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Conserved domains on  [gi|1772790774|ref|NP_001362771|]
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acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1 [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 69-285 3.22e-42

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 145.84  E-value: 3.22e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774  69 VASWGWYAGYTVMEWGEDIKaVSKDEAVMLVNHQATGDVCTLMMCLQDKGLVVAQMMWLMDHIFKYTNFGIVSLVHGDFF 148
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPK-LPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774 149 IRQgRSYRDqqLLLLKKHLENNYRSRDRKWIVLFPEGGFL-RKRRETSQAFAKKNNLPFLTNVTLPRSGATKIILNALva 227
Cdd:cd07990    80 LKR-KWEKD--EKTIKRQLKRLKDSPEPFWLLIFPEGTRFtEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETL-- 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1772790774 228 qqkngspaggdakeldskSKGLQWIIDTTIAYPKAEPIDIQTWILGyRKPTVTHVHYR 285
Cdd:cd07990   155 ------------------RDAVDAVYDVTIAYPDGKPPSEQRLLLG-GKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 274-344 5.26e-20

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 83.00  E-value: 5.26e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1772790774 274 YRKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFPPSKGHKEAvSREMTLSNLWI 344
Cdd:pfam16076   4 NGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEHIIP-RRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 69-285 3.22e-42

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 145.84  E-value: 3.22e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774  69 VASWGWYAGYTVMEWGEDIKaVSKDEAVMLVNHQATGDVCTLMMCLQDKGLVVAQMMWLMDHIFKYTNFGIVSLVHGDFF 148
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPK-LPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774 149 IRQgRSYRDqqLLLLKKHLENNYRSRDRKWIVLFPEGGFL-RKRRETSQAFAKKNNLPFLTNVTLPRSGATKIILNALva 227
Cdd:cd07990    80 LKR-KWEKD--EKTIKRQLKRLKDSPEPFWLLIFPEGTRFtEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETL-- 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1772790774 228 qqkngspaggdakeldskSKGLQWIIDTTIAYPKAEPIDIQTWILGyRKPTVTHVHYR 285
Cdd:cd07990   155 ------------------RDAVDAVYDVTIAYPDGKPPSEQRLLLG-GKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 274-344 5.26e-20

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 83.00  E-value: 5.26e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1772790774 274 YRKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFPPSKGHKEAvSREMTLSNLWI 344
Cdd:pfam16076   4 NGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEHIIP-RRLKSLLVFIF 73
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 173-324 1.14e-19

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 89.37  E-value: 1.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774 173 SRDRKWIVLFPEG-GFLRKRRETSQAFAKKNNLPFLTNVTLPRsgaTKIILNALvaQQKNGSpaggdakeLDSkskglqw 251
Cdd:PLN02510  169 PRDPLWLALFPEGtDYTEAKCQRSQKFAAEHGLPILNNVLLPK---TKGFVSCL--QELRCS--------LDA------- 228

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1772790774 252 IIDTTIAYPKAEPIDIQTwILGYrKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFP 324
Cdd:PLN02510  229 VYDVTIGYKHRCPSFLDN-VFGI-DPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFP 299
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 95-192 1.22e-08

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 52.74  E-value: 1.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774   95 AVMLVNHQATGDVCTLMMCLQDKGLVVAQMMWlmDHIFKYTNFGIVSLVHGDFFIRQGRSYRDQQLLLLKKhlennYRSR 174
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAK--KELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAV-----ELLK 73

                           90
                   ....*....|....*...
gi 1772790774  175 DRKWIVLFPEGGFLRKRR 192
Cdd:smart00563  74 EGEWLLIFPEGTRSRPGK 91
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 69-285 3.22e-42

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 145.84  E-value: 3.22e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774  69 VASWGWYAGYTVMEWGEDIKaVSKDEAVMLVNHQATGDVCTLMMCLQDKGLVVAQMMWLMDHIFKYTNFGIVSLVHGDFF 148
Cdd:cd07990     1 VFLFEWLSGVKVVVYGDEPK-LPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774 149 IRQgRSYRDqqLLLLKKHLENNYRSRDRKWIVLFPEGGFL-RKRRETSQAFAKKNNLPFLTNVTLPRSGATKIILNALva 227
Cdd:cd07990    80 LKR-KWEKD--EKTIKRQLKRLKDSPEPFWLLIFPEGTRFtEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETL-- 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1772790774 228 qqkngspaggdakeldskSKGLQWIIDTTIAYPKAEPIDIQTWILGyRKPTVTHVHYR 285
Cdd:cd07990   155 ------------------RDAVDAVYDVTIAYPDGKPPSEQRLLLG-GKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 274-344 5.26e-20

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 83.00  E-value: 5.26e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1772790774 274 YRKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFPPSKGHKEAvSREMTLSNLWI 344
Cdd:pfam16076   4 NGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEHIIP-RRLKSLLVFIF 73
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 173-324 1.14e-19

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 89.37  E-value: 1.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774 173 SRDRKWIVLFPEG-GFLRKRRETSQAFAKKNNLPFLTNVTLPRsgaTKIILNALvaQQKNGSpaggdakeLDSkskglqw 251
Cdd:PLN02510  169 PRDPLWLALFPEGtDYTEAKCQRSQKFAAEHGLPILNNVLLPK---TKGFVSCL--QELRCS--------LDA------- 228

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1772790774 252 IIDTTIAYPKAEPIDIQTwILGYrKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFP 324
Cdd:PLN02510  229 VYDVTIGYKHRCPSFLDN-VFGI-DPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFP 299
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 178-324 3.03e-12

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 67.07  E-value: 3.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774 178 WIVLFPEGG-FLRKRRETSQAFAKKNNLPFLTNVTLPRsgaTKIILNAlVAQQKNGSPAggdakeldskskglqwIIDTT 256
Cdd:PLN02380  166 WLALFVEGTrFTQAKLLAAQEYAASRGLPVPRNVLIPR---TKGFVSA-VSNMRSFVPA----------------IYDVT 225

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1772790774 257 IAYPKAEPIDIQTWILGyRKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFP 324
Cdd:PLN02380  226 VAVPKGQPAPTMLRIFR-GQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKHFAEDTFG 292
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 95-192 1.22e-08

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 52.74  E-value: 1.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1772790774   95 AVMLVNHQATGDVCTLMMCLQDKGLVVAQMMWlmDHIFKYTNFGIVSLVHGDFFIRQGRSYRDQQLLLLKKhlennYRSR 174
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAK--KELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAV-----ELLK 73

                           90
                   ....*....|....*...
gi 1772790774  175 DRKWIVLFPEGGFLRKRR 192
Cdd:smart00563  74 EGEWLLIFPEGTRSRPGK 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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