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Conserved domains on  [gi|1800417243|ref|NP_001364985|]
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ETS homologous factor isoform 9 [Homo sapiens]

Protein Classification

erythroblast transformation specific family transcription factor( domain architecture ID 10337522)

erythroblast transformation specific (ETS) family transcription factor may be involved in the regulation of immunoglobulin heavy-chain gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 119-206 6.77e-46

erythroblast transformation specific domain; variation of the helix-turn-helix motif


:

Pssm-ID: 197710  Cd Length: 87  Bit Score: 147.03  E-value: 6.77e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417243  119 GTHLWEFIRDILLNPDkNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLV 198
Cdd:smart00413   1 GIQLWQFLLDLLLDPE-NSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLV 79


                   ....*...
gi 1800417243  199 YKFGKNAR 206
Cdd:smart00413  80 YKFVKNPL 87
SAM_superfamily super family cl15755
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 1-29 1.57e-13

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


The actual alignment was detected with superfamily member cd08539:

Pssm-ID: 472832  Cd Length: 78  Bit Score: 63.51  E-value: 1.57e-13
                          10        20
                  ....*....|....*....|....*....
gi 1800417243   1 MSLQEFTRAAGTAGQLLYSNLQHLKWNGQ 29
Cdd:cd08539    50 MSLQEFTRAAGTAGQLLYSNLQHLKWNGQ 78
 
Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 119-206 6.77e-46

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 147.03  E-value: 6.77e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417243  119 GTHLWEFIRDILLNPDkNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLV 198
Cdd:smart00413   1 GIQLWQFLLDLLLDPE-NSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLV 79


                   ....*...
gi 1800417243  199 YKFGKNAR 206
Cdd:smart00413  80 YKFVKNPL 87
Ets pfam00178
Ets-domain;
121-201 4.52e-41

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 134.16  E-value: 4.52e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417243 121 HLWEFIRDILLNPDkNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYK 200
Cdd:pfam00178   1 QLWQFLLDLLTDPE-YSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYR 79


                  .
gi 1800417243 201 F 201
Cdd:pfam00178  80 F 80
SAM_PNT-ESE-3-like cd08539
Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM ...
 1-29 1.57e-13

Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM Pointed domain of ESE-3-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. The ESE-3 transcriptional activator is involved in regulation of glandular epithelium differentiation through the MAP kinase signaling cascade. It is found to be expressed in glandular epithelium of prostate, pancreas, salivary gland, and trachea. Additionally, ESE-3 is differentially expressed during monocyte-derived dendritic cells development. DNA binding consensus motif for ESE-3 consists of purine-rich GGAA/T core sequence. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188882  Cd Length: 78  Bit Score: 63.51  E-value: 1.57e-13
                          10        20
                  ....*....|....*....|....*....
gi 1800417243   1 MSLQEFTRAAGTAGQLLYSNLQHLKWNGQ 29
Cdd:cd08539    50 MSLQEFTRAAGTAGQLLYSNLQHLKWNGQ 78
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
1-28 2.33e-04

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 38.81  E-value: 2.33e-04
                          10        20
                  ....*....|....*....|....*...
gi 1800417243   1 MSLQEFTRAAGTAGQLLYSNLQHLKWNG 28
Cdd:pfam02198  56 LGKEEFLQRAPGPGDILWSHLQILRKAS 83
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 1-27 3.29e-04

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 38.01  E-value: 3.29e-04
                           10        20
                   ....*....|....*....|....*..
gi 1800417243    1 MSLQEFTRAAGTAGQLLYSNLQHLKWN 27
Cdd:smart00251  56 MSKEEFLERAPFGGDILWSHLQILRKA 82
 
Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 119-206 6.77e-46

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 147.03  E-value: 6.77e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417243  119 GTHLWEFIRDILLNPDkNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLV 198
Cdd:smart00413   1 GIQLWQFLLDLLLDPE-NSDIIKWTDRDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLV 79


                   ....*...
gi 1800417243  199 YKFGKNAR 206
Cdd:smart00413  80 YKFVKNPL 87
Ets pfam00178
Ets-domain;
121-201 4.52e-41

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 134.16  E-value: 4.52e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417243 121 HLWEFIRDILLNPDkNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYK 200
Cdd:pfam00178   1 QLWQFLLDLLTDPE-YSDIIKWTDKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYR 79


                  .
gi 1800417243 201 F 201
Cdd:pfam00178  80 F 80
SAM_PNT-ESE-3-like cd08539
Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM ...
 1-29 1.57e-13

Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM Pointed domain of ESE-3-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. The ESE-3 transcriptional activator is involved in regulation of glandular epithelium differentiation through the MAP kinase signaling cascade. It is found to be expressed in glandular epithelium of prostate, pancreas, salivary gland, and trachea. Additionally, ESE-3 is differentially expressed during monocyte-derived dendritic cells development. DNA binding consensus motif for ESE-3 consists of purine-rich GGAA/T core sequence. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188882  Cd Length: 78  Bit Score: 63.51  E-value: 1.57e-13
                          10        20
                  ....*....|....*....|....*....
gi 1800417243   1 MSLQEFTRAAGTAGQLLYSNLQHLKWNGQ 29
Cdd:cd08539    50 MSLQEFTRAAGTAGQLLYSNLQHLKWNGQ 78
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
1-28 2.33e-04

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 38.81  E-value: 2.33e-04
                          10        20
                  ....*....|....*....|....*...
gi 1800417243   1 MSLQEFTRAAGTAGQLLYSNLQHLKWNG 28
Cdd:pfam02198  56 LGKEEFLQRAPGPGDILWSHLQILRKAS 83
SAM_PNT_ESE cd08757
Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM ...
 1-26 2.91e-04

Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM Pointed domain of ESE-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ETS factors are important for cell differentiation. They can be involved in regulation of gene expression in different types of epithelial cells. They are expressed in salivary gland, intestine, stomach, pancreas, lungs, kidneys, colon, mammary gland, and prostate. Members of this group are proto-oncogenes. Expression profiles of these factors are altered in epithelial cancers, which makes them potential targets for cancer therapy.


Pssm-ID: 188885  Cd Length: 69  Bit Score: 38.09  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 1800417243   1 MSLQEFTRAAGTAGQLLYSNLQHLKW 26
Cdd:cd08757    44 MSLEEFIERDGVYGNLLYAELRRLLS 69
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 1-27 3.29e-04

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 38.01  E-value: 3.29e-04
                           10        20
                   ....*....|....*....|....*..
gi 1800417243    1 MSLQEFTRAAGTAGQLLYSNLQHLKWN 27
Cdd:smart00251  56 MSKEEFLERAPFGGDILWSHLQILRKA 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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