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Conserved domains on  [gi|1843978346|ref|NP_001369694|]
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fibrinogen beta chain isoform 9 preproprotein [Homo sapiens]

Protein Classification

fibrinogen C-terminal domain-containing protein( domain architecture ID 11179727)

fibrinogen C-terminal and EGF-like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
237-478 2.16e-111

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 328.33  E-value: 2.16e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLS--------- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 317 glPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNAlmdgasqLMGENRT 396
Cdd:pfam00147  72 --PGEFWLGNDKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYIGDAGDA-------LDTAGRS 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 397 MTIHNGMFFSTLTSD---PRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWdmakhgtDDGVVWMNWKGSWYSMRKMS 473
Cdd:pfam00147 143 MTYHNGMQFSTWDRDndsPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAE 215

                  ....*
gi 1843978346 474 MKIRP 478
Cdd:pfam00147 216 MKIRP 220
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
91-234 2.44e-67

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


:

Pssm-ID: 462570  Cd Length: 143  Bit Score: 212.40  E-value: 2.44e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978346 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
237-478 2.16e-111

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 328.33  E-value: 2.16e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLS--------- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 317 glPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNAlmdgasqLMGENRT 396
Cdd:pfam00147  72 --PGEFWLGNDKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYIGDAGDA-------LDTAGRS 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 397 MTIHNGMFFSTLTSD---PRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWdmakhgtDDGVVWMNWKGSWYSMRKMS 473
Cdd:pfam00147 143 MTYHNGMQFSTWDRDndsPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAE 215

                  ....*
gi 1843978346 474 MKIRP 478
Cdd:pfam00147 216 MKIRP 220
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
238-479 1.15e-106

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 316.10  E-value: 1.15e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 238 GKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknycg 317
Cdd:cd00087     3 PRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD---------- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 318 lpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALmdgasqlmgenrtm 397
Cdd:cd00087    73 --GEFWLGLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDAL-------------- 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 398 TIHNGMFFSTLTSDPRK---QCSKEDGGGWWYNRCHAANPNGRYYWGGQytwdmaKHGTDDGVVWMNWKGSWYSMRKMSM 474
Cdd:cd00087   137 SYHNGMKFSTFDRDNDGasgNCAESYSGGWWYNSCHASNLNGRYYSGGH------RNEYDNGINWATWKGSTYSLKFTEM 210

                  ....*
gi 1843978346 475 KIRPF 479
Cdd:cd00087   211 KIRPK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
237-479 2.94e-106

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 314.99  E-value: 2.94e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA--------- 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  317 glpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNAlmdgasqlmgenrT 396
Cdd:smart00186  72 ---GEFWLGNENIHLLTSQGKYELRIDLEDWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDA-------------S 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  397 MTIHNGMFFSTLTSDPRK---QCSKEDGGGWWYNRCHAANPNGRYYWggqytwdmaKHGTDDGVVWMNWKGSWYSMRKMS 473
Cdd:smart00186 136 LTYHNGMQFSTYDRDNDKysgNCAEEYGGGWWYNNCHAANLNGRYYP---------NNNYDNGINWATWKGSWYSLKFTE 206

                   ....*.
gi 1843978346  474 MKIRPF 479
Cdd:smart00186 207 MKIRPL 212
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
91-234 2.44e-67

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 212.40  E-value: 2.44e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978346 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
241-282 4.45e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 49.10  E-value: 4.45e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1843978346 241 CEEIIRKGGET-SEMYLIQPDSS--VKPYRVYCDMNTENGGWTVI 282
Cdd:NF040941    2 CWEILQAGPSApSGVYWIDPDGMggLAPFQVYCDMTTDGGGWTLV 46
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
237-478 2.16e-111

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 328.33  E-value: 2.16e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:pfam00147   1 FGRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLS--------- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 317 glPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNAlmdgasqLMGENRT 396
Cdd:pfam00147  72 --PGEFWLGNDKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYIGDAGDA-------LDTAGRS 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 397 MTIHNGMFFSTLTSD---PRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWdmakhgtDDGVVWMNWKGSWYSMRKMS 473
Cdd:pfam00147 143 MTYHNGMQFSTWDRDndsPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAE 215

                  ....*
gi 1843978346 474 MKIRP 478
Cdd:pfam00147 216 MKIRP 220
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
238-479 1.15e-106

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 316.10  E-value: 1.15e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 238 GKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknycg 317
Cdd:cd00087     3 PRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD---------- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 318 lpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALmdgasqlmgenrtm 397
Cdd:cd00087    73 --GEFWLGLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDAL-------------- 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346 398 TIHNGMFFSTLTSDPRK---QCSKEDGGGWWYNRCHAANPNGRYYWGGQytwdmaKHGTDDGVVWMNWKGSWYSMRKMSM 474
Cdd:cd00087   137 SYHNGMKFSTFDRDNDGasgNCAESYSGGWWYNSCHASNLNGRYYSGGH------RNEYDNGINWATWKGSTYSLKFTEM 210

                  ....*
gi 1843978346 475 KIRPF 479
Cdd:cd00087   211 KIRPK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
237-479 2.94e-106

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 314.99  E-value: 2.94e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  237 SGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVAtntdgknyc 316
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA--------- 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  317 glpGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNAlmdgasqlmgenrT 396
Cdd:smart00186  72 ---GEFWLGNENIHLLTSQGKYELRIDLEDWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDA-------------S 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  397 MTIHNGMFFSTLTSDPRK---QCSKEDGGGWWYNRCHAANPNGRYYWggqytwdmaKHGTDDGVVWMNWKGSWYSMRKMS 473
Cdd:smart00186 136 LTYHNGMQFSTYDRDNDKysgNCAEEYGGGWWYNNCHAANLNGRYYP---------NNNYDNGINWATWKGSWYSLKFTE 206

                   ....*.
gi 1843978346  474 MKIRPF 479
Cdd:smart00186 207 MKIRPL 212
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
91-234 2.44e-67

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 212.40  E-value: 2.44e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978346  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978346 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
241-282 4.45e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 49.10  E-value: 4.45e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1843978346 241 CEEIIRKGGET-SEMYLIQPDSS--VKPYRVYCDMNTENGGWTVI 282
Cdd:NF040941    2 CWEILQAGPSApSGVYWIDPDGMggLAPFQVYCDMTTDGGGWTLV 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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