NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1774222082|ref|NP_001362993|]
View 

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 14 [Homo sapiens]

Protein Classification

PAS and HDc domain-containing protein( domain architecture ID 11654464)

protein containing domains PDE8, PAS, and HDc

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
564-811 4.19e-99

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 307.94  E-value: 4.19e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 564 YHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAF 643
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 644 QLtVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEgsdcecnpagKNFPENQILIK 723
Cdd:pfam00233  81 QI-LQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFL----------ENEEDRRLLLL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 724 RMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPvVMPVFDRN-TCSIPKSQISFIDYFITDMFDAW-DAF 801
Cdd:pfam00233 150 SMLIKAADISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLP-VSPLMDREkKTSLPKSQIGFIDFIVLPLFEALaKLF 228

                         250
                  ....*....|
gi 1774222082 802 AHLPALMQHL 811
Cdd:pfam00233 229 PELQPLLDQL 238
PDE8 super family cl07304
PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. ...
 1-47 3.01e-23

PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. It is found with pfam00233.


The actual alignment was detected with superfamily member pfam08629:

Pssm-ID: 400795  Cd Length: 52  Bit Score: 93.32  E-value: 3.01e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1774222082   1 MGCAPSIHVSQSGVIY--CRDSDESSSPRQT-TSVSQ--GPAAPLPGLFVQT 47
Cdd:pfam08629   1 MGCAPSIHISDSGVIYhsCKDSDDSSSPNQTnTSMSQqlGNAAPLPGLFIKS 52
NtrB super family cl34682
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
273-345 1.00e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG3852:

Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 54.85  E-value: 1.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDknrADLLDTINTCIKKGKIHKIHR 345
Cdd:COG3852    11 AILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPED---SPLRELLERALAEGQPVTERE 80
PleD super family cl34659
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 154-235 2.61e-03

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


The actual alignment was detected with superfamily member COG3706:

Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 39.51  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 154 RAGYRCNIARTPESALECFLDKHHEIIVIDHrQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASvlplLHAG 233
Cdd:COG3706    23 AAGYEVVEAADGEEALELLQEHRPDLILLDL-EMPDMDGLELCRRLRADPRTADIPIIFLTALDDEEDRARA----LEAG 97


                  ..
gi 1774222082 234 FN 235
Cdd:COG3706    98 AD 99
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
564-811 4.19e-99

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 307.94  E-value: 4.19e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 564 YHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAF 643
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 644 QLtVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEgsdcecnpagKNFPENQILIK 723
Cdd:pfam00233  81 QI-LQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFL----------ENEEDRRLLLL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 724 RMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPvVMPVFDRN-TCSIPKSQISFIDYFITDMFDAW-DAF 801
Cdd:pfam00233 150 SMLIKAADISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLP-VSPLMDREkKTSLPKSQIGFIDFIVLPLFEALaKLF 228

                         250
                  ....*....|
gi 1774222082 802 AHLPALMQHL 811
Cdd:pfam00233 229 PELQPLLDQL 238
PDE8 pfam08629
PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. ...
 1-47 3.01e-23

PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. It is found with pfam00233.


Pssm-ID: 400795  Cd Length: 52  Bit Score: 93.32  E-value: 3.01e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1774222082   1 MGCAPSIHVSQSGVIY--CRDSDESSSPRQT-TSVSQ--GPAAPLPGLFVQT 47
Cdd:pfam08629   1 MGCAPSIHISDSGVIYhsCKDSDDSSSPNQTnTSMSQqlGNAAPLPGLFIKS 52
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
273-345 1.00e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 54.85  E-value: 1.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDknrADLLDTINTCIKKGKIHKIHR 345
Cdd:COG3852    11 AILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPED---SPLRELLERALAEGQPVTERE 80
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 564-754 6.65e-07

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 49.65  E-value: 6.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 564 YHNSTHAADVLHATAFFLGKERvkgsLDQLDEVAALIAATVHDVDHPGRTNSFlcnagselavlYNDTAVLESHHTALAF 643
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 644 QLtvkdtkcnifknIDRNHYRTLRQAIIDMVLATEMtKHFEHVNKFvnsinkpmaaeiegsdcecnPAGKNFPENQILIK 723
Cdd:cd00077    66 EI------------LRELLLEEVIKLIDELILAVDA-SHHERLDGL--------------------GYPDGLKGEEITLE 112

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1774222082 724 RMMIKCADV--ANPCRPLDLCIEWAGRISEEYF 754
Cdd:cd00077   113 ARIVKLADRldALRRDSREKRRRIAEEDLEELL 145
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 273-317 8.99e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 43.93  E-value: 8.99e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1774222082  273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADL 317
Cdd:smart00091   5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLEL 49
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 275-360 2.76e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 43.94  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 275 LDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELAD-LPKSDknRADLLDTINTCIKKGKIHKIHRDSGDNSQT 353
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAElLPPED--AARLERALRRALEGEEPIDFLEELLLNGEE 78


                  ....*..
gi 1774222082 354 EPHSFRY 360
Cdd:pfam08448  79 RHYELRL 85
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 273-317 5.01e-05

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 43.43  E-value: 5.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADL 317
Cdd:TIGR00229   7 AIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLEL 51
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 562-660 1.25e-04

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 42.67  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082  562 NAYHNSTHAADVLHaTAFFLGKErvkgsLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELavlyndtavlesHHTAL 641
Cdd:smart00471   1 SDYHVFEHSLRVAQ-LAAALAEE-----LGLLDIELLLLAALLHDIGKPGTPDSFLVKTSVLE------------DHHFI 62

                           90
                   ....*....|....*....
gi 1774222082  642 AFQLTVKDTKCNIFKNIDR 660
Cdd:smart00471  63 GAEILLEEEEPRILEEILR 81
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 284-317 6.83e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 39.92  E-value: 6.83e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1774222082 284 ITSDDHVIQYVNPAFERMMGYHKGELLGKELADL 317
Cdd:cd00130     7 VLDLDGRILYANPAAEQLLGYSPEELIGKSLLDL 40
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 154-235 2.61e-03

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 39.51  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 154 RAGYRCNIARTPESALECFLDKHHEIIVIDHrQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASvlplLHAG 233
Cdd:COG3706    23 AAGYEVVEAADGEEALELLQEHRPDLILLDL-EMPDMDGLELCRRLRADPRTADIPIIFLTALDDEEDRARA----LEAG 97


                  ..
gi 1774222082 234 FN 235
Cdd:COG3706    98 AD 99
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
564-811 4.19e-99

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 307.94  E-value: 4.19e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 564 YHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAF 643
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 644 QLtVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEgsdcecnpagKNFPENQILIK 723
Cdd:pfam00233  81 QI-LQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFL----------ENEEDRRLLLL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 724 RMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPvVMPVFDRN-TCSIPKSQISFIDYFITDMFDAW-DAF 801
Cdd:pfam00233 150 SMLIKAADISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLP-VSPLMDREkKTSLPKSQIGFIDFIVLPLFEALaKLF 228

                         250
                  ....*....|
gi 1774222082 802 AHLPALMQHL 811
Cdd:pfam00233 229 PELQPLLDQL 238
PDE8 pfam08629
PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. ...
 1-47 3.01e-23

PDE8 phosphodiesterase; This region is found in members of the PDE8 phosphodiesterase family. It is found with pfam00233.


Pssm-ID: 400795  Cd Length: 52  Bit Score: 93.32  E-value: 3.01e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1774222082   1 MGCAPSIHVSQSGVIY--CRDSDESSSPRQT-TSVSQ--GPAAPLPGLFVQT 47
Cdd:pfam08629   1 MGCAPSIHISDSGVIYhsCKDSDDSSSPNQTnTSMSQqlGNAAPLPGLFIKS 52
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
273-345 1.00e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 54.85  E-value: 1.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDknrADLLDTINTCIKKGKIHKIHR 345
Cdd:COG3852    11 AILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPED---SPLRELLERALAEGQPVTERE 80
PAS COG2202
PAS domain [Signal transduction mechanisms];
273-365 1.26e-07

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 53.88  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLpKSDKNRADLLDTINTCIKKGkihkihrdsgdnsq 352
Cdd:COG2202    15 ALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDL-LPPEDDDEFLELLRAALAGG-------------- 79

                          90
                  ....*....|...
gi 1774222082 353 tEPHSFRYKNRRK 365
Cdd:COG2202    80 -GVWRGELRNRRK 91
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 564-754 6.65e-07

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 49.65  E-value: 6.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 564 YHNSTHAADVLHATAFFLGKERvkgsLDQLDEVAALIAATVHDVDHPGRTNSFlcnagselavlYNDTAVLESHHTALAF 643
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 644 QLtvkdtkcnifknIDRNHYRTLRQAIIDMVLATEMtKHFEHVNKFvnsinkpmaaeiegsdcecnPAGKNFPENQILIK 723
Cdd:cd00077    66 EI------------LRELLLEEVIKLIDELILAVDA-SHHERLDGL--------------------GYPDGLKGEEITLE 112

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1774222082 724 RMMIKCADV--ANPCRPLDLCIEWAGRISEEYF 754
Cdd:cd00077   113 ARIVKLADRldALRRDSREKRRRIAEEDLEELL 145
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 273-317 8.99e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 43.93  E-value: 8.99e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1774222082  273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADL 317
Cdd:smart00091   5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLEL 49
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 273-352 2.70e-05

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 47.46  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKnradLLDTINTciKKGKIHKIHRDSGDNSQ 352
Cdd:COG3829    15 AILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSP----LLEVLKT--GKPVTGVIQKTGGKGKT 88
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 275-360 2.76e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 43.94  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 275 LDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELAD-LPKSDknRADLLDTINTCIKKGKIHKIHRDSGDNSQT 353
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAElLPPED--AARLERALRRALEGEEPIDFLEELLLNGEE 78


                  ....*..
gi 1774222082 354 EPHSFRY 360
Cdd:pfam08448  79 RHYELRL 85
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 288-350 4.45e-05

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 42.83  E-value: 4.45e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222082 288 DHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKIHKIHRDSGDN 350
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALREGKAVREFEVVLYRKDGE 63
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 273-317 5.01e-05

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 43.43  E-value: 5.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADL 317
Cdd:TIGR00229   7 AIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLEL 51
PAS COG2202
PAS domain [Signal transduction mechanisms];
260-339 1.10e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 44.63  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 260 RSQFKLRAcnsvftALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPkSDKNRADLLDTINTCIKKGK 339
Cdd:COG2202   134 ESEERLRL------LVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLL-HPEDRERLLELLRRLLEGGR 206
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 562-660 1.25e-04

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 42.67  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082  562 NAYHNSTHAADVLHaTAFFLGKErvkgsLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELavlyndtavlesHHTAL 641
Cdd:smart00471   1 SDYHVFEHSLRVAQ-LAAALAEE-----LGLLDIELLLLAALLHDIGKPGTPDSFLVKTSVLE------------DHHFI 62

                           90
                   ....*....|....*....
gi 1774222082  642 AFQLTVKDTKCNIFKNIDR 660
Cdd:smart00471  63 GAEILLEEEEPRILEEILR 81
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 284-317 6.83e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 39.92  E-value: 6.83e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1774222082 284 ITSDDHVIQYVNPAFERMMGYHKGELLGKELADL 317
Cdd:cd00130     7 VLDLDGRILYANPAAEQLLGYSPEELIGKSLLDL 40
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 273-330 7.41e-04

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 40.09  E-value: 7.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADL--PKSDKNRADLLDT 330
Cdd:pfam00989   5 AILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLipEEDDAEVAELLRQ 64
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 275-375 7.73e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 43.04  E-value: 7.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 275 LDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRadLLDTINTCIKKGKihkihrdsgdnsQTE 354
Cdd:COG5809    21 FENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEK--ELREILKLLKEGE------------SRD 86

                          90       100
                  ....*....|....*....|.
gi 1774222082 355 PHSFRYKNRRKESIDVKSISS 375
Cdd:COG5809    87 ELEFELRHKNGKRLEFSSKLS 107
PAS_8 pfam13188
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...
 273-332 1.08e-03

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463802 [Multi-domain]  Cd Length: 65  Bit Score: 38.30  E-value: 1.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1774222082 273 TALDHCHEAIEITSDDHVIQYVNPAFERMMGY-HKGELLGKELADLPKSDKNRADLLDTIN 332
Cdd:pfam13188   5 ALFESSPDGILVLDEGGRIIYVNPAALELLGYeLLGELLGELLDLLDPLLEDALELLRELR 65
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 154-235 2.61e-03

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 39.51  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 154 RAGYRCNIARTPESALECFLDKHHEIIVIDHrQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASvlplLHAG 233
Cdd:COG3706    23 AAGYEVVEAADGEEALELLQEHRPDLILLDL-EMPDMDGLELCRRLRADPRTADIPIIFLTALDDEEDRARA----LEAG 97


                  ..
gi 1774222082 234 FN 235
Cdd:COG3706    98 AD 99
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 125-224 6.63e-03

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 38.99  E-value: 6.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222082 125 MRLTQDPiQVLLIfakEDSQS--DGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTqNFDAEAVCRSIRAT 202
Cdd:COG3437     1 MRTGQAP-TVLIV---DDDPEnlELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMP-GMDGFELLRLLRAD 75

                          90       100
                  ....*....|....*....|..
gi 1774222082 203 NPSEHTVILAVVSRVSDDHEEA 224
Cdd:COG3437    76 PSTRDIPVIFLTALADPEDRER 97
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 293-365 7.38e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 36.55  E-value: 7.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774222082 293 YVNPAFERMMGYHKGELLGK--ELADLPKSDkNRADLLDTINTCIKKGkihkihrdsgdnsqtEPHSFRYKNRRK 365
Cdd:pfam08447   3 YWSPRFEEILGYTPEELLGKgeSWLDLVHPD-DRERVREALWEALKGG---------------EPYSGEYRIRRK 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH