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Conserved domains on  [gi|1843978484|ref|NP_001369691|]
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fibrinogen beta chain isoform 6 preproprotein [Homo sapiens]

Protein Classification

Fib_alpha and FReD domain-containing protein( domain architecture ID 10554875)

Fib_alpha and FReD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 91-234 2.58e-68

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


:

Pssm-ID: 462570  Cd Length: 143  Bit Score: 212.02  E-value: 2.58e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978484 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
FReD super family cl00085
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 249-386 1.96e-58

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


The actual alignment was detected with superfamily member pfam00147:

Pssm-ID: 412152 [Multi-domain]  Cd Length: 221  Bit Score: 189.66  E-value: 1.96e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484 249 GDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMdgasqlmGENRTMTIHNGMFFSTYDRDNDgwltsDPRKQCSKED 328
Cdd:pfam00147 102 GETVFALYDSFKVTNENDKYRLHVENYIGDAGDALD-------TAGRSMTYHNGMQFSTWDRDND-----SPDGNCALSY 169

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1843978484 329 GGGWWYNRCHAANPNGRYYWGGQYTWdmakhgtDDGVVWMNWKGSWYSMRKMSMKIRP 386
Cdd:pfam00147 170 GGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKIRP 220
 
Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 91-234 2.58e-68

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 212.02  E-value: 2.58e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978484 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
249-386 1.96e-58

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 189.66  E-value: 1.96e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484 249 GDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMdgasqlmGENRTMTIHNGMFFSTYDRDNDgwltsDPRKQCSKED 328
Cdd:pfam00147 102 GETVFALYDSFKVTNENDKYRLHVENYIGDAGDALD-------TAGRSMTYHNGMQFSTWDRDND-----SPDGNCALSY 169

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1843978484 329 GGGWWYNRCHAANPNGRYYWGGQYTWdmakhgtDDGVVWMNWKGSWYSMRKMSMKIRP 386
Cdd:pfam00147 170 GGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKIRP 220
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 248-387 1.11e-54

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 179.40  E-value: 1.11e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484  248 GGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNAlmdgasqlmgenrTMTIHNGMFFSTYDRDNDGWLTSdprkqCSKE 327
Cdd:smart00186 100 EGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDA-------------SLTYHNGMQFSTYDRDNDKYSGN-----CAEE 161

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484  328 DGGGWWYNRCHAANPNGRYYWggqytwdmaKHGTDDGVVWMNWKGSWYSMRKMSMKIRPF 387
Cdd:smart00186 162 YGGGWWYNNCHAANLNGRYYP---------NNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 247-387 1.53e-54

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 179.36  E-value: 1.53e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484 247 KGGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALmdgasqlmgenrtmTIHNGMFFSTYDRDNDGWLTSdprkqCSK 326
Cdd:cd00087   100 WEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDAL--------------SYHNGMKFSTFDRDNDGASGN-----CAE 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843978484 327 EDGGGWWYNRCHAANPNGRYYWGGQytwdmaKHGTDDGVVWMNWKGSWYSMRKMSMKIRPF 387
Cdd:cd00087   161 SYSGGWWYNSCHASNLNGRYYSGGH------RNEYDNGINWATWKGSTYSLKFTEMKIRPK 215
 
Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 91-234 2.58e-68

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 212.02  E-value: 2.58e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484  91 DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVN 170
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978484 171 EYSSELEKHQLYIDETVNSNIpTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIP 234
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQE-SNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
249-386 1.96e-58

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 189.66  E-value: 1.96e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484 249 GDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMdgasqlmGENRTMTIHNGMFFSTYDRDNDgwltsDPRKQCSKED 328
Cdd:pfam00147 102 GETVFALYDSFKVTNENDKYRLHVENYIGDAGDALD-------TAGRSMTYHNGMQFSTWDRDND-----SPDGNCALSY 169

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1843978484 329 GGGWWYNRCHAANPNGRYYWGGQYTWdmakhgtDDGVVWMNWKGSWYSMRKMSMKIRP 386
Cdd:pfam00147 170 GGGWWYNNCHAANLNGVYYYGGTYSK-------QNGIIWATWKGRWYSMKKAEMKIRP 220
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 248-387 1.11e-54

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 179.40  E-value: 1.11e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484  248 GGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNAlmdgasqlmgenrTMTIHNGMFFSTYDRDNDGWLTSdprkqCSKE 327
Cdd:smart00186 100 EGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDA-------------SLTYHNGMQFSTYDRDNDKYSGN-----CAEE 161

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484  328 DGGGWWYNRCHAANPNGRYYWggqytwdmaKHGTDDGVVWMNWKGSWYSMRKMSMKIRPF 387
Cdd:smart00186 162 YGGGWWYNNCHAANLNGRYYP---------NNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 247-387 1.53e-54

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 179.36  E-value: 1.53e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978484 247 KGGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALmdgasqlmgenrtmTIHNGMFFSTYDRDNDGWLTSdprkqCSK 326
Cdd:cd00087   100 WEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDAL--------------SYHNGMKFSTFDRDNDGASGN-----CAE 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843978484 327 EDGGGWWYNRCHAANPNGRYYWGGQytwdmaKHGTDDGVVWMNWKGSWYSMRKMSMKIRPF 387
Cdd:cd00087   161 SYSGGWWYNSCHASNLNGRYYSGGH------RNEYDNGINWATWKGSTYSLKFTEMKIRPK 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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