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Conserved domains on  [gi|1826689155|ref|NP_001366241|]
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complement factor H-related protein 1 isoform 8 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 26-248 2.12e-21

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 89.71  E-value: 2.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  26 GDTVQIICNTGYRLQN-NENNISCVERGWSTPPKCrsTDTSCVNPPTVQNAHIlsrQMSKYPSGERVRYECRSPYEMFGD 104
Cdd:PHA02927   47 GDTIEYLCLPGYRKQKmGPIYAKCTGTGWTLFNQC--IKRRCPSPRDIDNGQL---DIGGVDFGSSITYSCNSGYQLIGE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155 105 EEVMCLNGN-----WT-EPPQCKdsTGKCGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP 178
Cdd:PHA02927  122 SKSYCELGStgsmvWNpEAPICE--SVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDP 198

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1826689155 179 P-----KCLHPCVISREIMENYNIALRWTakqklylrtgESAEFVCKRGYRLSSRShtlRTTCWDGKL---EYPTCAK 248
Cdd:PHA02927  199 PtcqivKCPHPTISNGYLSSGFKRSYSYN----------DNVDFKCKYGYKLSGSS---SSTCSPGNTwqpELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 26-248 2.12e-21

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 89.71  E-value: 2.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  26 GDTVQIICNTGYRLQN-NENNISCVERGWSTPPKCrsTDTSCVNPPTVQNAHIlsrQMSKYPSGERVRYECRSPYEMFGD 104
Cdd:PHA02927   47 GDTIEYLCLPGYRKQKmGPIYAKCTGTGWTLFNQC--IKRRCPSPRDIDNGQL---DIGGVDFGSSITYSCNSGYQLIGE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155 105 EEVMCLNGN-----WT-EPPQCKdsTGKCGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP 178
Cdd:PHA02927  122 SKSYCELGStgsmvWNpEAPICE--SVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDP 198

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1826689155 179 P-----KCLHPCVISREIMENYNIALRWTakqklylrtgESAEFVCKRGYRLSSRShtlRTTCWDGKL---EYPTCAK 248
Cdd:PHA02927  199 PtcqivKCPHPTISNGYLSSGFKRSYSYN----------DNVDFKCKYGYKLSGSS---SSTCSPGNTwqpELPKCVR 263
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 127-181 5.08e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 5.08e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689155 127 CGPPPPIDNGDITSfPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 181
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 127-181 5.44e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.99  E-value: 5.44e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689155  127 CGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 181
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
127-181 4.68e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 4.68e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689155 127 CGPPPPIDNGDITSfPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 181
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 26-248 2.12e-21

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 89.71  E-value: 2.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  26 GDTVQIICNTGYRLQN-NENNISCVERGWSTPPKCrsTDTSCVNPPTVQNAHIlsrQMSKYPSGERVRYECRSPYEMFGD 104
Cdd:PHA02927   47 GDTIEYLCLPGYRKQKmGPIYAKCTGTGWTLFNQC--IKRRCPSPRDIDNGQL---DIGGVDFGSSITYSCNSGYQLIGE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155 105 EEVMCLNGN-----WT-EPPQCKdsTGKCGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP 178
Cdd:PHA02927  122 SKSYCELGStgsmvWNpEAPICE--SVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDP 198

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1826689155 179 P-----KCLHPCVISREIMENYNIALRWTakqklylrtgESAEFVCKRGYRLSSRShtlRTTCWDGKL---EYPTCAK 248
Cdd:PHA02927  199 PtcqivKCPHPTISNGYLSSGFKRSYSYN----------DNVDFKCKYGYKLSGSS---SSTCSPGNTwqpELPKCVR 263
PHA02831 PHA02831
EEV host range protein; Provisional
 19-195 3.93e-12

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 64.24  E-value: 3.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  19 EGQTHLEGDTVQIICNTGYrlqnNENNISCVERGWSTPPKCRSTdTSCVNPPTVQNAHILSRQmSKYPSGERVRYECR-- 96
Cdd:PHA02831   36 ENKVYEENENLEYKCNNNF----DKVFVTCNNGSWSTKNMCIGK-RNCKDPVTILNGYIKNKK-DQYSFGDSVTYACKvn 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  97 --SPYEMFGDEEVMCLNGNWT-EPPQCKDSTGKCgppPPIDNGDITSFPLSVYApASSVEYQCQNLYQLEGNKRITCR-N 172
Cdd:PHA02831  110 klEKYSIVGNETVKCINKQWVpKYPVCKLIRCKY---PALQNGFLNVFEKKFYY-GDIVNFKCKKGFILLGSSVSTCDiN 185

                         170       180
                  ....*....|....*....|....
gi 1826689155 173 GQW-SEPPKCLHPCViSREIMENY 195
Cdd:PHA02831  186 SIWyPGIPKCVKDKV-HNEIQPNY 208
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 127-181 5.08e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 5.08e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689155 127 CGPPPPIDNGDITSfPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 181
Cdd:cd00033     1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 62-248 8.01e-10

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 57.69  E-value: 8.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  62 TDTSCV---NPPTVQNAHILSRQMSKYPSGERVRYECRSPyemFGDEEVMCLNGNWTEPPQCKDSTgKCGPPPPIDNGDI 138
Cdd:PHA02831   14 SKTWCIcvfNKNDAKYSNVDSYENKVYEENENLEYKCNNN---FDKVFVTCNNGSWSTKNMCIGKR-NCKDPVTILNGYI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155 139 TSfPLSVYAPASSVEYQCQ----NLYQLEGNKRITCRNGQW-SEPP-----KCLHPcVISREIMENYnialrwtaKQKLY 208
Cdd:PHA02831   90 KN-KKDQYSFGDSVTYACKvnklEKYSIVGNETVKCINKQWvPKYPvckliRCKYP-ALQNGFLNVF--------EKKFY 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1826689155 209 LrtGESAEFVCKRGYRLSSrshTLRTTCWDGKLEYPTCAK 248
Cdd:PHA02831  160 Y--GDIVNFKCKKGFILLG---SSVSTCDINSIWYPGIPK 194
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 127-181 5.44e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.99  E-value: 5.44e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689155  127 CGPPPPIDNGDITSFPlSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 181
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 66-121 1.04e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 50.15  E-value: 1.04e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1826689155  66 CVNPPTVQNAHILSRQmSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCK 121
Cdd:cd00033     1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
127-181 4.68e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 4.68e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689155 127 CGPPPPIDNGDITSfPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC 181
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 66-120 7.51e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.91  E-value: 7.51e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689155   66 CVNPPTVQNAHILSRQmSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQC 120
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 66-248 8.41e-08

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 51.97  E-value: 8.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  66 CVNPPTVQNAHIlSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL----NGNWT-EPPQCKdsTGKCGPPPPIDNGDITS 140
Cdd:PHA02639   22 CDKPDDISNGFI-TELMEKYEIGKLIEYTCNTDYALIGDRFRTCIkdknNAIWSnKAPFCM--LKECNDPPSIINGKIYN 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155 141 fPLSVYAPASSVEYQCQN----LYQLEGNKRITC-RNGQWS-EPPKCLHPCVISREIMENYNIALrwTAKQKLYLRTgeS 214
Cdd:PHA02639   99 -KREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCiQDKSWKpDPPICKMINCRFPALQNGYINGI--PSNKKFYYKT--R 173

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1826689155 215 AEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 248
Cdd:PHA02639  174 VGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVR 207
Sushi pfam00084
Sushi repeat (SCR repeat);
66-120 1.18e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 1.18e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1826689155  66 CVNPPTVQNAHIlSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQC 120
Cdd:pfam00084   1 CPPPPDIPNGKV-SATKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 23-120 4.65e-07

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 49.65  E-value: 4.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  23 HLEGDTVQIICNTGYRLQNNeNNISCVERGWSTPPKCRStdTSCVNpPTVQNAHILSRQMSKYPSGERVRYECRSPYEMF 102
Cdd:PHA02927  166 YTDGSVVTYSCNSGYSLIGN-SGVLCSGGEWSDPPTCQI--VKCPH-PTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLS 241

                          90       100
                  ....*....|....*....|
gi 1826689155 103 GDEEVMCLNGNWTEP--PQC 120
Cdd:PHA02927  242 GSSSSTCSPGNTWQPelPKC 261
PHA02817 PHA02817
EEV Host range protein; Provisional
 120-181 1.62e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 41.85  E-value: 1.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1826689155 120 CKDSTGKCGPPPPIDNGDITSfPLSVYAPASSVEYQCQN-----LYQLEGNKRITC-RNGQWS-EPPKC 181
Cdd:PHA02817   17 SLCDLNKCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNkEFPVC 84
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 84-176 2.24e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 41.61  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689155  84 KYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDstgKCGpPPPIDNGDITSfplSVYAPASSVEYQCQNLYQLE 163
Cdd:PHA02954  146 KYSFGEHITINCDVGYEVIGASYISCTANSWNVIPSCQQ---KCD-IPSLSNGLISG---STFSIGGVIHLSCKSGFTLT 218

                          90
                  ....*....|...
gi 1826689155 164 GNKRITCRNGQWS 176
Cdd:PHA02954  219 GSPSSTCIDGKWN 231
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 18-60 7.48e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 33.98  E-value: 7.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1826689155  18 GEGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WS-TPPKCR 60
Cdd:cd00033    14 GSKGSYSYGSTVTYSCNEGYTLVGSS-TITCTENGgWSpPPPTCE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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