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Conserved domains on  [gi|1824611535|ref|NP_001366148|]
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podocalyxin-like protein 2 isoform 2 [Mus musculus]

Protein Classification

Herpes_BLLF1 and CD34_antigen domain-containing protein( domain architecture ID 10533843)

Herpes_BLLF1 and CD34_antigen domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 328-539 8.68e-84

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


:

Pssm-ID: 461884  Cd Length: 211  Bit Score: 259.29  E-value: 8.68e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 328 ILNMTENIDCEVFRRHRGLRLLALVEEVLPRHRSGHRGDWHISLSKPSEKEQHLLMTLVGEQGVvPTQDVLSMLSGIRRS 407
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGL-PPKAVLELLKDKRRD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 408 LEEIGIQNYSTTSSCQARATQVRSDYGTLFVVLVIIGVICFIIIVLGLLYNCWQRRMPKLKHVSH-GEELRFVENGCHDN 486
Cdd:pfam06365  80 LEELGIQNFTYGTECQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYGCLHRRRSKSKAGERlGEELQTVENGYHDN 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1824611535 487 PTLDVASDSQSEMQEKqPSLNGGA-INGPSSWSALMgSKRDPEDSDVFEEDTHL 539
Cdd:pfam06365 160 PTLSVAPDTQSEMQEK-PSVNGGAqENGTGSWIVPL-SRNGHSDRQHVEEDTHL 211
PRK14959 super family cl33044
DNA polymerase III subunits gamma and tau; Provisional
 201-283 2.93e-03

DNA polymerase III subunits gamma and tau; Provisional


The actual alignment was detected with superfamily member PRK14959:

Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 201 SGGTEWPTGGLGVQSevpQGAGEGATVGAADFDGQQGALPSSSLPQTVPPSGTEVPSEGPlYPRIP-DSLPPGPQDTEST 279
Cdd:PRK14959  374 SGGGASAPSGSAAEG---PASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAP-SPRVPwDDAPPAPPRSGIP 449


                  ....
gi 1824611535 280 PSSA 283
Cdd:PRK14959  450 PRPA 453
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 328-539 8.68e-84

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 259.29  E-value: 8.68e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 328 ILNMTENIDCEVFRRHRGLRLLALVEEVLPRHRSGHRGDWHISLSKPSEKEQHLLMTLVGEQGVvPTQDVLSMLSGIRRS 407
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGL-PPKAVLELLKDKRRD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 408 LEEIGIQNYSTTSSCQARATQVRSDYGTLFVVLVIIGVICFIIIVLGLLYNCWQRRMPKLKHVSH-GEELRFVENGCHDN 486
Cdd:pfam06365  80 LEELGIQNFTYGTECQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYGCLHRRRSKSKAGERlGEELQTVENGYHDN 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1824611535 487 PTLDVASDSQSEMQEKqPSLNGGA-INGPSSWSALMgSKRDPEDSDVFEEDTHL 539
Cdd:pfam06365 160 PTLSVAPDTQSEMQEK-PSVNGGAqENGTGSWIVPL-SRNGHSDRQHVEEDTHL 211
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 201-283 2.93e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 201 SGGTEWPTGGLGVQSevpQGAGEGATVGAADFDGQQGALPSSSLPQTVPPSGTEVPSEGPlYPRIP-DSLPPGPQDTEST 279
Cdd:PRK14959  374 SGGGASAPSGSAAEG---PASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAP-SPRVPwDDAPPAPPRSGIP 449


                  ....
gi 1824611535 280 PSSA 283
Cdd:PRK14959  450 PRPA 453
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 328-539 8.68e-84

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 259.29  E-value: 8.68e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 328 ILNMTENIDCEVFRRHRGLRLLALVEEVLPRHRSGHRGDWHISLSKPSEKEQHLLMTLVGEQGVvPTQDVLSMLSGIRRS 407
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGL-PPKAVLELLKDKRRD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 408 LEEIGIQNYSTTSSCQARATQVRSDYGTLFVVLVIIGVICFIIIVLGLLYNCWQRRMPKLKHVSH-GEELRFVENGCHDN 486
Cdd:pfam06365  80 LEELGIQNFTYGTECQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYGCLHRRRSKSKAGERlGEELQTVENGYHDN 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1824611535 487 PTLDVASDSQSEMQEKqPSLNGGA-INGPSSWSALMgSKRDPEDSDVFEEDTHL 539
Cdd:pfam06365 160 PTLSVAPDTQSEMQEK-PSVNGGAqENGTGSWIVPL-SRNGHSDRQHVEEDTHL 211
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 201-283 2.93e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824611535 201 SGGTEWPTGGLGVQSevpQGAGEGATVGAADFDGQQGALPSSSLPQTVPPSGTEVPSEGPlYPRIP-DSLPPGPQDTEST 279
Cdd:PRK14959  374 SGGGASAPSGSAAEG---PASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAP-SPRVPwDDAPPAPPRSGIP 449


                  ....
gi 1824611535 280 PSSA 283
Cdd:PRK14959  450 PRPA 453
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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