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Conserved domains on  [gi|1772677818|ref|NP_001362779|]
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sodium/potassium/calcium exchanger 2 isoform 1 [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 115-661 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 732.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLI 194
Cdd:TIGR00927  437 HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLI 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  195 GVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYF 274
Cdd:TIGR00927  517 GVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYA 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  275 CYVVFMKFNVQVEKWVKQMINRNKVVKVTAPE-------AQAKPSAARDKDE---PTLPAKPRLQRGGSSASL------- 337
Cdd:TIGR00927  597 LYVFTMKWNKQIELWVKEQLSRRPVAKVMALGdlskgdvAEAEHTGERTGEEgerPTEAEGENGEESGGEAEQegetetk 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  338 -----------------------------HNSLMRNSIFQLMIHTLDPLAE-----ELGSYGKLKYYDTMTE-------- 375
Cdd:TIGR00927  677 genesegeipaerkgeqegegeieakeadHKGETEAEEVEHEGETEAEGTEdegeiETGEEGEEVEDEGEGEaegkheve 756

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  376 -----------------------EGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEM---TPSSD 429
Cdd:TIGR00927  757 tegdrketehegeteaegkededEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVkdeTGEQE 836

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  430 ASEPVQ----------------NGNLSHNIEGAEAQTADEEED------------QPLSLAWPSETRKQVTFLIVFPIVF 481
Cdd:TIGR00927  837 LNAENQgeakqdekgvdggggsDGGDSEEEEEEEEEEEEEEEEeeeeeeeeeeneEPLSLEWPETRQKQAIYLFLLPIVF 916

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  482 PLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 561
Cdd:TIGR00927  917 PLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 996

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 641
Cdd:TIGR00927  997 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYF 1076

                          650       660
                   ....*....|....*....|
gi 1772677818  642 VFLVVSVLLEDRILTCPVSI 661
Cdd:TIGR00927 1077 VFLIISVMLEDRIISCPVSV 1096
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 115-661 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 732.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLI 194
Cdd:TIGR00927  437 HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLI 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  195 GVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYF 274
Cdd:TIGR00927  517 GVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYA 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  275 CYVVFMKFNVQVEKWVKQMINRNKVVKVTAPE-------AQAKPSAARDKDE---PTLPAKPRLQRGGSSASL------- 337
Cdd:TIGR00927  597 LYVFTMKWNKQIELWVKEQLSRRPVAKVMALGdlskgdvAEAEHTGERTGEEgerPTEAEGENGEESGGEAEQegetetk 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  338 -----------------------------HNSLMRNSIFQLMIHTLDPLAE-----ELGSYGKLKYYDTMTE-------- 375
Cdd:TIGR00927  677 genesegeipaerkgeqegegeieakeadHKGETEAEEVEHEGETEAEGTEdegeiETGEEGEEVEDEGEGEaegkheve 756

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  376 -----------------------EGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEM---TPSSD 429
Cdd:TIGR00927  757 tegdrketehegeteaegkededEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVkdeTGEQE 836

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  430 ASEPVQ----------------NGNLSHNIEGAEAQTADEEED------------QPLSLAWPSETRKQVTFLIVFPIVF 481
Cdd:TIGR00927  837 LNAENQgeakqdekgvdggggsDGGDSEEEEEEEEEEEEEEEEeeeeeeeeeeneEPLSLEWPETRQKQAIYLFLLPIVF 916

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  482 PLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 561
Cdd:TIGR00927  917 PLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 996

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 641
Cdd:TIGR00927  997 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYF 1076

                          650       660
                   ....*....|....*....|
gi 1772677818  642 VFLVVSVLLEDRILTCPVSI 661
Cdd:TIGR00927 1077 VFLIISVMLEDRIISCPVSV 1096
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
155-646 1.58e-40

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 149.90  E-value: 1.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 155 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 234
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMkfnvqvekwvkqminrnkvvkvtapeaqakpsaa 314
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 315 rdkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkyydtmteegrfrekasilhkiakkkc 394
Cdd:COG0530       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 395 hvdenerqngaanhvekielpnststdvemtpssdasepvqngnlshnIEGAEAQTADEEEDQPLSLAWPSETRKQVTFL 474
Cdd:COG0530   126 ------------------------------------------------IRRARKEPAWEEVEEELEEKPKMSLWKALLLL 157

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 475 IVfpivfplwitlpdvrkpssrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVI 554
Cdd:COG0530   158 VL-----------------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIV 208

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 555 VARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytvihrFQPVAVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMNKILG 633
Cdd:COG0530   209 AARKGEDDLAVGNIIGSNIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIGRWEG 279

                         490
                  ....*....|...
gi 1772677818 634 FIMFGLYFVFLVV 646
Cdd:COG0530   280 LLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 138-282 1.20e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 120.01  E-value: 1.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 138 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 217
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1772677818 218 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKF 282
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 529-646 8.07e-15

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.84  E-value: 8.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 529 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNglfcaiv 608
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISP--GEINPLAFSRD------- 275

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1772677818 609 lLFIMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 646
Cdd:PRK10734  276 -YWVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 115-661 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 732.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLI 194
Cdd:TIGR00927  437 HPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLI 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  195 GVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYF 274
Cdd:TIGR00927  517 GVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYA 596

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  275 CYVVFMKFNVQVEKWVKQMINRNKVVKVTAPE-------AQAKPSAARDKDE---PTLPAKPRLQRGGSSASL------- 337
Cdd:TIGR00927  597 LYVFTMKWNKQIELWVKEQLSRRPVAKVMALGdlskgdvAEAEHTGERTGEEgerPTEAEGENGEESGGEAEQegetetk 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  338 -----------------------------HNSLMRNSIFQLMIHTLDPLAE-----ELGSYGKLKYYDTMTE-------- 375
Cdd:TIGR00927  677 genesegeipaerkgeqegegeieakeadHKGETEAEEVEHEGETEAEGTEdegeiETGEEGEEVEDEGEGEaegkheve 756

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  376 -----------------------EGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEM---TPSSD 429
Cdd:TIGR00927  757 tegdrketehegeteaegkededEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVkdeTGEQE 836

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  430 ASEPVQ----------------NGNLSHNIEGAEAQTADEEED------------QPLSLAWPSETRKQVTFLIVFPIVF 481
Cdd:TIGR00927  837 LNAENQgeakqdekgvdggggsDGGDSEEEEEEEEEEEEEEEEeeeeeeeeeeneEPLSLEWPETRQKQAIYLFLLPIVF 916

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  482 PLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 561
Cdd:TIGR00927  917 PLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG 996

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 641
Cdd:TIGR00927  997 DMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYF 1076

                          650       660
                   ....*....|....*....|
gi 1772677818  642 VFLVVSVLLEDRILTCPVSI 661
Cdd:TIGR00927 1077 VFLIISVMLEDRIISCPVSV 1096
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 137-643 3.44e-93

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 290.38  E-value: 3.44e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 137 LHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNI 216
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 217 LFVIGMCALFSrEILNLTWWpLFRDVSFYIVDLIMLIIFFLDNVimwWESLLLLTAYFCYVVFMKFNVQVEKWVKqminr 296
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQ---ISRIDGVVLLILYIVYLLFLVKNERWVK----- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 297 nkvvkvtapeaqakpsaardkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkyYDTMTEE 376
Cdd:TIGR00367 151 -------------------------------------------------------------------------YDTYTEE 157

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 377 grfrekasilhkiakkkcHVDENERqngaanhvekielpnststdvemtpssdasepvqngnlshniegaeaqtadeeed 456
Cdd:TIGR00367 158 ------------------NLDENNR------------------------------------------------------- 164

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 457 qplslawpsetRKQVTFLIVFPIVFplwitlpdvrkpssrkffpitffgsITWIAVFSYLMVWWAHQVGETIGISEEIMG 536
Cdd:TIGR00367 165 -----------RPQIFFSLVLLIIG-------------------------LIGLVVGSRLLVDGAVKIAEILGISEKIIG 208

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 537 LTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNGLFCAIVLLFIMLLF 616
Cdd:TIGR00367 209 LTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMP--IPVEPLAYNLDAPVMVIVTLLLMLFF 286

                         490       500
                  ....*....|....*....|....*..
gi 1772677818 617 VIlSIALCKWrmnkiLGFIMFGLYFVF 643
Cdd:TIGR00367 287 KT-SMKLGRW-----EGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
155-646 1.58e-40

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 149.90  E-value: 1.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 155 EFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLT 234
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMkfnvqvekwvkqminrnkvvkvtapeaqakpsaa 314
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 315 rdkdeptlpakprlqrggssaslhnslmrnsifqlmihtldplaeelgsygklkyydtmteegrfrekasilhkiakkkc 394
Cdd:COG0530       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 395 hvdenerqngaanhvekielpnststdvemtpssdasepvqngnlshnIEGAEAQTADEEEDQPLSLAWPSETRKQVTFL 474
Cdd:COG0530   126 ------------------------------------------------IRRARKEPAWEEVEEELEEKPKMSLWKALLLL 157

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 475 IVfpivfplwitlpdvrkpssrkffpitffgSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVI 554
Cdd:COG0530   158 VL-----------------------------GLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIV 208

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 555 VARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytvihrFQPVAVSSNGL-FCAIVLLFIMLLFVILSIAlcKWRMNKILG 633
Cdd:COG0530   209 AARKGEDDLAVGNIIGSNIFNILLVLGIGAL-------ITPIPVDPAVLsFDLPVMLAATLLLLGLLRT--GGRIGRWEG 279

                         490
                  ....*....|...
gi 1772677818 634 FIMFGLYFVFLVV 646
Cdd:COG0530   280 LLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 138-282 1.20e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 120.01  E-value: 1.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 138 HVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 217
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1772677818 218 FVIGMCALFSREILNLTW----WPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKF 282
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 498-649 1.14e-29

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 114.62  E-value: 1.14e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 498 FFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 577
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1772677818 578 VGLPLPWLLYTVIHRFQPVAVSSnGLFCAIVLLFIMLLFVILSIALckWRMNKILGFIMFGLYFVFLVVSVL 649
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDL-GVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
114-280 9.31e-22

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 95.97  E-value: 9.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 114 DHAQGDYPKDIFSLEERRKGAIILHVIGMIymfiALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSL 193
Cdd:COG0530   132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 194 IGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSReiLNLTWWPLFRDVSFYIVDLIMLIIFFL-DNVIMWWESLLLLTA 272
Cdd:COG0530   208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285


                  ....*...
gi 1772677818 273 YFCYVVFM 280
Cdd:COG0530   286 YLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
521-653 1.01e-17

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 84.03  E-value: 1.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 521 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYtvihrfqPVAVSS 600
Cdd:COG0530     8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-------PLAVDR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1772677818 601 NGLFCAI-VLLFIMLLFVILSIALckwRMNKILGFIMFGLYFVFLVVSVLLEDR 653
Cdd:COG0530    81 RVLRRDLpFLLLASLLLLALLLDG---TLSRIDGVILLLLYVLYLYYLIRRARK 131
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 103-276 2.66e-15

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 76.98  E-value: 2.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 103 LSKEGESENSTDHAQGDYPKDIFSLEerrkgAIILHVIGMIYMFIALAIvcdefFVPSLTVITEKLGISDDVAGATFMAA 182
Cdd:TIGR00367 145 NERWVKYDTYTEENLDENNRRPQIFF-----SLVLLIIGLIGLVVGSRL-----LVDGAVKIAEILGISEKIIGLTLLAI 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 183 GGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSR-EILNLTwwpLFRDVSF-YIVDLIMLIIFFLDNV 260
Cdd:TIGR00367 215 GTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPiPVEPLA---YNLDAPVmVIVTLLLMLFFKTSMK 291

                         170
                  ....*....|....*.
gi 1772677818 261 IMWWESLLLLTAYFCY 276
Cdd:TIGR00367 292 LGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 529-646 8.07e-15

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 75.84  E-value: 8.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 529 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTviHRFQPVAVSSNglfcaiv 608
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISP--GEINPLAFSRD------- 275

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1772677818 609 lLFIMLLFVILSIALC---KWRMNKILGFIMFGLYFVFLVV 646
Cdd:PRK10734  276 -YWVMLLVSVIFALLCwrrKRRIGRGAGALLLGGFIVWLAM 315
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 76-279 1.25e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 77.52  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  76 PRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGD----------YPKDIfSLEERRKGAIILHVIgMIYM 145
Cdd:TIGR00845   8 PLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYckegvilpiwEPQNP-SVGDKIARATVYFVA-MVYM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 146 FIALAIVCDEFfVPSLTVITEK-----------------LGI-SDDVAGATFMAAGGSAPELFTSLIGV----FIAhSNV 203
Cdd:TIGR00845  86 FLGVSIIADRF-MASIEVITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA-GDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 204 GIGTIVGSAVFNILFVIGMCALF-----SREILNL------TWWPLFRDVSFYIVdlimlIIFFLDNVIMWWESLLLLTA 272
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVipdgeTRKIKHLrvffvtAAWSVFAYVWLYLI-----LAVFSPGVVEVWEGLLTFFF 238


                  ....*..
gi 1772677818 273 YFCYVVF 279
Cdd:TIGR00845 239 FPLCVVF 245
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 524-651 5.31e-13

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 70.43  E-value: 5.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 524 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLlytvihrFQPVAVSSNGL 603
Cdd:TIGR00367  28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAI-------FSPIIVDKDWL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1772677818 604 FCAIvlLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLE 651
Cdd:TIGR00367 101 RRDI--LFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNE 146
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 140-648 3.53e-10

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 63.24  E-value: 3.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 140 IGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSlIGVFIAHS--NVGIGTIVGSAVFNIL 217
Cdd:PLN03151  145 VWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLGGAVFVTC 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 218 FVIGMCAL-FSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMinR 296
Cdd:PLN03151  224 VVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRL--K 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 297 NKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMrnsifQLMihtldpLAEELGSYGKLKYYDTMTEE 376
Cdd:PLN03151  302 LDVVTPLLPVQGSIFSPSVEEDESMYSPLLESDTESDVPRLQTSLP-----QWM------WASNVAIYSNHFAKGSVHDE 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 377 GRFREKASilhkiakkkchvDENERQNGAANHVEK----IELPnststdveMTPSSDASEP-VQNGNLSHNIEGAEAQTA 451
Cdd:PLN03151  371 ERPPWGWT------------DEGAEVESSLFSCSKlfslLEMP--------LTIPRRLTIPiVEEDRWSKTYAVASASLA 430

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 452 deeedqPLSLA--W-----PSETRKQVTFLIVFPIVFPLWI-----TLPDvrKPSSRKFFPIT---FFGSITWIAVFSYL 516
Cdd:PLN03151  431 ------PVLLAflWssqddVSLQARIAAYFIGVAIGSTLGFlaykyTEPD--RPPRRFLIPWVlggFIMSIVWFYMIANE 502

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 517 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDITVGLPLPWLLYTVIHRF 593
Cdd:PLN03151  503 LVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSP 581

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1772677818 594 QPVAV-SSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSV 648
Cdd:PLN03151  582 ESYMLpEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 139-227 6.41e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.20  E-value: 6.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 139 VIGMIYMFIALAIVCDeffvpSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 218
Cdd:PRK10734  180 GIALIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254


                  ....*....
gi 1772677818 219 VIGMCALFS 227
Cdd:PRK10734  255 VLGLPALIS 263
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 517-631 1.40e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 53.88  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 517 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLytvihrfQPV 596
Cdd:PRK10734   22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALI-------RPF 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1772677818 597 AVSSN------------GLFCAIVLLFIML-----LFVILSIALCKWRMNKI 631
Cdd:PRK10734   95 TVHSDvlrrelplmllvSVLAGSVLYDGQLsrsdgIFLLLLAVLWLLFIVKI 146
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 105-287 3.84e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 50.38  E-value: 3.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  105 KEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIY-MFIALAIV----CDEFFVPS-------------LTV--- 163
Cdd:TIGR00927  877 EEEEEEEEEEEEENEEPLSLEWPETRQKQAIYLFLLPIVFpLWLTVPDVrrqeARKFFVITflgsimwiamfsyLMVwwa 956

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818  164 --ITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRD 241
Cdd:TIGR00927  957 hqVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSN 1036

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1772677818  242 VSFYIVDLIMLIIFFLDNVIM---W-WESLLLLTAYFCYVVFMKFNVQVE 287
Cdd:TIGR00927 1037 GLFCAIVLLFLMLLFVISSIAsckWrMNKILGFTMFLLYFVFLIISVMLE 1086
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 502-633 1.60e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 48.25  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772677818 502 TFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGL 580
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1772677818 581 PLPWLLYTVIHRFQ--PVAVSSNGLFCAiVLLFIMLLFVILSIALCkwRMNKILG 633
Cdd:TIGR00845 838 GVAWSIAAIYHAANgtQFKVSPGTLAFS-VTLFTIFAFICIGVLLY--RRRPEIG 889
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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