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Conserved domains on  [gi|1824163972|ref|NP_001366085|]
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granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL3Ra_N pfam18611
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 35-112 5.01e-30

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


:

Pssm-ID: 436618  Cd Length: 76  Bit Score: 110.52  E-value: 5.01e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1824163972  35 SLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNtsQRGFQQKLLYP 112
Cdd:pfam18611   1 ILNLRVDPRKRRLTWDCHGNVTEIECFLNSKENSPIEKKVAEKNCYCTFPDLSLHEGANLTVRVT--QPPFSEWLLYP 76
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 123-215 4.92e-25

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


:

Pssm-ID: 401252  Cd Length: 96  Bit Score: 97.87  E-value: 4.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824163972 123 NFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRN---YFLVNGTSR 199
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFhqvYICVNGSSS 80

                          90
                  ....*....|....*.
gi 1824163972 200 EIGIQFFDSLLDTKKI 215
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
 
Name Accession Description Interval E-value
IL3Ra_N pfam18611
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 35-112 5.01e-30

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


Pssm-ID: 436618  Cd Length: 76  Bit Score: 110.52  E-value: 5.01e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1824163972  35 SLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNtsQRGFQQKLLYP 112
Cdd:pfam18611   1 ILNLRVDPRKRRLTWDCHGNVTEIECFLNSKENSPIEKKVAEKNCYCTFPDLSLHEGANLTVRVT--QPPFSEWLLYP 76
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 123-215 4.92e-25

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 97.87  E-value: 4.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824163972 123 NFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRN---YFLVNGTSR 199
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFhqvYICVNGSSS 80

                          90
                  ....*....|....*.
gi 1824163972 200 EIGIQFFDSLLDTKKI 215
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
 
Name Accession Description Interval E-value
IL3Ra_N pfam18611
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 35-112 5.01e-30

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


Pssm-ID: 436618  Cd Length: 76  Bit Score: 110.52  E-value: 5.01e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1824163972  35 SLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNtsQRGFQQKLLYP 112
Cdd:pfam18611   1 ILNLRVDPRKRRLTWDCHGNVTEIECFLNSKENSPIEKKVAEKNCYCTFPDLSLHEGANLTVRVT--QPPFSEWLLYP 76
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 123-215 4.92e-25

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 97.87  E-value: 4.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824163972 123 NFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRN---YFLVNGTSR 199
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFhqvYICVNGSSS 80

                          90
                  ....*....|....*.
gi 1824163972 200 EIGIQFFDSLLDTKKI 215
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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