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Conserved domains on  [gi|1818159982|ref|NP_001365603|]
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interleukin 11 receptor, alpha chain 2-like isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 45-107 8.10e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 8.10e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1818159982   45 PGVQYGQPGRPVMLCCPGVSAGTP-VSWFRDGDSRLLQGPD-----SGLGHRLVLAQVDSPDEGTYVCQ 107
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPeVTWYKQGGKLLAESGRfsvsrSGSTSTLTISNVTPEDSGTYTCA 69
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 230-322 1.92e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818159982 230 PDPPQGLRVESVPgyPRRLHASWTYPASWRRQphfLLKFRLQYRPAQHPAWSTVEPIGLEE---VITDTVAGLPHAVRVS 306
Cdd:cd00063     1 PSPPTNLRVTDVT--STSVTLSWTPPEDDGGP---ITGYVVEYREKGSGDWKEVEVTPGSEtsyTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*.
gi 1818159982 307 ARdflDAGTWSAWSPE 322
Cdd:cd00063    76 AV---NGGGESPPSES 88
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 45-107 8.10e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 8.10e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1818159982   45 PGVQYGQPGRPVMLCCPGVSAGTP-VSWFRDGDSRLLQGPD-----SGLGHRLVLAQVDSPDEGTYVCQ 107
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPeVTWYKQGGKLLAESGRfsvsrSGSTSTLTISNVTPEDSGTYTCA 69
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 230-322 1.92e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818159982 230 PDPPQGLRVESVPgyPRRLHASWTYPASWRRQphfLLKFRLQYRPAQHPAWSTVEPIGLEE---VITDTVAGLPHAVRVS 306
Cdd:cd00063     1 PSPPTNLRVTDVT--STSVTLSWTPPEDDGGP---ITGYVVEYREKGSGDWKEVEVTPGSEtsyTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*.
gi 1818159982 307 ARdflDAGTWSAWSPE 322
Cdd:cd00063    76 AV---NGGGESPPSES 88
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 39-107 1.79e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1818159982  39 PQAWGPPGVQYGQPGRPVMLCCpgVSAGTP---VSWFRDG----DSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCQ 107
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTC--EATGSPpptITWYKNGepisSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 230-309 1.18e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818159982  230 PDPPQGLRVESVPgyPRRLHASWTYPASWRRQpHFLLKFRLQYRPAQHPaWSTVEPIGLEE--VITDTVAGLPHAVRVSA 307
Cdd:smart00060   1 PSPPSNLRVTDVT--STSVTLSWEPPPDDGIT-GYIVGYRVEYREEGSE-WKEVNVTPSSTsyTLTGLKPGTEYEFRVRA 76


                   ..
gi 1818159982  308 RD 309
Cdd:smart00060  77 VN 78
IgC2_D1_IL-6RA cd20939
Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as ...
 52-119 1.18e-03

Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains; The members here are composed of the immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126). The IL-6RA ectodomain, which is highly modular, consisting of three domains (D1, D2, and D3). Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, hemopoiesis, the acute phase response and inflammation. It is generated in an infectious lesion and sends out a warning signal to the entire body. IL-6 binds first to its cognate alpha-chain receptor (IL-6R), and then the IL-6/IL-6R complex which in turn induces homodimerization of gp130. As a result, a high-affinity functional receptor complex of IL-6, IL-6R and gp130 is formed, and subsequently the complex triggers a downstream signal cascade. Aberrant production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409533  Cd Length: 77  Bit Score: 37.63  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1818159982  52 PGRPVMLCCPGVSAG--TPVSW-FRDGDSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCqTLDGVSGGMVTL 119
Cdd:cd20939     6 PGASVTLTCPGVEPEdnATIHWvLRKPAAGSHPSRWAGMGRRLLLRSVQLSDSGNYSC-YRAGRPAGTVHL 75
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 45-107 8.10e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 8.10e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1818159982   45 PGVQYGQPGRPVMLCCPGVSAGTP-VSWFRDGDSRLLQGPD-----SGLGHRLVLAQVDSPDEGTYVCQ 107
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPeVTWYKQGGKLLAESGRfsvsrSGSTSTLTISNVTPEDSGTYTCA 69
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 230-322 1.92e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818159982 230 PDPPQGLRVESVPgyPRRLHASWTYPASWRRQphfLLKFRLQYRPAQHPAWSTVEPIGLEE---VITDTVAGLPHAVRVS 306
Cdd:cd00063     1 PSPPTNLRVTDVT--STSVTLSWTPPEDDGGP---ITGYVVEYREKGSGDWKEVEVTPGSEtsyTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*.
gi 1818159982 307 ARdflDAGTWSAWSPE 322
Cdd:cd00063    76 AV---NGGGESPPSES 88
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 39-107 1.79e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1818159982  39 PQAWGPPGVQYGQPGRPVMLCCpgVSAGTP---VSWFRDG----DSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCQ 107
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTC--EATGSPpptITWYKNGepisSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCV 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 230-309 1.18e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1818159982  230 PDPPQGLRVESVPgyPRRLHASWTYPASWRRQpHFLLKFRLQYRPAQHPaWSTVEPIGLEE--VITDTVAGLPHAVRVSA 307
Cdd:smart00060   1 PSPPSNLRVTDVT--STSVTLSWEPPPDDGIT-GYIVGYRVEYREEGSE-WKEVNVTPSSTsyTLTGLKPGTEYEFRVRA 76


                   ..
gi 1818159982  308 RD 309
Cdd:smart00060  77 VN 78
IgC2_D1_IL-6RA cd20939
Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as ...
 52-119 1.18e-03

Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains; The members here are composed of the immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126). The IL-6RA ectodomain, which is highly modular, consisting of three domains (D1, D2, and D3). Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, hemopoiesis, the acute phase response and inflammation. It is generated in an infectious lesion and sends out a warning signal to the entire body. IL-6 binds first to its cognate alpha-chain receptor (IL-6R), and then the IL-6/IL-6R complex which in turn induces homodimerization of gp130. As a result, a high-affinity functional receptor complex of IL-6, IL-6R and gp130 is formed, and subsequently the complex triggers a downstream signal cascade. Aberrant production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409533  Cd Length: 77  Bit Score: 37.63  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1818159982  52 PGRPVMLCCPGVSAG--TPVSW-FRDGDSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCqTLDGVSGGMVTL 119
Cdd:cd20939     6 PGASVTLTCPGVEPEdnATIHWvLRKPAAGSHPSRWAGMGRRLLLRSVQLSDSGNYSC-YRAGRPAGTVHL 75
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 56-107 4.04e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.77  E-value: 4.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1818159982  56 VMLCCPGVSAGTP-VSWFRDGDSRLLQGPDS----GLGHRLVLAQVDSPDEGTYVCQ 107
Cdd:cd00096     1 VTLTCSASGNPPPtITWYKNGKPLPPSSRDSrrseLGNGTLTISNVTLEDSGTYTCV 57
IgI_2_Robo cd05724
Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 56-106 5.96e-03

Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of the Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit-2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409389 [Multi-domain]  Cd Length: 87  Bit Score: 35.84  E-value: 5.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1818159982  56 VMLCCPGVSAGTP-VSWFRDGDSRLLQGP-----DSGlghRLVLAQVDSPDEGTYVC 106
Cdd:cd05724    16 VLECSPPRGHPEPtVSWRKDGQPLNLDNErvrivDDG---NLLIAEARKSDEGTYKC 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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