BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991   9 IGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmGAGGSGTATGGAGAGV 88
Cdd:cd18327     1 IGIPFPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTG-------GGGGSGDLGAGGGQDV 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1796386991  89 CELDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQ 142
Cdd:cd18327    74 CELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991 345 PQECPVCHKIIHGAGKLPRHMRTHTGEKPFACEV--CGVRFTRNDKLKIHMRKHTGERPYSC--PHCPARFLHSYDLKNH 420
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSS 112

                  ....
gi 1796386991 421 MHLH 424
Cdd:COG5048   113 SSSN 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991   9 IGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmGAGGSGTATGGAGAGV 88
Cdd:cd18327     1 IGIPFPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTG-------GGGGSGDLGAGGGQDV 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1796386991  89 CELDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQ 142
Cdd:cd18327    74 CELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991   35 DLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGaggsgtatggagagVCELDFVGPEALGALLEFAYTATLTTS 114
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS--------------EIYLDDVSPEDFRALLNFLYTGKLDLP 66

                           90       100
                   ....*....|....*....|....*..
gi 1796386991  115 SANMPAVLQAARLLEIPCVIAACMEIL 141
Cdd:smart00225  67 EENVEELLELADYLQIPGLVELCEEFL 93

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991 345 PQECPVCHKIIHGAGKLPRHMRTHTGEKPFACEV--CGVRFTRNDKLKIHMRKHTGERPYSC--PHCPARFLHSYDLKNH 420
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSS 112

                  ....
gi 1796386991 421 MHLH 424
Cdd:COG5048   113 SSSN 116

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 1796386991 416 DLKNHMHLHTGDRPYECHLCHKAFAK 441
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991   9 IGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmGAGGSGTATGGAGAGV 88
Cdd:cd18327     1 IGIPFPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTG-------GGGGSGDLGAGGGQDV 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1796386991  89 CELDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQ 142
Cdd:cd18327    74 CELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991   9 IGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTeggggavmgaggsgTATGGAGAGV 88
Cdd:cd18328     1 IGIPFPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFT--------------AGTLADQPYV 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1796386991  89 CELDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQ 142
Cdd:cd18328    67 YEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  24 LNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGAGgsgtatggagagvcELDFVGPEALGALL 103
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEI--------------TLDDVSPEDFEALL 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1796386991 104 EFAYTATLTTSSaNMPAVLQAARLLEIPCVIAACMEILQGS 144
Cdd:pfam00651  67 EFMYTGKLISEE-NVDDLLAAADKLQIPSLVDKCEEFLIKS 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  16 HSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmGAGGSGTATGGAGAGVCELDFVG 95
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVG-------QASPRLVLVSPAGKCVLDLHHVT 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1796386991  96 PEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGS 144
Cdd:cd18228    75 VTGFAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSS 123

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991   35 DLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGaggsgtatggagagVCELDFVGPEALGALLEFAYTATLTTS 114
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS--------------EIYLDDVSPEDFRALLNFLYTGKLDLP 66

                           90       100
                   ....*....|....*....|....*..
gi 1796386991  115 SANMPAVLQAARLLEIPCVIAACMEIL 141
Cdd:smart00225  67 EENVEELLELADYLQIPGLVELCEEFL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  33 LCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmgaggsgtATGGAGAGVCELDFVGPEALGALLEFAYTATLT 112
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSS--------------GMKESSSSEIELDDVSPEAFEALLDYIYTGELE 66

                          90
                  ....*....|....*.
gi 1796386991 113 TSSANMPAVLQAARLL 128
Cdd:cd18186    67 LSEENVEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  21 LSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTeggggavmgaggsgTATGGAGAGVCELDFVGPEALG 100
Cdd:cd18240     5 CNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFT--------------NGWNETEKKVYKIPGVSPEMME 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1796386991 101 ALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEIL 141
Cdd:cd18240    71 LIIEYAYTRTVPITAENVEELLPAADQFNIMGIVKACCDFL 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  13 FPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGAGGSgtatggagagvcelD 92
Cdd:cd18324     3 FPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNS--------------D 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1796386991  93 FVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEIL-QGSGLEAPSPDEDD 155
Cdd:cd18324    69 IVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLkEKATTEADSTKKEE 132

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  11 IPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFkklfteggggavmgaggSGTATGGAGAGVCE 90
Cdd:cd18227     3 VEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYF-----------------CDQVLLKNSRRIVL 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1796386991  91 LDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQG 143
Cdd:cd18227    66 PDVMNPRVFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLEG 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  13 FPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmgaggsgtaTGGAGAGVC-EL 91
Cdd:cd18323     3 FPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKE---------------QLDKRDLVCiNN 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  92 DFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGSGL-EAPS 150
Cdd:cd18323    68 EIVTAPAFSLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQARALaEADS 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  16 HSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmgaggsgtATGGAGAGVCELDFVG 95
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTG--------------GMRESSQDEIELKGVS 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1796386991  96 PEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQ 142
Cdd:cd18255    67 AKGLKHILDFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  16 HSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTeggggavmgaggsgtATGGAGAGVCELDFVG 95
Cdd:cd18278    14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALV---------------GQTENDLVVSLPEEVT 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1796386991  96 PEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEIL 141
Cdd:cd18278    79 ARGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  14 PDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmgaggsgTATGGAGAGVCELDF 93
Cdd:cd18230     2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQ-------------VQKTSDQATVTHLDI 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1796386991  94 VGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGS 144
Cdd:cd18230    69 VTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAA 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991   8 LIGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGAGGsgtatggagag 87
Cdd:cd18289     4 MLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPAT----------- 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1796386991  88 vceldfVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILqgsgLEAPSPDED 154
Cdd:cd18289    73 ------VPPACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLM----FKVSSPHCD 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  14 PDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGAggsgtatggagagvCELDF 93
Cdd:cd18250     2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADR--------------VVLHG 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1796386991  94 VGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQ 142
Cdd:cd18250    68 VSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQ 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  16 HSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmgaggsgtaTGGAGAGVCELD-FV 94
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTD---------------QLKNNVSVINLDpEI 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1796386991  95 GPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAAC 137
Cdd:cd18215    67 EPEGFRILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  15 DHSSELLSCLNEQRQLGHLCDLTIR----TQGLEYRTHRAVLAACSHYFKKLFTeggggavmgaggsgTATGGAGAGVCE 90
Cdd:cd18248     3 DHTKEAFQIMNELRLSQQLCDVTLKvkyqDPKEEFMAHKVVLASSSPYFKAMFT--------------SGLRECGMEVVP 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1796386991  91 LDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEIL 141
Cdd:cd18248    69 IEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  13 FPDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKlfteggggavmgaggsgTATGGAGAGVCELD 92
Cdd:cd18210     1 FPEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHD-----------------QVLLKNMSSISLPG 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1796386991  93 FVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEIL 141
Cdd:cd18210    64 VMDPGAFESVLASAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  16 HSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGAVMGAGGSGtatggagagvceldfvG 95
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPS----------------G 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1796386991  96 PEALG--ALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQ 142
Cdd:cd18332    66 LEARGfqLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  14 PDHSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTeggggavmgaggsgTATGGAGAGVCELDF 93
Cdd:cd18265     4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFG--------------GHLKESRQAVVEIQK 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1796386991  94 VGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQG 143
Cdd:cd18265    70 VSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEG 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  16 HSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmgaggsgtaTGGAGAGVCELDFVG 95
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKK---------------LEVDSSSVIEIDFLR 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1796386991  96 PEALGALLEFAYTATLTTSSANMPAVLQAARLLEI 130
Cdd:cd18204    66 SDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGI 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  16 HSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmgaggsgtatgGAGAGVCELDFVG 95
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKK-----------------DPSLQRVELNDIS 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1796386991  96 PEALGALLEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEIL 141
Cdd:cd18260    64 PLGLATVITYAYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796386991  16 HSSELLSCLNEQRQLGHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEggggavmgaggsgtaTGGAGAGVCELDFVG 95
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTE---------------KENESQSVFQLDFCE 65

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1796386991  96 PEALGALLEFAYTATLTTSSANMPAVLQAARLLEIP 131
Cdd:cd18209    66 PDAFENVLNYIYSSSLFVEKSSLAAVQELGYSLGIS 101