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Conserved domains on  [gi|1834395622|ref|NP_001369166|]
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transportin-2 isoform 2 [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-756 5.29e-20

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 95.78  E-value: 5.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622  22 SPNTATQRIVQDKLKQLNQ--FPDFNNYLIFVLTRLKSEDEpTRSLSGLILKNNVKAH-----------YQSFPPPVADF 88
Cdd:COG5215    16 SPDPNARLRAEAQLLELQSgdFEQFISLLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKEQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622  89 IKQECLNNIGDASSLIRATIGILITTIASKgEL--QMWPELLPQLC-NLLNSEDYNTCEGAFGALQKICEDSsellDSDA 165
Cdd:COG5215    95 VKGMALRALKSPEPRFCTMAAQLLAAIARM-ELpnSLWPGLMEEMVrNVGDEQPVSGKCESLGICGYHCESE----APED 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 166 LNRPLNIMIPKFLQFFKHCSP--KIRSHAIACVNQFIMDrAQALMD---NIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
Cdd:COG5215   170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMDSLMF-VQGNFCyeeERNYFMQVVCEATQGNDEELQHAAFGCLNKI 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 241 LEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDII--LLK 317
Cdd:COG5215   249 MMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLS 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 318 GDVEEDeavPDSEQDIkprfhksrtvtlpheaerpdgsedaeddddddalsdWNLRKCSAAALDVLANVFREELLPHLLP 397
Cdd:COG5215   329 LLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQLFAQLKGDKIMRPVLG 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 398 LLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA-HWVVSQPPDMHL 475
Cdd:COG5215   370 FVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHL 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 476 KPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLL--ILYDAIGTL 545
Cdd:COG5215   450 VLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTL 527

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 546 ----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA 618
Cdd:COG5215   528 ilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILE 607

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 619 QAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIH 698
Cdd:COG5215   608 STKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTD 673

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1834395622 699 VKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVEIIN 756
Cdd:COG5215   674 FNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-756 5.29e-20

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 95.78  E-value: 5.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622  22 SPNTATQRIVQDKLKQLNQ--FPDFNNYLIFVLTRLKSEDEpTRSLSGLILKNNVKAH-----------YQSFPPPVADF 88
Cdd:COG5215    16 SPDPNARLRAEAQLLELQSgdFEQFISLLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKEQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622  89 IKQECLNNIGDASSLIRATIGILITTIASKgEL--QMWPELLPQLC-NLLNSEDYNTCEGAFGALQKICEDSsellDSDA 165
Cdd:COG5215    95 VKGMALRALKSPEPRFCTMAAQLLAAIARM-ELpnSLWPGLMEEMVrNVGDEQPVSGKCESLGICGYHCESE----APED 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 166 LNRPLNIMIPKFLQFFKHCSP--KIRSHAIACVNQFIMDrAQALMD---NIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
Cdd:COG5215   170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMDSLMF-VQGNFCyeeERNYFMQVVCEATQGNDEELQHAAFGCLNKI 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 241 LEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDII--LLK 317
Cdd:COG5215   249 MMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLS 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 318 GDVEEDeavPDSEQDIkprfhksrtvtlpheaerpdgsedaeddddddalsdWNLRKCSAAALDVLANVFREELLPHLLP 397
Cdd:COG5215   329 LLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQLFAQLKGDKIMRPVLG 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 398 LLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA-HWVVSQPPDMHL 475
Cdd:COG5215   370 FVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHL 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 476 KPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLL--ILYDAIGTL 545
Cdd:COG5215   450 VLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTL 527

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 546 ----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA 618
Cdd:COG5215   528 ilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILE 607

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 619 QAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIH 698
Cdd:COG5215   608 STKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTD 673

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1834395622 699 VKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVEIIN 756
Cdd:COG5215   674 FNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 408-462 1.62e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 68.55  E-value: 1.62e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1834395622 408 WVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRY 462
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 36-99 1.44e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 51.86  E-value: 1.44e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1834395622   36 KQLNQFPDFNNYLIFVLTRL-KSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGD 99
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEILaNSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-756 5.29e-20

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 95.78  E-value: 5.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622  22 SPNTATQRIVQDKLKQLNQ--FPDFNNYLIFVLTRLKSEDEpTRSLSGLILKNNVKAH-----------YQSFPPPVADF 88
Cdd:COG5215    16 SPDPNARLRAEAQLLELQSgdFEQFISLLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKEQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622  89 IKQECLNNIGDASSLIRATIGILITTIASKgEL--QMWPELLPQLC-NLLNSEDYNTCEGAFGALQKICEDSsellDSDA 165
Cdd:COG5215    95 VKGMALRALKSPEPRFCTMAAQLLAAIARM-ELpnSLWPGLMEEMVrNVGDEQPVSGKCESLGICGYHCESE----APED 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 166 LNRPLNIMIPKFLQFFKHCSP--KIRSHAIACVNQFIMDrAQALMD---NIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
Cdd:COG5215   170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMDSLMF-VQGNFCyeeERNYFMQVVCEATQGNDEELQHAAFGCLNKI 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 241 LEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDII--LLK 317
Cdd:COG5215   249 MMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLS 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 318 GDVEEDeavPDSEQDIkprfhksrtvtlpheaerpdgsedaeddddddalsdWNLRKCSAAALDVLANVFREELLPHLLP 397
Cdd:COG5215   329 LLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQLFAQLKGDKIMRPVLG 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 398 LLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA-HWVVSQPPDMHL 475
Cdd:COG5215   370 FVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHL 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 476 KPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLL--ILYDAIGTL 545
Cdd:COG5215   450 VLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTL 527

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 546 ----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA 618
Cdd:COG5215   528 ilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILE 607

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 619 QAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIH 698
Cdd:COG5215   608 STKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTD 673

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1834395622 699 VKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVEIIN 756
Cdd:COG5215   674 FNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 408-462 1.62e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 68.55  E-value: 1.62e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1834395622 408 WVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRY 462
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N pfam03810
Importin-beta N-terminal domain;
32-99 8.50e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 58.40  E-value: 8.50e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1834395622  32 QDKLKQLNQFPDFNNYLIFVLTRLKSeDEPTRSLSGLILKNNVKAHYQ----SFPPPVADFIKQECLNNIGD 99
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSEN-PLEVRQLAALYLKNLITRHWEeeknSLPPEEKEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 36-99 1.44e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 51.86  E-value: 1.44e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1834395622   36 KQLNQFPDFNNYLIFVLTRL-KSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGD 99
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEILaNSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
 21-186 1.63e-08

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 58.67  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622  21 QSPNTATQRIVQDKLKQLNQFPDFNnYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHY-----QSFPPPVADFIKQECLN 95
Cdd:COG5657    14 QSPDPPSVKCAEERLRQWEKQHGFA-LKLLSINLSAFNSMSLRWAALIQFKNYIDKHWreengNSILPDENVLIRDELFS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622  96 NIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIP 175
Cdd:COG5657    93 LIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSDALFLEIAPVLL 172

                         170
                  ....*....|.
gi 1834395622 176 KFLQFFKHCSP 186
Cdd:COG5657   173 SILCPFLFSSA 183
HEAT COG1413
HEAT repeat [General function prediction only];
125-276 2.86e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.62  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 125 PELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSelldsdalnrplnimIPKFLQFFKHCSPKIRSHAIACVNQFIMDRA 204
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGRIGDPEA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1834395622 205 qalmdnidtfIEHLFALAVDDDPEVRKNVCRALVMLLEVRidrliphmhsIIQYMLQRTQDHDENVALEACE 276
Cdd:COG1413    80 ----------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAAAR 131
HEAT COG1413
HEAT repeat [General function prediction only];
410-580 3.99e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.54  E-value: 3.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 410 VKESGILVLGAIAEgcmqgmvpylPELIPHLIQCLSDKKALVRSIACWTLSRyahwvvsqppdMHLKPLMTELLKRILDG 489
Cdd:COG1413     1 VRRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGR-----------LGDPRAVPALLEALKDP 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 490 NKRVQEAACSAFATL-EEEACTELVPYLsyildtlvfafgkyQHKNLLILYDAIGTLAdsvghHLNQPEYIqklmPPLIQ 568
Cdd:COG1413    60 DPEVRAAAAEALGRIgDPEAVPALIAAL--------------KDEDPEVRRAAAEALG-----RLGDPAAV----PALLE 116

                         170
                  ....*....|..
gi 1834395622 569 KwneLKDEDKDL 580
Cdd:COG1413   117 A---LKDPDWEV 125
HEAT COG1413
HEAT repeat [General function prediction only];
377-517 3.09e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.84  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395622 377 AAALDVLANVFREELLPHLLPLLKgllfHPEWVVKESGILVLGAIAEgcmqgmvpylPELIPHLIQCLSDKKALVRSIAC 456
Cdd:COG1413     3 RAAARALGRLGDPAAVPALIAALA----DEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAA 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1834395622 457 WTLSRYAhwvvsqppDMHLKPLMTELLKrilDGNKRVQEAACSAFATL-EEEACTELVPYLS 517
Cdd:COG1413    69 EALGRIG--------DPEAVPALIAALK---DEDPEVRRAAAEALGRLgDPAAVPALLEALK 119
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 186-237 4.61e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 4.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1834395622 186 PKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRAL 237
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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