|
Name |
Accession |
Description |
Interval |
E-value |
| RasGEF |
smart00147 |
Guanine nucleotide exchange factor for Ras-like small GTPases; |
985-1214 |
1.07e-86 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases;
:
Pssm-ID: 214539 Cd Length: 242 Bit Score: 281.06 E-value: 1.07e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 985 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKE-QNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1061
Cdd:smart00147 1 LLLLDPKELAEQLTLLDFELFRKIDPSELLgsVWGKRsKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1062 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEVE-PPCIPYLG 1135
Cdd:smart00147 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSkykklFEELEELLSPERNYKNYREALSSCNlPPCIPFLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1136 LILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRND-DIINFFNDFSDHLAEEA-LWELSLKIKP 1212
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRsDIQSLLQQLLDHLDEEEeLYQLSLKIEP 240
|
..
gi 1799657597 1213 RN 1214
Cdd:smart00147 241 RV 242
|
|
| RasGEFN |
smart00229 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
837-978 |
4.63e-29 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).
:
Pssm-ID: 214571 Cd Length: 127 Bit Score: 112.81 E-value: 4.63e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 837 DGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKrvskntffvlvrvVD 916
Cdd:smart00229 1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESWVEEK-------------VN 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1799657597 917 ELCLVELTEEILKLLMELVFRlVCNGELSLARVLRkNILDKVDQKKLLRCATSSQPLAARGV 978
Cdd:smart00229 68 PRRVKNRVLNILRTWVENYWE-DFEDDPKLISFLL-EFLELVDDEKYPGLVTSLLNLLRRLS 127
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
190-448 |
1.31e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 190 GRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTEllPDATDEEVAPPKPPLPGIRVVDNSPPPAlPPKK 269
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTVGSLTSLADPPP-PPPT 2707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 270 RQSAPSPTRVAVVAPMSRATSGSSLPVGINRQdfdvdcyAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQL------ 343
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-------APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAApaagpp 2780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 344 SSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQ--LPLGGHPQPDG 421
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPpsLPLGGSVAPGG 2860
|
250 260
....*....|....*....|....*..
gi 1799657597 422 PLAPGQQTDTPPALPEKKRRSAASQTA 448
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
|
| PHA03307 super family |
cl33723 |
transcriptional regulator ICP4; Provisional |
675-846 |
1.16e-03 |
|
transcriptional regulator ICP4; Provisional
The actual alignment was detected with superfamily member PHA03307:
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 675 PPTSSSSPHFPPAHQSqssdlavptmAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASEEAGEGEYVNLYS 754
Cdd:PHA03307 108 PPGPSSPDPPPPTPPP----------ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 755 SGQSSEELAPSRGEPPAGK--------DGHPRDPSAVSGV------PGKDSRDGSERAPKSPDALESAQSEEEVDELSLI 820
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPStppaaaspRPPRRSSPISASAsspapaPGRSAADDAGASSSDSSSSESSGCGWGPENECPL 257
|
170 180
....*....|....*....|....*...
gi 1799657597 821 DHNEIMSRLTLKQEG--DDGPDVRGGSG 846
Cdd:PHA03307 258 PRPAPITLPTRIWEAsgWNGPSSRPGPA 285
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RasGEF |
smart00147 |
Guanine nucleotide exchange factor for Ras-like small GTPases; |
985-1214 |
1.07e-86 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases;
Pssm-ID: 214539 Cd Length: 242 Bit Score: 281.06 E-value: 1.07e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 985 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKE-QNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1061
Cdd:smart00147 1 LLLLDPKELAEQLTLLDFELFRKIDPSELLgsVWGKRsKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1062 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEVE-PPCIPYLG 1135
Cdd:smart00147 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSkykklFEELEELLSPERNYKNYREALSSCNlPPCIPFLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1136 LILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRND-DIINFFNDFSDHLAEEA-LWELSLKIKP 1212
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRsDIQSLLQQLLDHLDEEEeLYQLSLKIEP 240
|
..
gi 1799657597 1213 RN 1214
Cdd:smart00147 241 RV 242
|
|
| RasGEF |
cd00155 |
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ... |
985-1209 |
6.08e-85 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.
Pssm-ID: 238087 [Multi-domain] Cd Length: 237 Bit Score: 276.06 E-value: 6.08e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 985 LHDFHSHEIAEQLTLLDAELFYKIEIPE---VLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1061
Cdd:cd00155 1 FLSLDPKELAEQLTLLDFELFRKIEPFEllgSLWSKKDKNIHLSPNLERFIERFNNLSNWVASEILLCTNPKKRARLLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1062 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEV--EPPCIPYL 1134
Cdd:cd00155 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSklkklFEELEELVDPSRNFKNYRKLLKSVgpNPPCVPFL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799657597 1135 GLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDF-SDHLAEEALWELSLK 1209
Cdd:cd00155 161 GVYLKDLTFLHEGNPDFLEGNlVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKLlELILNEDELYELSLE 237
|
|
| RasGEF |
pfam00617 |
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases. |
992-1162 |
3.57e-71 |
|
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
Pssm-ID: 459872 Cd Length: 179 Bit Score: 235.18 E-value: 3.57e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 992 EIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHL 1069
Cdd:pfam00617 1 ELARQLTLIEFELFRKIKPRELLgsAWSKKDKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKKFIKIAEHC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1070 RKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFV 1144
Cdd:pfam00617 81 RELNNFNSLMAILSGLNSSPISRLKktWELvskKYKKTLEELEKLMSPSRNFKNYREALSSASPPCIPFLGLYLTDLTFI 160
|
170
....*....|....*....
gi 1799657597 1145 HLGNPDYIDGK-VNFSKRW 1162
Cdd:pfam00617 161 EEGNPDFLEGGlINFEKRR 179
|
|
| RasGEFN |
smart00229 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
837-978 |
4.63e-29 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).
Pssm-ID: 214571 Cd Length: 127 Bit Score: 112.81 E-value: 4.63e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 837 DGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKrvskntffvlvrvVD 916
Cdd:smart00229 1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESWVEEK-------------VN 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1799657597 917 ELCLVELTEEILKLLMELVFRlVCNGELSLARVLRkNILDKVDQKKLLRCATSSQPLAARGV 978
Cdd:smart00229 68 PRRVKNRVLNILRTWVENYWE-DFEDDPKLISFLL-EFLELVDDEKYPGLVTSLLNLLRRLS 127
|
|
| REM |
cd06224 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ... |
845-959 |
4.18e-17 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.
Pssm-ID: 100121 Cd Length: 122 Bit Score: 78.61 E-value: 4.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 845 SGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSP-------FADTFKKRVSKNTFFVLVRVVDE 917
Cdd:cd06224 1 TLEALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenleyndWDKKKSKPIRLRVLNVLRTWVEN 80
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1799657597 918 LCLV-ELTEEILKLLMELVFRLVCNGELSlaRVLRKNILDKVD 959
Cdd:cd06224 81 YPYDfFDDEELLELLEEFLNRLVQEGALL--QELKKLLRKLLK 121
|
|
| RasGEF_N |
pfam00618 |
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ... |
841-936 |
1.49e-11 |
|
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.
Pssm-ID: 459873 Cd Length: 104 Bit Score: 61.94 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 841 VRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKK-RVSKNTFFVLVRVVdelc 919
Cdd:pfam00618 2 VKAGTLEKLVEYLTSTRIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSyWISKKTLPIRIRVL---- 77
|
90
....*....|....*..
gi 1799657597 920 lvelteEILKLLMELVF 936
Cdd:pfam00618 78 ------SVLRHWVENYF 88
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
190-448 |
1.31e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 190 GRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTEllPDATDEEVAPPKPPLPGIRVVDNSPPPAlPPKK 269
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTVGSLTSLADPPP-PPPT 2707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 270 RQSAPSPTRVAVVAPMSRATSGSSLPVGINRQdfdvdcyAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQL------ 343
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-------APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAApaagpp 2780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 344 SSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQ--LPLGGHPQPDG 421
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPpsLPLGGSVAPGG 2860
|
250 260
....*....|....*....|....*..
gi 1799657597 422 PLAPGQQTDTPPALPEKKRRSAASQTA 448
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
675-846 |
1.16e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 675 PPTSSSSPHFPPAHQSqssdlavptmAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASEEAGEGEYVNLYS 754
Cdd:PHA03307 108 PPGPSSPDPPPPTPPP----------ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 755 SGQSSEELAPSRGEPPAGK--------DGHPRDPSAVSGV------PGKDSRDGSERAPKSPDALESAQSEEEVDELSLI 820
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPStppaaaspRPPRRSSPISASAsspapaPGRSAADDAGASSSDSSSSESSGCGWGPENECPL 257
|
170 180
....*....|....*....|....*...
gi 1799657597 821 DHNEIMSRLTLKQEG--DDGPDVRGGSG 846
Cdd:PHA03307 258 PRPAPITLPTRIWEAsgWNGPSSRPGPA 285
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RasGEF |
smart00147 |
Guanine nucleotide exchange factor for Ras-like small GTPases; |
985-1214 |
1.07e-86 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases;
Pssm-ID: 214539 Cd Length: 242 Bit Score: 281.06 E-value: 1.07e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 985 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKE-QNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1061
Cdd:smart00147 1 LLLLDPKELAEQLTLLDFELFRKIDPSELLgsVWGKRsKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1062 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEVE-PPCIPYLG 1135
Cdd:smart00147 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSkykklFEELEELLSPERNYKNYREALSSCNlPPCIPFLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1136 LILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRND-DIINFFNDFSDHLAEEA-LWELSLKIKP 1212
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRsDIQSLLQQLLDHLDEEEeLYQLSLKIEP 240
|
..
gi 1799657597 1213 RN 1214
Cdd:smart00147 241 RV 242
|
|
| RasGEF |
cd00155 |
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ... |
985-1209 |
6.08e-85 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.
Pssm-ID: 238087 [Multi-domain] Cd Length: 237 Bit Score: 276.06 E-value: 6.08e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 985 LHDFHSHEIAEQLTLLDAELFYKIEIPE---VLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1061
Cdd:cd00155 1 FLSLDPKELAEQLTLLDFELFRKIEPFEllgSLWSKKDKNIHLSPNLERFIERFNNLSNWVASEILLCTNPKKRARLLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1062 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEV--EPPCIPYL 1134
Cdd:cd00155 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSklkklFEELEELVDPSRNFKNYRKLLKSVgpNPPCVPFL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799657597 1135 GLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDF-SDHLAEEALWELSLK 1209
Cdd:cd00155 161 GVYLKDLTFLHEGNPDFLEGNlVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKLlELILNEDELYELSLE 237
|
|
| RasGEF |
pfam00617 |
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases. |
992-1162 |
3.57e-71 |
|
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
Pssm-ID: 459872 Cd Length: 179 Bit Score: 235.18 E-value: 3.57e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 992 EIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHL 1069
Cdd:pfam00617 1 ELARQLTLIEFELFRKIKPRELLgsAWSKKDKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKKFIKIAEHC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 1070 RKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFV 1144
Cdd:pfam00617 81 RELNNFNSLMAILSGLNSSPISRLKktWELvskKYKKTLEELEKLMSPSRNFKNYREALSSASPPCIPFLGLYLTDLTFI 160
|
170
....*....|....*....
gi 1799657597 1145 HLGNPDYIDGK-VNFSKRW 1162
Cdd:pfam00617 161 EEGNPDFLEGGlINFEKRR 179
|
|
| RasGEFN |
smart00229 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
837-978 |
4.63e-29 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).
Pssm-ID: 214571 Cd Length: 127 Bit Score: 112.81 E-value: 4.63e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 837 DGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKrvskntffvlvrvVD 916
Cdd:smart00229 1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESWVEEK-------------VN 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1799657597 917 ELCLVELTEEILKLLMELVFRlVCNGELSLARVLRkNILDKVDQKKLLRCATSSQPLAARGV 978
Cdd:smart00229 68 PRRVKNRVLNILRTWVENYWE-DFEDDPKLISFLL-EFLELVDDEKYPGLVTSLLNLLRRLS 127
|
|
| REM |
cd06224 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ... |
845-959 |
4.18e-17 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.
Pssm-ID: 100121 Cd Length: 122 Bit Score: 78.61 E-value: 4.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 845 SGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSP-------FADTFKKRVSKNTFFVLVRVVDE 917
Cdd:cd06224 1 TLEALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenleyndWDKKKSKPIRLRVLNVLRTWVEN 80
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1799657597 918 LCLV-ELTEEILKLLMELVFRLVCNGELSlaRVLRKNILDKVD 959
Cdd:cd06224 81 YPYDfFDDEELLELLEEFLNRLVQEGALL--QELKKLLRKLLK 121
|
|
| RasGEF_N |
pfam00618 |
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ... |
841-936 |
1.49e-11 |
|
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.
Pssm-ID: 459873 Cd Length: 104 Bit Score: 61.94 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 841 VRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKK-RVSKNTFFVLVRVVdelc 919
Cdd:pfam00618 2 VKAGTLEKLVEYLTSTRIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSyWISKKTLPIRIRVL---- 77
|
90
....*....|....*..
gi 1799657597 920 lvelteEILKLLMELVF 936
Cdd:pfam00618 78 ------SVLRHWVENYF 88
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
190-448 |
1.31e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 190 GRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTEllPDATDEEVAPPKPPLPGIRVVDNSPPPAlPPKK 269
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTVGSLTSLADPPP-PPPT 2707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 270 RQSAPSPTRVAVVAPMSRATSGSSLPVGINRQdfdvdcyAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQL------ 343
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-------APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAApaagpp 2780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 344 SSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQ--LPLGGHPQPDG 421
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPpsLPLGGSVAPGG 2860
|
250 260
....*....|....*....|....*..
gi 1799657597 422 PLAPGQQTDTPPALPEKKRRSAASQTA 448
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
189-787 |
4.24e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 189 QGRPSPTSPVKPSSPA-----SKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATdeevaPPKPPLPGIRVVDNSPP- 262
Cdd:PHA03247 2566 RSVPPPRPAPRPSEPAvtsraRRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTH-----APDPPPPSPSPAANEPDp 2640
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 263 ----PALPPKKRQSAPSPTRVAV---VAPMSRATSGSSLPVGINRQdfdvdcyAQRRLSGGSHSYGGESPRLSPCSSIGK 335
Cdd:PHA03247 2641 hpppTVPPPERPRDDPAPGRVSRprrARRLGRAAQASSPPQRPRRR-------AARPTVGSLTSLADPPPPPPTPEPAPH 2713
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 336 LSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDlSNADQIPQQTAWNLSPLPESlgesgSPFLGPPFQLPlgg 415
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-PARPARPPTTAGPPAPAPPA-----APAAGPPRRLT--- 2784
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 416 hPQPDGPLAPGQqtdtpPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAIlpfqhG 495
Cdd:PHA03247 2785 -RPAVASLSESR-----ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL-----G 2853
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 496 GSSAPvefVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLledysEPQPSMFYQTPqnehiyqqknkllmevygfsdsf 575
Cdd:PHA03247 2854 GSVAP---GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAV-----SRSTESFALPP----------------------- 2902
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 576 sgvDSVQELAPPPALPPKQRQLQASCAASSFSSVSHCVQQTKVAFTPEDGSAAQGLSVSVSNSFLSR--HGSLPVPSYKs 653
Cdd:PHA03247 2903 ---DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAlvPGRVAVPRFR- 2978
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 654 vfrsysqdfVPHHQASVPPFLPPTSSSSPHFPPAHQSQSSDLAVPTMAGPPPSTVDGPLSASQEssfhgntvclpSETSF 733
Cdd:PHA03247 2979 ---------VPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDD-----------TEDSD 3038
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 1799657597 734 TDSSENASEEAGEGEYVNlyssGQSSEELAPSRGEP--PAGKDGHPRDPSAVSGVP 787
Cdd:PHA03247 3039 ADSLFDSDSERSDLEALD----PLPPEPHDPFAHEPdpATPEAGARESPSSQFGPP 3090
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
192-500 |
9.15e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 47.09 E-value: 9.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 192 PSPTSPVKPSSPASKPdGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQ 271
Cdd:PHA03307 73 PGPGTEAPANESRSTP-TWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAAS 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 272 SAP-------------SPTRVAVVAPMSRAT----SGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIG 334
Cdd:PHA03307 152 PPAagaspaavasdaaSSRQAALPLSSPEETarapSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADD 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 335 KLSKSDEQLSSLDRDSGQCSRNTScetldhydPDYEFLQQDLsnADQIPQQTAWNLSPLPESLGESGSPFLGPpfqlplG 414
Cdd:PHA03307 232 AGASSSDSSSSESSGCGWGPENEC--------PLPRPAPITL--PTRIWEASGWNGPSSRPGPASSSSSPRER------S 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 415 GHPQPDGPLAPGQQTdTPPALPEKKR--------RSAASQTADGSGCRVSYERHPSQyDNISGEDLQSTAPIPSVPYAPF 486
Cdd:PHA03307 296 PSPSPSSPGSGPAPS-SPRASSSSSSsresssssTSSSSESSRGAAVSPGPSPSRSP-SPSRPPPPADPSSPRKRPRPSR 373
|
330
....*....|....
gi 1799657597 487 AAILPFQHGGSSAP 500
Cdd:PHA03307 374 APSSPAASAGRPTR 387
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
675-846 |
1.16e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 675 PPTSSSSPHFPPAHQSqssdlavptmAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASEEAGEGEYVNLYS 754
Cdd:PHA03307 108 PPGPSSPDPPPPTPPP----------ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 755 SGQSSEELAPSRGEPPAGK--------DGHPRDPSAVSGV------PGKDSRDGSERAPKSPDALESAQSEEEVDELSLI 820
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPStppaaaspRPPRRSSPISASAsspapaPGRSAADDAGASSSDSSSSESSGCGWGPENECPL 257
|
170 180
....*....|....*....|....*...
gi 1799657597 821 DHNEIMSRLTLKQEG--DDGPDVRGGSG 846
Cdd:PHA03307 258 PRPAPITLPTRIWEAsgWNGPSSRPGPA 285
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
647-847 |
4.89e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 41.31 E-value: 4.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 647 PVPSYKSVFRSYSQDFVPHHQASVPPFLPPTSSSSPHFPPAHQSQSSDLAVPTMAGPPPSTVDGPLSASQESSFHGNTVC 726
Cdd:PHA03307 130 PAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 727 LPSETSFTDSSENASEEAGEGEYVNLYSSGQSSEEL-------------------APSRGEPPAGKDGHPRDPSAVSGVP 787
Cdd:PHA03307 210 SSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgwgpenecplprpapitLPTRIWEASGWNGPSSRPGPASSSS 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799657597 788 GkDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKqEGDDGPDVRGGSGD 847
Cdd:PHA03307 290 S-PRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSS-ESSRGAAVSPGPSP 347
|
|
| |
