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Conserved domains on  [gi|1802446895|ref|NP_001364989|]
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solute carrier family 49 member A3 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
28-344 5.07e-129

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17399:

Pssm-ID: 475125  Cd Length: 419  Bit Score: 380.07  E-value: 5.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAA--------- 98
Cdd:cd17399     1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAiilgawlnf 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895     --------------------------------------------------------------------------------
Cdd:cd17399    81 igavirvisslpfvdpsfrfpvlmtgqtlaafaqpfilflptklaalwfpdnqraianmlasmsnplgvllanllspliv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  99 ---------LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFS 169
Cdd:cd17399   161 kssedifllLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 170 ALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATC 249
Cdd:cd17399   240 TLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLC 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 250 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTV 324
Cdd:cd17399   320 GLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTV 399
                         410       420
                  ....*....|....*....|
gi 1802446895 325 SLLLMAGLCTFFSCILAVFF 344
Cdd:cd17399   400 PLLVMAGLAAVLAIIFVVFF 419
PHA03381 super family cl31824
tegument protein VP22; Provisional
354-459 1.23e-04

tegument protein VP22; Provisional


The actual alignment was detected with superfamily member PHA03381:

Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.85  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 354 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 429
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802446895 430 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 459
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
 
Name Accession Description Interval E-value
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
28-344 5.07e-129

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 380.07  E-value: 5.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAA--------- 98
Cdd:cd17399     1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAiilgawlnf 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895     --------------------------------------------------------------------------------
Cdd:cd17399    81 igavirvisslpfvdpsfrfpvlmtgqtlaafaqpfilflptklaalwfpdnqraianmlasmsnplgvllanllspliv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  99 ---------LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFS 169
Cdd:cd17399   161 kssedifllLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 170 ALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATC 249
Cdd:cd17399   240 TLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLC 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 250 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTV 324
Cdd:cd17399   320 GLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTV 399
                         410       420
                  ....*....|....*....|
gi 1802446895 325 SLLLMAGLCTFFSCILAVFF 344
Cdd:cd17399   400 PLLVMAGLAAVLAIIFVVFF 419
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-289 2.11e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.75  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  84 VAAIWILDSVGLRAALGVytipAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWnkAYVILAVCLGGMIG 163
Cdd:COG2814   152 LLGGLLADLFGWRWVFLV----NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL--LLLLAFLLGFGFFA 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 164 ISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtL 243
Cdd:COG2814   226 LFTYLPLYLQEVL---GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----W 297
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1802446895 244 ALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQA 289
Cdd:COG2814   298 LLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
PHA03381 PHA03381
tegument protein VP22; Provisional
354-459 1.23e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.85  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 354 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 429
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802446895 430 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 459
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
 
Name Accession Description Interval E-value
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
28-344 5.07e-129

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 380.07  E-value: 5.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAA--------- 98
Cdd:cd17399     1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAiilgawlnf 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895     --------------------------------------------------------------------------------
Cdd:cd17399    81 igavirvisslpfvdpsfrfpvlmtgqtlaafaqpfilflptklaalwfpdnqraianmlasmsnplgvllanllspliv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  99 ---------LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFS 169
Cdd:cd17399   161 kssedifllLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 170 ALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATC 249
Cdd:cd17399   240 TLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLC 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 250 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTV 324
Cdd:cd17399   320 GLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTV 399
                         410       420
                  ....*....|....*....|
gi 1802446895 325 SLLLMAGLCTFFSCILAVFF 344
Cdd:cd17399   400 PLLVMAGLAAVLAIIFVVFF 419
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
28-344 3.62e-95

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 292.77  E-value: 3.62e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAA--------- 98
Cdd:cd17334     1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGvligaalna 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895     --------------------------------------------------------------------------------
Cdd:cd17334    81 lgsvlkciplgqqpkfallvlgqvlnalaqvlvlslppliaavwfppkerttataiaslanflgcaigfllppvvvpppk 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  99 ------LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEK-------FLDGLKLLMWNKAYVILAVCLGGMIGIS 165
Cdd:cd17334   161 gtkkefGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNsehvileLQKSISELLRNEPFVLLAVAFSIMMGVF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 166 ASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQ---LQGQT 242
Cdd:cd17334   241 AGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLPYVT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 243 LALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVrrsepslstcqqgedPLDW 322
Cdd:cd17334   321 LAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLG---------------PTPT 385
                         410       420
                  ....*....|....*....|..
gi 1802446895 323 TVSLLLMAGLCTFFSCILAVFF 344
Cdd:cd17334   386 ESKYLLWFILCTVGSCLGALFF 407
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
28-301 9.04e-27

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 111.56  E-value: 9.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRA---------- 97
Cdd:cd17398     1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVtvllgsflnc 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  98 -----------------------------------------------------ALGV----------------------- 101
Cdd:cd17398    81 lgawlklfssspdlfwvamagqticalaqvfilgipprlaavwfgpdevstatAIGVfgnqlgvalgfvlppllvpnsen 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 102 -----------YTIPAGV--VCLLSTICLWESVPPTPPSAGAASSTSEK-----FLDGLKLLMWNKAYVILAVCLGGMIG 163
Cdd:cd17398   161 kdeigkglsilFYGVAGIctALFILVIIFFKEKPPIPPSRAQAAAQELRsedqsYLGSLKRLFKNKGFLLLLITYGINTG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 164 ISASFSALLEQ-ILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQLQGQT 242
Cdd:cd17398   241 VYYAISTLLNQmVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETT-IIVYILSFIGMVAFTFTLDLGSI 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1802446895 243 LALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTAL 301
Cdd:cd17398   320 WVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGAL 378
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
108-299 3.37e-17

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 83.12  E-value: 3.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 108 VVCLLSTICLWESVPPTPPSAgAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSGFSG 187
Cdd:cd17397   165 ALIFLAMLIYFPSKPPTPPSV-SASTQRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLDVNLTPFGVSQVEAG 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 188 LCGALFITFGILGALALGPYVDRTKHFTEatKIGLCLFSLACVPFALVSQLQ-----GQTLALAATCSLLGLFGFSVGPV 262
Cdd:cd17397   244 WIGFYSTVAGCVGGIIVGRFADRFGGRMK--LILLLLFSGATGSFLWFTLIClkllpFSTVSLYTSCILLGVFLNGSVPL 321
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1802446895 263 AMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMT 299
Cdd:cd17397   322 FYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
28-302 3.14e-14

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 74.10  E-value: 3.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRA---------A 98
Cdd:cd17455     1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVtallgaglnC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  99 LGVY-------------TIPAGVVC------------------------------------------------------- 110
Cdd:cd17455    81 LGAWvkcasvrpdlfgvTMLAQVLCsvaqvfilglpsriasvwfgprevstacavavlgnqlgtaigfllppvlvpntvd 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 111 -----------------------LLSTICLWESVPPTPPSAGAA-----SSTSEKFLDGLKLLMWNKAYVILAVCLGGMI 162
Cdd:cd17455   161 didlmghnisimfygtaavstllFILTIIVFKEKPPLPPSQAQAvlqgiPSEDYSYKQSIINLFKNVPFVLLLISYGIMT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 163 GISASFSALLEQILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLq 239
Cdd:cd17455   241 GTFYSVSTLLNQMIIT--HYEGeevNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDL- 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802446895 240 GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALT 302
Cdd:cd17455   318 GYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
28-297 1.60e-10

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 62.88  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRA---------- 97
Cdd:cd17456     1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVialvgsalnc 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  98 ------------------------------------------------------------ALGV---------------- 101
Cdd:cd17456    81 lgawiktgsarpdlfpvtvlgqlvcsvaqvfilgmpsriasvwfgssevstacsigvfgnQLGVaigfllppvlvpnidd 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 102 -----------YTIPAGVVCLLS--TICLWESVPPTPPS---AGAASSTSEK--FLDGLKLLMWNKAYVILAVCLGGMIG 163
Cdd:cd17456   161 ldelayhisimFYGTAAVATLLFilVIIVFQEKPKIPPSqaqAAIQSIPSQDysYLQSILRLLKNVNFILLVVSYGLNTG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 164 ISASFSALLEQILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLA-CVPFALVSQLq 239
Cdd:cd17456   241 CFYALSTLLNRMVIF--HYPGeevNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTT-LAVYIMSLVgMVVYTFTLNL- 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1802446895 240 GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLA 297
Cdd:cd17456   317 GHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTIS 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-289 2.11e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.75  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  84 VAAIWILDSVGLRAALGVytipAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWnkAYVILAVCLGGMIG 163
Cdd:COG2814   152 LLGGLLADLFGWRWVFLV----NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL--LLLLAFLLGFGFFA 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 164 ISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtL 243
Cdd:COG2814   226 LFTYLPLYLQEVL---GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----W 297
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1802446895 244 ALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQA 289
Cdd:COG2814   298 LLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
30-304 3.18e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 55.51  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  30 WVFLLAISLLNCSNATLWLSF-APVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAALGVYTIPAGV 108
Cdd:cd06174    85 WLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALL 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 109 VCLLSTICLweSVPPTPPSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSG-FSG 187
Cdd:cd06174   165 AAILLLLVV--PDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVaVAG 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 188 LCGALFITFGILGALALGPYVDRtkHFTEATKIGLCLFSLACVPFALVsqLQGQTLALAATCSLLGLFGFSVGPVAMELA 267
Cdd:cd06174   243 LLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1802446895 268 VECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVR 304
Cdd:cd06174   319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
84-287 8.50e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 54.11  E-value: 8.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  84 VAAIWILDSVGLRAALGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSekfldglklLMWNKAYVILAVCLGGMIG 163
Cdd:COG2807   159 GLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS---------LWRSPLAWLLTLFFGLQSL 229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 164 ISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHfteatKIGLCLFSLACVPFALVSQLQGQTL 243
Cdd:COG2807   230 LYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGS 304
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1802446895 244 ALAATCSLLGLFGFSVGPVAMELAVECSFPVGE-GAATGMIFVLG 287
Cdd:COG2807   305 LPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVG 349
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
82-301 6.80e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.42  E-value: 6.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  82 FGVAAIWILDSVGLRAALGVYtipaGVVCLLSTICLWESVPPTPPSAGAASSTSEK-FLDGLKLLMWNKAYVILAVCLGG 160
Cdd:COG2223   145 AAFLAPLLIAAFGWRNAFLIL----GILLLVVAVLAWLFLRDPPAGAAAAAKASLRdQLEALRDPRFWLLSLLYFGTFGS 220
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 161 MIGISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKhfteATKIGLCLFSLACVPFALVSQLQG 240
Cdd:COG2223   221 FIGFSSWLPPYLVDQF---GLSAATAGLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALG 293
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802446895 241 QTLALAATCSLLGLF-GFSVGPVAMELAVecSFPVGE-GAATGMIFVLGQAEGILIMLAMTAL 301
Cdd:COG2223   294 SLWLFLVLFLLLGLAlGGGNGAVFALVPD--IFPTKNaGAVYGLVGAAGGLGGFLGPLLFGAL 354
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
82-350 1.72e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  82 FGVAAIWILDSVGLRAALGVYTIPAGVVCLLSTICLWesvpptppsagaasstsekfldglkllmwnkayVILAVCLGGM 161
Cdd:COG2271   150 APPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLLA---------------------------------LAYFLVYFAL 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 162 IGISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRtkhFTEATKIGLCLFSLACVPFALVSQLQGQ 241
Cdd:COG2271   197 YGFLTWLPTYLVEVR---GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---LGRRRKLVLAIGLLLAALALLLLALLPS 270
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 242 TLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTvrrsepslstcqqgeDPLD 321
Cdd:COG2271   271 PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL---------------DATG 335
                         250       260
                  ....*....|....*....|....*....
gi 1802446895 322 WTVSLLLMAGLCtFFSCILAVFFHTPYRR 350
Cdd:COG2271   336 YQAAFLLLAALA-LLAALLALLLLRETRK 363
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
82-264 1.96e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.82  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  82 FGVAAIWILDSVGLRAALGvYTIPAGVVCLLSTICLW-------ESVPPTPPSAGaasstsekFLDGLKLLMWNKAYVIL 154
Cdd:COG2211   163 ASVLPPPLVAAFGGDAALG-YRLTALIFAVLGLLAFLltffgtkERPVPEEEKVS--------LKESLKALLKNRPFLLL 233
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 155 -AVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRT-KHFTeaTKIGLCLFSLACVPF 232
Cdd:COG2211   234 lLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKKA--FIIGLLLAALGLLLL 311
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1802446895 233 ALVSqlQGQTLALAATCSLLGLF--GFSVGPVAM 264
Cdd:COG2211   312 FFLG--PGNLWLLLVLAALAGIGlgAILVLPWAM 343
PHA03381 PHA03381
tegument protein VP22; Provisional
354-459 1.23e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.85  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 354 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 429
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802446895 430 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 459
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
88-288 5.44e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  88 WILDSVGLRAALGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEkFLDGLKLLMWNKAYVIL----AVCLGGMIG 163
Cdd:cd17355   150 ALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS-PGSTLKEALRSASFWLLalafFLCGFAVVG 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 164 ISASFSALLeqilCASGHSSGFSGLCGALFITFGILGALALGPYVDRtkhfTEATKIGLCLFSLACVPFALVSQLQGQTL 243
Cdd:cd17355   229 LIVHLVPYL----ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR----YSPRRLLAASYALRALGLALLLLLPFPPL 300
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1802446895 244 ALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQ 288
Cdd:cd17355   301 ALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQ 345
MATE_rft1 cd13130
Rft1-like subfamily of the multidrug and toxic compound extrusion family (MATE); This ...
223-348 6.89e-03

Rft1-like subfamily of the multidrug and toxic compound extrusion family (MATE); This eukaryotic family may function as a transporter, shuttling phospholipids, lipopolysaccharides or oligosaccharides from cytoplasmic to the lumenal side of the endoplasmic reticulum. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance.


Pssm-ID: 240535  Cd Length: 441  Bit Score: 38.86  E-value: 6.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 223 CLFSLACVPFALVSQ--------LQGQTLALAATCslLGLFGFSVGPVAMELAVecsfpvgegaatgMIFVLGQ-AEGIL 293
Cdd:cd13130   131 CILELLSEPLYILSQnllkfrlrAIVETAATLVRC--LTTFILIVLGTGKEPKV-------------LVFALGQlAYGVC 195
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1802446895 294 IMLAM--TALTVRRSEPSLSTCQQGEDPLDWTVSLLLMAGLCTFFSC----------ILAVFFHTPY 348
Cdd:cd13130   196 LFFGYwyYFLQCFVSKKSSLFPLRNSNLMFFDKPTLRMCGLFTIQSFfkhlltegdkIVLVWFDTPY 262
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
50-282 7.00e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 38.68  E-value: 7.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895  50 FAPVADVIAEDLVLSMEQINWLSLVY--LVVSTPFGV-AAIWILDSVGLRAALGVytipAGVVCLLSTICLWESVPPTPP 126
Cdd:cd17324   104 FWAIAAAYAADLVPPEKRGRAIGLVFsgLTLGLVLGRpLGGLLGQLLGWRAAFLA----IAVLALLAALLLWRLLPSLPP 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446895 127 SAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQIlcaSGHSSGFSGLCGALFITFGILGALALGP 206
Cdd:cd17324   180 KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDV---PGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802446895 207 YVDRTKHFTEATKIGLCLFSLACVPFALvsqlqGQTLALAATCSLLGLFGFSVGPVAMELAVECSfPVGEGAATGM 282
Cdd:cd17324   257 LADRGGRRALLIALLLLAAALLLLTLLG-----PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSL 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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