIFDTAFEFPTKE 229
Cdd:pfam01582  78 KILECALDLGQKVIPIFYEVDPSDVRK 104
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 1-38 2.04e-07

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 47.26  E-value: 2.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1845973720   1 MVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTLK 38
Cdd:pfam00536  28 YIDGDALLQLTEDDLL-KLGVTLLGHRKKILYAIQRLK 64
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 2-38 1.12e-05

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 42.67  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1845973720    2 VDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLK 38
Cdd:smart00454  30 IDGALLLLLTSEEDLKELGITKLGHRKKILKAIQKLK 66
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 62-108 1.84e-05

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 41.84  E-value: 1.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1845973720  62 LSVYTYQMLTNGVNRSLLSSLTDEMMQnACGITNPIHRLKLTQAFET 108
Cdd:cd09487    11 LEQYADLFRKNEIDGDALLLLTDEDLK-ELGITSPGHRKKILRAIQR 56
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 1-36 2.28e-05

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 41.46  E-value: 2.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1845973720   1 MVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQT 36
Cdd:cd09487    22 EIDGDALLLLTDEDLK-ELGITSPGHRKKILRAIQR 56
SAM_liprin-kazrin_repeat1 cd09494
SAM domain of liprin/kazrin proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 of ...
 55-107 2.00e-04

SAM domain of liprin/kazrin proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 of liprin/kazrin proteins is a protein-protein interaction domain. The long form of liprin/kazrin proteins contains three copies (repeats) of the SAM domain. Liprin-alpha may form heterodimers with liprin-beta through their SAM domains. Liprins were originally identified as LAR (leukocyte common antigen-related) transmembrane protein-tyrosine phosphatase-interacting proteins. They participate in mammary gland development and in axon guidance. In particular, liprin-alpha is involved in formation of the presynaptic active zone; liprin-beta is involved in the maintenance of lymphatic vessel integrity. Kazrins are involved in interplay between desmosomes and adherens junctions; additionally they play a role in regulation of intercellular differentiation, junction assembly, and cytoskeletal organization.


Pssm-ID: 188893  Cd Length: 58  Bit Score: 38.75  E-value: 2.00e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1845973720  55 LMGLSPELSVYTYQMLTNGvnrSLLSSLTDEMMQNACGITNPIHRLKLTQAFE 107
Cdd:cd09494     8 DFGLMPMYVIFCRQNVKSG---HTLLTLSDQEMEKELGIKNPLHRKKLRLAIK 57
SAM_liprin-alpha1,2,3,4_repeat1 cd09562
SAM domain of liprin-alpha1,2,3,4 proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 ...
 77-105 8.04e-04

SAM domain of liprin-alpha1,2,3,4 proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 of liprin-alpha1,2,3,4 proteins is a protein-protein interaction domain. Liprin-alpha proteins contain three copies (repeats) of SAM domain. They may form heterodimers with liprin-beta proteins through their SAM domains. Liprins were originally identified as LAR (leukocyte common antigen-related) transmembrane protein-tyrosine phosphatase-interacting proteins. They participate in mammary gland development and in axon guidance; in particular, liprin-alpha is involved in formation of the presynaptic active zone.


Pssm-ID: 188961  Cd Length: 71  Bit Score: 37.54  E-value: 8.04e-04
                          10        20
                  ....*....|....*....|....*....
gi 1845973720  77 SLLSSLTDEMMQNACGITNPIHRLKLTQA 105
Cdd:cd09562    35 AIMSALSDTEIQREIGISNPLHRLKLRLA 63
SAM_caskin1,2_repeat1 cd09497
SAM domain of caskin protein repeat 1; SAM (sterile alpha motif) domain repeat 1 of caskin1,2 ...
 62-113 2.91e-03

SAM domain of caskin protein repeat 1; SAM (sterile alpha motif) domain repeat 1 of caskin1,2 proteins is a protein-protein interaction domain. Caskin has two tandem SAM domains. Caskin protein is known to interact with membrane-associated guanylate kinase CASK, and apparently may play a role in neural development, synaptic protein targeting, and regulation of gene expression.


Pssm-ID: 188896  Cd Length: 66  Bit Score: 35.70  E-value: 2.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1845973720  62 LSVYTYQMLTNGVNRSLLSSLTDEMMqNACGITNPIHRLKLTQAFETAKHPD 113
Cdd:cd09497    16 LEEYTPNFIKAGYDLPTISRMTPEDL-TAIGITKPGHRKKLKSEIAQLQIPD 66
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
49-107 7.58e-03

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 34.55  E-value: 7.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845973720  49 SNLDNFLMGLSpeLSVYTYQMLTNGVN-RSLLSSLTDEMMQnACGITNPIHRLKLTQAFE 107
Cdd:pfam07647   7 ESVADWLRSIG--LEQYTDNFRDQGITgAELLLRLTLEDLK-RLGITSVGHRRKILKKIQ 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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