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Conserved domains on  [gi|1833303504|ref|NP_001368873|]
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dicarboxylate carrier SLC25A8 isoform a [Homo sapiens]

Protein Classification

solute carrier family 25 protein( domain architecture ID 10445172)

solute carrier 25 family (SLC25) protein which transfers molecules across the membranes of organelles, usually mitochondria

Gene Ontology:  GO:0016020|GO:1990542
TCDB:  2.A.29

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
112-206 1.77e-26

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 100.04  E-value: 1.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 112 EHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQaRAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNC 191
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ-GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAA 79
                          90
                  ....*....|....*
gi 1833303504 192 AELVTYDLIKDALLK 206
Cdd:pfam00153  80 IYFGTYETLKRLLLK 94
Mito_carr pfam00153
Mitochondrial carrier protein;
10-111 3.73e-21

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 85.79  E-value: 3.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  10 PPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESqgpvratASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQ 89
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGS-------GKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRV 74
                          90       100
                  ....*....|....*....|..
gi 1833303504  90 MSFASVRIGLYDSVKQFYTKGS 111
Cdd:pfam00153  75 APAAAIYFGTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
217-299 1.08e-19

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 81.93  E-value: 1.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 217 HFTSAFGAGFCTTVIASPVDVVKTRYMN---SALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQ 293
Cdd:pfam00153   8 SLLAGGIAGAIAVTVTYPLDVVKTRLQVqggSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYET 87

                  ....*.
gi 1833303504 294 LKRALM 299
Cdd:pfam00153  88 LKRLLL 93
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
112-206 1.77e-26

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 100.04  E-value: 1.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 112 EHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQaRAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNC 191
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ-GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAA 79
                          90
                  ....*....|....*
gi 1833303504 192 AELVTYDLIKDALLK 206
Cdd:pfam00153  80 IYFGTYETLKRLLLK 94
Mito_carr pfam00153
Mitochondrial carrier protein;
10-111 3.73e-21

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 85.79  E-value: 3.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  10 PPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESqgpvratASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQ 89
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGS-------GKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRV 74
                          90       100
                  ....*....|....*....|..
gi 1833303504  90 MSFASVRIGLYDSVKQFYTKGS 111
Cdd:pfam00153  75 APAAAIYFGTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
217-299 1.08e-19

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 81.93  E-value: 1.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 217 HFTSAFGAGFCTTVIASPVDVVKTRYMN---SALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQ 293
Cdd:pfam00153   8 SLLAGGIAGAIAVTVTYPLDVVKTRLQVqggSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYET 87

                  ....*.
gi 1833303504 294 LKRALM 299
Cdd:pfam00153  88 LKRLLL 93
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
16-204 1.07e-16

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 78.66  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  16 KFLGA-----GTAACIADLITFPLDTAKVRLQiqgesqGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQM 90
Cdd:PTZ00169  111 KFFGVnilsgGLAGASSLLIVYPLDFARTRLA------SDIGKGGDREFTGLFDCLMKISKQTGFLSLYQGFGVSVQGII 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  91 SFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRR--YQSTVNAYKTIAR 168
Cdd:PTZ00169  185 VYRGAYFGLYDSAKALLFGNDKNTNILYKWAVAQTVTILAGLISYPFDTVRRRMMMMSGRKAKSEiqYTGTLDCWKKILK 264
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1833303504 169 EEGFRGLWKGTSPNVAR---NAIVncaeLVTYDLIKDAL 204
Cdd:PTZ00169  265 NEGLGGFFKGAWANVLRgagGALV----LVFYDELQKLL 299
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
17-299 1.73e-16

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 78.27  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  17 FLGAGTAACIADLITFPLDTAKVRLQIQgESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVR 96
Cdd:PTZ00169   11 FLMGGISAAISKTAVAPIERVKMLIQTQ-DSIPEIKSGKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  97 IGLYDSVKQFYTKGSEHASI----GSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGF 172
Cdd:PTZ00169   90 FAFKDYFKNMFPKYNQKTDFwkffGVNILSGGLAGASSLLIVYPLDFARTRLASDIGKGGDREFTGLFDCLMKISKQTGF 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 173 RGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHF---TSAFGAGfcttVIASPVDVVKTRYMNSALG- 248
Cdd:PTZ00169  170 LSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKNTNILYKWAvaqTVTILAG----LISYPFDTVRRRMMMMSGRk 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1833303504 249 -----QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRlGSWNVVMFVTYEQLKRALM 299
Cdd:PTZ00169  246 akseiQYTGTLDCWKKILKNEGLGGFFKGAWANVLR-GAGGALVLVFYDELQKLLK 300
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
112-206 1.77e-26

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 100.04  E-value: 1.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 112 EHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQaRAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNC 191
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ-GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAA 79
                          90
                  ....*....|....*
gi 1833303504 192 AELVTYDLIKDALLK 206
Cdd:pfam00153  80 IYFGTYETLKRLLLK 94
Mito_carr pfam00153
Mitochondrial carrier protein;
10-111 3.73e-21

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 85.79  E-value: 3.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  10 PPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESqgpvratASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQ 89
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGS-------GKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRV 74
                          90       100
                  ....*....|....*....|..
gi 1833303504  90 MSFASVRIGLYDSVKQFYTKGS 111
Cdd:pfam00153  75 APAAAIYFGTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
217-299 1.08e-19

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 81.93  E-value: 1.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 217 HFTSAFGAGFCTTVIASPVDVVKTRYMN---SALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQ 293
Cdd:pfam00153   8 SLLAGGIAGAIAVTVTYPLDVVKTRLQVqggSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYET 87

                  ....*.
gi 1833303504 294 LKRALM 299
Cdd:pfam00153  88 LKRLLL 93
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
16-204 1.07e-16

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 78.66  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  16 KFLGA-----GTAACIADLITFPLDTAKVRLQiqgesqGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQM 90
Cdd:PTZ00169  111 KFFGVnilsgGLAGASSLLIVYPLDFARTRLA------SDIGKGGDREFTGLFDCLMKISKQTGFLSLYQGFGVSVQGII 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  91 SFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRR--YQSTVNAYKTIAR 168
Cdd:PTZ00169  185 VYRGAYFGLYDSAKALLFGNDKNTNILYKWAVAQTVTILAGLISYPFDTVRRRMMMMSGRKAKSEiqYTGTLDCWKKILK 264
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1833303504 169 EEGFRGLWKGTSPNVAR---NAIVncaeLVTYDLIKDAL 204
Cdd:PTZ00169  265 NEGLGGFFKGAWANVLRgagGALV----LVFYDELQKLL 299
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
17-299 1.73e-16

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 78.27  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  17 FLGAGTAACIADLITFPLDTAKVRLQIQgESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVR 96
Cdd:PTZ00169   11 FLMGGISAAISKTAVAPIERVKMLIQTQ-DSIPEIKSGKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  97 IGLYDSVKQFYTKGSEHASI----GSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGF 172
Cdd:PTZ00169   90 FAFKDYFKNMFPKYNQKTDFwkffGVNILSGGLAGASSLLIVYPLDFARTRLASDIGKGGDREFTGLFDCLMKISKQTGF 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 173 RGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHF---TSAFGAGfcttVIASPVDVVKTRYMNSALG- 248
Cdd:PTZ00169  170 LSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKNTNILYKWAvaqTVTILAG----LISYPFDTVRRRMMMMSGRk 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1833303504 249 -----QYSSAGHCALTMLQKEGPRAFYKGFMPSFLRlGSWNVVMFVTYEQLKRALM 299
Cdd:PTZ00169  246 akseiQYTGTLDCWKKILKNEGLGGFFKGAWANVLR-GAGGALVLVFYDELQKLLK 300
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
75-281 2.01e-04

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 42.22  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504  75 PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQ-PTDVVKVRFQAQARAggg 153
Cdd:PTZ00168   42 IKKLYSGILPTLVGTVPASAFFYCFYELSKKLLTEYRENISKTNLYLISTSIAEITACIVRlPFEIVKQNMQVSGNI--- 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303504 154 rryqSTVNAYKTIAREEGFRG-LWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFG-------AG 225
Cdd:PTZ00168  119 ----SVLKTIYEITQREGLPSfLGKSYFVMIVREIPFDCIQYFLWETLKEKAKKDFGKFSKKYPSITSAICgglaggiAG 194
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1833303504 226 FCTTviasPVDVVKTRYMnsalgQYSSAGHCALTMLQKEGPRAFYKG--FMPSFLRLG 281
Cdd:PTZ00168  195 FLTT----PVDVIKSRQI-----IYGKSYIETVTEIAEEGYLTFYKGccFRSSYLFFG 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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