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Conserved domains on  [gi|1811242742|ref|NP_001365441|]
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calcium-transporting ATPase type 2C member 1 isoform 1d [Homo sapiens]

Protein Classification

calcium-transporting ATPase type 2C( domain architecture ID 11550604)

calcium-transporting ATPase type 2C is an ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
54-896 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1586.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  54 RRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSK 133
Cdd:cd02085     1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 134 LVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213
Cdd:cd02085    81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILE 293
Cdd:cd02085   161 SNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 294 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglha 373
Cdd:cd02085   241 MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------ 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 374 evtgvgynqfgevivdgdvvhgfynpavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYP 453
Cdd:cd02085   315 ----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIP 360
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 454 FSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPE 532
Cdd:cd02085   361 FSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPE 440
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 533 LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVP 612
Cdd:cd02085   441 LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVR 520
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 613 KVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:cd02085   521 KVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEG 600
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 693 KGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILT 772
Cdd:cd02085   601 KGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILT 680
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 773 KNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSI 852
Cdd:cd02085   681 RSLILNVLLSAAIIVSGTLWVFWKEMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSL 760
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....
gi 1811242742 853 MGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 896
Cdd:cd02085   761 IGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
 
Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
54-896 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1586.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  54 RRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSK 133
Cdd:cd02085     1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 134 LVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213
Cdd:cd02085    81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILE 293
Cdd:cd02085   161 SNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 294 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglha 373
Cdd:cd02085   241 MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------ 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 374 evtgvgynqfgevivdgdvvhgfynpavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYP 453
Cdd:cd02085   315 ----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIP 360
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 454 FSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPE 532
Cdd:cd02085   361 FSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPE 440
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 533 LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVP 612
Cdd:cd02085   441 LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVR 520
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 613 KVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:cd02085   521 KVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEG 600
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 693 KGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILT 772
Cdd:cd02085   601 KGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILT 680
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 773 KNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSI 852
Cdd:cd02085   681 RSLILNVLLSAAIIVSGTLWVFWKEMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSL 760
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....
gi 1811242742 853 MGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 896
Cdd:cd02085   761 IGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
23-903 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 1584.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  23 SKKASELPVSEVASILQADLQNGLN-KCEVSHRRAFHGWNEFDISEDEPLWKKYISQF-KNPLIMLLLASAVISVLMHQF 100
Cdd:TIGR01522   1 SKQYCELSVEETCSKLQTDLQNGLNsSQEASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 101 DDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVD 180
Cdd:TIGR01522  81 DDAVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAVD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 181 LSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQK 260
Cdd:TIGR01522 161 LSIDESNLTGETTPVSKVTAPIPAATNGDLAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTPLQK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 261 SMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 340
Cdd:TIGR01522 241 SMDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSVET 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 341 LGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNN- 419
Cdd:TIGR01522 321 LGSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEVIVDGDVLHGFYTVAVSRILEAGNLCNNAKFRNEa 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 420 -TLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRtqQDRPEICFMKGAYEQVIKYCTTYQSK-G 497
Cdd:TIGR01522 401 dTLLGNPTDVALIELLMKFGLDDLRETYIRVAEVPFSSERKWMAVKCVHR--QDRSEMCFMKGAYEQVLKYCTYYQKKdG 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 498 QTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 577
Cdd:TIGR01522 479 KTLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETA 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 578 VAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 657
Cdd:TIGR01522 559 VSIARRLGMPSKTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 658 GVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWI 737
Cdd:TIGR01522 639 GVAMGQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWI 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 738 NIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVF 817
Cdd:TIGR01522 719 NILMDGPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTLFVFVREMQDGVITARDTTMTFTCFVF 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 818 FDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKK 897
Cdd:TIGR01522 799 FDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEALSIKDLLFLLLITSSVCIVDEIRKK 878

                  ....*.
gi 1811242742 898 VERSRE 903
Cdd:TIGR01522 879 VERSRE 884
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
22-904 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 1017.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  22 TSKKASELPVSEVASILQADlQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFD 101
Cdd:COG0474     4 ALKDWHALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALLGDWV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 102 DAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDL 181
Cdd:COG0474    83 DAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKDL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 182 SIDESSLTGETTPCSKVTAPQPAATNgdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKS 261
Cdd:COG0474   163 QVDESALTGESVPVEKSADPLPEDAP--LGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEKTPLQKQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 262 MDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETL 341
Cdd:COG0474   241 LDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 342 GCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAevtgvgynqfgevivdgdvVHGFYNPAVSRIVEAGCVCNDAVIRNNTL 421
Cdd:COG0474   321 GSVTVICTDKTGTLTQNKMTVERVYTGGGTYE-------------------VTGEFDPALEELLRAAALCSDAQLEEETG 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 422 MGKPTEGALIALAMKMGLD--GLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPeICFMKGAYEQVIKYCTTYQSKGQT 499
Cdd:COG0474   382 LGDPTEGALLVAAAKAGLDveELRKEYPRVDEIPFDSERKRMST--VHEDPDGKR-LLIVKGAPEVVLALCTRVLTGGGV 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 500 LTLTQQQRDVYQQEKARMGSAGLRVLALA-----SGPEL------GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKM 568
Cdd:COG0474   459 VPLTEEDRAEILEAVEELAAQGLRVLAVAykelpADPELdseddeSDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKM 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 569 ITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVND 648
Cdd:COG0474   539 ITGDHPATARAIARQLGLGDDGDRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVND 618
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 649 AVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNP 728
Cdd:COG0474   619 APALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLP 698
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 729 LNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDT 808
Cdd:COG0474   699 LTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALARGASLALAR 778
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 809 TMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSV 888
Cdd:COG0474   779 TMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLY 858
                         890
                  ....*....|....*.
gi 1811242742 889 CIVAEIIKKVERSREK 904
Cdd:COG0474   859 LLLVELVKLLRRRFGR 874
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
18-794 3.93e-104

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 345.13  E-value: 3.93e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  18 IPVLTSKKASELPVSEVASILQA--DLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV 95
Cdd:PRK10517   38 VPPSLSARCLKAAVMPEEELWKTfdTHPEGLNEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISY 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  96 LMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR--EGKLEHTLA----RDLVPGDTVCLSVGDRV 169
Cdd:PRK10517  118 ATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRviNDKGENGWLeipiDQLVPGDIIKLAAGDMI 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 170 PADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQ 249
Cdd:PRK10517  198 PADLRILQARDLFVAQASLTGESLPVEKFATTRQPEHSNPL-ECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVS 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 250 AEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV-GWLLGkDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:PRK10517  277 EQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLInGYTKG-DWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQ 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 329 RAIVKKLPIVETLGCCNVICSDKTGTLTKNEmtvthIFTSDglHAEVtgvgynqFGEviVDGDVVH-----GFYNPAVSR 403
Cdd:PRK10517  356 KVIVKRLDAIQNFGAMDILCTDKTGTLTQDK-----IVLEN--HTDI-------SGK--TSERVLHsawlnSHYQTGLKN 419
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 404 IVEAgcvcndAVIrnntlmgkptEGALIALAMKMGldglqQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPE-ICfmKGA 482
Cdd:PRK10517  420 LLDT------AVL----------EGVDEESARSLA-----SRWQKIDEIPFDFERRRMSV--VVAENTEHHQlIC--KGA 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 483 YEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGP-----------ELGQLTFLGLVGIIDPPRTG 551
Cdd:PRK10517  475 LEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYlparegdyqraDESDLILEGYIAFLDPPKET 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 552 VKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKS 631
Cdd:PRK10517  555 TAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTL 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 632 LQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSI 711
Cdd:PRK10517  633 LKREGHVVGFMGDGINDAPALRAADIGISV-DGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNF 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 712 AAL--TLISLATLmnfPN-PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKPPRnWKDSILTKNLILKILVSSII-I 786
Cdd:PRK10517  712 GNVfsVLVASAFL---PFlPMLPLHLLIQNLLYD--VSQvAIPFDNVDDEQIQKPQR-WNPADLGRFMVFFGPISSIFdI 785
                         810
                  ....*....|
gi 1811242742 787 VCGTL--FVF 794
Cdd:PRK10517  786 LTFCLmwWVF 795
E1-E2_ATPase pfam00122
E1-E2 ATPase;
133-328 1.33e-49

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 173.14  E-value: 1.33e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 133 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaS 212
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSA-SVDESLLTGESLPVEK--------------K 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 213 RSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIL 292
Cdd:pfam00122  66 KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPL 145
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1811242742 293 EMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:pfam00122 146 RALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
29-97 2.68e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 77.24  E-value: 2.68e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811242742   29 LPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLM 97
Cdd:smart00831   7 LSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
54-896 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1586.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  54 RRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSK 133
Cdd:cd02085     1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 134 LVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213
Cdd:cd02085    81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILE 293
Cdd:cd02085   161 SNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 294 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglha 373
Cdd:cd02085   241 MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------ 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 374 evtgvgynqfgevivdgdvvhgfynpavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYP 453
Cdd:cd02085   315 ----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIP 360
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 454 FSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPE 532
Cdd:cd02085   361 FSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPE 440
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 533 LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVP 612
Cdd:cd02085   441 LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVR 520
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 613 KVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:cd02085   521 KVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEG 600
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 693 KGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILT 772
Cdd:cd02085   601 KGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILT 680
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 773 KNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSI 852
Cdd:cd02085   681 RSLILNVLLSAAIIVSGTLWVFWKEMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSL 760
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....
gi 1811242742 853 MGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 896
Cdd:cd02085   761 IGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
23-903 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 1584.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  23 SKKASELPVSEVASILQADLQNGLN-KCEVSHRRAFHGWNEFDISEDEPLWKKYISQF-KNPLIMLLLASAVISVLMHQF 100
Cdd:TIGR01522   1 SKQYCELSVEETCSKLQTDLQNGLNsSQEASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 101 DDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVD 180
Cdd:TIGR01522  81 DDAVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAVD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 181 LSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQK 260
Cdd:TIGR01522 161 LSIDESNLTGETTPVSKVTAPIPAATNGDLAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTPLQK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 261 SMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 340
Cdd:TIGR01522 241 SMDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSVET 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 341 LGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNN- 419
Cdd:TIGR01522 321 LGSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEVIVDGDVLHGFYTVAVSRILEAGNLCNNAKFRNEa 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 420 -TLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRtqQDRPEICFMKGAYEQVIKYCTTYQSK-G 497
Cdd:TIGR01522 401 dTLLGNPTDVALIELLMKFGLDDLRETYIRVAEVPFSSERKWMAVKCVHR--QDRSEMCFMKGAYEQVLKYCTYYQKKdG 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 498 QTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 577
Cdd:TIGR01522 479 KTLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETA 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 578 VAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 657
Cdd:TIGR01522 559 VSIARRLGMPSKTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 658 GVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWI 737
Cdd:TIGR01522 639 GVAMGQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWI 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 738 NIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVF 817
Cdd:TIGR01522 719 NILMDGPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTLFVFVREMQDGVITARDTTMTFTCFVF 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 818 FDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKK 897
Cdd:TIGR01522 799 FDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEALSIKDLLFLLLITSSVCIVDEIRKK 878

                  ....*.
gi 1811242742 898 VERSRE 903
Cdd:TIGR01522 879 VERSRE 884
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
22-904 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 1017.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  22 TSKKASELPVSEVASILQADlQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFD 101
Cdd:COG0474     4 ALKDWHALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALLGDWV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 102 DAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDL 181
Cdd:COG0474    83 DAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKDL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 182 SIDESSLTGETTPCSKVTAPQPAATNgdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKS 261
Cdd:COG0474   163 QVDESALTGESVPVEKSADPLPEDAP--LGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEKTPLQKQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 262 MDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETL 341
Cdd:COG0474   241 LDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 342 GCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAevtgvgynqfgevivdgdvVHGFYNPAVSRIVEAGCVCNDAVIRNNTL 421
Cdd:COG0474   321 GSVTVICTDKTGTLTQNKMTVERVYTGGGTYE-------------------VTGEFDPALEELLRAAALCSDAQLEEETG 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 422 MGKPTEGALIALAMKMGLD--GLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPeICFMKGAYEQVIKYCTTYQSKGQT 499
Cdd:COG0474   382 LGDPTEGALLVAAAKAGLDveELRKEYPRVDEIPFDSERKRMST--VHEDPDGKR-LLIVKGAPEVVLALCTRVLTGGGV 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 500 LTLTQQQRDVYQQEKARMGSAGLRVLALA-----SGPEL------GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKM 568
Cdd:COG0474   459 VPLTEEDRAEILEAVEELAAQGLRVLAVAykelpADPELdseddeSDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKM 538
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 569 ITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVND 648
Cdd:COG0474   539 ITGDHPATARAIARQLGLGDDGDRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVND 618
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 649 AVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNP 728
Cdd:COG0474   619 APALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLP 698
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 729 LNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDT 808
Cdd:COG0474   699 LTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALARGASLALAR 778
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 809 TMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSV 888
Cdd:COG0474   779 TMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLY 858
                         890
                  ....*....|....*.
gi 1811242742 889 CIVAEIIKKVERSREK 904
Cdd:COG0474   859 LLLVELVKLLRRRFGR 874
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
45-896 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 772.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:cd02080     1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHWVDAIVIFGVVLINAIIGYIQEGKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 125 EKSLEELSKLVPPECHCVREGKlEHTL-ARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQP 203
Cdd:cd02080    81 EKALAAIKNMLSPEATVLRDGK-KLTIdAEELVPGDIVLLEAGDKVPADLRLIEARNLQIDESALTGESVPVEKQEGPLE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 204 AATNgdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV 283
Cdd:cd02080   160 EDTP--LGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLIVILVLAALTFVF 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 284 GWLLGK-DILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTV 362
Cdd:cd02080   238 GLLRGDySLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICSDKTGTLTRNEMTV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 363 THIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcVCNDAVIRNN----TLMGKPTEGALIALAMKMG 438
Cdd:cd02080   318 QAIVT------------------------------------------LCNDAQLHQEdghwKITGDPTEGALLVLAAKAG 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 439 LD--GLQQDYIRKAEYPFSSEQKWMAVkcvhRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLtqqQRDVYQQEKAR 516
Cdd:cd02080   356 LDpdRLASSYPRVDKIPFDSAYRYMAT----LHRDDGQRVIYVKGAPERLLDMCDQELLDGGVSPL---DRAYWEAEAED 428
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 517 MGSAGLRVLALASGPE------------LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRL 584
Cdd:cd02080   429 LAKQGLRVLAFAYREVdseveeidhadlEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQL 508
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 585 GLySKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQT 664
Cdd:cd02080   509 GL-GDGKKVLTGAELDALDDEELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGIK 587
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 665 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGP 744
Cdd:cd02080   588 GTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAIT 667
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 745 PAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNAL 824
Cdd:cd02080   668 LGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLGGAFGLFLWALDRGYSLETARTMAVNTIVVAQIFYLF 747
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1811242742 825 SSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 896
Cdd:cd02080   748 NCRSLHRSILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFIVVELEK 819
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
45-764 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 755.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSItVAILIVVTV-AFVQEYR 123
Cdd:cd02089     1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVLGEYVDAIVI-IAIVILNAVlGFVQEYK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 124 SEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQP 203
Cdd:cd02089    80 AEKALAALKKMSAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLRVEESSLTGESEPVEKDADTLL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 204 AATNGdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV 283
Cdd:cd02089   160 EEDVP-LGDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAIAALIICALVFAL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 284 GWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVT 363
Cdd:cd02089   239 GLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGTLTQNKMTVE 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 364 HIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnntlMGKPTEGALIALAMKMGLD--G 441
Cdd:cd02089   319 KIYT------------------------------------------------------IGDPTETALIRAARKAGLDkeE 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 442 LQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRpeICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAG 521
Cdd:cd02089   345 LEKKYPRIAEIPFDSERKLMTT--VHKDAGKY--IVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVNEEFSEEA 420
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 522 LRVLALA----------SGPEL-GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKT 590
Cdd:cd02089   421 LRVLAVAykpldedpteSSEDLeNDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILEDG 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 591 SQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCK 670
Cdd:cd02089   501 DKALTGEELDKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGITGTDVAK 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 671 EAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLG 750
Cdd:cd02089   581 EAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALG 660
                         730
                  ....*....|....
gi 1811242742 751 VEPVDKDVIRKPPR 764
Cdd:cd02089   661 VEPAEPDIMDRKPR 674
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
29-870 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 677.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  29 LPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSIT- 107
Cdd:cd02083     3 KTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEGVt 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 108 ------VAILIVV---TVAFVQEYRSEKSLEELSKLVPPECHCVREGK-LEHTLARDLVPGDTVCLSVGDRVPADLRL-- 175
Cdd:cd02083    83 afvepfVILLILIanaVVGVWQERNAEKAIEALKEYEPEMAKVLRNGKgVQRIRARELVPGDIVEVAVGDKVPADIRIie 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 176 FEAVDLSIDESSLTGETTPCSKVTA--PQPAATNGDlasRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEA 253
Cdd:cd02083   163 IKSTTLRVDQSILTGESVSVIKHTDvvPDPRAVNQD---KKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 254 PKTPLQKSMDLLGKQLSFYSFGIIGIIMLV------------GWLLGKdiLEMFTISVSLAVAAIPEGLPIVVTVTLALG 321
Cdd:cd02083   240 EKTPLQQKLDEFGEQLSKVISVICVAVWAInighfndpahggSWIKGA--IYYFKIAVALAVAAIPEGLPAVITTCLALG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 322 VMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHA-------EVTGVGYNQFGEVIVDGDVVH 394
Cdd:cd02083   318 TRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDdsslnefEVTGSTYAPEGEVFKNGKKVK 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 395 GFYNPAVSRIVEAGCVCNDAVIRNN------TLMGKPTEGALIALAMKMGLDG------------------LQQDYIRKA 450
Cdd:cd02083   398 AGQYDGLVELATICALCNDSSLDYNeskgvyEKVGEATETALTVLVEKMNVFNtdksglskreranacndvIEQLWKKEF 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 451 EYPFSSEQKWMAVKCVHRTQQDRPEIcFMKGAYEQVIKYCTTYQSKGQTLT-LTQQQRDVYQQEKARMGSAGLRVLALAS 529
Cdd:cd02083   478 TLEFSRDRKSMSVYCSPTKASGGNKL-FVKGAPEGVLERCTHVRVGGGKVVpLTAAIKILILKKVWGYGTDTLRCLALAT 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 530 GPELGQ------------------LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTS 591
Cdd:cd02083   557 KDTPPKpedmdledstkfykyetdLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDE 636
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 592 Q----SVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTD 667
Cdd:cd02083   637 DttgkSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMG-SGTA 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 668 VCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQ 747
Cdd:cd02083   716 VAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPAT 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 748 SLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVF--------------WRELR-------------- 799
Cdd:cd02083   796 ALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFawwfmyyeegpqvsFYQLThfmqcsswepnfeg 875
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1811242742 800 ---DNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQT 870
Cdd:cd02083   876 vdcEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQI 949
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
76-900 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 601.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  76 ISQFKNPLIMLLLASAVISVLMHQFDDAVSIT-------VAILIVV---TVAFVQEYRSEKSLEELSKLVPPECHCVREG 145
Cdd:TIGR01116   2 LEQFEDLLVRILLLAACVSFVLAWFEEGEETVtafvepfVILLILVanaIVGVWQERNAEKAIEALKEYESEHAKVLRDG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 146 KLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAaTNGDLASRSNIAFMGTLVRC 225
Cdd:TIGR01116  82 RWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTESVPD-ERAVNQDKKNMLFSGTLVVA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 226 GKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSfysfGIIGIIMLVGWLLG--------------KDI 291
Cdd:TIGR01116 161 GKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLS----KVIGLICILVWVINighfndpalgggwiQGA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 292 LEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGL 371
Cdd:TIGR01116 237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVALDPS 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 372 HAE-----VTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTL------MGKPTEGALIALAMKMGLD 440
Cdd:TIGR01116 317 SSSlnefcVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERkgvyekVGEATEAALKVLVEKMGLP 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 441 G------------------LQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDrpeiCFMKGAYEQVIKYCTTYQSK-GQTLT 501
Cdd:TIGR01116 397 AtkngvsskrrpalgcnsvWNDKFKKLATLEFSRDRKSMSVLCKPSTGNK----LFVKGAPEGVLERCTHILNGdGRAVP 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 502 LTQQQRDVYQQEKARMGSA-GLRVLALASGPELGQ------------------LTFLGLVGIIDPPRTGVKEAVTTLIAS 562
Cdd:TIGR01116 473 LTDKMKNTILSVIKEMGTTkALRCLALAFKDIPDPreedllsdpanfeaiesdLTFIGVVGMLDPPRPEVADAIEKCRTA 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 563 GVSIKMITGDSQETAVAIASRLGLYSK----TSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSV 638
Cdd:TIGR01116 553 GIRVIMITGDNKETAEAICRRIGIFSPdedvTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELLQEQGEI 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 639 VAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLIS 718
Cdd:TIGR01116 633 VAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIF 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 719 LATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSI--IIVCGTLFVFWR 796
Cdd:TIGR01116 712 LTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVyvGLATVGGFVWWY 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 797 EL-------RDNVITPRD---------------TTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMG 854
Cdd:TIGR01116 792 LLthftgcdEDSFTTCPDfedpdcyvfegkqpaRTISLSVLVVIEMFNALNALSEDQSLLRMPPWVNKWLIGAICLSMAL 871
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*.
gi 1811242742 855 QLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVER 900
Cdd:TIGR01116 872 HFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
51-773 7.83e-162

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 491.72  E-value: 7.83e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  51 VSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV---LMHQFDDA---------VSITVAILIVVTVAF 118
Cdd:cd02081     1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLglgFYTPFGEGegktgwiegVAILVAVILVVLVTA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 119 VQEYRSEKSLEEL-SKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSK 197
Cdd:cd02081    81 GNDYQKEKQFRKLnSKKEDQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTGESDPIKK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 198 VTapqpaatngDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFG-- 275
Cdd:cd02081   161 TP---------DNQIPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGLIva 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 276 -IIGIIMLVGWLL--------------GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 340
Cdd:cd02081   232 aLTFIVLIIRFIIdgfvndgksfsaedLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACET 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 341 LGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnnt 420
Cdd:cd02081   312 MGNATAICSDKTGTLTQNRMTVVQGYI----------------------------------------------------- 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 421 lmGKPTEGALIALAMKMGLDglqQDYIRKAE-------YPFSSEQKWMAVkcVHRTQQDRPEIcFMKGAYEQVIKYCTTY 493
Cdd:cd02081   339 --GNKTECALLGFVLELGGD---YRYREKRPeekvlkvYPFNSARKRMST--VVRLKDGGYRL-YVKGASEIVLKKCSYI 410
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 494 QSK-GQTLTLTQQQRDVYQQEKARMGSAGLRVLALASG------------------PELGQLTFLGLVGIIDPPRTGVKE 554
Cdd:cd02081   411 LNSdGEVVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRdfspdeeptaerdwddeeDIESDLTFIGIVGIKDPLRPEVPE 490
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 555 AVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSV----------SGEEIDAMDVQQLSQIVPKVAVFYRASPRH 624
Cdd:cd02081   491 AVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLvlegkefrelIDEEVGEVCQEKFDKIWPKLRVLARSSPED 570
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 625 KMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVR 704
Cdd:cd02081   571 KYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQ 650
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811242742 705 FQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTK 773
Cdd:cd02081   651 FQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISR 719
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
45-868 4.38e-161

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 496.21  E-value: 4.38e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:cd02086     1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSFAVKDWIEGGVIAAVIALNVIVGFIQEYKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 125 EKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKvTAPQPA 204
Cdd:cd02086    81 EKTMDSLRNLSSPNAHVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGESLPVIK-DAELVF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 205 ATNGDL--ASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQ----AEEAPK----------------------- 255
Cdd:cd02086   160 GKEEDVsvGDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKALRgkggLISRDRvkswlygtlivtwdavgrflgtn 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 256 --TPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDilEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVK 333
Cdd:cd02086   240 vgTPLQRKLSKLAYLLFFIAVILAIIVFAVNKFDVDN--EVIIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVR 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 334 KLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvCND 413
Cdd:cd02086   318 KLDALEALGAVTDICSDKTGTLTQGKMVVRQVWIPAAL---------------------------------------CNI 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 414 AVIRNN------TLMGKPTEGALIALAMKMGL------DGLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPEICFMKG 481
Cdd:cd02086   359 ATVFKDeetdcwKAHGDPTEIALQVFATKFDMgknaltKGGSAQFQHVAEFPFDSTVKRMSV--VYYNNQAGDYYAYMKG 436
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 482 AYEQVIKYCTTYQSKGQTLTLTQQQRD--VYQQEKarMGSAGLRVLALAS--------------GPELGQ------LTFL 539
Cdd:cd02086   437 AVERVLECCSSMYGKDGIIPLDDEFRKtiIKNVES--LASQGLRVLAFASrsftkaqfnddqlkNITLSRadaesdLTFL 514
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 540 GLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGL-------YSKT---------SQ--SVSGEEIDA 601
Cdd:cd02086   515 GLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGIlppnsyhYSQEimdsmvmtaSQfdGLSDEEVDA 594
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 602 MDVQQLsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDD 681
Cdd:cd02086   595 LPVLPL--------VIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDN 666
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 682 FQTIMSAIEEGKGIYNNIKNFVRFQLSTSIA--ALTLISLA-----TLMNFpnPLNAMQILWINIIMDGPPAQSLGVEPV 754
Cdd:cd02086   667 FASIVNAIEEGRRMFDNIQKFVLHLLAENVAqvILLLIGLAfkdedGLSVF--PLSPVEILWINMVTSSFPAMGLGLEKA 744
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 755 DKDVIRKPPRNWKDSILTKNLILKILVSSII--IVCGTLFVF-----------------WRELRDNVITPRDTtmTFTCF 815
Cdd:cd02086   745 SPDVMQRPPHDLKVGIFTRELIIDTFVYGTFmgVLCLASFTLviygigngdlgsdcnesYNSSCEDVFRARAA--VFATL 822
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1811242742 816 VFFDMFNALSSRSQTKSVFEIG-------------LCSNRMFCYAVLGSIMGQLLVIYFPPL-QKVF 868
Cdd:cd02086   823 TWCALILAWEVVDMRRSFFNMHpdtdspvksffktLWKNKFLFWSVVLGFVSVFPTLYIPVInDDVF 889
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
78-752 2.06e-142

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 438.39  E-value: 2.06e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  78 QFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVRE--GKLEHTLARDL 155
Cdd:cd07539    35 QLELPPVALLGLAAGASASTGGGVDAVLIVGVLTVNAVIGGVQRLRAERALAALLAQQQQPARVVRApaGRTQTVPAESL 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 156 VPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAAtngDLASRSNIAFMGTLVRCGKAKGVVIGT 235
Cdd:cd07539   115 VPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDKQVAPTPGA---PLADRACMLYEGTTVVSGQGRAVVVAT 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 236 GENSEFGEVFKMMQAEEApKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVT 315
Cdd:cd07539   192 GPHTEAGRAQSLVAPVET-ATGVQAQLRELTSQLLPLSLGGGAAVTGLGLLRGAPLRQAVADGVSLAVAAVPEGLPLVAT 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 316 VTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhg 395
Cdd:cd07539   271 LAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRLRVVQVRP---------------------------- 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 396 fynpavsriveagcvcndavirnntlmgkPTegalialamkmgldglqqdyirkAEYPFSSEQKWMAVkcVHRTQQDRPE 475
Cdd:cd07539   323 -----------------------------PL-----------------------AELPFESSRGYAAA--IGRTGGGIPL 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 476 ICfMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALA-----SGPEL------GQLTFLGLVGI 544
Cdd:cd07539   349 LA-VKGAPEVVLPRCDRRMTGGQVVPLTEADRQAIEEVNELLAGQGLRVLAVAyrtldAGTTHaveavvDDLELLGLLGL 427
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 545 IDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLySKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRH 624
Cdd:cd07539   428 ADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL-PRDAEVVTGAELDALDEEALTGLVADIDVFARVSPEQ 506
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 625 KMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVR 704
Cdd:cd07539   507 KLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVH 586
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 1811242742 705 FQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVE 752
Cdd:cd07539   587 VLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
31-872 3.68e-142

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 447.69  E-value: 3.68e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  31 VSEVASILQADLQNGL--NKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFD------- 101
Cdd:TIGR01517  45 AEGIATKLKTDLNEGVrlSSSTLERREKVYGKNELPEKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVpsvgedk 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 102 --------DAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPP-ECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPAD 172
Cdd:TIGR01517 125 adtetgwiEGVAILVSVILVVLVTAVNDYKKELQFRQLNREKSAqKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPAD 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 173 LRLFEAVDLSIDESSLTGETTPcSKVTAPQPaatngdlasrsNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEE 252
Cdd:TIGR01517 205 GVFISGLSLEIDESSITGESDP-IKKGPVQD-----------PFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 253 APKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLL------------------GKDILEMFTISVSLAVAAIPEGLPIVV 314
Cdd:TIGR01517 273 EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRyvfriirgdgrfedteedAQTFLDHFIIAVTIVVVAVPEGLPLAV 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 315 TVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSdGLHAEVTGVGYNQFGEVIVDGDVVH 394
Cdd:TIGR01517 353 TIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIG-EQRFNVRDEIVLRNLPAAVRNILVE 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 395 GFY-NPAVSRIVEAGcvcndaviRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAE-----YPFSSEQKWMAVKCVHR 468
Cdd:TIGR01517 432 GISlNSSSEEVVDRG--------GKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEkvvkiYPFNSERKFMSVVVKHS 503
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 469 TQQDRpeiCFMKGAYEQVIKYCTTYQSKGQTLT-LTQQQRDVYQQEKARMGSAGLRVLALA-----------SGPELGQL 536
Cdd:TIGR01517 504 GGKYR---EFRKGASEIVLKPCRKRLDSNGEATpISEDDKDRCADVIEPLASDALRTICLAyrdfapeefprKDYPNKGL 580
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 537 TFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAV 616
Cdd:TIGR01517 581 TLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGGLAMEGKEFRSLVYEEMDPILPKLRV 660
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 617 FYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIY 696
Cdd:TIGR01517 661 LARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVY 740
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 697 NNIKNFVRFQLSTSIAALTLISLATLM--NFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKN 774
Cdd:TIGR01517 741 DNIRKFLQFQLTVNVVAVILTFVGSCIssSHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRS 820
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 775 LILKILVSSI--IIVCGTLFVFWRELRD----NVITPRDT----TMTFTCFVFFDMFNALSSRS--QTKSVFEiGLCSNR 842
Cdd:TIGR01517 821 MWKNILGQAGyqLVVTFILLFAGGSIFDvsgpDEITSHQQgelnTIVFNTFVLLQLFNEINARKlyEGMNVFE-GLFKNR 899
                         890       900       910
                  ....*....|....*....|....*....|
gi 1811242742 843 MFCYAVLGSIMGQLLVIYFppLQKVFQTES 872
Cdd:TIGR01517 900 IFVTIMGFTFGFQVIIVEF--GGSFFSTVS 927
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
45-778 1.69e-138

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 428.78  E-value: 1.69e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:cd07538     1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLGDPREGLILLIFVVVIIAIEVVQEWRT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 125 EKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPA 204
Cdd:cd07538    81 ERALEALKNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLGVDESTLTGESVPVWKRIDGKAM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 205 ATNGdlASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVG 284
Cdd:cd07538   161 SAPG--GWDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCALAALVFCALIVAVY 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 285 WLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTH 364
Cdd:cd07538   239 GVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTLTKNQMEVVE 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 365 IFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndaVIRnntlmgkptegalialamkmgldglqq 444
Cdd:cd07538   319 LTS-----------------------------------------------LVR--------------------------- 324
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 445 dyirkaEYPFSSEQKWMAvkcvHRTQQDRPEICFMKGAYEQVIKYCTtyqskgqtltLTQQQRDVYQQEKARMGSAGLRV 524
Cdd:cd07538   325 ------EYPLRPELRMMG----QVWKRPEGAFAAAKGSPEAIIRLCR----------LNPDEKAAIEDAVSEMAGEGLRV 384
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 525 LALASG--------PELGQLTF--LGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLySKTSQSV 594
Cdd:cd07538   385 LAVAACridesflpDDLEDAVFifVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGL-DNTDNVI 463
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 595 SGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAAD 674
Cdd:cd07538   464 TGQELDAMSDEELAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASD 543
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 675 MILVDDDFQTIMSAIEEGKGIYNNIKN---FVrFQLSTSIAALTLisLATLMNFPNPLNAMQILWINIIMDGPPAQSLGV 751
Cdd:cd07538   544 IVLLDDNFSSIVSTIRLGRRIYDNLKKaitYV-FAIHVPIAGLAL--LPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEA 620
                         730       740
                  ....*....|....*....|....*..
gi 1811242742 752 EPVDKDVIRKPPRNWKDSILTKNLILK 778
Cdd:cd07538   621 EPAERDIMRRPPRPPDEPLFGPRLVIK 647
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
33-794 4.03e-130

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 418.65  E-value: 4.03e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742   33 EVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILI 112
Cdd:TIGR01523   14 EAAEFIGTSIPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAMHDWIEGGVISAIIAL 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  113 VVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGET 192
Cdd:TIGR01523   94 NILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIETKNFDTDEALLTGES 173
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  193 TPCSK----VTAPQPAATNGDlasRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAE---------EAPK---- 255
Cdd:TIGR01523  174 LPVIKdahaTFGKEEDTPIGD---RINLAFSSSAVTKGRAKGICIATALNSEIGAIAAGLQGDgglfqrpekDDPNkrrk 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  256 ----------------------TPLQKSMDLLGKQLsFYSFGIIGIIMLVGWLLGKDiLEMFTISVSLAVAAIPEGLPIV 313
Cdd:TIGR01523  251 lnkwilkvtkkvtgaflglnvgTPLHRKLSKLAVIL-FCIAIIFAIIVMAAHKFDVD-KEVAIYAICLAISIIPESLIAV 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  314 VTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIF----------TSD-------------- 369
Cdd:TIGR01523  329 LSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWiprfgtisidNSDdafnpnegnvsgip 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  370 ------GLHAEVTGVGYNQ-FGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNT------LMGKPTEGALIALAMK 436
Cdd:TIGR01523  409 rfspyeYSHNEAADQDILKeFKDELKEIDLPEDIDMDLFIKLLETAALANIATVFKDDatdcwkAHGDPTEIAIHVFAKK 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  437 MGL-----------------------------DGLQQDYIRkaEYPFSSEQKWMAVkcVHRTQQDRPEICFMKGAYEQVI 487
Cdd:TIGR01523  489 FDLphnaltgeedllksnendqsslsqhnekpGSAQFEFIA--EFPFDSEIKRMAS--IYEDNHGETYNIYAKGAFERII 564
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  488 KYCTTYQSKG--QTLTLTQQQRDVYQQEKARMGSAGLRVLALAS---------GPELGQLT-----------FLGLVGII 545
Cdd:TIGR01523  565 ECCSSSNGKDgvKISPLEDCDRELIIANMESLAAEGLRVLAFASksfdkadnnDDQLKNETlnrataesdleFLGLIGIY 644
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  546 DPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLG-----LYSKTSQSVS-----GEEIDAMDVQQLSQIVPKVA 615
Cdd:TIGR01523  645 DPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGiippnFIHDRDEIMDsmvmtGSQFDALSDEEVDDLKALCL 724
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  616 VFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGI 695
Cdd:TIGR01523  725 VIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRM 804
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  696 YNNIKNFVRFQLSTSIAALTLISLATLMNFPN-----PLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSI 770
Cdd:TIGR01523  805 FDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGI 884
                          890       900
                   ....*....|....*....|....
gi 1811242742  771 LTKNLILKILVSSIIIVCGTLFVF 794
Cdd:TIGR01523  885 FQKELIIDMFAYGFFLGGSCLASF 908
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
45-794 8.75e-130

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 409.72  E-value: 8.75e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVIS----VLMHQ----FDDAVSITVAILIVVTV 116
Cdd:cd02077     1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSfftdVLLAPgefdLVGALIILLMVLISGLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 117 AFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARD-LVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPC 195
Cdd:cd02077    81 DFIQEIRSLKAAEKLKKMVKNTATVIRDGSKYMEIPIDeLVPGDIVYLSAGDMIPADVRIIQSKDLFVSQSSLTGESEPV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 196 SKVTAPQpAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQaEEAPKTPLQKSMDLLGKQLSFYSFG 275
Cdd:cd02077   161 EKHATAK-KTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSIT-EKRPETSFDKGINKVSKLLIRFMLV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 276 IIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTL 355
Cdd:cd02077   239 MVPVVFLINGLTKGDWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILCTDKTGTL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 356 TKNEMTVTHIFTSDGlhaevtgvgynQFGEVIVDgdvvHGFYNPavsrIVEAGcvcndavIRNntLMGKptegALIALAM 435
Cdd:cd02077   319 TQDKIVLERHLDVNG-----------KESERVLR----LAYLNS----YFQTG-------LKN--LLDK----AIIDHAE 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 436 KMGLDGLQQDYIRKAEYPFSSEQKWMAVkCVHRTQQDRPEICfmKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKA 515
Cdd:cd02077   367 EANANGLIQDYTKIDEIPFDFERRRMSV-VVKDNDGKHLLIT--KGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQVE 443
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 516 RMGSAGLRVLALA----SGPELG-------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRL 584
Cdd:cd02077   444 ELNREGLRVLAIAykklPAPEGEysvkdekELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQV 523
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 585 GLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQT 664
Cdd:cd02077   524 GL--DINRVLTGSEIEALSDEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISV-DS 600
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 665 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLAT-LMNFpNPLNAMQILWINIIMDg 743
Cdd:cd02077   601 AVDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSNFGNVFSVLVASaFLPF-LPMLPIQLLLQNLLYD- 678
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1811242742 744 pPAQ-SLGVEPVDKDVIRKpPRNWKDSILTKNLILKILVSSI---IIVCGTLFVF 794
Cdd:cd02077   679 -FSQlAIPFDNVDEEFLKK-PQKWDIKNIGRFMIWIGPISSIfdiLTFLVMWFVF 731
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
45-776 1.44e-127

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 407.89  E-value: 1.44e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMH----QFDDAVS-------ITVAILIV 113
Cdd:cd02608     1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYgiqaATEEEPSndnlylgIVLAAVVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 114 VT--VAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGE 191
Cdd:cd02608    81 VTgcFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 192 TTPCSKvtapQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMD-------- 263
Cdd:cd02608   161 SEPQTR----SPEFTHENPLETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREIEhfihiitg 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 264 ---LLGkqlsfYSFGIIGIIMLVGWLlgkdilEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 340
Cdd:cd02608   237 vavFLG-----VSFFILSLILGYTWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVET 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 341 LGCCNVICSDKTGTLTKNEMTVTHIFtsdglhaevtgvgynqFGEVIVDGDVVHGFYN----------PAVSRIVeagCV 410
Cdd:cd02608   306 LGSTSTICSDKTGTLTQNRMTVAHMW----------------FDNQIHEADTTEDQSGasfdkssatwLALSRIA---GL 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 411 CNDAVIRNN---------TLMGKPTEGALIALA-MKMG-LDGLQQDYIRKAEYPFSSEQKWMAvkCVHRTQQDRPE--IC 477
Cdd:cd02608   367 CNRAEFKAGqenvpilkrDVNGDASESALLKCIeLSCGsVMEMRERNPKVAEIPFNSTNKYQL--SIHENEDPGDPryLL 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 478 FMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALA-------SGPE------------LGQLTF 538
Cdd:cd02608   445 VMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNAYLELGGLGERVLGFChlylpddKFPEgfkfdtdevnfpTENLCF 524
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 539 LGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeidamdvqqlsqivpkVAVFY 618
Cdd:cd02608   525 VGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVG----------------------------IIVFA 576
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 619 RASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNN 698
Cdd:cd02608   577 RTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 656
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811242742 699 IKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRN-WKDSILTKNLI 776
Cdd:cd02608   657 LKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNpKTDKLVNERLI 735
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
28-776 4.30e-127

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 409.18  E-value: 4.30e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  28 ELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQF------- 100
Cdd:TIGR01106  19 KLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIqasteee 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 101 --DDAVSITVAILIVVTV----AFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLR 174
Cdd:TIGR01106  99 pqNDNLYLGVVLSAVVIItgcfSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLR 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 175 LFEAVDLSIDESSLTGETTPCSKvtapQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAP 254
Cdd:TIGR01106 179 IISAQGCKVDNSSLTGESEPQTR----SPEFTHENPLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRIASLASGLENG 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 255 KTPLQKSMD-----LLGKQLSF-YSFGIIGIIMLVGWLlgkdilEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:TIGR01106 255 KTPIAIEIEhfihiITGVAVFLgVSFFILSLILGYTWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARK 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 329 RAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLH-AEVT----GVGYNQFGEVIVdgdvvhgfynpAVSR 403
Cdd:TIGR01106 329 NCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHeADTTedqsGVSFDKSSATWL-----------ALSR 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 404 IVEagcVCNDAVIRNN---------TLMGKPTEGALIA-LAMKMG-LDGLQQDYIRKAEYPFSSEQKWMAvkCVHRTQ-- 470
Cdd:TIGR01106 398 IAG---LCNRAVFKAGqenvpilkrAVAGDASESALLKcIELCLGsVMEMRERNPKVVEIPFNSTNKYQL--SIHENEdp 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 471 QDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVL-----ALASG--PE----------- 532
Cdd:TIGR01106 473 RDPRHLLVMKGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLgfchlYLPDEqfPEgfqfdtddvnf 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 533 -LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVS---------------- 595
Cdd:TIGR01106 553 pTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEdiaarlnipvsqvnpr 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 596 --------GEEIDAMDVQQLSQIV---PKVaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQT 664
Cdd:TIGR01106 633 dakacvvhGSDLKDMTSEQLDEILkyhTEI-VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 665 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGP 744
Cdd:TIGR01106 712 GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMV 791
                         810       820       830
                  ....*....|....*....|....*....|...
gi 1811242742 745 PAQSLGVEPVDKDVIRKPPRN-WKDSILTKNLI 776
Cdd:TIGR01106 792 PAISLAYEKAESDIMKRQPRNpKTDKLVNERLI 824
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
105-735 3.06e-120

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 377.43  E-value: 3.06e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 105 SITVAILIVVTVAFVQEYRSEKSLEELSKLV--PPECHCVREGKLEHTlARDLVPGDTVCLSVGDRVPADLRLFEAvDLS 182
Cdd:TIGR01494   1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLvnTATVLVLRNGWKEIS-SKDLVPGDVVLVKSGDTVPADGVLLSG-SAF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 183 IDESSLTGETTPCSKVTAPQPAATNGdlasrsniafmGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSM 262
Cdd:TIGR01494  79 VDESSLTGESLPVLKTALPDGDAVFA-----------GTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLQSKA 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 263 DLLGKQLSFYSFGIIGIIMLVGWLL----GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIV 338
Cdd:TIGR01494 148 DKFENFIFILFLLLLALAVFLLLPIggwdGNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNAL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 339 ETLGCCNVICSDKTGTLTKNEMTVTHIFTsDGLHAEVTGVGYNQFGEvivdgdvvhgfynpavsriveagcvcndavirN 418
Cdd:TIGR01494 228 EELGKVDVICFDKTGTLTTNKMTLQKVII-IGGVEEASLALALLAAS--------------------------------L 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 419 NTLMGKPTEGALIALAMKMG-LDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPeicFMKGAYEQVIKYCTtyqskg 497
Cdd:TIGR01494 275 EYLSGHPLERAIVKSAEGVIkSDEINVEYKILDVFPFSSVLKRMGVIVEGANGSDLL---FVKGAPEFVLERCN------ 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 498 qtltltqqQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 577
Cdd:TIGR01494 346 --------NENDYDEKVDEYARQGLRVLAFASKKLPDDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTA 417
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 578 VAIASRLGLysktsqsvsgeeidamdvqqlsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 657
Cdd:TIGR01494 418 KAIAKELGI----------------------------DVFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADV 469
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811242742 658 GVAMGQtgTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 735
Cdd:TIGR01494 470 GIAMGS--GDVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVIILLPPLLAALAL 545
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
45-860 7.79e-120

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 383.89  E-value: 7.79e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  45 GLNKCEVSHRRAFHGWNEFDiSEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:cd02076     1 GLTSEEAAKRLKEYGPNELP-EKKENPILKFLSFFWGPIPWMLEAAAILAAALGDWVDFAIILLLLLINAGIGFIEERQA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 125 EKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKvtapqpa 204
Cdd:cd02076    80 GNAVAALKKSLAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQVDQSALTGESLPVTK------- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 205 aTNGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEaPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVG 284
Cdd:cd02076   153 -HPGD------EAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAE-EQGHLQKVLNKIGNFLILLALILVLIIVIVA 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 285 WLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTH 364
Cdd:cd02076   225 LYRHDPFLEILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTGTLTLNKLSLDE 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 365 IFTSDGLHAEvtgvgynqfgEVIVdgdvvhgfynpavsriveAGCVCNDAviRNNTLMGKPTEGALIALamKMGLDGLQQ 444
Cdd:cd02076   305 PYSLEGDGKD----------ELLL------------------LAALASDT--ENPDAIDTAILNALDDY--KPDLAGYKQ 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 445 -DYirkaeYPFSSEqkwmaVKCVHRTQQDRPEICF--MKGAYEQVIKYCttyqskgqtlTLTQQQRDVYQQEKARMGSAG 521
Cdd:cd02076   353 lKF-----TPFDPV-----DKRTEATVEDPDGERFkvTKGAPQVILELV----------GNDEAIRQAVEEKIDELASRG 412
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 522 LRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK---TSQSVSGEE 598
Cdd:cd02076   413 YRSLGVARKEDGGRWELLGLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGMGTNilsAERLKLGGG 492
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 599 IDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILV 678
Cdd:cd02076   493 GGGMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAV-SGATDAARAAADIVLT 571
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 679 DDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGpPAQSLGvepVDKDV 758
Cdd:cd02076   572 APGLSVIIDAIKTSRQIFQRMKSYVIYRIAETLRILVFFTLGILILNFYPLPLIMIVLIAILNDG-ATLTIA---YDNVP 647
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 759 IRKPPRNWKdsiLTKNLILKIL------VSSIIIVC---GTLFVFWRELRDNVItprdTTMTFTCFVFFDMFNALSSRsq 829
Cdd:cd02076   648 PSPRPVRWN---MPELLGIATVlgvvltISSFLLLWlldDQGWFEDIVLSAGEL----QTILYLQLSISGHLTIFVTR-- 718
                         810       820       830
                  ....*....|....*....|....*....|.
gi 1811242742 830 TKSVFEIGLCSNRMFCYAVLGSIMGQLLVIY 860
Cdd:cd02076   719 TRGPFWRPRPSPLLFIAVVLTQILATLLAVY 749
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
45-744 1.62e-112

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 363.57  E-value: 1.62e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  45 GLNKCEVSHRRAFHGWNEFdISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNEL-PEKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALENWVDFVIILGLLLLNATIGFIEENKA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 125 EKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTapqpa 204
Cdd:TIGR01647  80 GNAVEALKQSLAPKARVLRDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGESLPVTKKT----- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 205 atnGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVG 284
Cdd:TIGR01647 155 ---GD------IAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILSKIGLFLIVLIGVLVLIELVVL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 285 WLL-GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVT 363
Cdd:TIGR01647 226 FFGrGESFREGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDILCSDKTGTLTLNKLSID 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 364 HIFTsdglhaevtgvgynQFGEVIVDGDVVHGFYnpaVSRivEAGcvcNDAVirNNTLMGKptegaLIALAMKMgldglq 443
Cdd:TIGR01647 306 EILP--------------FFNGFDKDDVLLYAAL---ASR--EED---QDAI--DTAVLGS-----AKDLKEAR------ 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 444 qDYIRKAEY-PFSSEQKwmAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYqskgqtltltQQQRDVYQQEKARMGSAGL 522
Cdd:TIGR01647 351 -DGYKVLEFvPFDPVDK--RTEATVEDPETGKRFKVTKGAPQVILDLCDNK----------KEIEEKVEEKVDELASRGY 417
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 523 RVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK--TSQSVSGEEID 600
Cdd:TIGR01647 418 RALGVARTDEEGRWHFLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGLGTNiyTADVLLKGDNR 497
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 601 AMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDD 680
Cdd:TIGR01647 498 DDLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAV-AGATDAARSAADIVLTEP 576
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1811242742 681 DFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATL-MNFpnPLNAMQILWINIIMDGP 744
Cdd:TIGR01647 577 GLSVIVDAILESRKIFQRMKSYVIYRIAETIRIVFFFGLLILiLNF--YFPPIMVVIIAILNDGT 639
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
346-749 1.13e-107

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 335.96  E-value: 1.13e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 346 VICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnntlmgkp 425
Cdd:cd01431     1 VICSDKTGTLTKNGMTVTKLFI---------------------------------------------------------- 22
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 426 tegalialamkmgldglqqdyirkAEYPFSSEQKWMAVKCVHrtqqDRPEICFMKGAYEQVIKYCTTyqskgqtlTLTQQ 505
Cdd:cd01431    23 ------------------------EEIPFNSTRKRMSVVVRL----PGRYRAIVKGAPETILSRCSH--------ALTEE 66
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 506 QRDVYQQEKARMGSAGLRVLALASGP---------ELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQET 576
Cdd:cd01431    67 DRNKIEKAQEESAREGLRVLALAYREfdpetskeaVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLT 146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 577 AVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAAD 656
Cdd:cd01431   147 AIAIAREIGIDTKASGVILGEEADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQAD 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 657 IGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILW 736
Cdd:cd01431   227 VGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILW 306
                         410
                  ....*....|...
gi 1811242742 737 INIIMDGPPAQSL 749
Cdd:cd01431   307 INLVTDLIPALAL 319
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
18-794 3.93e-104

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 345.13  E-value: 3.93e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  18 IPVLTSKKASELPVSEVASILQA--DLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV 95
Cdd:PRK10517   38 VPPSLSARCLKAAVMPEEELWKTfdTHPEGLNEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISY 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  96 LMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR--EGKLEHTLA----RDLVPGDTVCLSVGDRV 169
Cdd:PRK10517  118 ATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRviNDKGENGWLeipiDQLVPGDIIKLAAGDMI 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 170 PADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQ 249
Cdd:PRK10517  198 PADLRILQARDLFVAQASLTGESLPVEKFATTRQPEHSNPL-ECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVS 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 250 AEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV-GWLLGkDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:PRK10517  277 EQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLInGYTKG-DWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQ 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 329 RAIVKKLPIVETLGCCNVICSDKTGTLTKNEmtvthIFTSDglHAEVtgvgynqFGEviVDGDVVH-----GFYNPAVSR 403
Cdd:PRK10517  356 KVIVKRLDAIQNFGAMDILCTDKTGTLTQDK-----IVLEN--HTDI-------SGK--TSERVLHsawlnSHYQTGLKN 419
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 404 IVEAgcvcndAVIrnntlmgkptEGALIALAMKMGldglqQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPE-ICfmKGA 482
Cdd:PRK10517  420 LLDT------AVL----------EGVDEESARSLA-----SRWQKIDEIPFDFERRRMSV--VVAENTEHHQlIC--KGA 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 483 YEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGP-----------ELGQLTFLGLVGIIDPPRTG 551
Cdd:PRK10517  475 LEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYlparegdyqraDESDLILEGYIAFLDPPKET 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 552 VKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKS 631
Cdd:PRK10517  555 TAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTL 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 632 LQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSI 711
Cdd:PRK10517  633 LKREGHVVGFMGDGINDAPALRAADIGISV-DGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNF 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 712 AAL--TLISLATLmnfPN-PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKPPRnWKDSILTKNLILKILVSSII-I 786
Cdd:PRK10517  712 GNVfsVLVASAFL---PFlPMLPLHLLIQNLLYD--VSQvAIPFDNVDDEQIQKPQR-WNPADLGRFMVFFGPISSIFdI 785
                         810
                  ....*....|
gi 1811242742 787 VCGTL--FVF 794
Cdd:PRK10517  786 LTFCLmwWVF 795
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
25-795 5.57e-103

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 341.08  E-value: 5.57e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  25 KASELPVSEVASILQAdLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAV 104
Cdd:TIGR01524  14 KESQMGKETLLRKLGV-HETGLTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSYLTDDLEATV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 105 SITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR------EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEA 178
Cdd:TIGR01524  93 IIALMVLASGLLGFIQESRAERAAYALKNMVKNTATVLRvinengNGSMDEVPIDALVPGDLIELAAGDIIPADARVISA 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 179 VDLSIDESSLTGETTPCSKVTAPQPAATNgDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMqAEEAPKTPL 258
Cdd:TIGR01524 173 RDLFINQSALTGESLPVEKFVEDKRARDP-EILERENLCFMGTNVLSGHAQAVVLATGSSTWFGSLAIAA-TERRGQTAF 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 259 QKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIV 338
Cdd:TIGR01524 251 DKGVKSVSKLLIRFMLVMVPVVLMINGLMKGDWLEAFLFALAVAVGLTPEMLPMIVSSNLAKGAINMSKKKVIVKELSAI 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 339 ETLGCCNVICSDKTGTLTKNEMTVTHiftsdglHAEVTGVGYNQfgevivdgdVVHGFYNPAVSRiVEAGCVCNDAVIRn 418
Cdd:TIGR01524 331 QNFGAMDILCTDKTGTLTQDKIELEK-------HIDSSGETSER---------VLKMAWLNSYFQ-TGWKNVLDHAVLA- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 419 ntlmgKPTEGALIALAMKmgldglqqdYIRKAEYPFSSEQKWMAVkCVHRTQQDRPEICfmKGAYEQVIKYCTTYQSKGQ 498
Cdd:TIGR01524 393 -----KLDESAARQTASR---------WKKVDEIPFDFDRRRLSV-VVENRAEVTRLIC--KGAVEEMLTVCTHKRFGGA 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 499 TLTLTQQQRDVYQQEKARMGSAGLRVLALAS--GPELG---------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIK 567
Cdd:TIGR01524 456 VVTLSESEKSELQDMTAEMNRQGIRVIAVATktLKVGEadftktdeeQLIIEGFLGFLDPPKESTKEAIAALFKNGINVK 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 568 MITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVN 647
Cdd:TIGR01524 536 VLTGDNEIVTARICQEVGI--DANDFLLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGIN 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 648 DAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPN 727
Cdd:TIGR01524 614 DAPALRKADVGISV-DTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASAFIPFL 692
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811242742 728 PLNAMQILWINIIMDGPPAqSLGVEPVDKDVIRKpPRNWKDSILTKNLILKILVSSIIIVCGTLFVFW 795
Cdd:TIGR01524 693 PMLSLHLLIQNLLYDFSQL-TLPWDKMDREFLKK-PHQWEQKGMGRFMLCIGPVSSIFDIATFLLMWF 758
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
43-766 1.07e-90

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 308.49  E-value: 1.07e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  43 QNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLM------HQFDDAVSITVAILIV-VT 115
Cdd:PRK15122   43 RQGLTEEDAAERLQRYGPNEVAHEKPPHALVQLLQAFNNPFIYVLMVLAAISFFTdywlplRRGEETDLTGVIIILTmVL 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 116 VA----FVQEYRSEKSLEELSKLVPPECHCVR------EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDE 185
Cdd:PRK15122  123 LSgllrFWQEFRSNKAAEALKAMVRTTATVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQ 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 186 SSLTGETTPCSKV---------TAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEaPKT 256
Cdd:PRK15122  203 AVLTGEALPVEKYdtlgavagkSADALADDEGSLLDLPNICFMGTNVVSGTATAVVVATGSRTYFGSLAKSIVGTR-AQT 281
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 257 PLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLP 336
Cdd:PRK15122  282 AFDRGVNSVSWLLIRFMLVMVPVVLLINGFTKGDWLEALLFALAVAVGLTPEMLPMIVSSNLAKGAIAMARRKVVVKRLN 361
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 337 IVETLGCCNVICSDKTGTLTKNEMTVTHiftsdglHaevtgvgynqfgeviVDgdvVHGFYNPAVSRIV------EAGcv 410
Cdd:PRK15122  362 AIQNFGAMDVLCTDKTGTLTQDRIILEH-------H---------------LD---VSGRKDERVLQLAwlnsfhQSG-- 414
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 411 cndavIRNntLMGKptegALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVkCVHRTQQDRPEICfmKGAYEQVIKYC 490
Cdd:PRK15122  415 -----MKN--LMDQ----AVVAFAEGNPEIVKPAGYRKVDELPFDFVRRRLSV-VVEDAQGQHLLIC--KGAVEEMLAVA 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 491 TTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASgPELGQ--------------LTFLGLVGIIDPPRTGVKEAV 556
Cdd:PRK15122  481 THVRDGDTVRPLDEARRERLLALAEAYNADGFRVLLVAT-REIPGgesraqystaderdLVIRGFLTFLDPPKESAAPAI 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 557 TTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNG 636
Cdd:PRK15122  560 AALRENGVAVKVLTGDNPIVTAKICREVGL--EPGEPLLGTEIEAMDDAALAREVEERTVFAKLTPLQKSRVLKALQANG 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 637 SVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTsiaaltl 716
Cdd:PRK15122  638 HTVGFLGDGINDAPALRDADVGISV-DSGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYLNMTASS------- 709
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1811242742 717 islatlmNFPN--------------PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKpPRNW 766
Cdd:PRK15122  710 -------NFGNvfsvlvasafipflPMLAIHLLLQNLMYD--ISQlSLPWDKMDKEFLRK-PRKW 764
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
86-766 1.62e-82

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 280.32  E-value: 1.62e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  86 LLLASAVISVLMHQFDDAVSITVAILIVVtVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSV 165
Cdd:cd02609    42 INFVIAVLLILVGSYSNLAFLGVIIVNTV-IGIVQEIRAKRQLDKLSILNAPKVTVIRDGQEVKIPPEELVLDDILILKP 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 166 GDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTapqpaatnGDLAsrsniaFMGTLVRCGKAKGVVIGTGENSefgevF 245
Cdd:cd02609   121 GEQIPADGEVVEGGGLEVDESLLTGESDLIPKKA--------GDKL------LSGSFVVSGAAYARVTAVGAES-----Y 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 246 KMMQAEEAPK-----TPLQKSMDLLGKqlsFYSFGII--GIIMLVG--WLLGKDILEMFTISVSLAVAAIPEGLPIVVTV 316
Cdd:cd02609   182 AAKLTLEAKKhklinSELLNSINKILK---FTSFIIIplGLLLFVEalFRRGGGWRQAVVSTVAALLGMIPEGLVLLTSV 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 317 TLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLhaevtgvgynqfgevivdgdvvhgf 396
Cdd:cd02609   259 ALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEA------------------------- 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 397 YNPAVSRIVEAGCvcnDAVIRNNtlmgkPTEGALialamkmgLDGLQQD--YIRKAEYPFSSEQKWMAVkcvhrTQQDR- 473
Cdd:cd02609   314 NEAEAAAALAAFV---AASEDNN-----ATMQAI--------RAAFFGNnrFEVTSIIPFSSARKWSAV-----EFRDGg 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 474 ------PEIcFMKGAYEQVikycttyqskgqtltltQQQRDVYQQEkarmgsaGLRVLALASGPE-------LGQLTFLG 540
Cdd:cd02609   373 twvlgaPEV-LLGDLPSEV-----------------LSRVNELAAQ-------GYRVLLLARSAGaltheqlPVGLEPLA 427
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 541 LVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysktsqsvSGEEIDA-----MDVQQLSQIVPKVA 615
Cdd:cd02609   428 LILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGL--------EGAESYIdastlTTDEELAEAVENYT 499
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 616 VFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGI 695
Cdd:cd02609   500 VFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRV 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 696 YNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRK----------PPRN 765
Cdd:cd02609   579 VNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKRRIEGGflrrvltkalPPLN 658

                  .
gi 1811242742 766 W 766
Cdd:cd02609   659 R 659
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
84-731 3.53e-58

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 209.79  E-value: 3.53e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  84 IMLLLASAVI-SVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR-EGKLEHTLARDLVPGDTV 161
Cdd:TIGR01525   1 MDTLMALAAIaAYAMGLVLEGALLLFLFLLGETLEERAKSRASDALSALLALAPSTARVLQgDGSEEEVPVEELQVGDIV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 162 CLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEF 241
Cdd:TIGR01525  81 IVRPGERIPVDGVVISGES-EVDESALTGESMPVEK--------------KEGDEVFAGTINGDGSLTIRVTKLGEDSTL 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 242 GEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALG 321
Cdd:TIGR01525 146 AQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREALYRALTVLVVACPCALGLATPVAILVA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 322 VMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHI-FTSDGLHAEVTGVgynqfgevivdgdvvhgfynpa 400
Cdd:TIGR01525 226 IGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIePLDDASEEELLAL---------------------- 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 401 vsriveAGCvcndavirnntlMGKPTEGAlIALAMkmgldglqQDYIRKAEYPFSSEQkwmavkcvhrtQQDRPEiCFMK 480
Cdd:TIGR01525 284 ------AAA------------LEQSSSHP-LARAI--------VRYAKERGLELPPED-----------VEEVPG-KGVE 324
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 481 GAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELgqltfLGLVGIIDPPRTGVKEAVTTLI 560
Cdd:TIGR01525 325 ATVDGGREVRIGNPRFLGNRELAIEPISASPDLLNEGESQGKTVVFVAVDGEL-----LGVIALRDQLRPEAKEAIAALK 399
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 561 ASGV-SIKMITGDSQETAVAIASRLGLYSKtsqsvsgeeidamdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVV 639
Cdd:TIGR01525 400 RAGGiKLVMLTGDNRSAAEAVAAELGIDDE--------------------------VHAELLPEDKLAIVKKLQEEGGPV 453
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 640 AMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NFVrfqlstsiAALTLIS 718
Cdd:TIGR01525 454 AMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKqNLA--------WALGYNL 524
                         650
                  ....*....|....*.
gi 1811242742 719 LA---TLMNFPNPLNA 731
Cdd:TIGR01525 525 VAiplAAGGLLPLWLA 540
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
83-703 4.68e-57

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 210.00  E-value: 4.68e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  83 LIML-LLASAVISVL------MHQFDDAVsitVAILIVVTVA-FVQEY---RSEKSLEELSKLVPPECHCVREGKLEHTL 151
Cdd:COG2217   151 LVALgTLAAFLYSLYatlfgaGHVYFEAA---AMIIFLLLLGrYLEARakgRARAAIRALLSLQPKTARVLRDGEEVEVP 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 152 ARDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTapqpaatnGDlasrsnIAFMGTLVRCGKAKGV 231
Cdd:COG2217   228 VEELRVGDRVLVRPGERIPVDGVVLEG-ESSVDESMLTGESLPVEKTP--------GD------EVFAGTINLDGSLRVR 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 232 VIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGL- 310
Cdd:COG2217   293 VTKVGSDTTLARIIRLVEEAQSSKAPIQRLADRIARYFVPAVLAIAALTFLVWLLFGGDFSTALYRAVAVLVIACPCALg 372
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 311 ---PIVVTVtlALGvmRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVI 387
Cdd:COG2217   373 latPTAIMV--GTG--RAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDVVPLDGLDED----------ELL 438
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 388 vdgdvvhgfynpAVSRIVEAGcvcndavirnntlmgkpTE----GALIALAMKMGLDGLQQDYIR-------KAEYpfsS 456
Cdd:COG2217   439 ------------ALAAALEQG-----------------SEhplaRAIVAAAKERGLELPEVEDFEaipgkgvEATV---D 486
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 457 EQKWMAVkcvhrtqqdRPEicFMKgayeqvikycttyqSKGQTLTltqqqrDVYQQEKARMGSAGLRVLALASGpelGQL 536
Cdd:COG2217   487 GKRVLVG---------SPR--LLE--------------EEGIDLP------EALEERAEELEAEGKTVVYVAVD---GRL 532
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 537 tfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqqlsqivpkvaV 616
Cdd:COG2217   533 --LGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELG-------------IDE--------------V 583
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 617 FYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIY 696
Cdd:COG2217   584 RAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATM 662

                  ....*...
gi 1811242742 697 NNIK-NFV 703
Cdd:COG2217   663 RIIRqNLF 670
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
82-732 8.87e-54

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 198.21  E-value: 8.87e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  82 PLIMLLLASAVI-----SVLMHQ------FDDAVSITVAILIVvtvAFVQEY---RSEKSLEELSKLVPPECHCVREGKL 147
Cdd:cd02079    59 LNMDVLVSLAAIgafvaSLLTPLlggigyFEEAAMLLFLFLLG---RYLEERarsRARSALKALLSLAPETATVLEDGST 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 148 EHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKVTapqpaatnGDlasrsnIAFMGTLVRCGK 227
Cdd:cd02079   136 EEVPVDDLKVGDVVLVKPGERIPVDGVVVSGES-SVDESSLTGESLPVEKGA--------GD------TVFAGTINLNGP 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 228 AKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIP 307
Cdd:cd02079   201 LTIEVTKTGEDTTLAKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSLALYRALAVLVVACP 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 308 EGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVI 387
Cdd:cd02079   281 CALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEIEPLEGFSED----------ELL 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 388 vdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPtegalIALAMkmgldglqQDYIRKAEypfsseqkwmAVKCVH 467
Cdd:cd02079   351 ------------ALAAALEQHS-------------EHP-----LARAI--------VEAAEEKG----------LPPLEV 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 468 RTQQDRPEicfmKGAYEQVIkycttyqskGQTLTLTQQ---QRDVYQQEKARMGSAG-LRVLALASGPELgqltfLGLVG 543
Cdd:cd02079   383 EDVEEIPG----KGISGEVD---------GREVLIGSLsfaEEEGLVEAADALSDAGkTSAVYVGRDGKL-----VGLFA 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 544 IIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSktsqsvsgeeidamdvqqlsqivpkvaVFYRASPR 623
Cdd:cd02079   445 LEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGIDE---------------------------VHAGLLPE 497
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 624 HKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQtGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NF 702
Cdd:cd02079   498 DKLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGS-GTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKqNL 576
                         650       660       670
                  ....*....|....*....|....*....|
gi 1811242742 703 VrFQLSTSIAALTLislaTLMNFPNPLNAM 732
Cdd:cd02079   577 A-WALGYNAIALPL----AALGLLTPWIAA 601
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
86-731 1.60e-50

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 187.53  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  86 LLLASAVISVLMHQFDDAVSItvaILIVVTVAFVQEY---RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVC 162
Cdd:TIGR01512   4 LMALAALGAVAIGEYLEGALL---LLLFSIGETLEEYasgRARRALKALMELAPDTARRLQGDSLEEVAVEELKVGDVVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 163 LSVGDRVPADLRLfEAVDLSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFG 242
Cdd:TIGR01512  81 VKPGERVPVDGEV-LSGTSSVDESALTGESVPVEK--------------APGDEVFAGAINLDGVLTIEVTKLPADSTIA 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 243 EVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKD-ILEMFTISVSLAVAAIPEGLPIVVTVTLALG 321
Cdd:TIGR01512 146 KIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVPPLLGAGpFLEWIYRALVLLVVASPCALVISAPAAYLSA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 322 VMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgevivdgdvvhGFYNPAV 401
Cdd:TIGR01512 226 ISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTDVHPADGHSES--------------------EVLRLAA 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 402 SriVEAGCVcndavirnntlmgKPtegalIALAMkmgldglqQDYIRKAEYPFSSEQkwmavkcvhrtQQDRPEicfmKG 481
Cdd:TIGR01512 286 A--AEQGST-------------HP-----LARAI--------VDYARARELAPPVED-----------VEEVPG----EG 322
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 482 AYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQekarmgSAGLRVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIA 561
Cdd:TIGR01512 323 VRAVVDGGEVRIGNPRSLSEAVGASIAVPES------AGKTIVLVARDG------TLLGYIALSDELRPDAAEAIAELKA 390
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 562 SGVS-IKMITGDSQETAVAIASRLGlysktsqsvsgeeIDamdvqqlsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVA 640
Cdd:TIGR01512 391 LGIKrLVMLTGDRRAVAEAVARELG-------------ID--------------EVHAELLPEDKLEIVKELREKAGPVA 443
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 641 MTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFqlstSIAALTLISLA 720
Cdd:TIGR01512 444 MVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVI----ALGIILVLILL 519
                         650
                  ....*....|.
gi 1811242742 721 TLMNFPNPLNA 731
Cdd:TIGR01512 520 ALFGVLPLWLA 530
E1-E2_ATPase pfam00122
E1-E2 ATPase;
133-328 1.33e-49

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 173.14  E-value: 1.33e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 133 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaS 212
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSA-SVDESLLTGESLPVEK--------------K 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 213 RSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIL 292
Cdd:pfam00122  66 KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPL 145
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1811242742 293 EMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:pfam00122 146 RALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
128-733 5.95e-49

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 184.43  E-value: 5.95e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 128 LEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQ--PAA 205
Cdd:cd07552   122 LKKLAELLPKTAHLVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEG-ESSVNESMVTGESKPVEKKPGDEviGGS 200
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 206 TNGDlasrsniafmGTL-VRcgkakgvVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLsFYSFGIIGIIMLVG 284
Cdd:cd07552   201 VNGN----------GTLeVK-------VTKTGEDSYLSQVMELVAQAQASKSRAENLADKVAGWL-FYIALGVGIIAFII 262
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 285 WLLGKDILEMFTISVSLAVAAIPEGL----PIVVTVTLALGVMR--MVKKRaivKKLPIVETLgccNVICSDKTGTLTKN 358
Cdd:cd07552   263 WLILGDLAFALERAVTVLVIACPHALglaiPLVVARSTSIAAKNglLIRNR---EALERARDI---DVVLFDKTGTLTEG 336
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 359 EMTVTHIFTSDGLHAEvtgvgynqfgEVI-----VDGDVVHgfynPAVSRIVEAgcvcndavirnntlmgkptegalial 433
Cdd:cd07552   337 KFGVTDVITFDEYDED----------EILslaaaLEAGSEH----PLAQAIVSA-------------------------- 376
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 434 amkmgldgLQQdyiRKAEYPFSSEQKWMAVKCVHRTQQDRpeicfmkgayeqvikyctTYQSKGQTLtLTQQQRDVYQQE 513
Cdd:cd07552   377 --------AKE---KGIRPVEVENFENIPGVGVEGTVNGK------------------RYQVVSPKY-LKELGLKYDEEL 426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 514 KARMGSAGLRVLALASGPELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSktsqs 593
Cdd:cd07552   427 VKRLAQQGNTVSFLIQDGEV-----IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGIDE----- 496
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 594 vsgeeidamdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAA 673
Cdd:cd07552   497 ----------------------YFAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESA 553
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1811242742 674 DMILVDDDFQTIMSAIEEGKGIYNNIK---------NFVRFQLSTSIAALTLISL-----ATLMNFPN---PLNAMQ 733
Cdd:cd07552   554 DVVLVKSDPRDIVDFLELAKATYRKMKqnlwwgagyNVIAIPLAAGVLAPIGIILspavgAVLMSLSTvivAINAMT 630
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
43-869 4.14e-48

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 186.03  E-value: 4.14e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742   43 QNGLNKCEVSHRRAFHGWNEFDI---SEDEPLWKkyisQFKNPLIMLLLASaVISVLMHQFDDAVSITVAILIVVTVAFV 119
Cdd:TIGR01657  137 SNGLTTGDIAQRKAKYGKNEIEIpvpSFLELLKE----EVLHPFYVFQVFS-VILWLLDEYYYYSLCIVFMSSTSISLSV 211
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  120 QEYRseKSLEELSKLV-PPECHCV-REGKLEHTLARDLVPGDtvCLSVGDR----VPADLRLFEAvDLSIDESSLTGETT 193
Cdd:TIGR01657  212 YQIR--KQMQRLRDMVhKPQSVIViRNGKWVTIASDELVPGD--IVSIPRPeektMPCDSVLLSG-SCIVNESMLTGESV 286
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  194 PCSKVTAPQPAATNGDLA----SRSNIAFMGTLV-------RCGKAKGVVIGTGENSEFGE-VFKMMQAEEAPKTPLQKS 261
Cdd:TIGR01657  287 PVLKFPIPDNGDDDEDLFlyetSKKHVLFGGTKIlqirpypGDTGCLAIVVRTGFSTSKGQlVRSILYPKPRVFKFYKDS 366
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  262 MDLLGKQLSFYSFGIIGIImLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMvKKRAIVKKLPI-VET 340
Cdd:TIGR01657  367 FKFILFLAVLALIGFIYTI-IELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARL-KKKGIFCTSPFrINF 444
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  341 LGCCNVICSDKTGTLTknemtvthiftSDGLHAE-VTGVGYNQFGEVIVDGDVvhgfyNPAVSRIVEAGCVCNDAVIRNN 419
Cdd:TIGR01657  445 AGKIDVCCFDKTGTLT-----------EDGLDLRgVQGLSGNQEFLKIVTEDS-----SLKPSITHKALATCHSLTKLEG 508
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  420 TLMGKPTEGAL-------------------IALAMKMGLDGLQQDYIRKaeYPFSSEQKWMAVKCvhRTQQDRPEICFMK 480
Cdd:TIGR01657  509 KLVGDPLDKKMfeatgwtleeddesaeptsILAVVRTDDPPQELSIIRR--FQFSSALQRMSVIV--STNDERSPDAFVK 584
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  481 GAYEQVIKYCttyqsKGQTLtltqqQRDvYQQEKARMGSAGLRVLALASGPeLGQ-----------------LTFLGLVG 543
Cdd:TIGR01657  585 GAPETIQSLC-----SPETV-----PSD-YQEVLKSYTREGYRVLALAYKE-LPKltlqkaqdlsrdavesnLTFLGFIV 652
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  544 IIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK---------------------------TSQSVSG 596
Cdd:TIGR01657  653 FENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNPsntlilaeaeppesgkpnqikfevidsIPFASTQ 732
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  597 EEID-----------------------------AMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVN 647
Cdd:TIGR01657  733 VEIPyplgqdsvedllasryhlamsgkafavlqAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGAN 812
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  648 DAVALKAADIGVAMGQTGTDVckeAADMILVDDDFQTIMSAIEEGKGiyNNIKNFVRFQLSTSIAALTLISLATLMNFPN 727
Cdd:TIGR01657  813 DCGALKQADVGISLSEAEASV---AAPFTSKLASISCVPNVIREGRC--ALVTSFQMFKYMALYSLIQFYSVSILYLIGS 887
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  728 PLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPrnwKDSILTKNLILKILvSSIIIVCGTLFVFWREL-------RD 800
Cdd:TIGR01657  888 NLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERP---PSNLFSVYILTSVL-IQFVLHILSQVYLVFELhaqpwykPE 963
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  801 NVITPRDT---TMTFTCFVFFDMFNALSsrsqTKSVFEIG------LCSNRMFCYAVLGSIMG-QLLVIYFPPLQ-KVFQ 869
Cdd:TIGR01657  964 NPVDLEKEnfpNLLNTVLFFVSSFQYLI----TAIVNSKGppfrepIYKNKPFVYLLITGLGLlLVLLLDPHPLLgKILQ 1039
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
100-703 8.40e-48

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 179.78  E-value: 8.40e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 100 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLA-RDLVPGDTVCLSVGDRVPADLRLFEA 178
Cdd:TIGR01511  54 FDASAMLITFILLGRWLEMLAKGRASDALSKLAKLQPSTATLLTKDGSIEEVPvALLQPGDIVKVLPGEKIPVDGTVIEG 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 179 vDLSIDESSLTGETTPCSKVTapqpaatnGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPL 258
Cdd:TIGR01511 134 -ESEVDESLVTGESLPVPKKV--------GD------PVIAGTVNGTGSLVVRATATGEDTTLAQIVRLVRQAQQSKAPI 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 259 QKSMDLLGKQLsFYSFGIIGIIMLVGWLLGkdilemFTISVSLAVAAIPEGL----PIVVTVTLALGVMRMVkkraIVKK 334
Cdd:TIGR01511 199 QRLADKVAGYF-VPVVIAIALITFVIWLFA------LEFAVTVLIIACPCALglatPTVIAVATGLAAKNGV----LIKD 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 335 LPIVETLGCCNVICSDKTGTLTKNEMTVTHI-FTSDGLHAEVTgvgynqfgevivdgdvvhgfynpavsriveagcvcnd 413
Cdd:TIGR01511 268 GDALERAANIDTVVFDKTGTLTQGKPTVTDVhVFGDRDRTELL------------------------------------- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 414 avirnnTLMGKPTEGALIALAMKMgldglqQDYIRKAEYPFSSEQKWMAVK-CVHRTQQDRPEICFMKGAYEQVIKYCTT 492
Cdd:TIGR01511 311 ------ALAAALEAGSEHPLAKAI------VSYAKEKGITLVTVSDFKAIPgIGVEGTVEGTKIQLGNEKLLGENAIKID 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 493 YQSKGQTltltqqqrdvyqqekarmgsagLRVLALASGpELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGD 572
Cdd:TIGR01511 379 GKAGQGS----------------------TVVLVAVNG-EL-----AGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGD 430
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 573 SQETAVAIASRLGlysktsqsvsgeeIDamdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVAL 652
Cdd:TIGR01511 431 NRKTAKAVAKELG-------------ID---------------VRAEVLPDDKAALIKKLQEKGPVVAMVGDGINDAPAL 482
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1811242742 653 KAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NFV 703
Cdd:TIGR01511 483 AQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKqNLL 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
83-703 2.25e-46

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 176.90  E-value: 2.25e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  83 LIMLLLASAVISVLMHQFDDAVsitvailiVVTVAFVQ-----EYRS-EKSLEELSKLV---PPECHCVREGKLEHTLAR 153
Cdd:cd02094    84 LVALLFPALFPGGAPHVYFEAA--------AVIITFILlgkylEARAkGKTSEAIKKLLglqPKTARVIRDGKEVEVPIE 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 154 DLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSK-----VTApqpAATNGDlasrsniafmGTLVrcGKA 228
Cdd:cd02094   156 EVQVGDIVRVRPGEKIPVDGVVVEG-ESSVDESMLTGESLPVEKkpgdkVIG---GTINGN----------GSLL--VRA 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 229 KGVvigtGENSEFGEVFKMMQAEEAPKTPLQKSMDllgkQLSFYsF--GIIGI--IMLVGWLL---GKDILEMFTISVSL 301
Cdd:cd02094   220 TRV----GADTTLAQIIRLVEEAQGSKAPIQRLAD----RVSGV-FvpVVIAIaiLTFLVWLLlgpEPALTFALVAAVAV 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 302 AVAAIPEGL----PIVVTVtlalGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtg 377
Cdd:cd02094   291 LVIACPCALglatPTAIMV----GTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTDVVPLPGDDED--- 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 378 vgynqfgEVIvdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPTEGALIALAMKMGLDGLQQDYIR-------KA 450
Cdd:cd02094   364 -------ELL------------RLAASLEQGS-------------EHPLAKAIVAAAKEKGLELPEVEDFEaipgkgvRG 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 451 EYP----FSSEQKWMAVKCVHRTQQDrpeicfmkgayeqvikycttyqskgqtltltqqqrdvyqQEKARMGSAGLRVLA 526
Cdd:cd02094   412 TVDgrrvLVGNRRLMEENGIDLSALE---------------------------------------AEALALEEEGKTVVL 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 527 LASGPELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDamdvqq 606
Cdd:cd02094   453 VAVDGEL-----AGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELG-------------ID------ 508
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 607 lsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIM 686
Cdd:cd02094   509 --------EVIAEVLPEDKAEKVKKLQAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRGVV 579
                         650
                  ....*....|....*...
gi 1811242742 687 SAIEEGKGIYNNIK-NFV 703
Cdd:cd02094   580 TAIDLSRATMRNIKqNLF 597
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
726-898 1.07e-45

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 162.02  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 726 PNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITP 805
Cdd:pfam00689   1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 806 RDT--TMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLG 883
Cdd:pfam00689  81 SQNaqTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLL 160
                         170
                  ....*....|....*
gi 1811242742 884 LTSSVCIVAEIIKKV 898
Cdd:pfam00689 161 LALVVLLVVELRKLL 175
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
50-793 4.88e-45

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 174.74  E-value: 4.88e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  50 EVSHRRAFHGWNEFDISEDePLWKKYISQFKNPLIMLllasAVISVLMHQFDDAVSITVAILIV----VTVAFVQEYRSE 125
Cdd:cd07542     2 EQSDRRLIYGPNEIDVPLK-SILKLLFKEVLNPFYVF----QLFSVILWSSDDYYYYAACIVIIsvisIFLSLYETRKQS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 126 KSLEELSKLVPPECHCvREGKLEHTLARDLVPGDTVCLSV-GDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQPA 204
Cdd:cd07542    77 KRLREMVHFTCPVRVI-RDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSG-SCIVNESMLTGESVPVTKTPLPDES 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 205 ATNGDLAS-----RSNIAFMGTLV------RCGKAKGVVIGTGENSEFGE-VFKMMQAEEAPKTPLQKSMDLLGKQ--LS 270
Cdd:cd07542   155 NDSLWSIYsiedhSKHTLFCGTKViqtrayEGKPVLAVVVRTGFNTTKGQlVRSILYPKPVDFKFYRDSMKFILFLaiIA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 271 FYSFGIIGIIMLvgwLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMvKKRAIVKKLPI-VETLGCCNVICS 349
Cdd:cd07542   235 LIGFIYTLIILI---LNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRL-KKKGIFCISPQrINICGKINLVCF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 350 DKTGTLTKNEMTVTHIFTSDGlhaevtgvgyNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPtega 429
Cdd:cd07542   311 DKTGTLTEDGLDLWGVRPVSG----------NNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSLTLIDGELVGDP---- 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 430 liaLAMKM------GLDGLQQdyirkaeYPFSSEQKWMAVKCVHrTQQDRPEIcFMKGAYEQVIKYC------TTYQSKG 497
Cdd:cd07542   377 ---LDLKMfeftgwSLEILRQ-------FPFSSALQRMSVIVKT-PGDDSMMA-FTKGAPEMIASLCkpetvpSNFQEVL 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 498 QTLTltqqqrdvyqqekarmgSAGLRVLALAS-----GPELGQ----------LTFLGLVGIIDPPRTGVKEAVTTLIAS 562
Cdd:cd07542   445 NEYT-----------------KQGFRVIALAYkalesKTWLLQklsreevesdLEFLGLIVMENRLKPETAPVINELNRA 507
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 563 GVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGE--EIDAMDVQQLS-QIVPKVAVFYRASPRHKMKIIKSLQKNGSVV 639
Cdd:cd07542   508 NIRTVMVTGDNLLTAISVARECGMISPSKKVILIEavKPEDDDSASLTwTLLLKGTVFARMSPDQKSELVEELQKLDYTV 587
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 640 AMTGDGVNDAVALKAADIGVAMGQTGTDVckeAADMILVDDDFQTIMSAIEEGkgiynniknfvRFQLSTSIAALTLISL 719
Cdd:cd07542   588 GMCGDGANDCGALKAADVGISLSEAEASV---AAPFTSKVPDISCVPTVIKEG-----------RAALVTSFSCFKYMAL 653
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 720 ATLMNF---------PNPLNAMQILWINIIMDGPPAQSLG-VEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCG 789
Cdd:cd07542   654 YSLIQFisvlilysiNSNLGDFQFLFIDLVIITPIAVFMSrTGAYPKLSSKRPPASLVSPPVLVSLLGQIVLILLFQVIG 733

                  ....
gi 1811242742 790 TLFV 793
Cdd:cd07542   734 FLIV 737
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
85-726 1.01e-44

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 171.66  E-value: 1.01e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  85 MLLLASAVISVLMHQFDDAvsitvAILIVV--TVAFVQEY---RSEKSLEELSKLVPPECHCV-REGKLEHTLARDLVPG 158
Cdd:cd07551    60 LLMILAAIGAAAIGYWAEG-----ALLIFIfsLSHALEDYamgRSKRAITALMQLAPETARRIqRDGEIEEVPVEELQIG 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 159 DTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaaTNGDLAsrsniaFMGTLVRCGKAKGVVIGTGEN 238
Cdd:cd07551   135 DRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEK--------TPGDEV------FAGTINGSGALTVRVTKLSSD 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 239 SEFGEVFKMMQAEEAPKTPLQKSMDllgKQLSFYSFGIIGII---MLVG-WLLGKDILEMFTISVSLAVAAIPEGLPIVV 314
Cdd:cd07551   200 TVFAKIVQLVEEAQSEKSPTQSFIE---RFERIYVKGVLLAVlllLLLPpFLLGWTWADSFYRAMVFLVVASPCALVAST 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 315 TVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVIvdgdvvh 394
Cdd:cd07551   277 PPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVIPAEGVDEE----------ELL------- 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 395 gfynpavsRIVEAgcvcndavirnntlMGKPTEGALiALAMkmgldglqqdyIRKAEypfsseqkwmavkcvHRTQQDRP 474
Cdd:cd07551   340 --------QVAAA--------------AESQSEHPL-AQAI-----------VRYAE---------------ERGIPRLP 370
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 475 EICFmkgayEQVIKYCTTYQSKGQTLTLTQQQRdvYQQEKARMGSAGLRVLALASGPEL-----GQlTFLGLVGIIDPPR 549
Cdd:cd07551   371 AIEV-----EAVTGKGVTATVDGQTYRIGKPGF--FGEVGIPSEAAALAAELESEGKTVvyvarDD-QVVGLIALMDTPR 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 550 TGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqqlsqivpkvavfYRAS--PRHKMK 627
Cdd:cd07551   443 PEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELG-------------IDE----------------VVANllPEDKVA 493
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 628 IIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQL 707
Cdd:cd07551   494 IIRELQQEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRRIIKQNLIFAL 572
                         650
                  ....*....|....*....
gi 1811242742 708 sTSIAALTLISLATLMNFP 726
Cdd:cd07551   573 -AVIALLIVANLFGLLNLP 590
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
70-703 1.37e-43

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 167.84  E-value: 1.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  70 PLWKKYISQFKN--PLIMLLLASAVI-SVLMHQFDDAVSIT----VAILIVVTVAfvqeYRSEKSLEELSKLVPPECHCV 142
Cdd:cd07550    30 PVLRRALESLKErrLNVDVLDSLAVLlSLLTGDYLAANTIAflleLGELLEDYTA----RKSEKALLDLLSPQERTVWVE 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 143 REGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLsIDESSLTGETTPCSKvtapqpaaTNGDLAsrsniaFMGTL 222
Cdd:cd07550   106 RDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK--------REGDLV------FASTV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 223 VRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIImlvgWLLGKDI---LEMFTISV 299
Cdd:cd07550   171 VEEGQLVIRAERVGRETRAARIAELIEQSPSLKARIQNYAERLADRLVPPTLGLAGLV----YALTGDIsraAAVLLVDF 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 300 SLAVaaipeGLPIVVTVtlaLGVMRMVKKRAI-VKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGV 378
Cdd:cd07550   247 SCGI-----RLSTPVAV---LSALNHAARHGIlVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAIITFDGRLSEEDLL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 379 GYNqfgevivdGDVVHGFYNPAVSRIVEAgcvcndAVIRNNTLMGKPTEGALIALAMKMGLDGLQqdyIRKAEYPFsseq 458
Cdd:cd07550   319 YLA--------ASAEEHFPHPVARAIVRE------AEERGIEHPEHEEVEYIVGHGIASTVDGKR---IRVGSRHF---- 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 459 kwMAvkcvhrtQQDRPEICFMKGAYEqvikyctTYQSKGQTLtltqqqrdvyqqekarmgsaglrvLALASGPELgqltf 538
Cdd:cd07550   378 --ME-------EEEIILIPEVDELIE-------DLHAEGKSL------------------------LYVAIDGRL----- 412
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 539 LGLVGIIDPPRTGVKEAVTTLIASGV-SIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqqlsqivpkvaVF 617
Cdd:cd07550   413 IGVIGLSDPLRPEAAEVIARLRALGGkRIIMLTGDHEQRARALAEQLG-------------IDR--------------YH 465
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 618 YRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQtGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYN 697
Cdd:cd07550   466 AEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADVGISMRG-GTDIARETADVVLLEDDLRGLAEAIELARETMA 544

                  ....*..
gi 1811242742 698 NIK-NFV 703
Cdd:cd07550   545 LIKrNIA 551
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
123-722 1.10e-42

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 165.27  E-value: 1.10e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 123 RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKVT-AP 201
Cdd:cd07546    85 RARSGVKALMALVPETALREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAAgDK 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 202 QPA-ATNGDLASRsniafmgtlVRCGKAKgvvigtGENSeFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSFGIIGII 280
Cdd:cd07546   164 VFAgSINVDGVLR---------IRVTSAP------GDNA-IDRILHLIEEAEERRAPIERFIDRFSR---WYTPAIMAVA 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 281 MLVG----WLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 356
Cdd:cd07546   225 LLVIvvppLLFGADWQTWIYRGLALLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALEQLGRVTTVAFDKTGTLT 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 357 KNEMTVTHIFTSDGLHAevtgvgynqfGEVIvdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPTEGALIALAMK 436
Cdd:cd07546   305 RGKPVVTDVVPLTGISE----------AELL------------ALAAAVEMGS-------------SHPLAQAIVARAQA 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 437 MGLdglqqdyirkaEYPFSSEQKWMAVKCVHRTQQDRP-EICFMKGAYEQVikyctTYQSKGQTLTLTQQQRDVyqqeka 515
Cdd:cd07546   350 AGL-----------TIPPAEEARALVGRGIEGQVDGERvLIGAPKFAADRG-----TLEVQGRIAALEQAGKTV------ 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 516 rmgsaglrVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYsktsqsvs 595
Cdd:cd07546   408 --------VVVLANG------RVLGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGLD-------- 465
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 596 geeidamdvqqlsqivpkvavfYRAS--PRHKMKIIKSLQKNGSvVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAA 673
Cdd:cd07546   466 ----------------------FRAGllPEDKVKAVRELAQHGP-VAMVGDGINDAPAMKAASIGIAMG-SGTDVALETA 521
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1811242742 674 DMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLS-------TSIAALTLISLATL 722
Cdd:cd07546   522 DAALTHNRLGGVAAMIELSRATLANIRQNITIALGlkavflvTTLLGITGLWLAVL 577
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
50-661 8.64e-37

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 149.28  E-value: 8.64e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  50 EVSHRRAFHGWNEFDI---SEDEPLWKkyisQFKNPLIMLLLASAVISVLMHQFDDAVSItVAILIVVTVAFVQEYRSEK 126
Cdd:cd02082     1 RVDQLLAYYGKNEIEInvpSFLTLMWR----EFKKPFNFFQYFGVILWGIDEYVYYAITV-VFMTTINSLSCIYIRGVMQ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 127 SLEELSKLVPPECHCVREGKLEHTLARD-LVPGDTVCLSV-GDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQPA 204
Cdd:cd02082    76 KELKDACLNNTSVIVQRHGYQEITIASNmIVPGDIVLIKRrEVTLPCDCVLLEG-SCIVTEAMLTGESVPIGKCQIPTDS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 205 ATNG---DLASRSNIAFMGTLVRCGKA------KGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLgkQLSFYSFG 275
Cdd:cd02082   155 HDDVlfkYESSKSHTLFQGTQVMQIIPpeddilKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKF--TLLLATLA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 276 IIGIIMLvgWLLGKDI----LEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDK 351
Cdd:cd02082   233 LIGFLYT--LIRLLDIelppLFIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDK 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 352 TGTLTKNEMTVTHIftsdglhaevTGVGYNQFGevivdgDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALI 431
Cdd:cd02082   311 TGTLTEDKLDLIGY----------QLKGQNQTF------DPIQCQDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMA 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 432 -ALAMKMGLDGLQQDYIRKA---------EYPFSSEQKWMAVKC--VHRTQQDRPEICFMKGAYEQVIKYCTTYQS--KG 497
Cdd:cd02082   375 eASTWDLDYDHEAKQHYSKSgtkrfyiiqVFQFHSALQRMSVVAkeVDMITKDFKHYAFIKGAPEKIQSLFSHVPSdeKA 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 498 QTLTLTQQqrdvyqqekarmgsaGLRVLALASgPELGQLT-----------------FLGLVGIIDPPRTGVKEAVTTLI 560
Cdd:cd02082   455 QLSTLINE---------------GYRVLALGY-KELPQSEidafldlsreaqeanvqFLGFIIYKNNLKPDTQAVIKEFK 518
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 561 ASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEI---DAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGS 637
Cdd:cd02082   519 EACYRIVMITGDNPLTALKVAQELEIINRKNPTIIIHLLipeIQKDNSTQWILIIHTNVFARTAPEQKQTIIRLLKESDY 598
                         650       660
                  ....*....|....*....|....
gi 1811242742 638 VVAMTGDGVNDAVALKAADIGVAM 661
Cdd:cd02082   599 IVCMCGDGANDCGALKEADVGISL 622
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
143-661 1.08e-36

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 149.07  E-value: 1.08e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 143 REGKLEHTLARDLVPGDTVCLSVGDR---VPADLRLFEAVDLsIDESSLTGETTPCSK---VTAPQPAATNGDLASRSNI 216
Cdd:cd07543    92 RDGKWVPISSDELLPGDLVSIGRSAEdnlVPCDLLLLRGSCI-VNEAMLTGESVPLMKepiEDRDPEDVLDDDGDDKLHV 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 217 AFMGTLV-------RCG-KAK-----GVVIGTGENSEFGEVFKMM--QAEEAPKTPLQKSMDLL-----GKQLSFYSFgI 276
Cdd:cd07543   171 LFGGTKVvqhtppgKGGlKPPdggclAYVLRTGFETSQGKLLRTIlfSTERVTANNLETFIFILfllvfAIAAAAYVW-I 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 277 IGIIMlvGWLLGKDILEMFTISVSLavaaIPEGLPIvvtvTLALGV---MRMVKKRAIVKKLPI-VETLGCCNVICSDKT 352
Cdd:cd07543   250 EGTKD--GRSRYKLFLECTLILTSV----VPPELPM----ELSLAVntsLIALAKLYIFCTEPFrIPFAGKVDICCFDKT 319
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 353 GTLTKNEMtvthiftsdglhaEVTGV-GYNQFGEVIVDGDVVHGfynpavsRIVEAGCVCNDAVIR-NNTLMGKPTEGA- 429
Cdd:cd07543   320 GTLTSDDL-------------VVEGVaGLNDGKEVIPVSSIEPV-------ETILVLASCHSLVKLdDGKLVGDPLEKAt 379
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 430 LIALAMKMGLD--------GLQQDYIRKAeYPFSSEQKWMAVKCVHR--TQQDRPEICFMKGAYEqvikycttyqskgqt 499
Cdd:cd07543   380 LEAVDWTLTKDekvfprskKTKGLKIIQR-FHFSSALKRMSVVASYKdpGSTDLKYIVAVKGAPE--------------- 443
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 500 lTLTQQQRDV---YQQEKARMGSAGLRVLALASG--PELGQ--------------LTFLGLVGIIDPPRTGVKEAVTTLI 560
Cdd:cd07543   444 -TLKSMLSDVpadYDEVYKEYTRQGSRVLALGYKelGHLTKqqardykredvesdLTFAGFIVFSCPLKPDSKETIKELN 522
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 561 ASGVSIKMITGDSQETAVAIASRLGLyskTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVA 640
Cdd:cd07543   523 NSSHRVVMITGDNPLTACHVAKELGI---VDKPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFIITTLKELGYVTL 599
                         570       580
                  ....*....|....*....|.
gi 1811242742 641 MTGDGVNDAVALKAADIGVAM 661
Cdd:cd07543   600 MCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
71-742 2.71e-34

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 139.86  E-value: 2.71e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  71 LWKKYISQFKNPLIMLLLAS-AVI-SVLMHQFDDAVSitVAILIVVTVAfVQEY---RSEKSLEELSKLVPPECHCVREG 145
Cdd:cd07545    28 FKKGWRNLIRRNFDMKTLMTiAVIgAALIGEWPEAAM--VVFLFAISEA-LEAYsmdRARRSIRSLMDIAPKTALVRRDG 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 146 KLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaaTNGDLAsrsniaFMGTLVRC 225
Cdd:cd07545   105 QEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGES-SVNQAAITGESLPVEK--------GVGDEV------FAGTLNGE 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 226 GKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSFGIIGIIMLVG----WLLGKDILEMFTISVSL 301
Cdd:cd07545   170 GALEVRVTKPAEDSTIARIIHLVEEAQAERAPTQAFVDRFAR---YYTPVVMAIAALVAivppLFFGGAWFTWIYRGLAL 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 302 AVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEmtvthiftsdglhaevtgvgyn 381
Cdd:cd07545   247 LVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGK---------------------- 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 382 qfgevivdgdvvhgfynPAVSRIVEAGCvcndavirnntlmgkPTEGALIALAMKMGldglqqdyiRKAEYPFSS----- 456
Cdd:cd07545   305 -----------------PVVTDVVVLGG---------------QTEKELLAIAAALE---------YRSEHPLASaivkk 343
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 457 -EQKWMAVKCVHrtqqdrpEICFMKGAYEQVIKYCTTYQSKGQTL--TLTQQQRDVYQQEKARMGSAGLRVLALASGPel 533
Cdd:cd07545   344 aEQRGLTLSAVE-------EFTALTGRGVRGVVNGTTYYIGSPRLfeELNLSESPALEAKLDALQNQGKTVMILGDGE-- 414
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 534 gqlTFLGLVGIIDPPRTGVKEAVTTLIASGVS-IKMITGDSQETAVAIASRLGLysktsQSVSGEEIdamdvqqlsqivp 612
Cdd:cd07545   415 ---RILGVIAVADQVRPSSRNAIAALHQLGIKqTVMLTGDNPQTAQAIAAQVGV-----SDIRAELL------------- 473
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 613 kvavfyrasPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:cd07545   474 ---------PQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLS 544
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|
gi 1811242742 693 KGIYNNIKNFVRFQLSTSIAALTLIslatlmnFPnplnAMQILWINIIMD 742
Cdd:cd07545   545 RKTLAIIKQNIAFALGIKLIALLLV-------IP----GWLTLWMAVFAD 583
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
83-690 5.87e-34

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 138.61  E-value: 5.87e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  83 LIMLLLASAVISVLMHQFDDA------VSITVAILIVVTVAfVQEY----------------------RSEKSLEELSKL 134
Cdd:cd07544    29 IVLIGGVVIALSLLWEMIKTLrrgrygVDLLAILAIVATLL-VGEYwasliillmltggealedyaqrRASRELTALLDR 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 135 VPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLfEAVDLSIDESSLTGETTPCSKVTAPQ--PAATNGDLAs 212
Cdd:cd07544   108 APRIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEV-VSGTATLDESSLTGESKPVSKRPGDRvmSGAVNGDSA- 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 213 rsniafmgtlvrcgkAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGkqlsfYSFGIIGI-IMLVGWLLGKDI 291
Cdd:cd07544   186 ---------------LTMVATKLAADSQYAGIVRLVKEAQANPAPFVRLADRYA-----VPFTLLALaIAGVAWAVSGDP 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 292 lemfTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGL 371
Cdd:cd07544   246 ----VRFAAVLVVATPCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDVVPAPGV 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 372 HA-EVTGVGYNqfgeviVDGDVVHgfynPAVSRIVEAGcvcndaviRNNTL-MGKPTEgalIALAMKMGLDG-LQQDYIR 448
Cdd:cd07544   322 DAdEVLRLAAS------VEQYSSH----VLARAIVAAA--------RERELqLSAVTE---LTEVPGAGVTGtVDGHEVK 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 449 KAEYPFSSEQKWMAvkcvhrtqqdrpeicfmkgayeqvikycttyqskgqtltltqqqrdvyqQEKARMGSAGLRVLALA 528
Cdd:cd07544   381 VGKLKFVLARGAWA-------------------------------------------------PDIRNRPLGGTAVYVSV 411
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 529 SGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVS-IKMITGDSQETAVAIASRLGLysktsQSVSGEeidamdvqql 607
Cdd:cd07544   412 DG------KYAGAITLRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGI-----DEVRAE---------- 470
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 608 sqivpkvavfyrASPRHKMKIIKSLQKNGsVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMS 687
Cdd:cd07544   471 ------------LLPEDKLAAVKEAPKAG-PTIMVGDGVNDAPALAAADVGIAMGARGSTAASEAADVVILVDDLDRVVD 537

                  ...
gi 1811242742 688 AIE 690
Cdd:cd07544   538 AVA 540
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
78-735 8.12e-33

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 135.85  E-value: 8.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  78 QFKNPLIMLLLASAVISVLMHQFDDAVS--------ITVAILIVVTVAF------VQEYRSE---KSL-----EELSKLV 135
Cdd:cd02078    21 LAKNPVMFVVEIGSIITTVLTFFPLLFSgggpagfnLAVSLWLWFTVLFanfaeaIAEGRGKaqaDSLrktktETQAKRL 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 136 ppechcVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKVTAPQPAATNGdlasrsn 215
Cdd:cd02078   101 ------RNDGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPVIRESGGDRSSVTG------- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 216 iafmGTLVRCGKAKGVVigtgeNSEFGEVF--KMMQAEEAP---KTPLQKSMDllgkqlsfysfgiigiIMLVGwllgkd 290
Cdd:cd02078   167 ----GTKVLSDRIKVRI-----TANPGETFldRMIALVEGAsrqKTPNEIALT----------------ILLVG------ 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 291 ilemFTISVSLAVAAIP-----EGLPIVVTVTLAL-------------------GVMRMVKKRAIVKKLPIVETLGCCNV 346
Cdd:cd02078   216 ----LTLIFLIVVATLPpfaeySGAPVSVTVLVALlvclipttiggllsaigiaGMDRLLRFNVIAKSGRAVEAAGDVDT 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 347 ICSDKTGTLT-KNEMTVTHIftsdglhaEVTGVGYNQFGEVivdgdvvhgfynpavsriveagcvCNDAVIRNNTLMGKp 425
Cdd:cd02078   292 LLLDKTGTITlGNRQATEFI--------PVGGVDEKELADA------------------------AQLASLADETPEGR- 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 426 tegALIALAMKMGLDGLQQDYiRKAEY-PFSSEQKWMAVKCVHRTQqdrpeicFMKGAYEQVIKYCTTYQSKgqtltLTQ 504
Cdd:cd02078   339 ---SIVILAKQLGGTERDLDL-SGAEFiPFSAETRMSGVDLPDGTE-------IRKGAVDAIRKYVRSLGGS-----IPE 402
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 505 QQRDVYQqEKARMGSAGLRVLALAsgpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRL 584
Cdd:cd02078   403 ELEAIVE-EISKQGGTPLVVAEDD--------RVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEA 473
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 585 GLYSKTSQsvsgeeidamdvqqlsqivpkvavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQT 664
Cdd:cd02078   474 GVDDFLAE---------------------------AKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALAQADVGVAM-NS 525
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1811242742 665 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 735
Cdd:cd02078   526 GTQAAKEAGNMVDLDSDPTKLIEVVEIGKQLLMTRGALTTFSIANDVAKYFAIIPAMFAAAYPQLGALNIM 596
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
77-735 2.91e-28

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 121.91  E-value: 2.91e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  77 SQFKNPLIMLL----LASAVISVLMHQFDDA------VSITVAILIVVTVAF------VQEYRSEKSL--------EELS 132
Cdd:TIGR01497  28 AQWRNPVMFIVwvgsLLTTCITIAPASFGMPgnnlalFNAIITGILFITVLFanfaeaVAEGRGKAQAdslkgtkkTTFA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 133 KLVPPEchcvreGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKvtapqpaATNGDLAS 212
Cdd:TIGR01497 108 KLLRDD------GAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIK-------ESGGDFAS 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 213 RSNiafmGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIl 292
Cdd:TIGR01497 174 VTG----GTRILSDWLVVECTANPGETFLDRMIALVEGAQRRKTPNEIALTILLIALTLVFLLVTATLWPFAAYGGNAI- 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 293 eMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTknemtvthiftsdglh 372
Cdd:TIGR01497 249 -SVTVLVALLVCLIPTTIGGLLSAIGIAGMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTIT---------------- 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 373 aevtgVGYNQFGEVIVDGDVvhgfynpAVSRIVEAGCVCNdavIRNNTLMGKptegALIALAMKMGLDGLQQDYIRKAEY 452
Cdd:TIGR01497 312 -----LGNRLASEFIPAQGV-------DEKTLADAAQLAS---LADDTPEGK----SIVILAKQLGIREDDVQSLHATFV 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 453 PFSSEQKWMAVKCVHRTQqdrpeicFMKGAYEQVIKYCttyQSKGQTLTltqQQRDVYQQEKARMGSAGLrvlALASGPE 532
Cdd:TIGR01497 373 EFTAQTRMSGINLDNGRM-------IRKGAVDAIKRHV---EANGGHIP---TDLDQAVDQVARQGGTPL---VVCEDNR 436
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 533 LgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQsvsgeeidamdvqqlsqivp 612
Cdd:TIGR01497 437 I-----YGVIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGVDDFIAE-------------------- 491
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 613 kvavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:TIGR01497 492 -------ATPEDKIALIRQEQAEGKLVAMTGDGTNDAPALAQADVGVAM-NSGTQAAKEAANMVDLDSDPTKLIEVVHIG 563
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 1811242742 693 KGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 735
Cdd:TIGR01497 564 KQLLITRGALTTFSIANDVAKYFAIIPAIFAAAYPQLQALNIM 606
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
123-700 3.03e-25

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 112.39  E-value: 3.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 123 RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQ 202
Cdd:PRK11033  229 RARRGVSALMALVPETATRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSP-FASFDESALTGESIPVERATGEK 307
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 203 PAAtnGDLASRSniafmgtLVRCGkakgVVIGTGENSeFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSfgiiGIIML 282
Cdd:PRK11033  308 VPA--GATSVDR-------LVTLE----VLSEPGASA-IDRILHLIEEAEERRAPIERFIDRFSR---IYT----PAIML 366
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 283 VgwllgkdilemftisvSLAVAAIP-------------EGL---------------PIVVTVTLALGVMRmvkkRAIVKK 334
Cdd:PRK11033  367 V----------------ALLVILVPpllfaapwqewiyRGLtllligcpcalvistPAAITSGLAAAARR----GALIKG 426
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 335 LPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVIvdgdvvhgfynpAVSRIVEAGCvcnda 414
Cdd:PRK11033  427 GAALEQLGRVTTVAFDKTGTLTEGKPQVTDIHPATGISES----------ELL------------ALAAAVEQGS----- 479
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 415 virnntlmGKPTEGALIALAMKMGLDglqqdyirkaeYPFSSEQKWMAVKCVH-RTQQDRPEICfmkgayeqvikyctty 493
Cdd:PRK11033  480 --------THPLAQAIVREAQVRGLA-----------IPEAESQRALAGSGIEgQVNGERVLIC---------------- 524
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 494 qSKGQTLTLTQQQrdvyQQEKARMGSAG-LRVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGD 572
Cdd:PRK11033  525 -APGKLPPLADAF----AGQINELESAGkTVVLVLRND------DVLGLIALQDTLRADARQAISELKALGIKGVMLTGD 593
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 573 SQETAVAIASRLGlysktsqsvsgeeidaMDvqqlsqivpkvavfYRAS--PRHKMKIIKSLQKNgSVVAMTGDGVNDAV 650
Cdd:PRK11033  594 NPRAAAAIAGELG----------------ID--------------FRAGllPEDKVKAVTELNQH-APLAMVGDGINDAP 642
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 1811242742 651 ALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK 700
Cdd:PRK11033  643 AMKAASIGIAMG-SGTDVALETADAALTHNRLRGLAQMIELSRATHANIR 691
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
100-743 8.74e-25

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 110.30  E-value: 8.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 100 FDdavSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVRE---GKLEHTLARDLVPGDTVCLSVGDRVPADLRLF 176
Cdd:cd07553    91 FD---SLSVLVFLMLVGRWLQVVTQERNRNRLADSRLEAPITEIEtgsGSRIKTRADQIKSGDVYLVASGQRVPVDGKLL 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 177 EAvDLSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKT 256
Cdd:cd07553   168 SE-QASIDMSWLTGESLPRIV--------------ERGDKVPAGTSLENQAFEIRVEHSLAESWSGSILQKVEAQEARKT 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 257 PLqksmDLLGKQLSFYSFGIIGIIMLVGWL--LGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKK 334
Cdd:cd07553   233 PR----DLLADKIIHYFTVIALLIAVAGFGvwLAIDLSIALKVFTSVLIVACPCALALATPFTDEIALARLKKKGVLIKN 308
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 335 LPIVETLGCCNVICSDKTGTLTKNEMTVthiftsdglhaevtgvgynqfgeVIVDGDVVHGFYNPAVSRIVEAgcvCNDA 414
Cdd:cd07553   309 ASSLERLSRVRTIVFDKTGTLTRGKSSF-----------------------VMVNPEGIDRLALRAISAIEAH---SRHP 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 415 VIRnntlmgkptegALIALAMKMGLdglqqdyirkaeypfsseqkwmavkcvhrtqqDRPEICFMKgayEQVIKYCTTYQ 494
Cdd:cd07553   363 ISR-----------AIREHLMAKGL--------------------------------IKAGASELV---EIVGKGVSGNS 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 495 SKGQTltltqqqrdvyqqekaRMGSAGLRVLALASGPELGQLTFLGLVGII-DPPRTGVKEAVTTLIASGVSIKMITGDS 573
Cdd:cd07553   397 SGSLW----------------KLGSAPDACGIQESGVVIARDGRQLLDLSFnDLLRPDSNREIEELKKGGLSIAILSGDN 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 574 QETAVAIASRLGLysktsqsvsgeeidamDVQQLsqivpkvavFYRASPRHKMKIIKSLQKNGSVvaMTGDGVNDAVALK 653
Cdd:cd07553   461 EEKVRLVGDSLGL----------------DPRQL---------FGNLSPEEKLAWIESHSPENTL--MVGDGANDALALA 513
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 654 AADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTL-----IS---LATLMnf 725
Cdd:cd07553   514 SAFVGIAV-AGEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNLVAIGLalsgwISplvAAILM-- 590
                         650
                  ....*....|....*...
gi 1811242742 726 pnPLNAMQILWINIIMDG 743
Cdd:cd07553   591 --PLSSITILGIVWAALG 606
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
110-665 1.08e-23

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 107.64  E-value: 1.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 110 ILIVVTVAFVQE----YRSEKSLEELSKLvppECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS--- 182
Cdd:cd02073    55 LLFVLGVTAIKEgyedIRRHKSDNEVNNR---PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDglc 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 183 -IDESSLTGET------------TPCS---------KVTAPQPaatNGDLASrsniaFMGTLVRCGKAK----------- 229
Cdd:cd02073   132 yVETANLDGETnlkirqalpetaLLLSeedlarfsgEIECEQP---NNDLYT-----FNGTLELNGGRElplspdnlllr 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 230 -----------GVVIGTGENSefgevfKMMQaeEAPKTPLQKS-MDLLGKQLSFYSFGIIGIIMLVG-----WLLGKDIL 292
Cdd:cd02073   204 gctlrntewvyGVVVYTGHET------KLML--NSGGTPLKRSsIEKKMNRFIIAIFCILIVMCLISaigkgIWLSKHGR 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 293 EMFTISVSLAVAAIPEGLPIVVT--------VTLALGV-MRMVK-------------------KRAIVKKLPIVETLGCC 344
Cdd:cd02073   276 DLWYLLPKEERSPALEFFFDFLTfiilynnlIPISLYVtIEVVKflqsffinwdldmydeetdTPAEARTSNLNEELGQV 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 345 NVICSDKTGTLTKNEMTvthiftsdglhaevtgvgynqFGEVIVDGdVVHGFYnpavsrivEAGCVCNDAVIRNNTLMGK 424
Cdd:cd02073   356 EYIFSDKTGTLTENIME---------------------FKKCSING-VDYGFF--------LALALCHTVVPEKDDHPGQ 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 425 -------PTEGALIALAMKMG--LDGLQQDYI------RKAEY------PFSSEQKWMAVkcVHRTQQDRpeIC-FMKGA 482
Cdd:cd02073   406 lvyqassPDEAALVEAARDLGfvFLSRTPDTVtinalgEEEEYeilhilEFNSDRKRMSV--IVRDPDGR--ILlYCKGA 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 483 ----YEQVIKycttyqSKGQTLTLTQQQRDVYQQEkarmgsaGLRVLALA------------------------------ 528
Cdd:cd02073   482 dsviFERLSP------SSLELVEKTQEHLEDFASE-------GLRTLCLAyreiseeeyeewnekydeastalqnreell 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 529 --SGPELGQ-LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVsGEEID----- 600
Cdd:cd02073   549 deVAEEIEKdLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDMENL-ALVIDgktlt 627
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1811242742 601 -AMDVQQLSQIVP-----KVAVFYRASPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVA-MGQTG 665
Cdd:cd02073   628 yALDPELERLFLElalkcKAVICCRVSPLQKALVVKLVKKSKKAVTLAiGDGANDVSMIQEAHVGVGiSGQEG 700
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
100-690 1.49e-23

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 106.29  E-value: 1.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 100 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR-EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEA 178
Cdd:cd02092    89 FDAAVMLLFFLLIGRYLDHRMRGRARSAAEELAALEARGAQRLQaDGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSG 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 179 VDLsIDESSLTGETtpcskvtAPQPAATNGDL-ASRSNIAfmGTL-VRcgkakgvVIGTGENSEFGEVFKMMQAEEAPKT 256
Cdd:cd02092   169 TSE-LDRSLLTGES-------APVTVAPGDLVqAGAMNLS--GPLrLR-------ATAAGDDTLLAEIARLMEAAEQGRS 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 257 plqKSMDLLGKQLSFYS--FGIIGIIMLVGW-LLGKDILEMFTISVSLAVAAIPEGL----PIVVTVtlALGvmRMVKKR 329
Cdd:cd02092   232 ---RYVRLADRAARLYApvVHLLALLTFVGWvAAGGDWRHALLIAVAVLIITCPCALglavPAVQVV--ASG--RLFRRG 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 330 AIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGvgynqfgevivdGDVVHGFYNPAVSRIVEAGC 409
Cdd:cd02092   305 VLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGAHAISADLLALAA------------ALAQASRHPLSRALAAAAGA 372
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 410 VcnDAVIRNNT-LMGKPTEGALIALAMKMGldglqqdyirkaeypfsseqkwmavkcvhrtqqdRPEICfmkGAYEQVIK 488
Cdd:cd02092   373 R--PVELDDAReVPGRGVEGRIDGARVRLG----------------------------------RPAWL---GASAGVST 413
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 489 YCTTYQSKGqtltltqqqrdvyQQEKARMGSAglrvlalasgpelgqltflglvgiiDPPRTGVKEAVTTLIASGVSIKM 568
Cdd:cd02092   414 ASELALSKG-------------GEEAARFPFE-------------------------DRPRPDAREAISALRALGLSVEI 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 569 ITGDSQETAVAIASRLGLysktsQSVSGEeidamdvqqlsqivpkvavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVND 648
Cdd:cd02092   456 LSGDREPAVRALARALGI-----EDWRAG----------------------LTPAEKVARIEELKAQGRRVLMVGDGLND 508
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 1811242742 649 AVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIE 690
Cdd:cd02092   509 APALAAAHVSMAPA-SAVDASRSAADIVFLGDSLAPVPEAIE 549
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
144-735 1.75e-23

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 106.71  E-value: 1.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 144 EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKvtapqpaATNGDLasrsNIAFMGTLV 223
Cdd:PRK14010  112 DGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGL-ATVDESAITGESAPVIK-------ESGGDF----DNVIGGTSV 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 224 RCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIleMFTISVSLAV 303
Cdd:PRK14010  180 ASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNEIALFTLLMTLTIIFLVVILTMYPLAKFLNFNL--SIAMLIALAV 257
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 304 AAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTknemtvthifTSDGLHAEVTGVGYNQF 383
Cdd:PRK14010  258 CLIPTTIGGLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTIT----------YGNRMADAFIPVKSSSF 327
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 384 gevivdgdvvhgfynpavSRIVEAGCVCNdavIRNNTlmgkPTEGALIALAMKMGLDgLQQDyiRKAEYPFSSEQKWMAV 463
Cdd:PRK14010  328 ------------------ERLVKAAYESS---IADDT----PEGRSIVKLAYKQHID-LPQE--VGEYIPFTAETRMSGV 379
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 464 KCVHRTqqdrpeicFMKGAYEQVIKycTTYQSKGQtltlTQQQRDVYQQEKARMGSAGLRVLAlasgpelgQLTFLGLVG 543
Cdd:PRK14010  380 KFTTRE--------VYKGAPNSMVK--RVKEAGGH----IPVDLDALVKGVSKKGGTPLVVLE--------DNEILGVIY 437
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 544 IIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQsvsgeeidamdvqqlsqivpkvavfyrASPR 623
Cdd:PRK14010  438 LKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVDRFVAE---------------------------CKPE 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 624 HKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFV 703
Cdd:PRK14010  491 DKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAM-NSGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLT 569
                         570       580       590
                  ....*....|....*....|....*....|..
gi 1811242742 704 RFQLSTSIAALTLISLATLMNFPNPLNAMQIL 735
Cdd:PRK14010  570 TFSIANDIAKYFAILPAMFMAAMPAMNHLNIM 601
copA PRK10671
copper-exporting P-type ATPase CopA;
123-724 3.12e-22

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 102.90  E-value: 3.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 123 RSEKSLEELSKLVPPECHCV-REGKLEHTLArDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTap 201
Cdd:PRK10671  309 RSSKALEKLLDLTPPTARVVtDEGEKSVPLA-DVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGE-- 384
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 202 qpaatnGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDllgKQLSFYSFGIIGIIM 281
Cdd:PRK10671  385 ------GD------SVHAGTVVQDGSVLFRASAVGSHTTLSRIIRMVRQAQSSKPEIGQLAD---KISAVFVPVVVVIAL 449
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 282 LVG--WLL---GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 356
Cdd:PRK10671  450 VSAaiWYFfgpAPQIVYTLVIATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLT 529
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 357 KNEMTVTHIFTsdglhaevtgvgYNQFGEVIV---DGDVVHGFYNPAVSRIVE-AGCVCNDAVIRNNTLMGKPTEGALIA 432
Cdd:PRK10671  530 EGKPQVVAVKT------------FNGVDEAQAlrlAAALEQGSSHPLARAILDkAGDMTLPQVNGFRTLRGLGVSGEAEG 597
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 433 LAMKMGldglqqdyirkaeypfssEQKWMAvkcvhrtqqdrpeicfmkgayeqvikycttyqskgqtltltQQQRDV--Y 510
Cdd:PRK10671  598 HALLLG------------------NQALLN-----------------------------------------EQQVDTkaL 618
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 511 QQEKARMGSAGLRVLALASGpelGQLTflGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlyskt 590
Cdd:PRK10671  619 EAEITAQASQGATPVLLAVD---GKAA--ALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAG----- 688
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 591 sqsvsgeeIDamdvqqlsQIVPKVAvfyrasPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCK 670
Cdd:PRK10671  689 --------ID--------EVIAGVL------PDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAI 745
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 671 EAADMILVDDDFQTIMSAIEEGKGIYNNIKN-----FVRFQLSTSIAALTLISL-ATLMN 724
Cdd:PRK10671  746 ETAAITLMRHSLMGVADALAISRATLRNMKQnllgaFIYNSLGIPIAAGILWPFtGTLLN 805
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
409-493 2.50e-20

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 86.50  E-value: 2.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 409 CVCNDAVIRNN------TLMGKPTEGALIALAMKMGLD--GLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPEICFMK 480
Cdd:pfam13246   1 ALCNSAAFDENeekgkwEIVGDPTESALLVFAEKMGIDveELRKDYPRVAEIPFNSDRKRMST--VHKLPDDGKYRLFVK 78
                          90
                  ....*....|...
gi 1811242742 481 GAYEQVIKYCTTY 493
Cdd:pfam13246  79 GAPEIILDRCTTI 91
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
26-93 2.20e-18

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 79.91  E-value: 2.20e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811242742  26 ASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVI 93
Cdd:pfam00690   1 WHALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
29-97 2.68e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 77.24  E-value: 2.68e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811242742   29 LPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLM 97
Cdd:smart00831   7 LSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
78-665 6.97e-17

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 85.90  E-value: 6.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742   78 QFKNPLIMLLLasaVISVLmhQFDDAVSIT------VAILIVVTVAFVQE----YRSEKS-LEELSKLVppecHCVRE-G 145
Cdd:TIGR01652   24 QFKRFANLYFL---VVALL--QQVPILSPTyrgtsiVPLAFVLIVTAIKEaiedIRRRRRdKEVNNRLT----EVLEGhG 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  146 KLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGET----------TPC-----------SKVTA 200
Cdd:TIGR01652   95 QFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvcyVETANLDGETnlklrqaleeTQKmldeddiknfsGEIEC 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  201 PQPAAT----NGDLA---------SRSNIAFMGTLVRCGK-AKGVVIGTGensefGEVFKMMQAEEAP--KTPLQKSMDL 264
Cdd:TIGR01652  175 EQPNASlysfQGNMTingdrqyplSPDNILLRGCTLRNTDwVIGVVVYTG-----HDTKLMRNATQAPskRSRLEKELNF 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  265 LGKQLSFYSFGIIgIIMLVG------------WLLGKDILEM---------FTISVSLAVAAIPEGLPI---VVTVTLAL 320
Cdd:TIGR01652  250 LIIILFCLLFVLC-LISSVGagiwndahgkdlWYIRLDVSERnaaangffsFLTFLILFSSLIPISLYVsleLVKSVQAY 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  321 ---GVMRMVKKR----AIVKKLPIVETLGCCNVICSDKTGTLTKNEM----------TVTHIFT--SDGLH--------- 372
Cdd:TIGR01652  329 finSDLQMYHEKtdtpASVRTSNLNEELGQVEYIFSDKTGTLTQNIMefkkcsiagvSYGDGFTeiKDGIRerlgsyven 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  373 ---AEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAV-IRNNTLMGK-------PTEGALIALAMKMGLD- 440
Cdd:TIGR01652  409 ensMLVESKGFTFVDPRLVDLLKTNKPNAKRINEFFLALALCHTVVpEFNDDGPEEityqaasPDEAALVKAARDVGFVf 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  441 ---------------GLQQDYIRKAEYPFSSEQKWMAVKCvhRTQQDRPEIcFMKGAYEQVIKYCTTYQSkgqtltltqQ 505
Cdd:TIGR01652  489 fertpksislliemhGETKEYEILNVLEFNSDRKRMSVIV--RNPDGRIKL-LCKGADTVIFKRLSSGGN---------Q 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  506 QRDVYQQEKARMGSAGLRVLALASgPELGQ----------------------------------LTFLGLVGIIDPPRTG 551
Cdd:TIGR01652  557 VNEETKEHLENYASEGLRTLCIAY-RELSEeeyeewneeyneastaltdreekldvvaesiekdLILLGATAIEDKLQEG 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  552 VKEAVTTLIASGVSIKMITGDSQETA--VAIASRL----------GLYSKTSQSVSGEEI-----DAMDVQQLSQIVPKV 614
Cdd:TIGR01652  636 VPETIELLRQAGIKIWVLTGDKVETAinIGYSCRLlsrnmeqiviTSDSLDATRSVEAAIkfgleGTSEEFNNLGDSGNV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  615 A------------------VFY------------RASPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVAM-G 662
Cdd:TIGR01652  716 AlvidgkslgyaldeelekEFLqlalkckaviccRVSPSQKADVVRLVKKSTGKTTLAiGDGANDVSMIQEADVGVGIsG 795

                   ...
gi 1811242742  663 QTG 665
Cdd:TIGR01652  796 KEG 798
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
108-722 2.06e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 83.82  E-value: 2.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 108 VAILIVVTVA-FVQEY---RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSI 183
Cdd:cd07548    76 VAVMLFYEVGeLFQDLaveRSRKSIKALLDIRPDYANLKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLKGES-FL 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 184 DESSLTGETTPcskvtapqpaatnGDLASRSNIaFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMD 263
Cdd:cd07548   155 DTSALTGESVP-------------VEVKEGSSV-LAGFINLNGVLEIKVTKPFKDSAVAKILELVENASARKAPTEKFIT 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 264 LLGKqlsFYSFGIIGI---IMLVGWLLGKDilEMFTISVSLA----VAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLP 336
Cdd:cd07548   221 KFAR---YYTPIVVFLallLAVIPPLFSPD--GSFSDWIYRAlvflVISCPCALVISIPLGYFGGIGAASRKGILIKGSN 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 337 IVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgevivdgDVVHgfynpaVSRIVEAGCvcndavi 416
Cdd:cd07548   296 YLEALSQVKTVVFDKTGTLTKGVFKVTEIVPAPGFSKE----------------ELLK------LAALAESNS------- 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 417 rnntlmGKPtegalIALAmkmgldglqqdyIRKAeypfsseqkwmavkCVHRTQQDRPEicfmkgAYEQVikycttyqsK 496
Cdd:cd07548   347 ------NHP-----IARS------------IQKA--------------YGKMIDPSEIE------DYEEI---------A 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 497 GQTLTLTQQQRDVYQQEKARMGSAGLR---------VLALASGpelgqLTFLGLVGIIDPPRTGVKEAVTTLIASGVS-I 566
Cdd:cd07548   375 GHGIRAVVDGKEILVGNEKLMEKFNIEhdedeiegtIVHVALD-----GKYVGYIVISDEIKEDAKEAIKGLKELGIKnL 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 567 KMITGDSQETAVAIASRLGLysktsQSVSGEeidamdvqqlsqIVP--KVAVFYRASPRHKMKiikslqkngsvVAMTGD 644
Cdd:cd07548   450 VMLTGDRKSVAEKVAKKLGI-----DEVYAE------------LLPedKVEKVEELKAESKGK-----------VAFVGD 501
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 645 GVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKG----IYNNIKnfvrFQLSTSIAALTL--IS 718
Cdd:cd07548   502 GINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAEAIKIARKtrriVWQNII----LALGVKAIVLILgaLG 577

                  ....
gi 1811242742 719 LATL 722
Cdd:cd07548   578 LATM 581
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
78-661 2.49e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 83.80  E-value: 2.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  78 QFKNPLIMLLLasaVISVLmhQFDDAVSIT------VAILIVVTVAFVQE----YRSEKSLEELSKlvpPECHCVREGKL 147
Cdd:cd07536    22 QFKRFLNLYFL---VIACL--QFVPALKPGylyttwAPLIFILAVTMTKEaiddFRRFQRDKEVNK---KQLYSKLTGRK 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 148 EHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGETTPCSKV--TAPQPAATNGDLASRS------- 214
Cdd:cd07536    94 VQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDLKLRVavSCTQQLPALGDLMKISayvecqk 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 215 ----------------------------NIAFMGT-LVRCGKAKGVVIGTGENSefgevfKMMQAEEAPKtPLQKSMDLL 265
Cdd:cd07536   174 pqmdihsfegnftledsdppiheslsieNTLLRAStLRNTGWVIGVVVYTGKET------KLVMNTSNAK-NKVGLLDLE 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 266 GKQLSFYSFGI---IGIIMLVGWLLGKD--------ILEMFTISVSLAVAAIPEGL------PIVVTVTLALG---VMRM 325
Cdd:cd07536   247 LNRLTKALFLAlvvLSLVMVTLQGFWGPwygeknwyIKKMDTTSDNFGRNLLRFLLlfsyiiPISLRVNLDMVkavYAWF 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 326 VKKR-----------AIVKKLPIVETLGCCNVICSDKTGTLTKNEMtvthIFTsdglHAEVTGVGYNqfGEVIVDGdvvh 394
Cdd:cd07536   327 IMWDenmyyigndtgTVARTSTIPEELGQVVYLLTDKTGTLTQNEM----IFK----RCHIGGVSYG--GQVLSFC---- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 395 gfynpavsrIVEAgcvcndavirnntlmgkptegalialamkmgldglqqdyirkaeYPFSSEQKWMAVkcVHRTQQDRP 474
Cdd:cd07536   393 ---------ILQL--------------------------------------------LEFTSDRKRMSV--IVRDESTGE 417
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 475 EICFMKGAYEQVIKYCTTYQSKGQTL------------TLTQQQRD-----------VYQQEKARMGSAGLRVLALASGP 531
Cdd:cd07536   418 ITLYMKGADVAISPIVSKDSYMEQYNdwleeecgeglrTLCVAKKAlteneyqewesRYTEASLSLHDRSLRVAEVVESL 497
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 532 ElGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTS-----QSVSGEEIDAMDVQQ 606
Cdd:cd07536   498 E-RELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLVSRTQdihllRQDTSRGERAAITQH 576
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 607 LS-----------------------------------QIVPKVAVFYRASPRHKMKIIKSLQK-NGSVVAMTGDGVNDAV 650
Cdd:cd07536   577 AHlelnafrrkhdvalvidgdslevalkyyrhefvelACQCPAVICCRVSPTQKARIVTLLKQhTGRRTLAIGDGGNDVS 656
                         730
                  ....*....|.
gi 1811242742 651 ALKAADIGVAM 661
Cdd:cd07536   657 MIQAADCGVGI 667
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
152-659 3.06e-15

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 80.53  E-value: 3.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 152 ARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGETTPCSKVTAP--QPAATNGDLASRS----------- 214
Cdd:cd07541    96 SSDIKVGDLIIVEKNQRIPADMVLLRTSEKSgscfIRTDQLDGETDWKLRIAVPctQKLPEEGILNSISavyaeapqkdi 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 215 ---------------------NIAFMGTLVRCGKAKGVVIGTGEnsefgEVFKMMQAEEaPKTP---LQKSMDLLGKQLS 270
Cdd:cd07541   176 hsfygtftinddptseslsveNTLWANTVVASGTVIGVVVYTGK-----ETRSVMNTSQ-PKNKvglLDLEINFLTKILF 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 271 FYSFGI-IGIIMLVGwLLGKDILEMFTIsvSLAVAAIpegLPIVVTVTLALGVM---RMVKK-----RAIVKKLPIVETL 341
Cdd:cd07541   250 CAVLALsIVMVALQG-FQGPWYIYLFRF--LILFSSI---IPISLRVNLDMAKIvysWQIEHdknipGTVVRTSTIPEEL 323
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 342 GCCNVICSDKTGTLTKNEMTVTHiftsdgLHaevtgVGYNQFGEVIVDGDVVHGFynpavsriveagcvcndavirnntl 421
Cdd:cd07541   324 GRIEYLLSDKTGTLTQNEMVFKK------LH-----LGTVSYGGQNLNYEILQIF------------------------- 367
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 422 mgkptegalialamkmgldglqqdyirkaeyPFSSEQKWMAVkcVHRTQQDRpEICF-MKGA---YEQVIKY-------C 490
Cdd:cd07541   368 -------------------------------PFTSESKRMGI--IVREEKTG-EITFyMKGAdvvMSKIVQYndwleeeC 413
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 491 TTYQSKG-QTLT-----LTQQQ----RDVYQQEKARMGSAGLRVLALASGPELGqLTFLGLVGIIDPPRTGVKEAVTTLI 560
Cdd:cd07541   414 GNMAREGlRTLVvakkkLSEEEyqafEKRYNAAKLSIHDRDLKVAEVVESLERE-LELLCLTGVEDKLQEDVKPTLELLR 492
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 561 ASGVSIKMITGDSQETAVAIASRLGLYSKTSQ----------------------------SVSGEEIDAM------DVQQ 606
Cdd:cd07541   493 NAGIKIWMLTGDKLETATCIAKSSKLVSRGQYihvfrkvttreeahlelnnlrrkhdcalVIDGESLEVClkyyehEFIE 572
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1811242742 607 LSQIVPKVaVFYRASPRHKMKIIKSLQK-NGSVVAMTGDGVNDAVALKAADIGV 659
Cdd:cd07541   573 LACQLPAV-VCCRCSPTQKAQIVRLIQKhTGKRTCAIGDGGNDVSMIQAADVGV 625
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
539-656 6.34e-11

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 62.60  E-value: 6.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 539 LGLVGIIDP--PRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIdamdvqqlsqivpkvaV 616
Cdd:pfam00702  88 LGVIALADElkLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDV----------------G 151
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1811242742 617 FYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAAD 656
Cdd:pfam00702 152 VGKPKPEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAAG 191
PLN03190 PLN03190
aminophospholipid translocase; Provisional
284-665 5.38e-09

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 60.30  E-value: 5.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  284 GWllGKDILEMFTISVSLAVAAIPEGLPI---VVTVTLALGVMRMVK-------KRAIVKKLPIVETLGCCNVICSDKTG 353
Cdd:PLN03190   385 GW--GWEIFFTFLMSVIVFQIMIPISLYIsmeLVRVGQAYFMIRDDQmydeasnSRFQCRALNINEDLGQIKYVFSDKTG 462
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  354 TLTKNEM-----TVTHIFTSDG----------LHAEVTGVGYNQFGEVIVDGDVVH----GFYNPAVSRIVE-----AGC 409
Cdd:PLN03190   463 TLTENKMefqcaSIWGVDYSDGrtptqndhagYSVEVDGKILRPKMKVKVDPQLLElsksGKDTEEAKHVHDfflalAAC 542
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  410 ------VCNDAVIRNNTLMG----KPTEGALIALAMKMG--------------LDGLQQDYIRKAEYPFSSEQKWMAV-- 463
Cdd:PLN03190   543 ntivpiVVDDTSDPTVKLMDyqgeSPDEQALVYAAAAYGfmliertsghividIHGERQRFNVLGLHEFDSDRKRMSVil 622
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  464 KCVHRTQQdrpeiCFMKGA-----------YEQVIKYCT-----TYQSKGQTlTLTQQQRDVYQQE------------KA 515
Cdd:PLN03190   623 GCPDKTVK-----VFVKGAdtsmfsvidrsLNMNVIRATeahlhTYSSLGLR-TLVVGMRELNDSEfeqwhfsfeaasTA 696
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  516 RMGSAGLrVLALASGPElGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAI--------------- 580
Cdd:PLN03190   697 LIGRAAL-LRKVASNVE-NNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIgyssklltnkmtqii 774
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742  581 -------------------ASRLGLYSKTSQSVSGEEIDAMDV-------------------QQLSQIVPKVAVFY--RA 620
Cdd:PLN03190   775 insnskescrksledalvmSKKLTTVSGISQNTGGSSAAASDPvaliidgtslvyvldseleEQLFQLASKCSVVLccRV 854
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1811242742  621 SPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVAM-GQTG 665
Cdd:PLN03190   855 APLQKAGIVALVKNRTSDMTLAiGDGANDVSMIQMADVGVGIsGQEG 901
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
643-702 5.36e-05

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 45.29  E-value: 5.36e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1811242742 643 GDGVNDAVALKAADIGVAMGQTGTDVcKEAADMIL--VDDDfqtimsaieegkGIYNNIKNF 702
Cdd:cd07517   164 GDGLNDIEMLEAVGIGIAMGNAHEEL-KEIADYVTkdVDED------------GILKALKHF 212
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
537-681 8.79e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 44.36  E-value: 8.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 537 TFLGLVGIIdPPRTgvKEAVTTLIASGVSIKMITGDSQETAVAIASRLGL------------YSKTSQSVSGEEIDAMDV 604
Cdd:COG0561    12 TLLNDDGEI-SPRT--KEALRRLREKGIKVVIATGRPLRSALPLLEELGLddplitsngaliYDPDGEVLYERPLDPEDV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 605 QQLSQIVPK----VAVFYRASPR---------HKMKIIKSLQK-----NGSVVAMtGDGVNDAVALKAADIGVAMGQtGT 666
Cdd:COG0561    89 REILELLREhglhLQVVVRSGPGfleilpkgvSKGSALKKLAErlgipPEEVIAF-GDSGNDLEMLEAAGLGVAMGN-AP 166
                         170
                  ....*....|....*..
gi 1811242742 667 DVCKEAADMIL--VDDD 681
Cdd:COG0561   167 PEVKAAADYVTgsNDED 183
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
624-681 1.33e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 44.57  E-value: 1.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1811242742 624 HKMKIIKSLQKNGSV----VAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMI--LVDDD 681
Cdd:TIGR00099 188 SKGSALQSLAEALGIsledVIAFGDGMNDIEMLEAAGYGVAMG-NADEELKALADYVtdSNNED 250
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
627-681 9.73e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.84  E-value: 9.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1811242742 627 KIIKSLQKNGS-VVAMtGDGVNDAVALKAADIGVAMGQtGTDVCKEAADMIL--VDDD 681
Cdd:pfam08282 194 ALAKHLNISLEeVIAF-GDGENDIEMLEAAGLGVAMGN-ASPEVKAAADYVTdsNNED 249
HAD_like cd01427
Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily ...
552-661 2.48e-03

Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others. This superfamily includes a variety of enzymes that catalyze the cleavage of substrate C-Cl, P-C, and P-OP bonds via nucleophilic substitution pathways. All of which use a nucleophilic aspartate in their phosphoryl transfer reaction. They catalyze nucleophilic substitution reactions at phosphorus or carbon centers, using a conserved Asp carboxylate in covalent catalysis. All members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. Members of this superfamily are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319763 [Multi-domain]  Cd Length: 106  Bit Score: 38.53  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 552 VKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEidamdvqqlsqivpkvavFYRASPRHKMKIIKS 631
Cdd:cd01427    12 AVELLKRLRAAGIKLAIVTNRSREALRALLEKLGLGDLFDGIIGSDG------------------GGTPKPKPKPLLLLL 73
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1811242742 632 LQKNGS--VVAMTGDGVNDAVALKAA-DIGVAM 661
Cdd:cd01427    74 LKLGVDpeEVLFVGDSENDIEAARAAgGRTVAV 106
Gph COG0546
Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion];
551-691 5.69e-03

Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion];


Pssm-ID: 440312 [Multi-domain]  Cd Length: 214  Bit Score: 39.14  E-value: 5.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811242742 551 GVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEidamdvqqlsqivpkvavFYRASPRHKM--KI 628
Cdd:COG0546    88 GVRELLEALKARGIKLAVVTNKPREFAERLLEALGLDDYFDAIVGGDD------------------VPPAKPKPEPllEA 149
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1811242742 629 IKSLQKNGSVVAMTGDGVNDAVALKAAD---IGVAMG-QTGTDVCKEAADMILvdDDFQTIMSAIEE 691
Cdd:COG0546   150 LERLGLDPEEVLMVGDSPHDIEAARAAGvpfIGVTWGyGSAEELEAAGADYVI--DSLAELLALLAE 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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