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Conserved domains on  [gi|1827280164|ref|NP_001366272|]
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guanine nucleotide-binding protein subunit beta-5 isoform c [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-301 3.18e-82

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.94  E-value: 3.18e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   4 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 78
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  79 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetgN 158
Cdd:cd00200    77 LWDLETGE------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---G 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 159 TFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgasS 236
Cdd:cd00200   148 TFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---S 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827280164 237 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 301
Cdd:cd00200   225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-301 3.18e-82

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.94  E-value: 3.18e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   4 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 78
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  79 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetgN 158
Cdd:cd00200    77 LWDLETGE------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---G 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 159 TFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgasS 236
Cdd:cd00200   148 TFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---S 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827280164 237 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 301
Cdd:cd00200   225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-300 1.47e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.83  E-value: 1.47e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   2 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 81
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  82 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 161
Cdd:COG2319   191 LATGK------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--GRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 162 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIifGASSVDFSL 241
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSP 340

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827280164 242 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:COG2319   341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 162-300 2.06e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 162 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYyPSGDA--FASGSDDATCRLYDLRADREVA-IYSKESIifgaSSVD 238
Cdd:PLN00181  550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDY-SSADPtlLASGSDDGSVKLWSINQGVSIGtIKTKANI----CCVQ 624

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827280164 239 F-SLSGRLLFAGYNDYTINVWDvLKGSRVSI--LFGHENRVSTLRVSpDGTAFCSGSWDHTLRVW 300
Cdd:PLN00181  625 FpSESGRSLAFGSADHKVYYYD-LRNPKLPLctMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1-39 3.44e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 3.44e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1827280164    1 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 39
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
263-300 2.36e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.36e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1827280164 263 GSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-301 3.18e-82

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.94  E-value: 3.18e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   4 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 78
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  79 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetgN 158
Cdd:cd00200    77 LWDLETGE------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---G 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 159 TFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgasS 236
Cdd:cd00200   148 TFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN---S 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827280164 237 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 301
Cdd:cd00200   225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-300 1.47e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.83  E-value: 1.47e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   2 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 81
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  82 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 161
Cdd:COG2319   191 LATGK------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--GRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 162 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIifGASSVDFSL 241
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSP 340

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827280164 242 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:COG2319   341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
4-300 2.05e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.43  E-value: 2.05e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   4 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYplt 83
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  84 fdkneNMAAKK--KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 161
Cdd:COG2319   148 -----DLATGKllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--GKLLA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 162 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSL 241
Cdd:COG2319   221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSP 298

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1827280164 242 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:COG2319   299 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
4-300 4.84e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.57  E-value: 4.84e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   4 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLT 83
Cdd:COG2319    29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  84 fdknenMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFVSG 163
Cdd:COG2319   109 ------TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD--GKLLASG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 164 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSLSG 243
Cdd:COG2319   181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS--GSVRSVAFSPDG 258

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1827280164 244 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:COG2319   259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
2-260 2.21e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.24  E-value: 2.21e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   2 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYp 81
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW- 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  82 ltfdkneNMAAKK--KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNT 159
Cdd:COG2319   232 -------DLATGKllRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD--GKL 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 160 FVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDF 239
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT--GAVTSVAF 380

                         250       260
                  ....*....|....*....|.
gi 1827280164 240 SLSGRLLFAGYNDYTINVWDV 260
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
2-217 3.85e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 3.85e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   2 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 81
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  82 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTFV 161
Cdd:COG2319   275 LATGE------LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--DGKTLA 346

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1827280164 162 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 217
Cdd:COG2319   347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-300 1.07e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 1.07e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 135 LLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 214
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPD--GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 215 DLRADREVAIYS--KESIifgaSSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGS 292
Cdd:cd00200    79 DLETGECVRTLTghTSYV----SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154


                  ....*...
gi 1827280164 293 WDHTLRVW 300
Cdd:cd00200   155 QDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
2-176 1.69e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 1.69e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   2 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 81
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  82 LtfdkneNMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLclDLAPSETGNTFV 161
Cdd:COG2319   317 L------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGRTLA 388

                         170
                  ....*....|....*
gi 1827280164 162 SGGCDKKAMVWDMRS 176
Cdd:COG2319   389 SGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
115-300 1.73e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 1.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 115 QILTASGDGTCALWDVESGQLLQSFHGHGADVLclDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVR 194
Cdd:COG2319     8 ALAAASADLALALLAAALGALLLLLLGLAAAVA--SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 195 YYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHEN 274
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                         170       180
                  ....*....|....*....|....*.
gi 1827280164 275 RVSTLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-173 5.98e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 5.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164   1 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDsfttnkehavtmpctwvmacayapsgcaiacggLDNKCSVY 80
Cdd:cd00200   167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD---------------------------------LSTGKCLG 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  81 PLTFdknenmaakkksvamHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTF 160
Cdd:cd00200   214 TLRG---------------HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP--DGKRL 276

                         170
                  ....*....|...
gi 1827280164 161 VSGGCDKKAMVWD 173
Cdd:cd00200   277 ASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 162-300 2.06e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 162 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYyPSGDA--FASGSDDATCRLYDLRADREVA-IYSKESIifgaSSVD 238
Cdd:PLN00181  550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDY-SSADPtlLASGSDDGSVKLWSINQGVSIGtIKTKANI----CCVQ 624

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1827280164 239 F-SLSGRLLFAGYNDYTINVWDvLKGSRVSI--LFGHENRVSTLRVSpDGTAFCSGSWDHTLRVW 300
Cdd:PLN00181  625 FpSESGRSLAFGSADHKVYYYD-LRNPKLPLctMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1-39 3.44e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 3.44e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1827280164    1 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 39
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 113-223 1.39e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 113 DMQILTASGDGTCALWDVESGQLLQS-------FHGHGADVLCLDLAPSeTGNTFVSGGCDKKAMVWDMRSGQCVQAFET 185
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPS-AMNVLASAGADMVVNVWDVERGKAVEVIKC 166

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1827280164 186 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA 223
Cdd:PTZ00421  167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 262-300 1.48e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1827280164  262 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
263-300 2.36e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.36e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1827280164 263 GSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
1-39 3.26e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.26e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1827280164   1 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 39
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 56-260 3.66e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 3.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164  56 VMACAYAPSGCAIACGGLDNKCSVYPLT--FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 133
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECEsiIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARS 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 134 QLLQSFHGHGADVLCLDLAPSETgNTFVSGGCDKKAMVWDMRSGQCVQAFEThESDINSVRyYPS--GDAFASGSDDATC 211
Cdd:PLN00181  566 QLVTEMKEHEKRVWSIDYSSADP-TLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQ-FPSesGRSLAFGSADHKV 642

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1827280164 212 RLYDLRADR----EVAIYSKEsiifgASSVDFSLSGRLLfAGYNDYTINVWDV 260
Cdd:PLN00181  643 YYYDLRNPKlplcTMIGHSKT-----VSYVRFVDSSTLV-SSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 176-215 4.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.76e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1827280164  176 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
198-300 5.98e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 5.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 198 SGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 277
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100
                  ....*....|....*....|...
gi 1827280164 278 TLRVSPDGTAFCSGSWDHTLRVW 300
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLW 105
WD40 pfam00400
WD domain, G-beta repeat;
177-215 1.15e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.15e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1827280164 177 GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 240-299 4.58e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 4.58e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 240 SLSGRLLFAGYnDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRV 299
Cdd:PTZ00421  136 SAMNVLASAGA-DMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 132-173 7.25e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 7.25e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1827280164  132 SGQLLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWD 173
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
133-173 2.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1827280164 133 GQLLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWD 173
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD--GKLLASGSDDGTVKVWD 39
WD40_like pfam17005
WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat ...
 188-268 3.47e-03

WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat family. Members are largely from microsporidia and related species.


Pssm-ID: 407205 [Multi-domain]  Cd Length: 301  Bit Score: 38.50  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 188 SDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS--KESIIFgassVDFsLSGRLLFAGYNDYTINVWDVLKGSR 265
Cdd:pfam17005   1 TEIYSIDISKKGSYILYGGKDDTCTVYDFENLDLVSIVEgfSDSVIF----CKF-LDDDLILVVTLDGTIMESLLKNDQE 75


                  ...
gi 1827280164 266 VSI 268
Cdd:pfam17005  76 IEN 78
PTZ00421 PTZ00421
coronin; Provisional
 100-188 7.44e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 37.57  E-value: 7.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1827280164 100 HTNYLSACSFTNSDMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLapSETGNTFVSGGCDKKAMVWDMRSGQ 178
Cdd:PTZ00421  124 HTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKCHSDQITSLEW--NLDGSLLCTTSKDKKLNIIDPRDGT 201

                          90
                  ....*....|
gi 1827280164 179 CVQAFETHES 188
Cdd:PTZ00421  202 IVSSVEAHAS 211
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-129 8.59e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.44  E-value: 8.59e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1827280164  100 HTNYLSACSFTNSDMQILTASGDGTCALWD 129
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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