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Conserved domains on  [gi|1831510237|ref|NP_001368535|]
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ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase [Caenorhabditis elegans]

Protein Classification

SAM_SARM1-like_repeat1 and SAM_SARM1-like_repeat2 domain-containing protein( domain architecture ID 10175649)

protein containing domains SAM_SARM1-like_repeat1, SAM_SARM1-like_repeat2, and TIR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SARM1_N cd24153
N-terminal ARM-repeat domain of SARM1 (sterile alpha and TIR motif containing 1); The ...
 232-547 5.62e-155

N-terminal ARM-repeat domain of SARM1 (sterile alpha and TIR motif containing 1); The nicotinamide adenine dinucleotidase SARM1 (sterile alpha and TIR motif containing 1) is involved in TLR (Toll-like receptor) signaling. It is responsible for targeted localization of the whole protein to post-synaptic regions of axons and plays a role in axon degeneration and therefore in several neurodegenerative conditions. Its NADase activity depletes the key cellular metabolite, NAD+, in response to nerve injury. SARM1 forms a homo-octamer, which avoids premature activation via a packed conformation that prevents dimerization and activation of the catalytic domains. The inactive conformation is stabilized by binding of the substrate NAD+ in an allosteric location distinct from the catalytic sites. This model characterizes the armadillo (ARM) repeat-containing N-terminal domain of SARM1.


:

Pssm-ID: 467946 [Multi-domain]  Cd Length: 308  Bit Score: 457.86  E-value: 5.62e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 232 IIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNtaacDQVRMECGKVLEECTSSANLEYIVNK 311
Cdd:cd24153     1 IIEGLAEVLKLMEEAWSTPKVGRDLAYGLCDALRLEGGLDLLIKNCQSPN----AEVRLASARLLEQCLTTENRDYVVRK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 312 SYTKKIMIVAMKLnKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPecPDILRHAALALANILLYTCF 391
Cdd:cd24153    77 GLDKVVNLAAEKL-KDVELARVSTGILEHLFKHSEETCSRLIELGGLDAILYWCRRTD--PETLRHCALALANLALYGGA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 392 EGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNT 471
Cdd:cd24153   154 ENQRKMIEKKVPEWLFPLAFSKDDLIRYYACLAIAVLAANKEIEAAVVKSGTLALVEPFIASHDPEEFARSDSKHSQGRS 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510237 472 KEWLERLLPMLQpSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGE 547
Cdd:cd24153   234 KEWLKRLVPLLD-SKRLEAQSLAAFHFCMEAGIKKEQGKTKVFSEIGAIESLKRVASSPNEVASKLAAEALRLIGE 308
SAM_SARM1-like_repeat1 cd09501
SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of ...
 557-625 7.05e-40

SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


:

Pssm-ID: 188900 [Multi-domain]  Cd Length: 69  Bit Score: 141.29  E-value: 7.05e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831510237 557 VPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAA 625
Cdd:cd09501     1 VPLWSVADVQTWLKQIGFEDYAEKFSESQVDGDLLLQLTEDELKQDLGMSSGLLRKRFLRELVELKTSA 69
SAM_SARM1-like_repeat2 cd09502
SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like ...
 626-695 2.26e-33

SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


:

Pssm-ID: 188901  Cd Length: 70  Bit Score: 122.79  E-value: 2.26e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 626 DYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKH 695
Cdd:cd09502     1 DYSSCDTTNLHNWLQSLGPEYSQYTYQMLNAGIDRNSLPSLTEDQLLEDCGITNGIHRLRILNAIKGMEH 70
TIR smart00255
Toll - interleukin 1 - resistance;
707-850 4.63e-26

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 104.33  E-value: 4.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237  707 QIDVFISYRRSTGNQLASLIKVLLQLRGYR--VFIDVDKLYAGKFDsSLLKNIQAAKHFILVLTPNSLDRLLNDDncEDW 784
Cdd:smart00255   1 EYDVFISYSGKEDVRNEFLSHLLEKLRGYGlcVFIDDFEPGGGDLE-EIDEAIEKSRIAIVVLSPNYAESEWCLD--ELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510237  785 VHKELKCAfEHQKNIIPIFDTafEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGE 850
Cdd:smart00255  78 AALENALE-EGGLRVIPIFYE--VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
 
Name Accession Description Interval E-value
SARM1_N cd24153
N-terminal ARM-repeat domain of SARM1 (sterile alpha and TIR motif containing 1); The ...
 232-547 5.62e-155

N-terminal ARM-repeat domain of SARM1 (sterile alpha and TIR motif containing 1); The nicotinamide adenine dinucleotidase SARM1 (sterile alpha and TIR motif containing 1) is involved in TLR (Toll-like receptor) signaling. It is responsible for targeted localization of the whole protein to post-synaptic regions of axons and plays a role in axon degeneration and therefore in several neurodegenerative conditions. Its NADase activity depletes the key cellular metabolite, NAD+, in response to nerve injury. SARM1 forms a homo-octamer, which avoids premature activation via a packed conformation that prevents dimerization and activation of the catalytic domains. The inactive conformation is stabilized by binding of the substrate NAD+ in an allosteric location distinct from the catalytic sites. This model characterizes the armadillo (ARM) repeat-containing N-terminal domain of SARM1.


Pssm-ID: 467946 [Multi-domain]  Cd Length: 308  Bit Score: 457.86  E-value: 5.62e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 232 IIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNtaacDQVRMECGKVLEECTSSANLEYIVNK 311
Cdd:cd24153     1 IIEGLAEVLKLMEEAWSTPKVGRDLAYGLCDALRLEGGLDLLIKNCQSPN----AEVRLASARLLEQCLTTENRDYVVRK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 312 SYTKKIMIVAMKLnKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPecPDILRHAALALANILLYTCF 391
Cdd:cd24153    77 GLDKVVNLAAEKL-KDVELARVSTGILEHLFKHSEETCSRLIELGGLDAILYWCRRTD--PETLRHCALALANLALYGGA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 392 EGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNT 471
Cdd:cd24153   154 ENQRKMIEKKVPEWLFPLAFSKDDLIRYYACLAIAVLAANKEIEAAVVKSGTLALVEPFIASHDPEEFARSDSKHSQGRS 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510237 472 KEWLERLLPMLQpSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGE 547
Cdd:cd24153   234 KEWLKRLVPLLD-SKRLEAQSLAAFHFCMEAGIKKEQGKTKVFSEIGAIESLKRVASSPNEVASKLAAEALRLIGE 308
SAM_SARM1-like_repeat1 cd09501
SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of ...
 557-625 7.05e-40

SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


Pssm-ID: 188900 [Multi-domain]  Cd Length: 69  Bit Score: 141.29  E-value: 7.05e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831510237 557 VPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAA 625
Cdd:cd09501     1 VPLWSVADVQTWLKQIGFEDYAEKFSESQVDGDLLLQLTEDELKQDLGMSSGLLRKRFLRELVELKTSA 69
SAM_SARM1-like_repeat2 cd09502
SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like ...
 626-695 2.26e-33

SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


Pssm-ID: 188901  Cd Length: 70  Bit Score: 122.79  E-value: 2.26e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 626 DYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKH 695
Cdd:cd09502     1 DYSSCDTTNLHNWLQSLGPEYSQYTYQMLNAGIDRNSLPSLTEDQLLEDCGITNGIHRLRILNAIKGMEH 70
TIR smart00255
Toll - interleukin 1 - resistance;
707-850 4.63e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 104.33  E-value: 4.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237  707 QIDVFISYRRSTGNQLASLIKVLLQLRGYR--VFIDVDKLYAGKFDsSLLKNIQAAKHFILVLTPNSLDRLLNDDncEDW 784
Cdd:smart00255   1 EYDVFISYSGKEDVRNEFLSHLLEKLRGYGlcVFIDDFEPGGGDLE-EIDEAIEKSRIAIVVLSPNYAESEWCLD--ELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510237  785 VHKELKCAfEHQKNIIPIFDTafEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGE 850
Cdd:smart00255  78 AALENALE-EGGLRVIPIFYE--VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 559-622 4.36e-19

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 81.93  E-value: 4.36e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831510237 559 GWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTLK 622
Cdd:pfam00536   2 GWSVEDVGEWLESIGLGQYIDSFRAGYIDGDALLQLTEDDLL-KLGVTLLGHRKKILYAIQRLK 64
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 557-622 5.45e-18

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 78.88  E-value: 5.45e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510237  557 VPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLK 622
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLLTSEEDLKELGITKLGHRKKILKAIQKLK 66
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 710-830 1.22e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 56.94  E-value: 1.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 710 VFISYRRStGNQLASLIKVLLQLRGYRVFIDVDKLYAGK-FDSSLLKNIQAAKHFILVLTPNSLDRllnddnceDWVHKE 788
Cdd:pfam13676   1 VFISYAGE-DRAWAEWLADALEAAGYRVWLDRWDIRPGDdWVEEIEEAIENSDRVLVVLSPNYLES--------PWCRAE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1831510237 789 LKCAFEHQKN---IIPI-FDTAFEFPTKEDQIPNDIRMITKYNGVK 830
Cdd:pfam13676  72 WEAALADPEGrkrLIPVrLECDLELPGLAGLQYIDLRDGDEFDAFE 117
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 627-696 9.82e-09

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 52.68  E-value: 9.82e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237  627 YSSVDESNLDNFLMGLSpeLSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHP 696
Cdd:smart00454   1 VSQWSPESVADWLESIG--LEQYADNFRKNGIDGALLLLLTSEEDLKELGITKLGHRKKILKAIQKLKEQ 68
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
633-691 6.54e-03

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 36.09  E-value: 6.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 633 SNLDNFLMGLSpeLSVYTYQMLTNGVN-RSLLSSLTDEMMQnACGITNPIHRLKLTQAFE 691
Cdd:pfam07647   7 ESVADWLRSIG--LEQYTDNFRDQGITgAELLLRLTLEDLK-RLGITSVGHRRKILKKIQ 63
 
Name Accession Description Interval E-value
SARM1_N cd24153
N-terminal ARM-repeat domain of SARM1 (sterile alpha and TIR motif containing 1); The ...
 232-547 5.62e-155

N-terminal ARM-repeat domain of SARM1 (sterile alpha and TIR motif containing 1); The nicotinamide adenine dinucleotidase SARM1 (sterile alpha and TIR motif containing 1) is involved in TLR (Toll-like receptor) signaling. It is responsible for targeted localization of the whole protein to post-synaptic regions of axons and plays a role in axon degeneration and therefore in several neurodegenerative conditions. Its NADase activity depletes the key cellular metabolite, NAD+, in response to nerve injury. SARM1 forms a homo-octamer, which avoids premature activation via a packed conformation that prevents dimerization and activation of the catalytic domains. The inactive conformation is stabilized by binding of the substrate NAD+ in an allosteric location distinct from the catalytic sites. This model characterizes the armadillo (ARM) repeat-containing N-terminal domain of SARM1.


Pssm-ID: 467946 [Multi-domain]  Cd Length: 308  Bit Score: 457.86  E-value: 5.62e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 232 IIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNtaacDQVRMECGKVLEECTSSANLEYIVNK 311
Cdd:cd24153     1 IIEGLAEVLKLMEEAWSTPKVGRDLAYGLCDALRLEGGLDLLIKNCQSPN----AEVRLASARLLEQCLTTENRDYVVRK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 312 SYTKKIMIVAMKLnKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPecPDILRHAALALANILLYTCF 391
Cdd:cd24153    77 GLDKVVNLAAEKL-KDVELARVSTGILEHLFKHSEETCSRLIELGGLDAILYWCRRTD--PETLRHCALALANLALYGGA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 392 EGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNT 471
Cdd:cd24153   154 ENQRKMIEKKVPEWLFPLAFSKDDLIRYYACLAIAVLAANKEIEAAVVKSGTLALVEPFIASHDPEEFARSDSKHSQGRS 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510237 472 KEWLERLLPMLQpSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGE 547
Cdd:cd24153   234 KEWLKRLVPLLD-SKRLEAQSLAAFHFCMEAGIKKEQGKTKVFSEIGAIESLKRVASSPNEVASKLAAEALRLIGE 308
SAM_SARM1-like_repeat1 cd09501
SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of ...
 557-625 7.05e-40

SAM domain ot SARM1-like proteins, repeat 1; SAM (sterile alpha motif) domain repeat 1 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


Pssm-ID: 188900 [Multi-domain]  Cd Length: 69  Bit Score: 141.29  E-value: 7.05e-40
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831510237 557 VPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAA 625
Cdd:cd09501     1 VPLWSVADVQTWLKQIGFEDYAEKFSESQVDGDLLLQLTEDELKQDLGMSSGLLRKRFLRELVELKTSA 69
SAM_SARM1-like_repeat2 cd09502
SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like ...
 626-695 2.26e-33

SAM domain of SARM1-like, repeat 2; SAM (sterile alpha motif) domain repeat 2 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.


Pssm-ID: 188901  Cd Length: 70  Bit Score: 122.79  E-value: 2.26e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 626 DYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKH 695
Cdd:cd09502     1 DYSSCDTTNLHNWLQSLGPEYSQYTYQMLNAGIDRNSLPSLTEDQLLEDCGITNGIHRLRILNAIKGMEH 70
TIR smart00255
Toll - interleukin 1 - resistance;
707-850 4.63e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 104.33  E-value: 4.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237  707 QIDVFISYRRSTGNQLASLIKVLLQLRGYR--VFIDVDKLYAGKFDsSLLKNIQAAKHFILVLTPNSLDRLLNDDncEDW 784
Cdd:smart00255   1 EYDVFISYSGKEDVRNEFLSHLLEKLRGYGlcVFIDDFEPGGGDLE-EIDEAIEKSRIAIVVLSPNYAESEWCLD--ELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510237  785 VHKELKCAfEHQKNIIPIFDTafEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGE 850
Cdd:smart00255  78 AALENALE-EGGLRVIPIFYE--VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
 559-622 4.36e-19

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 81.93  E-value: 4.36e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831510237 559 GWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTLK 622
Cdd:pfam00536   2 GWSVEDVGEWLESIGLGQYIDSFRAGYIDGDALLQLTEDDLL-KLGVTLLGHRKKILYAIQRLK 64
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 557-622 5.45e-18

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 78.88  E-value: 5.45e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510237  557 VPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLK 622
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLLTSEEDLKELGITKLGHRKKILKAIQKLK 66
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 564-620 3.06e-15

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 70.73  E-value: 3.06e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1831510237 564 DVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQT 620
Cdd:cd09487     1 DVAEWLESLGLEQYADLFRKNEIDGDALLLLTDEDLK-ELGITSPGHRKKILRAIQR 56
SAM_WDSUB1 cd09505
SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins ...
 560-627 1.71e-12

SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins is a putative protein-protein interaction domain. Proteins of this group contain multiple domains: SAM, one or more WD40 repeats and U-box (derived version of the RING-finger domain). Apparently the WDSUB1 subfamily proteins participate in protein degradation through ubiquitination, since U-box domain are known as a member of E3 ubiquitin ligase family, while SAM and WD40 domains most probably are responsible for an E2 ubiquitin-conjugating enzyme binding and a target protein binding.


Pssm-ID: 188904  Cd Length: 72  Bit Score: 63.49  E-value: 1.71e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831510237 560 WTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADY 627
Cdd:cd09505     5 WSEEDVCTWLRSIGLEQYVEVFRANNIDGKELLNLTKESLSKDLKIESLGHRNKILRKIEELKMKSDS 72
SAM_SGMS1-like cd09515
SAM domain of sphingomyelin synthase related subfamily; SAM (sterile alpha motif) domain of ...
 557-600 3.28e-11

SAM domain of sphingomyelin synthase related subfamily; SAM (sterile alpha motif) domain of SGMS-like (sphingomyelin synthase) subfamily is a potential protein-protein interaction domain. This group of proteins is related to sphingomyelin synthase 1, and contains an N-terminal SAM domain. The function of SGMS1-like proteins is unknown; they may play a role in sphingolipid metabolism.


Pssm-ID: 188914  Cd Length: 70  Bit Score: 59.57  E-value: 3.28e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1831510237 557 VPGWTCADVQYWVKKIGFEEYVEKFA-KQMVDGDLLLQLTENDLK 600
Cdd:cd09515     1 VHEWTCEDVAKWLKKEGFSKYVDLLCnKHRIDGKVLLSLTEEDLR 45
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
557-622 9.19e-11

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 58.43  E-value: 9.19e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831510237 557 VPGWTCADVQYWVKKIGFEEYVEKFAKQMVDG-DLLLQLTENDLKhDVGMISGLHRKRFLRELQTLK 622
Cdd:pfam07647   1 VESWSLESVADWLRSIGLEQYTDNFRDQGITGaELLLRLTLEDLK-RLGITSVGHRRKILKKIQELK 66
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 710-830 1.22e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 56.94  E-value: 1.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 710 VFISYRRStGNQLASLIKVLLQLRGYRVFIDVDKLYAGK-FDSSLLKNIQAAKHFILVLTPNSLDRllnddnceDWVHKE 788
Cdd:pfam13676   1 VFISYAGE-DRAWAEWLADALEAAGYRVWLDRWDIRPGDdWVEEIEEAIENSDRVLVVLSPNYLES--------PWCRAE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1831510237 789 LKCAFEHQKN---IIPI-FDTAFEFPTKEDQIPNDIRMITKYNGVK 830
Cdd:pfam13676  72 WEAALADPEGrkrLIPVrLECDLELPGLAGLQYIDLRDGDEFDAFE 117
SAM_Neurabin-like cd09512
SAM domain of SAM_Neurabin-like subfamily; SAM (sterile alpha motif) domain of Neurabin-like ...
 556-624 1.80e-09

SAM domain of SAM_Neurabin-like subfamily; SAM (sterile alpha motif) domain of Neurabin-like (Neural actin-binding) subfamily is a putative protein-protein interaction domain. This group currently includes the SAM domains of neurobin-I, SAMD14 and neurobin-I/SAMD14-like proteins. Most are multidomain proteins and in addition to SAM domain they contain other protein-binding domains such as PDZ and actin-binding domains. Members of this subfamily participate in signal transduction. Neurabin-I is involved in the regulation of Ca signaling intensity in alpha-adrenergic receptors; it forms a functional pair of opposing regulators with neurabin-II. Neurabins are expressed almost exclusively in neuronal cells. They are known to interact with protein phosphatase 1 and inhibit its activity; they also can bind actin filaments; however, the exact role of the SAM domain is unclear, since SAM doesn't participate in these interactions.


Pssm-ID: 188911 [Multi-domain]  Cd Length: 70  Bit Score: 54.58  E-value: 1.80e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831510237 556 QVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTLKVA 624
Cdd:cd09512     3 PVSEWSVQQVCQWLMGLGLEQYIPEFTANNIDGQQLLQLDSSKLK-ALGITSSSDRSLLKKKLKELKAQ 70
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
 627-696 9.82e-09

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 52.68  E-value: 9.82e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237  627 YSSVDESNLDNFLMGLSpeLSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHP 696
Cdd:smart00454   1 VSQWSPESVADWLESIG--LEQYADNFRKNGIDGALLLLLTSEEDLKELGITKLGHRKKILKAIQKLKEQ 68
SAM_Polycomb cd09509
SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a ...
 560-605 8.67e-08

SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a protein-protein interaction domain. The Polycomb group includes transcriptional repressors which are involved in the regulation of some key regulatory genes during development in many organisms. They are best known for silencing Hox (Homeobox) genes. Polycomb proteins work together in large multimeric and chromatin-associated complexes. They organize chromatin of the target genes and maintain repressed states during many cell divisions. Polycomb proteins are classified based on their common function, but not on conserved domains and/or motifs; however many Polycomb proteins (members of PRC1 class complex) contain SAM domains which are more similar to each other inside of the Polycomb group than to SAM domains outside of it. Most information about structure and function of Polycomb SAM domains comes from studies of Ph (Polyhomeotic) and Scm (Sex comb on midleg) proteins. Polycomb SAM domains usually can be found at the C-terminus of the proteins. Some members of this group contain, in addition to the SAM domain, MTB repeats, Zn finger, and/or DUF3588 domains. Polycomb SAM domains can form homo- and/or heterooligomers through ML and EH surfaces. SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Polycomb proteins are known to be highly expressed in some cells years before their cancer pathology; thus they are attractive markers for early cancer therapy.


Pssm-ID: 188908  Cd Length: 64  Bit Score: 49.79  E-value: 8.67e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1831510237 560 WTCADVQYWVKKI-GFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGM 605
Cdd:cd09509     4 WSVDDVAQFIKSLdGCAEYAEVFREQEIDGQALLLLTEDDLLKGMGL 50
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 709-813 2.87e-07

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 51.21  E-value: 2.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 709 DVFISYRRS-TGNQLASLIKVLLQLRGYRVFIDVDKLYAGK-FDSSLLKNIQAAKHFILVLTPNSLdrllNDDNCEDWVH 786
Cdd:pfam01582   2 DVFLSFRGSdTREWFVSHLLKELKQKGIKLFIDDRDLEPGEaIAPELLSAIEKSRRSVVVLSPNYA----SSGWCLDELV 77

                          90       100
                  ....*....|....*....|....*..
gi 1831510237 787 KELKCAFEHQKNIIPIFDTAFEFPTKE 813
Cdd:pfam01582  78 KILECALDLGQKVIPIFYEVDPSDVRK 104
SAM_Atherin-like cd09583
SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin ...
 560-598 5.74e-07

SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin and Atherin-like subfamily proteins is a putative protein-protein and/or protein-lipid interaction domain. In addition to the C-terminal SAM domain, the majority of proteins belonging to this group also have PHD (or Zn finger) domain. As potential members of the polycomb group, these proteins may be involved in regulation of some key regulatory genes during development. Atherin can be recruited by Ruk/CIN85 kinase-binding proteins via its SH3 domains thus participating in the signal transferring kinase cascades. Also, atherin was found associated with low density lipids (LDL) in atherosclerotic lesions in human. It was suggested that atherin plays an essential role in atherogenesis via immobilization of LDL in the arterial wall. SAM domains of atherins are predicted to form polymers. Inhibition of polymer formation could be a potential antiatherosclerotic therapy.


Pssm-ID: 188982  Cd Length: 69  Bit Score: 47.65  E-value: 5.74e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1831510237 560 WTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTEND 598
Cdd:cd09583     4 WSVEDVVQYFKTAGFPEEANAFKEQEIDGKSLLLLTRSD 42
SAM_Shank1,2,3 cd09506
SAM domain of Shank1,2,3 family proteins; SAM (sterile alpha motif) domain of Shank1,2,3 ...
 560-621 4.43e-06

SAM domain of Shank1,2,3 family proteins; SAM (sterile alpha motif) domain of Shank1,2,3 family proteins is a protein-protein interaction domain. Shank1,2,3 proteins are scaffold proteins that are known to interact with a variety of cytoplasmic and membrane proteins. SAM domains of the Shank1,2,3 family are prone to homooligomerization. They are highly enriched in the postsynaptic density, acting as scaffolds to organize assembly of postsynaptic proteins. SAM domains of Shank3 proteins can form large sheets of helical fibers. Shank genes show distinct patterns of expression, in rat Shank1 mRNA is found almost exclusively in brain, Shank2 in brain, kidney and liver, and Shank3 in heart, brain and spleen.


Pssm-ID: 188905  Cd Length: 66  Bit Score: 45.00  E-value: 4.43e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831510237 560 WTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTL 621
Cdd:cd09506     5 WTVDDVGDWLESLNLGEHRERFMDNEIDGSHLPNLDKEDLT-ELGVTRVGHRMNIERALKKL 65
SAM_DGK-delta-eta cd09507
SAM domain of diacylglycerol kinase delta and eta subunits; SAM (sterile alpha motif) domain ...
 557-621 6.68e-06

SAM domain of diacylglycerol kinase delta and eta subunits; SAM (sterile alpha motif) domain of DGK-eta-delta subfamily proteins is a protein-protein interaction domain. Proteins of this subfamily are multidomain diacylglycerol kinases with a SAM domain located at the C-terminus. DGK proteins participate in signal transduction. They regulate the level of second messengers such as diacylglycerol and phosphatidic acid. The SAM domain of DGK proteins can form high molecular weight homooligomers through head-to-tail interactions as well as heterooligomers between the SAM domains of DGK delta and eta proteins. The oligomerization plays a role in the regulation of DGK intracellular localization.


Pssm-ID: 188906  Cd Length: 65  Bit Score: 44.33  E-value: 6.68e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1831510237 557 VPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTL 621
Cdd:cd09507     2 VTNWTTEEVGAWLESLQLGEYRDIFARNDIRGSELLHLERRDLK-DLGITKVGHVKRILQAIKDL 65
SAM_liprin-beta1,2_repeat1 cd09563
SAM domain of liprin-beta1,2 proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 of ...
 560-619 7.11e-06

SAM domain of liprin-beta1,2 proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 of liprin-beta1,2 proteins is a protein-protein interaction domain. Liprin-beta protein contain three copies (repeats) of SAM domain. They may form heterodimers with liprins-alpha through their SAM domains. It was suggested based on bioinformatic approaches that the second SAM domain of liprin-beta is potentially able to form polymers. Liprins were originally identified as LAR (leukocyte common antigen-related) transmembrane protein-tyrosine phosphatase-interacting proteins. They participate in mammary gland development, in axon guidance, and in the maintenance of lymphatic vessel integrity.


Pssm-ID: 188962  Cd Length: 64  Bit Score: 44.53  E-value: 7.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831510237 560 WTCADVQYWVKKIGFEEYVEkFAKQMV-DGDLLLQLTENDLKHDVGMISGLHRKRFLRELQ 619
Cdd:cd09563     4 WSTEQVCDWLAELGLGQYVD-ECRRWVkSGQTLLKASPQELEKELGIKHPLHRKKLQLALQ 63
SAM_BAR cd09513
SAM domain of BAR subfamily; SAM (sterile alpha motif) domain of BAR (Bifunctional Apoptosis ...
 557-622 8.22e-06

SAM domain of BAR subfamily; SAM (sterile alpha motif) domain of BAR (Bifunctional Apoptosis Regulator) subfamily is a protein-protein interaction domain. In addition to the SAM domain, this type of regulator has a RING finger domain. Proteins of this subfamily are involved in the apoptosis signal network. Their overexpression in human neuronal cells significantly protects cells from a broad range of cell death stimuli. SAM domain can interact with Caspase8, Bcl-2 and Bcl-X resulting in suppression of Bax-induced cell death.


Pssm-ID: 188912  Cd Length: 71  Bit Score: 44.41  E-value: 8.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831510237 557 VPGWTCADVQYWVKKIG--FEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMI-SGLHRKRFLRELQTLK 622
Cdd:cd09513     1 VSKWTPEEVVLWLEQLGpwASLYRERFLSENVNGRLLLTLTEEELSKPPFNIeNSLHRRAILTELERVK 69
SAM_BOI-like_fungal cd09535
SAM domain of BOI-like fungal subfamily; SAM (sterile alpha motif) domain of BOI-like fungal ...
 560-600 1.57e-05

SAM domain of BOI-like fungal subfamily; SAM (sterile alpha motif) domain of BOI-like fungal subfamily is a potential protein-protein interaction domain. Proteins of this subfamily are apparently scaffold proteins, since most contain SH3 and PH domains, which are also protein-protein interaction domains, in addition to SAM domain. BOI-like proteins participate in cell cycle regulation. In particular BOI1 and BOI2 proteins of budding yeast S.cerevisiae are involved in bud formation, and POB1 protein of fission yeast S.pombe plays a role in cell elongation and separation. Among binding partners of BOI-like fungal subfamily members are such proteins as Bem1 and Cdc42 (they are known to be involved in cell polarization and bud formation).


Pssm-ID: 188934  Cd Length: 65  Bit Score: 43.31  E-value: 1.57e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1831510237 560 WTCADVQYWVKKIGFEEYV-EKFAKQMVDGDLLLQLTENDLK 600
Cdd:cd09535     3 WSPEQVAEWLLSAGFDDSVcEKFRENEITGDILLELDLEDLK 44
SAM_Samd14 cd09530
SAM domain of Samd14 subfamily; SAM (sterile alpha motif) domain of SamD14 (or FAM15A) ...
 560-594 2.96e-05

SAM domain of Samd14 subfamily; SAM (sterile alpha motif) domain of SamD14 (or FAM15A) subfamily is a putative protein-protein interaction domain. SAM is widespread domain in proteins involved in signal transduction and regulation. In many cases SAM mediates homodimerization/oligomerization. The exact function of proteins belonging to this subfamily is unknown.


Pssm-ID: 188929  Cd Length: 67  Bit Score: 42.69  E-value: 2.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1831510237 560 WTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQL 594
Cdd:cd09530     3 WDTEDVAEWIEGLGFPQYRECFTTNFIDGRKLILV 37
SAM_Ste11_fungal cd09534
SAM domain of Ste11_fungal subfamily; SAM (sterile alpha motif) domain of Ste11 subfamily is a ...
 560-600 3.10e-05

SAM domain of Ste11_fungal subfamily; SAM (sterile alpha motif) domain of Ste11 subfamily is a protein-protein interaction domain. Proteins of this subfamily have SAM domain at the N-terminus and protein kinase domain at the C-terminus. They participate in regulation of mating pheromone response, invasive growth and high osmolarity growth response. MAP triple kinase Ste11 from S.cerevisia is known to interact with Ste20 kinase and Ste50 regulator. These kinases are able to form homodimers interacting through their SAM domains as well as heterodimers or heterogenous complexes when either SAM domain of monomeric or homodimeric form of Ste11 interacts with Ste50 regulator.


Pssm-ID: 188933  Cd Length: 62  Bit Score: 42.58  E-value: 3.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1831510237 560 WTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLK 600
Cdd:cd09534     1 WDEEFVEEWLNELNCGQYLDIFEKNLITGDLLLELDKEALK 41
SAM_aveugle-like cd09510
SAM domain of aveugle-like subfamily; SAM (sterile alpha motif) domain of SAM_aveugle-like ...
 560-626 4.94e-05

SAM domain of aveugle-like subfamily; SAM (sterile alpha motif) domain of SAM_aveugle-like subfamily is a protein-protein interaction domain. In Drosophila, the aveugle (AVE) protein (also known as HYP (Hyphen)) is involved in normal photoreceptor differentiation, and required for epidermal growth factor receptor (EGFR) signaling between ras and raf genes during eye development and wing vein formation. SAM domain of the HYP(AVE) protein interacts with SAM domain of CNK, the multidomain scaffold protein connector enhancer of kinase suppressor of ras. CNK/HYP(AVE) complex interacts with KSR (kinase suppressor of Ras) protein. This interaction leads to stimulation of Ras-dependent Raf activation. This subfamily also includes vertebrate AVE homologs - Samd10 and Samd12 proteins. Their exact function is unknown, but they may play a role in signal transduction during embryogenesis.


Pssm-ID: 188909  Cd Length: 75  Bit Score: 42.29  E-value: 4.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 560 WTCADVQYWVKK---IGFEEYVEKFAKQMVDGDLLLQLTENDLKHdVGMISGLHRKRFLRELQTLKVAAD 626
Cdd:cd09510     6 WSVQDVCKWLKRhcpDYYLLYAELFLQHDITGRALLRLNDNKLER-MGITDEDHRQDILREILKLRLKTE 74
SAM_liprin-kazrin_repeat2 cd09495
SAM domain of liprin/kazrin proteins repeat 2; SAM (sterile alpha motif) domain repeat 2 of ...
 565-622 1.05e-04

SAM domain of liprin/kazrin proteins repeat 2; SAM (sterile alpha motif) domain repeat 2 of liprin/kazrin proteins is a protein-protein interaction domain. The long form of liprin/kazrin proteins contains three copies (repeats) of SAM domain. Liprin-alpha may form heterodimers with liprin-beta through their SAM domains. Liprins were originally identified as LAR (leukocyte common antigen-related) transmembrane protein-tyrosine phosphatase-interacting proteins. They participate in mammary gland development and in axon guidance. In particular, liprin-alpha is involved in formation of the presynaptic active zone; liprin-beta is involved in the maintenance of lymphatic vessel integrity. Kazrins are involved in interplay between desmosomes and in adheren junctions; additionally they play a role in regulation of intercellular differentiation, junction assembly, and cytoskeletal organization.


Pssm-ID: 188894  Cd Length: 60  Bit Score: 40.98  E-value: 1.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1831510237 565 VQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLK 622
Cdd:cd09495     3 VTRWLDDIGLPQYKDQFHESLVDRRMLQYLTVNDLLVHLKVTSQLHHLSLKCGIHVLH 60
SAM_Samd9_Samd9L cd09528
SAM domain of Samd9/Samd9L subfamily; SAM (sterile alpha motif) domain of Samd9/Samd9L ...
 560-618 1.32e-04

SAM domain of Samd9/Samd9L subfamily; SAM (sterile alpha motif) domain of Samd9/Samd9L subfamily is a putative protein-protein interaction domain. SAM is a widespread domain in signaling proteins. Samd9 is a tumor suppressor gene. It is involved in death signaling of malignant glioblastoma. Samd9 suppression blocks cancer cell death induced by HVJ-E or IFN-beta treatment. Deleterious mutations in Samd9 lead to normophosphatemic familial tumoral calcinosis, a cutaneous disorder characterized by cutaneous calcification or ossification.


Pssm-ID: 188927  Cd Length: 64  Bit Score: 40.86  E-value: 1.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831510237 560 WTCADVQYWVKKIGF-EEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISG--LHRKRFLREL 618
Cdd:cd09528     3 WTKEHVKQWLIEDLIdKKYAEILYEEEVTGAVLKELTEEDLV-DMGLPHGpaLLIIHSFNEL 63
SAM_liprin-beta1,2_repeat2 cd09566
SAM domain of liprin-beta1,2 proteins repeat 2; SAM (sterile alpha motif) domain repeat 2 of ...
 568-622 3.02e-04

SAM domain of liprin-beta1,2 proteins repeat 2; SAM (sterile alpha motif) domain repeat 2 of liprin-beta1,2 proteins is a protein-protein interaction domain. Liprin-beta proteins contain three copies (repeats) of SAM domain. They may form heterodimers with liprin-alpha proteins through their SAM domains. It was suggested based on bioinformatic approaches that the second SAM domain of liprin-beta potentially is able to form polymers. Liprins were originally identified as LAR (leukocyte common antigen-related) transmembrane protein-tyrosine phosphatase-interacting proteins. They participate in mammary gland development, in axon guidance, and in the maintenance of lymphatic vessel integrity.


Pssm-ID: 188965  Cd Length: 63  Bit Score: 39.60  E-value: 3.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1831510237 568 WVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHdVGMISGLHRKRFLRELQTLK 622
Cdd:cd09566    10 WLDDIGLPQYKDAFSEAKVDGRMLHYLTVDDLLH-LKVTSALHHASIRRGIQVLR 63
SAM_Ste50-like_fungal cd09533
SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or ...
 564-622 3.22e-04

SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or Ubc2 for Ustilago bypass of cyclase) subfamily is a putative protein-protein interaction domain. This group includes only fungal proteins. Basidiomycetes have an N-terminal SAM domain, central UBQ domain, and C-terminal SH3 domain, while Ascomycetes lack the SH3 domain. Ubc2 of Ustilago maydis is a major virulence and maize pathogenicity factor. It is required for filamentous growth (the budding haploid form of Ustilago maydis is a saprophyte, while filamentous dikaryotic form is a pathogen). Also the Ubc2 protein is involved in the pheromone-responsive morphogenesis via the MAP kinase cascade. The SAM domain is necessary for ubc2 function; deletion of SAM eliminates this function. A Lys-to-Glu mutation in the SAM domain of ubc2 gene induces temperature sensitivity.


Pssm-ID: 188932  Cd Length: 58  Bit Score: 39.61  E-value: 3.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1831510237 564 DVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTLK 622
Cdd:cd09533     1 DVADWLSSLGLPQYEDQFIENGITGDVLVALDHEDLK-EMGITSVGHRLTILKAVYELK 58
SAM_MLTK cd09529
SAM domain of MLTK subfamily; SAM (sterile alpha motif) domain of MLTK subfamily is a ...
 560-622 3.78e-04

SAM domain of MLTK subfamily; SAM (sterile alpha motif) domain of MLTK subfamily is a protein-protein interaction domain. Besides SAM domain, these proteins have N-terminal protein tyrosine kinase domain and leucine-zipper motif. Proteins of this group act as mitogen-activated protein triple kinase in a number of MAPK cascades. They can be activated by autophosphorylation in response to stress signals. MLTK-alpha is known to phosphorylate histone H3. In mammals, MLTKs participate in the activation of the JNK/SAPK, p38, ERK5 pathways, the transcriptional factor NF-kB, in the regulation of the cell cycle checkpoint, and in the induction of apoptosis in a hepatoma cell line. Some members of this subfamily are proto-oncogenes, thus MLTK-alpha is involved in neoplasmic cell transformation and/or skin cancer development in athymic nude mice. Based on in vivo coprecipitation experiments in mammalian cells, it has been demonstrated that MLTK proteins might form homodimers/oligomers via their SAM domains.


Pssm-ID: 188928  Cd Length: 71  Bit Score: 39.80  E-value: 3.78e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831510237 560 WTCADVQYWVKKIG--------FEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTLK 622
Cdd:cd09529     2 WTEEDVHFWMQQLVrkgghpseLSQYADLFKENHITGKRLLLLTEEDLR-DMGIGSKGHIIHLKSAIEKLT 71
SAM_SGMS1 cd09514
SAM domain of sphingomyelin synthase; SAM (sterile alpha motif) domain of SGMS-1 ...
 555-624 4.56e-04

SAM domain of sphingomyelin synthase; SAM (sterile alpha motif) domain of SGMS-1 (sphingomyelin synthase) subfamily is a potential protein-protein interaction domain. Sphingomyelin synthase 1 is a transmembrane protein with a SAM domain at the N-terminus and a catalytic domain at the C-terminus. Sphingomyelin synthase 1 is a Golgi-associated enzyme, and depending on the concentration of diacylglycerol and ceramide, can catalyze synthesis phosphocholine or sphingomyelin, respectively. It plays a central role in sphingolipid and glycerophospholipid metabolism.


Pssm-ID: 188913  Cd Length: 72  Bit Score: 39.39  E-value: 4.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831510237 555 QQVPGWTCADVQYWVKKIGFEEYVEkfAKQMVDGDLLLQLTENDLKH-DVGMISGLHRKRFLRELQTLKVA 624
Cdd:cd09514     2 KEVVQWSPKEVSDWLSEEGMQEYSE--ALRSFDGQALLNLTEEDFKKtPLSLVSSDSGRQLLEMIETLKIE 70
SAM_liprin-kazrin_repeat1 cd09494
SAM domain of liprin/kazrin proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 of ...
 639-691 5.55e-04

SAM domain of liprin/kazrin proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 of liprin/kazrin proteins is a protein-protein interaction domain. The long form of liprin/kazrin proteins contains three copies (repeats) of the SAM domain. Liprin-alpha may form heterodimers with liprin-beta through their SAM domains. Liprins were originally identified as LAR (leukocyte common antigen-related) transmembrane protein-tyrosine phosphatase-interacting proteins. They participate in mammary gland development and in axon guidance. In particular, liprin-alpha is involved in formation of the presynaptic active zone; liprin-beta is involved in the maintenance of lymphatic vessel integrity. Kazrins are involved in interplay between desmosomes and adherens junctions; additionally they play a role in regulation of intercellular differentiation, junction assembly, and cytoskeletal organization.


Pssm-ID: 188893  Cd Length: 58  Bit Score: 38.75  E-value: 5.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1831510237 639 LMGLSPELSVYTYQMLTNGvnrSLLSSLTDEMMQNACGITNPIHRLKLTQAFE 691
Cdd:cd09494     8 DFGLMPMYVIFCRQNVKSG---HTLLTLSDQEMEKELGIKNPLHRKKLRLAIK 57
SAM_DGK-eta cd09576
SAM domain of diacylglycerol kinase eta; SAM (sterile alpha motif) domain of DGK-eta subfamily ...
 557-621 2.30e-03

SAM domain of diacylglycerol kinase eta; SAM (sterile alpha motif) domain of DGK-eta subfamily proteins is a protein-protein interaction domain. Proteins of this subfamily are multidomain diacylglycerol kinases. The SAM domain is located at the C-terminus of two out of three isoforms of DGK-eta protein. DGK-eta proteins participate in signal transduction. They regulate the level of second messengers such as diacylglycerol and phosphatidic acid. The SAM domain of DCK-eta proteins can form high molecular weight homooligomers through head-to-tail interactions as well as heterooligomers with the SAM domain of DGK-delta proteins. The oligomerization plays a role in the regulation of the DGK-delta intracellular localization: it is responsible for sustained endosomal localization of the protein and resulted in negative regulation of DCK-eta catalytic activity.


Pssm-ID: 188975  Cd Length: 65  Bit Score: 37.26  E-value: 2.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1831510237 557 VPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTL 621
Cdd:cd09576     2 VQKWGTDEVAAWLDLLSLGEYKEIFIRHDIRGSELLHLERRDLK-DLGIPKVGHMKRILQGIKEL 65
SAM_liprin-alpha1,2,3,4_repeat1 cd09562
SAM domain of liprin-alpha1,2,3,4 proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 ...
 661-689 2.59e-03

SAM domain of liprin-alpha1,2,3,4 proteins repeat 1; SAM (sterile alpha motif) domain repeat 1 of liprin-alpha1,2,3,4 proteins is a protein-protein interaction domain. Liprin-alpha proteins contain three copies (repeats) of SAM domain. They may form heterodimers with liprin-beta proteins through their SAM domains. Liprins were originally identified as LAR (leukocyte common antigen-related) transmembrane protein-tyrosine phosphatase-interacting proteins. They participate in mammary gland development and in axon guidance; in particular, liprin-alpha is involved in formation of the presynaptic active zone.


Pssm-ID: 188961  Cd Length: 71  Bit Score: 37.54  E-value: 2.59e-03
                          10        20
                  ....*....|....*....|....*....
gi 1831510237 661 SLLSSLTDEMMQNACGITNPIHRLKLTQA 689
Cdd:cd09562    35 AIMSALSDTEIQREIGISNPLHRLKLRLA 63
SAM_caskin1,2_repeat1 cd09497
SAM domain of caskin protein repeat 1; SAM (sterile alpha motif) domain repeat 1 of caskin1,2 ...
 646-697 4.90e-03

SAM domain of caskin protein repeat 1; SAM (sterile alpha motif) domain repeat 1 of caskin1,2 proteins is a protein-protein interaction domain. Caskin has two tandem SAM domains. Caskin protein is known to interact with membrane-associated guanylate kinase CASK, and apparently may play a role in neural development, synaptic protein targeting, and regulation of gene expression.


Pssm-ID: 188896  Cd Length: 66  Bit Score: 36.47  E-value: 4.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1831510237 646 LSVYTYQMLTNGVNRSLLSSLTDEMMqNACGITNPIHRLKLTQAFETAKHPD 697
Cdd:cd09497    16 LEEYTPNFIKAGYDLPTISRMTPEDL-TAIGITKPGHRKKLKSEIAQLQIPD 66
SAM_DGK-delta cd09575
SAM domain of diacylglycerol kinase delta; SAM (sterile alpha motif) domain of DGK-delta ...
 560-621 6.11e-03

SAM domain of diacylglycerol kinase delta; SAM (sterile alpha motif) domain of DGK-delta subfamily proteins is a protein-protein interaction domain. Proteins of this subfamily are multidomain diacylglycerol kinases with a SAM domain located at the C-terminus. DGK-delta proteins participate in signal transduction. They regulate the level of second messengers such as diacylglycerol and phosphatidic acid. In particular DGK-delta is involved in the regulation of clathrin-dependent endocytosis. The SAM domain of DGK-delta proteins can form high molecular weight homooligomers through head-to-tail interactions as well as heterooligomers with the SAM domain of DGK-eta proteins. The oligomerization plays a role in the regulation of the DGK-delta intracellular localization: it inhibits the translocation of the protein to the plasma membrane from the cytoplasm. The SAM domain also can bind Zn at multiple (not conserved) sites driving the formation of highly ordered large sheets of polymers, thus suggesting that Zn may play important role in the function of DCK-delta.


Pssm-ID: 188974  Cd Length: 65  Bit Score: 36.08  E-value: 6.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831510237 560 WTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKhDVGMISGLHRKRFLRELQTL 621
Cdd:cd09575     5 WGTEEVAAWLEHLSLCEYKDIFTRHDVRGSELLHLERRDLK-DLGVTKVGHMKRILCGIKEL 65
SAM_Samd7,11 cd09579
SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a ...
 560-605 6.19e-03

SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a protein-protein interaction domain. Phylogenetic analysis suggests that proteins of this subfamily are most closely related to SAM-Ph1,2,3 subfamily of Polycomb group. They are predicted transcriptional repressors in photoreceptor cells and pinealocytes of vertebrates. SAM domain containing protein 11 is also known as Mr-s (major retinal SAM) protein. In mouse, it is predominantly expressed in developing retinal photoreceptors and in adult pineal gland. The SAM domain is involved in homooligomerization of whole proteins (it was shown based on immunoprecipitation assay and mutagenesis), however its repression activity is not due to SAM/SAM interactions but to the C-terminal region.


Pssm-ID: 188978  Cd Length: 68  Bit Score: 36.27  E-value: 6.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1831510237 560 WTCADVQYWVKKI-GFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGM 605
Cdd:cd09579     4 WTVDDVCSFIGSLpGCAEYAQVFREHSIDGETLPLLTEEHLLNTMGL 50
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
633-691 6.54e-03

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 36.09  E-value: 6.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510237 633 SNLDNFLMGLSpeLSVYTYQMLTNGVN-RSLLSSLTDEMMQnACGITNPIHRLKLTQAFE 691
Cdd:pfam07647   7 ESVADWLRSIG--LEQYTDNFRDQGITgAELLLRLTLEDLK-RLGITSVGHRRKILKKIQ 63
SAM_Scm-like-3MBT3,4 cd09582
SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
 557-599 8.24e-03

SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-3MBT3,4 (Sex comb on midleg, Malignant brain tumor) subfamily proteins (also known as L3mbtl3,4 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are predicted transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain three MBT repeats and Zn finger domain. Murine L3mbtl3 protein of this subfamily is essential for maturation of myeloid progenitor cells during differentiation. Human L3mbtl4 is a potential tumor suppressor gene in breast cancer, while deregulation of L3MBTL3 is associated with neuroblastoma.


Pssm-ID: 188981  Cd Length: 66  Bit Score: 35.71  E-value: 8.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1831510237 557 VPGWTCADVQYWVKKI-GFEEYVEKFAKQMVDGDLLLQLTENDL 599
Cdd:cd09582     1 VLRWSVDEVAEFVQSLpGCEEHAKVFRDEQIDGEAFLLLTQSDL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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