NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1772677996|ref|NP_001362780|]
View 

sodium/potassium/calcium exchanger 2 isoform 2 [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 115-644 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 727.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLI 194
Cdd:TIGR00927  437 HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLI 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  195 GVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYF 274
Cdd:TIGR00927  517 GVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYA 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  275 CYVVFMKFNVQVEKWVKQMINRNKVVKVTAPE-------AQAKPSAARDKDE---PTLPAKPRLQRGGSSASL------- 337
Cdd:TIGR00927  597 LYVFTMKWNKQIELWVKEQLSRRPVAKVMALGdlskgdvAEAEHTGERTGEEgerPTEAEGENGEESGGEAEQegetetk 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  338 --------------------------HNSLMRNSIFQLMIHTLDPLAEGRFREKASILHKIAKKKCHVDENERQNGAANH 391
Cdd:TIGR00927  677 genesegeipaerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVE 756

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  392 VE----KIELPNSTST---------------DVEM----------------------------------------TPSSD 412
Cdd:TIGR00927  757 TEgdrkETEHEGETEAegkededegeiqageDGEMkgdegaegkvehegeteagekdehegqsetqaddtevkdeTGEQE 836

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  413 ASEPVQ----------------NGNLSHNIEGAEAQTADEEED------------QPLSLAWPSETRKQVTFLIVFPIVF 464
Cdd:TIGR00927  837 LNAENQgeakqdekgvdggggsDGGDSEEEEEEEEEEEEEEEEeeeeeeeeeeneEPLSLEWPETRQKQAIYLFLLPIVF 916

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  465 PLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 544
Cdd:TIGR00927  917 PLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 996

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  545 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 624
Cdd:TIGR00927  997 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYF 1076

                          650       660
                   ....*....|....*....|
gi 1772677996  625 VFLVVSVLLEDRILTCPVSI 644
Cdd:TIGR00927 1077 VFLIISVMLEDRIISCPVSV 1096
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 115-644 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 727.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLI 194
Cdd:TIGR00927  437 HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLI 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  195 GVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYF 274
Cdd:TIGR00927  517 GVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYA 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  275 CYVVFMKFNVQVEKWVKQMINRNKVVKVTAPE-------AQAKPSAARDKDE---PTLPAKPRLQRGGSSASL------- 337
Cdd:TIGR00927  597 LYVFTMKWNKQIELWVKEQLSRRPVAKVMALGdlskgdvAEAEHTGERTGEEgerPTEAEGENGEESGGEAEQegetetk 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  338 --------------------------HNSLMRNSIFQLMIHTLDPLAEGRFREKASILHKIAKKKCHVDENERQNGAANH 391
Cdd:TIGR00927  677 genesegeipaerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVE 756

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  392 VE----KIELPNSTST---------------DVEM----------------------------------------TPSSD 412
Cdd:TIGR00927  757 TEgdrkETEHEGETEAegkededegeiqageDGEMkgdegaegkvehegeteagekdehegqsetqaddtevkdeTGEQE 836

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  413 ASEPVQ----------------NGNLSHNIEGAEAQTADEEED------------QPLSLAWPSETRKQVTFLIVFPIVF 464
Cdd:TIGR00927  837 LNAENQgeakqdekgvdggggsDGGDSEEEEEEEEEEEEEEEEeeeeeeeeeeneEPLSLEWPETRQKQAIYLFLLPIVF 916

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  465 PLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 544
Cdd:TIGR00927  917 PLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 996

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  545 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 624
Cdd:TIGR00927  997 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYF 1076

                          650       660
                   ....*....|....*....|
gi 1772677996  625 VFLVVSVLLEDRILTCPVSI 644
Cdd:TIGR00927 1077 VFLIISVMLEDRIISCPVSV 1096
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
155-629 2.96e-42

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 154.52  E-value: 2.96e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 155 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 234
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMkfnvqvekwvkqminrnkvvkvtapeaqakpsaa 314
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 315 rdkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaegrfrekasilhkiakkkchvdenerqngaanhvek 394
Cdd:COG0530       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 395 ielpnststdvemtpssdasepvqngnlshnIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVfpivfplwitlpdvr 474
Cdd:COG0530   126 -------------------------------IRRARKEPAWEEVEEELEEKPKMSLWKALLLLVL--------------- 159

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 475 kpssrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGS 554
Cdd:COG0530   160 --------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGS 225

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1772677996 555 NIFDITVGLPLPWLlytvihrFQPVAVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMNKILGFIMFGLYFVFLVV 629
Cdd:COG0530   226 NIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 138-282 3.35e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 118.86  E-value: 3.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 138 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 217
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1772677996 218 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKF 282
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 512-629 1.15e-14

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.45  E-value: 1.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 512 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNglfcaiv 591
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISP--GEINPLAFSRD------- 275

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1772677996 592 lLFIMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 629
Cdd:PRK10734  276 -YWVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 115-644 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 727.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLI 194
Cdd:TIGR00927  437 HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLI 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  195 GVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYF 274
Cdd:TIGR00927  517 GVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYA 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  275 CYVVFMKFNVQVEKWVKQMINRNKVVKVTAPE-------AQAKPSAARDKDE---PTLPAKPRLQRGGSSASL------- 337
Cdd:TIGR00927  597 LYVFTMKWNKQIELWVKEQLSRRPVAKVMALGdlskgdvAEAEHTGERTGEEgerPTEAEGENGEESGGEAEQegetetk 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  338 --------------------------HNSLMRNSIFQLMIHTLDPLAEGRFREKASILHKIAKKKCHVDENERQNGAANH 391
Cdd:TIGR00927  677 genesegeipaerkgeqegegeieakEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVE 756

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  392 VE----KIELPNSTST---------------DVEM----------------------------------------TPSSD 412
Cdd:TIGR00927  757 TEgdrkETEHEGETEAegkededegeiqageDGEMkgdegaegkvehegeteagekdehegqsetqaddtevkdeTGEQE 836

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  413 ASEPVQ----------------NGNLSHNIEGAEAQTADEEED------------QPLSLAWPSETRKQVTFLIVFPIVF 464
Cdd:TIGR00927  837 LNAENQgeakqdekgvdggggsDGGDSEEEEEEEEEEEEEEEEeeeeeeeeeeneEPLSLEWPETRQKQAIYLFLLPIVF 916

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  465 PLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 544
Cdd:TIGR00927  917 PLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 996

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  545 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 624
Cdd:TIGR00927  997 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYF 1076

                          650       660
                   ....*....|....*....|
gi 1772677996  625 VFLVVSVLLEDRILTCPVSI 644
Cdd:TIGR00927 1077 VFLIISVMLEDRIISCPVSV 1096
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 137-626 2.12e-92

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 288.07  E-value: 2.12e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 137 LHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNI 216
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 217 LFVIGMCALFSrEILNLTWWpLFRDVSFYIVDLIMLIIFFLDNVimwWESLLLLTAYFCYVVFMKFNVQVEKWVKQminr 296
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQ---ISRIDGVVLLILYIVYLLFLVKNERWVKY---- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 297 nkvvkvtapeaqakpsaardkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaEGRFREkasilhkiakkk 376
Cdd:TIGR00367 152 --------------------------------------------------------------DTYTEE------------ 157

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 377 cHVDENERqngaanhvekielpnststdvemtpssdasepvqngnlshniegaeaqtadeeedqplslawpsetRKQVTF 456
Cdd:TIGR00367 158 -NLDENNR------------------------------------------------------------------RPQIFF 170

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 457 LIVFPIVFplwitlpdvrkpssrkffpitffgsITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSV 536
Cdd:TIGR00367 171 SLVLLIIG-------------------------LIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSL 225

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 537 IVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNGLFCAIVLLFIMLLFVIlSIALCKWrmnkiLG 616
Cdd:TIGR00367 226 AAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMP--IPVEPLAYNLDAPVMVIVTLLLMLFFKT-SMKLGRW-----EG 297

                         490
                  ....*....|
gi 1772677996 617 FIMFGLYFVF 626
Cdd:TIGR00367 298 ILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
155-629 2.96e-42

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 154.52  E-value: 2.96e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 155 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 234
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMkfnvqvekwvkqminrnkvvkvtapeaqakpsaa 314
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 315 rdkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaegrfrekasilhkiakkkchvdenerqngaanhvek 394
Cdd:COG0530       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 395 ielpnststdvemtpssdasepvqngnlshnIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVfpivfplwitlpdvr 474
Cdd:COG0530   126 -------------------------------IRRARKEPAWEEVEEELEEKPKMSLWKALLLLVL--------------- 159

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 475 kpssrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGS 554
Cdd:COG0530   160 --------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGS 225

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1772677996 555 NIFDITVGLPLPWLlytvihrFQPVAVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMNKILGFIMFGLYFVFLVV 629
Cdd:COG0530   226 NIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 138-282 3.35e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 118.86  E-value: 3.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 138 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 217
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1772677996 218 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKF 282
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 481-632 3.19e-29

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 113.08  E-value: 3.19e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 481 FFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 560
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1772677996 561 VGLPLPWLLYTVIHRFQPVAVSSnGLFCAIVLLFIMLLFVILSIALckWRMNKILGFIMFGLYFVFLVVSVL 632
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDL-GVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
114-280 1.80e-21

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 95.20  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 114 DHAQGDYPKDIFSLEERRKGAIILHVIGMIymfiALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSL 193
Cdd:COG0530   132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 194 IGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLTWWPLFRDVSFYIVDLIMLIIFFL-DNVIMWWESLLLLTA 272
Cdd:COG0530   208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285


                  ....*...
gi 1772677996 273 YFCYVVFM 280
Cdd:COG0530   286 YLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
504-636 1.74e-17

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 83.26  E-value: 1.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 504 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYtvihrfqPVAVSS 583
Cdd:COG0530     8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-------PLAVDR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1772677996 584 NGLFCAI-VLLFIMLLFVILSIALckwRMNKILGFIMFGLYFVFLVVSVLLEDR 636
Cdd:COG0530    81 RVLRRDLpFLLLASLLLLALLLDG---TLSRIDGVILLLLYVLYLYYLIRRARK 131
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 103-276 4.17e-15

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 76.59  E-value: 4.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 103 LSKEGESENSTDHAQGDYPKDIFSLEerrkgAIILHVIGMIYMFIALAIvcdefFVPSLTVITEKLGISDDVAGATFMAA 182
Cdd:TIGR00367 145 NERWVKYDTYTEENLDENNRRPQIFF-----SLVLLIIGLIGLVVGSRL-----LVDGAVKIAEILGISEKIIGLTLLAI 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 183 GGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSR-EILNLTwwpLFRDVSF-YIVDLIMLIIFFLDNV 260
Cdd:TIGR00367 215 GTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPiPVEPLA---YNLDAPVmVIVTLLLMLFFKTSMK 291

                         170
                  ....*....|....*.
gi 1772677996 261 IMWWESLLLLTAYFCY 276
Cdd:TIGR00367 292 LGRWEGILLLALYIAY 307
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 76-380 4.32e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 79.07  E-value: 4.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  76 PRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGD----------YPKDIfSLEERRKGAIILHVIgMIYM 145
Cdd:TIGR00845   8 PLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYckegvilpiwEPQNP-SVGDKIARATVYFVA-MVYM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 146 FIALAIVCDEFfVPSLTVITEK-----------------LGI-SDDVAGATFMAAGGSAPELFTSLIGV----FIAhSNV 203
Cdd:TIGR00845  86 FLGVSIIADRF-MASIEVITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA-GDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 204 GIGTIVGSAVFNILFVIGMCALF-----SREILNL------TWWPLFRDVSFYIVdlimlIIFFLDNVIMWWESLLLLTA 272
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVipdgeTRKIKHLrvffvtAAWSVFAYVWLYLI-----LAVFSPGVVEVWEGLLTFFF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 273 YFCYVVFmkfnvqveKWV--KQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGgssasLHNSLMRNSIFQLM 350
Cdd:TIGR00845 239 FPLCVVF--------AWVadRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGK-----MVNSHVDNFLDGAL 305

                         330       340       350
                  ....*....|....*....|....*....|
gi 1772677996 351 IHTLDPLAEGRfREKASILHKIAKKKCHVD 380
Cdd:TIGR00845 306 VLEVKEFDEAR-REMIRILKELKQKHPDKD 334
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 512-629 1.15e-14

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.45  E-value: 1.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 512 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNglfcaiv 591
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISP--GEINPLAFSRD------- 275

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1772677996 592 lLFIMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 629
Cdd:PRK10734  276 -YWVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 507-634 7.87e-13

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 69.66  E-value: 7.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 507 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytvihrFQPVAVSSNGL 586
Cdd:TIGR00367  28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAI-------FSPIIVDKDWL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1772677996 587 FCAIvlLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLE 634
Cdd:TIGR00367 101 RRDI--LFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNE 146
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 140-631 2.43e-11

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 66.71  E-value: 2.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 140 IGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSlIGVFIAHS--NVGIGTIVGSAVFNIL 217
Cdd:PLN03151  145 VWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLGGAVFVTC 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 218 FVIGMCAL-FSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMinR 296
Cdd:PLN03151  224 VVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRL--K 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 297 NKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSL---MRNSifQLMIHTLDPLAEGRFREKASILHKIa 373
Cdd:PLN03151  302 LDVVTPLLPVQGSIFSPSVEEDESMYSPLLESDTESDVPRLQTSLpqwMWAS--NVAIYSNHFAKGSVHDEERPPWGWT- 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 374 kkkchvDENERQNGAANHVEK----IELPnststdveMTPSSDASEP-VQNGNLSHNIEGAEAQTAdeeedqPLSLA--W 446
Cdd:PLN03151  379 ------DEGAEVESSLFSCSKlfslLEMP--------LTIPRRLTIPiVEEDRWSKTYAVASASLA------PVLLAflW 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 447 -----PSETRKQVTFLIVFPIVFPLWI-----TLPDvrKPSSRKFFPIT---FFGSITWIAVFSYLMVWWAHQVGETIGI 513
Cdd:PLN03151  439 ssqddVSLQARIAAYFIGVAIGSTLGFlaykyTEPD--RPPRRFLIPWVlggFIMSIVWFYMIANELVALLVAFGVIFGI 516

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 514 SEEIMGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAV-SSNGLFCA 589
Cdd:PLN03151  517 NPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLpEDSSLFYT 595

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1772677996 590 IVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSV 631
Cdd:PLN03151  596 MGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 139-227 7.74e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 60.82  E-value: 7.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 139 VIGMIYMFIALAIVCDeffvpSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 218
Cdd:PRK10734  180 GIALIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254


                  ....*....
gi 1772677996 219 VIGMCALFS 227
Cdd:PRK10734  255 VLGLPALIS 263
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 500-614 1.72e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 53.50  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 500 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytvihrfQPV 579
Cdd:PRK10734   22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALI-------RPF 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1772677996 580 AVSSN------------GLFCAIVLLFIML-----LFVILSIALCKWRMNKI 614
Cdd:PRK10734   95 TVHSDvlrrelplmllvSVLAGSVLYDGQLsrsdgIFLLLLAVLWLLFIVKI 146
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 105-287 3.31e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 50.38  E-value: 3.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  105 KEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIY-MFIALAIV----CDEFFVPS-------------LTV--- 163
Cdd:TIGR00927  877 EEEEEEEEEEEEENEEPLSLEWPETRQKQAIYLFLLPIVFpLWLTVPDVrrqeARKFFVITflgsimwiamfsyLMVwwa 956

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996  164 --ITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRD 241
Cdd:TIGR00927  957 hqVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSN 1036

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1772677996  242 VSFYIVDLIMLIIFFLDNVIM---W-WESLLLLTAYFCYVVFMKFNVQVE 287
Cdd:TIGR00927 1037 GLFCAIVLLFLMLLFVISSIAsckWrMNKILGFTMFLLYFVFLIISVMLE 1086
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 485-616 1.54e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 48.25  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677996 485 TFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGL 563
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1772677996 564 PLPWLLYTVIHRFQ--PVAVSSNGLFCAiVLLFIMLLFVILSIALCkwRMNKILG 616
Cdd:TIGR00845 838 GVAWSIAAIYHAANgtQFKVSPGTLAFS-VTLFTIFAFICIGVLLY--RRRPEIG 889
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH