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Conserved domains on  [gi|1802563996|ref|NP_001365032|]
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WD repeat-containing protein 17 isoform 4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-683 6.92e-63

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.17  E-value: 6.92e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  357 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 436
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  437 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 513
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  514 VLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRVYYVATssDQPLKVFSGHTAKVFHVKWSPlrEG-ILCSGSDDGTV 591
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTV 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  592 RIWDYTQDACINILNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMA 669
Cdd:COG2319    313 RLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLA 388

                          330
                   ....*....|....
gi 1802563996  670 SCSRDSTVRLWSLT 683
Cdd:COG2319    389 SGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
74-503 1.60e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   74 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCwnaedvvafvshrgpl 151
Cdd:COG2319    153 KLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---------------- 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  152 fiwtisgPDSGVIvhkdahsflsdicmfrwhthqkgkvVFGHIDGSlsifhpgnknqkhvlrpeslegtdeedpvtalew 231
Cdd:COG2319    214 -------PDGKLL-------------------------ASGSADGT---------------------------------- 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  232 dplstdyllvvnlhygIRLVDSESLSCITTfnLPSAAASVQCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNLKlk 311
Cdd:COG2319    228 ----------------VRLWDLATGKLLRT--LTGHSGSVRSVAFSPD--GRLLASGSADGTVRLWDLATGELLRTLT-- 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  312 ktgfhclhvlnspprkkfsvqsptknhytsstseavppptltqnqafslppghavccfldggvglydmgakkwdflrdlG 391
Cdd:COG2319    286 -------------------------------------------------------------------------------G 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  392 HVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKI 471
Cdd:COG2319    287 HSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGEL 364

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1802563996  472 IQRFNEHgTNGIFCIAWSHkDSKRIATCSSDG 503
Cdd:COG2319    365 LRTLTGH-TGAVTSVAFSP-DGRTLASGSADG 394
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-683 6.92e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.17  E-value: 6.92e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  357 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 436
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  437 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 513
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  514 VLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRVYYVATssDQPLKVFSGHTAKVFHVKWSPlrEG-ILCSGSDDGTV 591
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTV 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  592 RIWDYTQDACINILNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMA 669
Cdd:COG2319    313 RLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLA 388

                          330
                   ....*....|....
gi 1802563996  670 SCSRDSTVRLWSLT 683
Cdd:COG2319    389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 391-681 1.54e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.72  E-value: 1.54e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  391 GHVETIFDCKFKPDdPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGK 470
Cdd:cd00200      7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  471 IIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFCII-RTIDGKVLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRV 548
Cdd:cd00200     85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  549 YYVATSSdqPLKVFSGHTAKVFHVKWSPlREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISG 628
Cdd:cd00200    162 WDLRTGK--CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1802563996  629 SWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 681
Cdd:cd00200    238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
74-503 1.60e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   74 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCwnaedvvafvshrgpl 151
Cdd:COG2319    153 KLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---------------- 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  152 fiwtisgPDSGVIvhkdahsflsdicmfrwhthqkgkvVFGHIDGSlsifhpgnknqkhvlrpeslegtdeedpvtalew 231
Cdd:COG2319    214 -------PDGKLL-------------------------ASGSADGT---------------------------------- 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  232 dplstdyllvvnlhygIRLVDSESLSCITTfnLPSAAASVQCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNLKlk 311
Cdd:COG2319    228 ----------------VRLWDLATGKLLRT--LTGHSGSVRSVAFSPD--GRLLASGSADGTVRLWDLATGELLRTLT-- 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  312 ktgfhclhvlnspprkkfsvqsptknhytsstseavppptltqnqafslppghavccfldggvglydmgakkwdflrdlG 391
Cdd:COG2319    286 -------------------------------------------------------------------------------G 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  392 HVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKI 471
Cdd:COG2319    287 HSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGEL 364

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1802563996  472 IQRFNEHgTNGIFCIAWSHkDSKRIATCSSDG 503
Cdd:COG2319    365 LRTLTGH-TGAVTSVAFSP-DGRTLASGSADG 394
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-298 2.03e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   74 KLHAIMSEHKKTITAISWCPHNPdLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFI 153
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  154 WTISgpdSGVIVHK-DAHSflSDICMFRWHtHQKGKVVFGHIDGSLSIFHPGNKNQKHVLRPEslegtdeEDPVTALEWD 232
Cdd:cd00200    162 WDLR---TGKCVATlTGHT--GEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-------ENGVNSVAFS 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1802563996  233 PlsTDYLLVVNLHYG-IRLVDSESLSCITTfnLPSAAASVQCLAWVPSAPgMFITGdSQVGVLRIWN 298
Cdd:cd00200    229 P--DGYLLASGSEDGtIRVWDLRTGECVQT--LSGHTNSVTSLAWSPDGK-RLASG-SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-595 2.44e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 2.44e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1802563996   555 SDQPLKVFSGHTAKVFHVKWSPlREGILCSGSDDGTVRIWD 595
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 558-638 2.49e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.42  E-value: 2.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  558 PLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYT-QDACIN-------ILNGHTAPVRGLMWNTEIPYLLISGS 629
Cdd:PTZ00420    66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKeikdpqcILKGHKKKISIIDWNPMNYYIMCSSG 145


                   ....*....
gi 1802563996  630 WDYTIKVWD 638
Cdd:PTZ00420   146 FDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
557-595 5.69e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 5.69e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1802563996  557 QPLKVFSGHTAKVFHVKWSPLREgILCSGSDDGTVRIWD 595
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 4.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 4.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802563996    73 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
73-112 1.26e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1802563996   73 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 59-134 2.64e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIpASLSW 134
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKKL-SSLKW 175
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-683 6.92e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.17  E-value: 6.92e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  357 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 436
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  437 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 513
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  514 VLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRVYYVATssDQPLKVFSGHTAKVFHVKWSPlrEG-ILCSGSDDGTV 591
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTV 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  592 RIWDYTQDACINILNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMA 669
Cdd:COG2319    313 RLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLA 388

                          330
                   ....*....|....
gi 1802563996  670 SCSRDSTVRLWSLT 683
Cdd:COG2319    389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 391-681 1.54e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.72  E-value: 1.54e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  391 GHVETIFDCKFKPDdPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGK 470
Cdd:cd00200      7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  471 IIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFCII-RTIDGKVLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRV 548
Cdd:cd00200     85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  549 YYVATSSdqPLKVFSGHTAKVFHVKWSPlREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISG 628
Cdd:cd00200    162 WDLRTGK--CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1802563996  629 SWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 681
Cdd:cd00200    238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
387-682 5.92e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 5.92e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  387 LRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNV 466
Cdd:COG2319     30 LLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG-RLLASASADGTVRLWDL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  467 QKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGF-CIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKdMIATGCEDT 544
Cdd:COG2319    108 ATGLLLRTLTGH-TGAVRSVAFSP-DGKTLASGSADGTvRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK-LLASGSDDG 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  545 NVRVYYVATssDQPLKVFSGHTAKVFHVKWSPlrEG-ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNteiP- 622
Cdd:COG2319    185 TVRLWDLAT--GKLLRTLTGHTGAVRSVAFSP--DGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS---Pd 257

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1802563996  623 -YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSL 682
Cdd:COG2319    258 gRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 363-638 1.37e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 169.44  E-value: 1.37e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  363 GHA----VCCFLDGG----VGLYDMGAKKWDF------LRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTA 428
Cdd:cd00200      7 GHTggvtCVAFSPDGkllaTGSGDGTIKVWDLetgellRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  429 VYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFciIR 508
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGT--IK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  509 TID---GKVLHKYK-HPAAVFGCDWSQNNKDMIATGCeDTNVRVYyvATSSDQPLKVFSGHTAKVFHVKWSPLREgILCS 584
Cdd:cd00200    161 LWDlrtGKCVATLTgHTGEVNSVAFSPDGEKLLSSSS-DGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPDGY-LLAS 236

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1802563996  585 GSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYlLISGSWDYTIKVWD 638
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 431-682 3.26e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.50  E-value: 3.26e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  431 TSPGNEGVIYSLSWAPGGLNCIAGGTSrNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFCII-RT 509
Cdd:cd00200      4 TLKGHTGGVTCVAFSPDGKLLATGSGD-GTIKVWDLETGELLRTLKGH-TGPVRDVAASA-DGTYLASGSSDKTIRLwDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  510 IDGKVLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRVYYVATSsdQPLKVFSGHTAKVFHVKWSPlREGILCSGSDD 588
Cdd:cd00200     81 ETGECVRTLTgHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSP-DGTFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  589 GTVRIWDYTQDACINILNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFtM 668
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-L 234

                          250
                   ....*....|....
gi 1802563996  669 ASCSRDSTVRLWSL 682
Cdd:cd00200    235 ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
224-640 1.64e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 1.64e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  224 DPVTALEWDPLSTdYLLVVNLHYGIRLVDSESLSCITTFNLPSAAasVQCLAWVPSApGMFITGdSQVGVLRIWNVsrtt 303
Cdd:COG2319     79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGA--VRSVAFSPDG-KTLASG-SADGTVRLWDL---- 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  304 pidnlklkKTGfHCLHVLNSPPRKKFSVqsptknhytsstseavppptltqnqAFSlPPGH-AVCCFLDGGVGLYDMGAK 382
Cdd:COG2319    150 --------ATG-KLLRTLTGHSGAVTSV-------------------------AFS-PDGKlLASGSDDGTVRLWDLATG 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  383 KWdfLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGA 461
Cdd:COG2319    195 KL--LRTLtGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTV 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  462 FIWNVQKGKIIQRFnEHGTNGIFCIAWSHkdskriatcssdgfciirtiDGKVLhkykhpaavfgcdwsqnnkdmiATGC 541
Cdd:COG2319    271 RLWDLATGELLRTL-TGHSGGVNSVAFSP--------------------DGKLL----------------------ASGS 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  542 EDTNVRVYYVATSsdQPLKVFSGHTAKVFHVKWSPLREgILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEI 621
Cdd:COG2319    308 DDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG 384

                          410
                   ....*....|....*....
gi 1802563996  622 PYlLISGSWDYTIKVWDTR 640
Cdd:COG2319    385 RT-LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 472-684 3.50e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 150.56  E-value: 3.50e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  472 IQRFNEHgTNGIFCIAWsHKDSKRIATCSSDGFCII-RTIDGKVLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRVY 549
Cdd:cd00200      2 RRTLKGH-TGGVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADGT-YLASGSSDKTIRLW 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  550 yvATSSDQPLKVFSGHTAKVFHVKWSPLREgILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGS 629
Cdd:cd00200     79 --DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1802563996  630 WDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRpFTMASCSRDSTVRLWSLTA 684
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 507-685 3.76e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 3.76e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  507 IRTIDGkvlhkykHPAAVFGCDWSQNNKdMIATGCEDTNVRVYyvATSSDQPLKVFSGHTAKVFHVKWSPLREGILcSGS 586
Cdd:cd00200      2 RRTLKG-------HTGGVTCVAFSPDGK-LLATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASADGTYLA-SGS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  587 DDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLiSGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPF 666
Cdd:cd00200     71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                          170
                   ....*....|....*....
gi 1802563996  667 TmASCSRDSTVRLWSLTAL 685
Cdd:cd00200    150 V-ASSSQDGTIKLWDLRTG 167
WD40 COG2319
WD40 repeat [General function prediction only];
100-553 5.11e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 5.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  100 ASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEDVVAFVSHRGPLFIWTISGPDSGVIVHkdaHSFLSDICMF 179
Cdd:COG2319     10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG---HTAAVLSVAF 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  180 RWHTHQkgkVVFGHIDGSLSIFHPGNKNQKHVLRPESlegtdeeDPVTALEWDPlSTDYLLVVNLHYGIRLVDSESLSCI 259
Cdd:COG2319     87 SPDGRL---LASASADGTVRLWDLATGLLLRTLTGHT-------GAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  260 TTFNLPSAAasVQCLAWvpSAPG-MFITGDSQvGVLRIWNVsrttpidnlklkKTGfHCLHVLNSPPRKKFSVqsptknh 338
Cdd:COG2319    156 RTLTGHSGA--VTSVAF--SPDGkLLASGSDD-GTVRLWDL------------ATG-KLLRTLTGHTGAVRSV------- 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  339 ytsstseavppptltqnqAFSlPPGH--AVCCFlDGGVGLYDMGAKKWdfLRDL-GHVETIFDCKFKPDDpNLLATASFD 415
Cdd:COG2319    211 ------------------AFS-PDGKllASGSA-DGTVRLWDLATGKL--LRTLtGHSGSVRSVAFSPDG-RLLASGSAD 267

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  416 GTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKR 495
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKT 344

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1802563996  496 IATCSSDGfcIIRTID---GKVLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRVYYVAT 553
Cdd:COG2319    345 LASGSDDG--TVRLWDlatGELLRTLTgHTGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 558-683 2.96e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 2.96e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  558 PLKVFSGHTAKVFHVKWSPLREgILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWnteIPY--LLISGSWDYTIK 635
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADgtYLASGSSDKTIR 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1802563996  636 VWDTREGTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWSLT 683
Cdd:cd00200     77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
74-503 1.60e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   74 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCwnaedvvafvshrgpl 151
Cdd:COG2319    153 KLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---------------- 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  152 fiwtisgPDSGVIvhkdahsflsdicmfrwhthqkgkvVFGHIDGSlsifhpgnknqkhvlrpeslegtdeedpvtalew 231
Cdd:COG2319    214 -------PDGKLL-------------------------ASGSADGT---------------------------------- 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  232 dplstdyllvvnlhygIRLVDSESLSCITTfnLPSAAASVQCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNLKlk 311
Cdd:COG2319    228 ----------------VRLWDLATGKLLRT--LTGHSGSVRSVAFSPD--GRLLASGSADGTVRLWDLATGELLRTLT-- 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  312 ktgfhclhvlnspprkkfsvqsptknhytsstseavppptltqnqafslppghavccfldggvglydmgakkwdflrdlG 391
Cdd:COG2319    286 -------------------------------------------------------------------------------G 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  392 HVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKI 471
Cdd:COG2319    287 HSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGEL 364

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1802563996  472 IQRFNEHgTNGIFCIAWSHkDSKRIATCSSDG 503
Cdd:COG2319    365 LRTLTGH-TGAVTSVAFSP-DGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
74-425 4.61e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 4.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   74 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEdVVAFVSHRGPL 151
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  152 FIW---------TISGPDSGVivhkdaHS--FLSDicmfrwhthqkGK-VVFGHIDGSLSIFHPGNKNQKHVLrpesleg 219
Cdd:COG2319    187 RLWdlatgkllrTLTGHTGAV------RSvaFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTL------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  220 TDEEDPVTALEWDPLSTdYLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSapG-MFITGdSQVGVLRIWN 298
Cdd:COG2319    243 TGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPD--GkLLASG-SDDGTVRLWD 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  299 VSrttpidnlklkkTGfHCLHVLNSPPRKKFSVqsptknhytsstseavppptltqnqAFSlPPG-HAVCCFLDGGVGLY 377
Cdd:COG2319    317 LA------------TG-KLLRTLTGHTGAVRSV-------------------------AFS-PDGkTLASGSDDGTVRLW 357

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1802563996  378 DMGAKKWdfLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINT 425
Cdd:COG2319    358 DLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-298 2.03e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   74 KLHAIMSEHKKTITAISWCPHNPdLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFI 153
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  154 WTISgpdSGVIVHK-DAHSflSDICMFRWHtHQKGKVVFGHIDGSLSIFHPGNKNQKHVLRPEslegtdeEDPVTALEWD 232
Cdd:cd00200    162 WDLR---TGKCVATlTGHT--GEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-------ENGVNSVAFS 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1802563996  233 PlsTDYLLVVNLHYG-IRLVDSESLSCITTfnLPSAAASVQCLAWVPSAPgMFITGdSQVGVLRIWN 298
Cdd:cd00200    229 P--DGYLLASGSEDGtIRVWDLRTGECVQT--LSGHTNSVTSLAWSPDGK-RLASG-SADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-326 7.58e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 7.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   75 LHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWC-----------------WN 137
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadgtylasgssdktirlWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  138 AED---VVAFVSHRGPLFIWTISgPDSGVIVhkdAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSI-FHPGNK------N 207
Cdd:cd00200     80 LETgecVRTLTGHTSYVSSVAFS-PDGRILS---SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVaFSPDGTfvasssQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  208 QKHV----LRPESLEGT--DEEDPVTALEWDPLSTDyLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSap 281
Cdd:cd00200    156 DGTIklwdLRTGKCVATltGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPD-- 230

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1802563996  282 GMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSPPR 326
Cdd:cd00200    231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-595 2.44e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 2.44e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1802563996   555 SDQPLKVFSGHTAKVFHVKWSPlREGILCSGSDDGTVRIWD 595
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 558-638 2.49e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.42  E-value: 2.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  558 PLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYT-QDACIN-------ILNGHTAPVRGLMWNTEIPYLLISGS 629
Cdd:PTZ00420    66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKeikdpqcILKGHKKKISIIDWNPMNYYIMCSSG 145


                   ....*....
gi 1802563996  630 WDYTIKVWD 638
Cdd:PTZ00420   146 FDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
557-595 5.69e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 5.69e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1802563996  557 QPLKVFSGHTAKVFHVKWSPLREgILCSGSDDGTVRIWD 595
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 529-683 2.20e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 2.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  529 WSQNNKDMIATGCEDTNVRVYYVATSsdQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGh 608
Cdd:PLN00181   540 WNSYIKSQVASSNFEGVVQVWDVARS--QLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802563996  609 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTC-VDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSLT 683
Cdd:PLN00181   617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 558-651 2.52e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.82  E-value: 2.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  558 PLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGSWDYTIKVW 637
Cdd:PTZ00421   117 PIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKKLNII 195

                           90
                   ....*....|....
gi 1802563996  638 DTREGTCVDTVYDH 651
Cdd:PTZ00421   196 DPRDGTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 601-638 4.67e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 4.67e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1802563996   601 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 638
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 341-609 5.95e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 5.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  341 SSTSEAVPPPTLTQNQA----FSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRDLGHVETI-FDckfkpDDPNLLATASFD 415
Cdd:PLN00181   430 SSMSNPAKPPDFYINDSrqggWIDPFLEGLCKYLSFSKLRVKADLKQGDLLNSSNLVCAIgFD-----RDGEFFATAGVN 504

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  416 GTIKVWDINTLTA-------VYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNgIFCIAW 488
Cdd:PLN00181   505 KKIKIFECESIIKdgrdihyPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKR-VWSIDY 583

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  489 SHKDSKRIATCSSDGFCIIRTIDGKV-LHKYKHPAAVFGCDWSQNNKDMIATGCEDTNVrVYYVATSSDQPLKVFSGHTA 567
Cdd:PLN00181   584 SSADPTLLASGSDDGSVKLWSINQGVsIGTIKTKANICCVQFPSESGRSLAFGSADHKV-YYYDLRNPKLPLCTMIGHSK 662

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1802563996  568 KVFHVKWspLREGILCSGSDDGTVRIWDYTQDAC------INILNGHT 609
Cdd:PLN00181   663 TVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHT 708
PTZ00420 PTZ00420
coronin; Provisional
 535-595 2.00e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 2.00e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1802563996  535 DMIATGCEDTNVRVYYVATSSDQ------PLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWD 595
Cdd:PTZ00420    88 EILASGSEDLTIRVWEIPHNDESvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 589-705 2.00e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 2.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  589 GTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-EGTCVDTVYD-------HGADVYGLTC 660
Cdd:PTZ00420    54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDW 133

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1802563996  661 HPSRPFTMASCSRDSTVRLWSLTALVTPVQINI---LADRSWeEIIGN 705
Cdd:PTZ00420   134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMpkkLSSLKW-NIKGN 180
PTZ00421 PTZ00421
coronin; Provisional
 390-547 2.63e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 2.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  390 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIYSLSWAPGGLNCIAGGTSRNGAF 462
Cdd:PTZ00421    72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  463 IWNVQKGKIIQRFNEHgTNGIFCIAWShKDSKRIATCSSDGfcIIRTID---GKVLHKYKHPAAVFG--CDWSQNNKDMI 537
Cdd:PTZ00421   152 VWDVERGKAVEVIKCH-SDQITSLEWN-LDGSLLCTTSKDK--KLNIIDprdGTIVSSVEAHASAKSqrCLWAKRKDLII 227

                          170
                   ....*....|
gi 1802563996  538 ATGCEDTNVR 547
Cdd:PTZ00421   228 TLGCSKSQQR 237
WD40 pfam00400
WD domain, G-beta repeat;
601-638 3.41e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 3.41e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1802563996  601 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 638
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 4.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 4.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802563996    73 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 391-422 8.13e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 8.13e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1802563996   391 GHVETIFDCKFKPDDpNLLATASFDGTIKVWD 422
Cdd:smart00320   10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-122 9.98e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 9.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   42 NKDVCAASGDRFaycatlaIYIYQLDhrynEFKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWNVAEQKVIAK 121
Cdd:cd00200    189 GEKLLSSSSDGT-------IKLWDLS----TGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT 256


                   .
gi 1802563996  122 L 122
Cdd:cd00200    257 L 257
PTZ00421 PTZ00421
coronin; Provisional
 564-679 1.62e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 1.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  564 GHTAKVFHVKWSPLREGILCSGSDDGTVRIWD-----YTQDACINI--LNGHTAPVRGLMWNTEIPYLLISGSWDYTIKV 636
Cdd:PTZ00421    73 GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGipeegLTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1802563996  637 WDTREGTCVDTVYDHGADVYGLTCHpSRPFTMASCSRDSTVRL 679
Cdd:PTZ00421   153 WDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
391-422 1.64e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.64e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1802563996  391 GHVETIFDCKFKPDDpNLLATASFDGTIKVWD 422
Cdd:pfam00400    9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 614-687 1.99e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 1.99e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1802563996  614 GLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVT 687
Cdd:PLN00181   537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVS 610
WD40 pfam00400
WD domain, G-beta repeat;
642-681 2.41e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1802563996  642 GTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 681
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 642-681 2.47e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.47e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802563996   642 GTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 681
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
584-699 2.93e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 2.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996  584 SGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPS 663
Cdd:COG2319     11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPD-GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1802563996  664 RPfTMASCSRDSTVRLWSLTALVTPVQINILADRSW 699
Cdd:COG2319     90 GR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVR 124
WD40 pfam00400
WD domain, G-beta repeat;
73-112 1.26e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1802563996   73 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 468-507 1.65e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802563996   468 KGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFCII 507
Cdd:smart00320    1 SGELLKTLKGH-TGPVTSVAFSP-DGKYLASGSDDGTIKL 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-112 2.32e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.32e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802563996   40 PWNKDVCAASGDRfaycatlAIYIYQLDHryneFKLHAIMSEHKKTITAISWCPHNPDLfASGSTDNLVIIWN 112
Cdd:cd00200    229 PDGYLLASGSEDG-------TIRVWDLRT----GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 59-134 2.64e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIpASLSW 134
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKKL-SSLKW 175
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-174 5.45e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 5.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802563996   37 GCQPWNKDVCAASGDRFAYCATL--AIYIYQLdhryNEFKLHAIMSEHKKTITAISWCPhNPDLFASGSTDNLVIIWNVA 114
Cdd:cd00200    133 GHTDWVNSVAFSPDGTFVASSSQdgTIKLWDL----RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLS 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1802563996  115 EQKVIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFIW---------TISGPDSGVI---VHKDAHSFLS 174
Cdd:cd00200    208 TGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWdlrtgecvqTLSGHTNSVTslaWSPDGKRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 511-549 8.90e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 8.90e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1802563996   511 DGKVLHKYK-HPAAVFGCDWSQNNKdMIATGCEDTNVRVY 549
Cdd:smart00320    1 SGELLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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