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Conserved domains on  [gi|1771661286|ref|NP_001362575|]
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interferon-induced protein 44-like isoform 1 [Homo sapiens]

Protein Classification

GTPase domain-containing protein( domain architecture ID 10096372)

GTPase domain-containing protein with a Ras-like GTPase domain, similar to human interferon-induced protein 44-like, which exhibits antiviral activity against hepatitis C virus, and ciliogenesis and planar polarity effector 2, which plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes

Gene Ontology:  GO:0005525|GO:0003924
PubMed:  15731001|11152757

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 201-286 3.25e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


:

Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 41.29  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661286 201 LLVGPVGSGKSSFFNsvkSIFHGHVTgqavVGSDITSITERYRIYSVKDGKNGKslPFMLCDTMGLDGAEGAGLcMDDIP 280
Cdd:cd00882     1 VVVGRGGVGKSSLLN---ALLGGEVG----EVSDVPGTTRDPDVYVKELDKGKV--KLVLVDTPGLDEFGGLGR-EELAR 70


                  ....*.
gi 1771661286 281 HILKGC 286
Cdd:cd00882    71 LLLRGA 76
 
Name Accession Description Interval E-value
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 201-286 3.25e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 41.29  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661286 201 LLVGPVGSGKSSFFNsvkSIFHGHVTgqavVGSDITSITERYRIYSVKDGKNGKslPFMLCDTMGLDGAEGAGLcMDDIP 280
Cdd:cd00882     1 VVVGRGGVGKSSLLN---ALLGGEVG----EVSDVPGTTRDPDVYVKELDKGKV--KLVLVDTPGLDEFGGLGR-EELAR 70


                  ....*.
gi 1771661286 281 HILKGC 286
Cdd:cd00882    71 LLLRGA 76
CDC3 COG5019
Septin family protein [Cell cycle control, cell division, chromosome partitioning, ...
 198-323 6.00e-03

Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 227352 [Multi-domain]  Cd Length: 373  Bit Score: 38.84  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661286 198 IRILLVGPVGSGKSSFFNSVKSIFHGHVTGQAVVGSDITSITERYRIYSVKDGKNGKSLPFMLCDTMGldgaEGAGL--- 274
Cdd:COG5019    24 FTIMVVGESGLGKTTFINTLFGTSLVDETEIDDIRAEGTSPTLEIKITKAELEEDGFHLNLTVIDTPG----FGDFIdns 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1771661286 275 -CMDDIPHILKGcMPDRYQFNSRKPitpehstfITSPSLKD-RIHCVAYVL 323
Cdd:COG5019   100 kCWEPIVDYIDD-QFDQYLDEEQKI--------KRNPKFKDtRVHACLYFI 141
 
Name Accession Description Interval E-value
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 201-286 3.25e-04

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 41.29  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661286 201 LLVGPVGSGKSSFFNsvkSIFHGHVTgqavVGSDITSITERYRIYSVKDGKNGKslPFMLCDTMGLDGAEGAGLcMDDIP 280
Cdd:cd00882     1 VVVGRGGVGKSSLLN---ALLGGEVG----EVSDVPGTTRDPDVYVKELDKGKV--KLVLVDTPGLDEFGGLGR-EELAR 70


                  ....*.
gi 1771661286 281 HILKGC 286
Cdd:cd00882    71 LLLRGA 76
CDC3 COG5019
Septin family protein [Cell cycle control, cell division, chromosome partitioning, ...
 198-323 6.00e-03

Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 227352 [Multi-domain]  Cd Length: 373  Bit Score: 38.84  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1771661286 198 IRILLVGPVGSGKSSFFNSVKSIFHGHVTGQAVVGSDITSITERYRIYSVKDGKNGKSLPFMLCDTMGldgaEGAGL--- 274
Cdd:COG5019    24 FTIMVVGESGLGKTTFINTLFGTSLVDETEIDDIRAEGTSPTLEIKITKAELEEDGFHLNLTVIDTPG----FGDFIdns 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1771661286 275 -CMDDIPHILKGcMPDRYQFNSRKPitpehstfITSPSLKD-RIHCVAYVL 323
Cdd:COG5019   100 kCWEPIVDYIDD-QFDQYLDEEQKI--------KRNPKFKDtRVHACLYFI 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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